LOCUS       XM_017002064           20549 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript
            variant X6, mRNA.
ACCESSION   XM_017002064
VERSION     XM_017002064.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017002064.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..20549
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 11 ESTs, 478 long SRA reads, 2 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     CDS             309..2567
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform X6"
                     /protein_id="XP_016857553.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSA
                     AALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGS
                     SSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCI
                     HQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHR
                     WQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAQLEQIQKELSVLEEDIKRVEEM
                     SGLYSPVSEDSTVPQFEAPSPSHSLEFSSDMHRIFVNGILIISIIDSTEYSQPPGFSG
                     SSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLS
                     KFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQ
                     DAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHE
                     KRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHL
                     AFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGK
                     PYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVL
                     DKDRKEDDTNEFVSAVCWRALPDGYPRIAWEKQRSHLCHIQSWSHRWKFRSAKVFPTV
                     AAANLFFLYRSD"
     polyA_site      20549
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gctcgcgcgc gcgcgcacgg ccggccacgg cgcgccgggg ttggctgcta cagggaccgc
       61 ggtggcggcg gcggcctcga cagcggtagt gccttctact ccgctttttt agtttcctcc
      121 gccccctccc gtgggacgct gttgtgtggc tgccttaaaa aaaaacgcaa ctttattgtt
      181 cctcagcccc acctccggct cggcgggcgt cctcaggatg cactgaggct gaggggaggg
      241 gaggcggcgg agggtcgagg tcgcggtccc tctcctccga gcgcccggct ggaggggagg
      301 gagtcacgat gtctggtagc cgccaggccg ggtcgggctc cgctgggaca agccccgggt
      361 cctcggcggc ctcctcggtg acttccgcct cctcgtcttt atcctcttcc ccgtcgccgc
      421 cttccgtggc ggtttcggcg gcagcgctgg tgtccggcgg ggtggcccag gccgccggct
      481 cgggcggcct cgggggcccg gtgcggcctg tgttggtggc gcccgccgta tcgggtagcg
      541 gcggcggggc ggtgtccacg ggcctgtccc ggcacagctg cgcggccagg cccagcgccg
      601 gcgtaggagg cagcagctcc agcctaggca gcggcagcag gaagcgacct ctcctcgccc
      661 ccctctgcaa cgggctcatc aactcctacg aggacaaaag caacgacttc gtatgcccca
      721 tctgctttga tatgattgaa gaagcataca tgacaaaatg tggccacagc ttttgctaca
      781 agtgtattca tcagagtttg gaggacaata atagatgtcc caagtgtaac tatgttgtgg
      841 acaatattga ccatctgtat cctaatttct tggtgaatga actcattctt aaacagaagc
      901 aaagatttga ggaaaagagg ttcaaattgg accactcagt gagtagcacc aatggccaca
      961 ggtggcagat atttcaagat tggttgggaa ctgaccaaga taaccttgat ttggccaatg
     1021 tcaatcttat gttggagtta ctagtgcaga agaagaaaca actggaagca caactggaac
     1081 agatccagaa ggagctaagt gttttggaag aggatattaa gagagtggaa gaaatgagtg
     1141 gcttatactc tcctgtcagt gaggatagca cagtgcctca atttgaagct ccttctccat
     1201 cacacagcct tgaattcagt tctgatatgc acaggatctt tgtcaatgga atacttatta
     1261 ttagtattat tgattccaca gaatacagcc aacctccagg tttcagtggc agttctcaga
     1321 caaagaaaca gccttggtat aatagcacgt tagcatcaag acgaaaacga cttactgctc
     1381 attttgaaga cttggagcag tgttactttt ctacaaggat gtctcgtatc tcagatgaca
     1441 gtcgaactgc aagccagttg gatgaatttc aggaatgctt gtccaagttt actcgatata
     1501 attcagtacg acctttagcc acattgtcat atgctagtga tctctataat ggttccagta
     1561 tagtctctag tattgaattt gaccgggatt gtgactattt tgcgattgct ggagttacaa
     1621 agaagattaa agtctatgaa tatgacactg tcatccagga tgcagtggat attcattacc
     1681 ctgagaatga aatgacctgc aattcgaaaa tcagctgtat cagttggagt agttaccata
     1741 agaacctgtt agctagcagt gattatgaag gcactgttat tttatgggat ggattcacag
     1801 gacagaggtc aaaggtctat caggagcatg agaagaggtg ttggagtgtt gactttaatt
     1861 tgatggatcc taaactcttg gcttcaggtt ctgatgatgc aaaagtgaag ctgtggtcta
     1921 ccaatctaga caactcagtg gcaagcattg aggcaaaggc taatgtgtgc tgtgttaaat
     1981 tcagcccctc ttccagatac catttggctt tcggctgtgc agatcactgt gtccactact
     2041 atgatcttcg taacactaaa cagccaatca tggtattcaa aggacaccgt aaagcagtct
     2101 cttatgcaaa gtttgtgagt ggtgaggaaa ttgtctctgc ctcaacagac agtcagctaa
     2161 aactgtggaa tgtagggaaa ccatactgcc tacgttcctt caagggtcat atcaatgaaa
     2221 aaaactttgt aggcctggct tccaatggag attatatagc ttgtggaagt gaaaataact
     2281 ctctctacct gtactataaa ggactttcta agactttgct aacttttaag tttgatacag
     2341 tcaaaagtgt tctcgacaaa gaccgaaaag aagatgatac aaatgaattt gttagtgctg
     2401 tgtgctggag ggcactacca gatgggtatc ctagaattgc atgggagaag caaagatccc
     2461 atctctgtca catccaatct tggagccacc ggtggaaatt tagaagtgcc aaagtgtttc
     2521 caacagtcgc tgccgcaaac ctattctttc tttacaggag tgattaggta ctgtctcaaa
     2581 ccctcctgag tgccacatca ggaggctctc tatggtctgt tggtcacttt ggaagatgta
     2641 gagactaaat ccaagggaga cattagataa taagccaggg ttctcatcag tctcctcagt
     2701 agcaaaagca aaggctagaa cattctggta gtgctcatta ttaattggaa cattacagct
     2761 ggagtcaaag atctgcctcc tgaaaggtac tgtgttctga tgtttacagc caaattccat
     2821 taaacattga ctgatttatt acaatggata caactcagaa atagctcatg ggaagagatg
     2881 catagggcaa ggtattggag agtggcgggt ggagtacaca gaataggtct gtgctggtga
     2941 ctcttggaaa cactttggca ttttcttccc agatgggtac cctcctagta cctcaatgtt
     3001 ttcaccaacc tggaggccct ggaacctcca ttttcaacaa actccctttg ggatttatat
     3061 ataataaaat gctataaaat atcagttttt gagctctttt ctgtttgtat atttgcttaa
     3121 taagaatttg ctaaatgaat aaattttatc tgattaagtt ttcaaggacc caaatgacca
     3181 aaataagaac ttactgtaag actcaaaata taacaaatga ggttaattta aatcaggcag
     3241 tgagtttttg gagaatatgt tctgtacaac aaaaaaaaag ttactacaaa atacccttcc
     3301 aactttgaca tattaacatc cttatttcct tctggcttta tcagtctttc taagtcattt
     3361 aagtctaaaa ccccagaatc attattgttg catctcttta ttttccatct aattattcat
     3421 caaatagcag taatgctttc tttgaaatgt cttctatata tctttgtttt cgtttctgct
     3481 tttcatctcc tcatttctgt tccttcccct tccccttctc tcgatttact tctaacagct
     3541 ttatgtccct ttcagtcggc ctttatgcac taccaaatat tcatctttat acagagataa
     3601 tcaatcaaac attgcttgtt acctttagtt gacccaggtc tttcagaaaa gtttttttca
     3661 aattcagcat ttgcatgtac ctctatctgg tatattttgg ccaacactaa aaataagggg
     3721 aaattttgat aaatatatta cctgaacttg ttagttattt aatctatttc acttcagata
     3781 tctgtatcta attttaaaat tatatttacc cttactatta aatatgatcc ttaagaaaat
     3841 tataggaaaa agtacaatag aaaaaaatac tcaaaggtaa ctcagatttc aaaatttact
     3901 agtatttaga aaattagcct ttataataag tatagaacaa tgtcgttcct atatctactt
     3961 cttaactgct ctatttcctg atctcatgtg tttgcactta gactatcgta tctaaactat
     4021 tacattcaag attttcaata atctaatata atgctatcca tctaacttta tttctgtttt
     4081 ctaacacagt tcacctactt cattaagaaa gtttcttcat tgtcccatac tattcccatt
     4141 ccggcttcta aactcgtatt catgttgttc ttcatattgc cttatcctct tatttctgct
     4201 taactaagtt ctcatcattt tttagcccaa tcactgcttc tctttccctc ttttaaccat
     4261 tttatctcct tggtttctgg tttctcacag ctattgatga acctatagaa tgcagtctac
     4321 caactgatgt tcacattcat cttgaattgt ttgttatgct tcattagtgt tgccccaggt
     4381 acattccttg cttcaacttg gagagcaaaa aaatacaaac accagcagct accagagtaa
     4441 gagctactta gttttctagg aaagaggagt taaagattga gtgagaataa aatttaagtc
     4501 tgcctaaccc agagagccta cttttatcaa tttcataaga tcataaatat actgactaga
     4561 ataatacact agtattatta ctactagtac actgtgatac tgacagtact aatatgatac
     4621 taatagtact atcattgctt gagataacta ccctttaact gtaaagaaat taaggttata
     4681 tagtatttta gtaaaagcaa ctaccattca tttgtttagt gcctatagtg tgccagttac
     4741 tctttggtta catgctgtaa gggagaaaag atttttctca cctgttggct tgattcatga
     4801 cggagacctc tgtaagtttt acatgacata gaagttttac gtgacacaga aggcttcaga
     4861 aatgaagacc caaagaatgg gtaaacttgt atatgtttat gcttaggttt gatgaagaaa
     4921 tgaatagtct catggagaag tatgattgga ggacaaaggg gtatgatcta atggtaataa
     4981 actgggggca acttagcaag acctgtttgt tgagcttctt ctctgtgtct ctgtctccag
     5041 agataagggc attcctttcc tcaggtaagg ataggcaact ctggaatgag agtcttatga
     5101 cctgcttcag tggaagggca gagaattctt ttatgacctg cttcagagga gaagtgtggg
     5161 agaaggtctt cctgcttctg ctgttttttc aaataccaag gtgactattt ggaggtagtg
     5221 tgttctggtc cctaacaatg ctctactgtg ttttccttga atcttcatac agattctacc
     5281 taagagtatc tgctttatat ttggagaaat tgaatgtcta aaaggattaa gcagaaccaa
     5341 aattcagatc caggtttcca tgccttgaat gtattgcttt ttctgttaac atggtattcc
     5401 ccaaatagta ctgaattcta gaatcagctt taccagagta gtctggagga aatttgcgaa
     5461 tagctctctt aaatatgcac ggttctatgc tcagaggagc tcttctcagt attaatcagc
     5521 aatccagtca tttttttccc ctcatacttg tcattgtaag cacatttttc tcaagcttta
     5581 ctcagaagat catccagaga tattaactgt taacatgtgc tgcaagttga aagtgtttag
     5641 agagaatatt tgagtgcagt gtgacaagga taatcaagtt gtttagggcc agttggcgag
     5701 aagactttgg aaagcattga gaaaggaatg atgaatgtat gtgttgtttt gtatctaaat
     5761 ccttcttccc ttgtgtatgt tcttcacagc cttttctccc tgaataagga tcactttgac
     5821 tttgtatgct aagtgtgcct tcttaatggt tcttttcctg ttatctgaat cctgaagtat
     5881 atttaaatga gaatttgatg cagttagtta attggaatat aaaagactgg ttaacaaaag
     5941 tcttcttaat aatgaagcac accagaaatg gaagctgctg gaaccagcca tgtggacaaa
     6001 tgaaaaaatg ccttttgtct acagattgca gcgatcctac ataaatatat ggaggtctct
     6061 gtctggctta ggacagctgg ctaagtctga tcgttcccct ccgtacagcc tttaaaactg
     6121 ccactctaaa tacttggttt ccttgccatt ttattcagta tctgctggtt atgagtactg
     6181 tattattttt taaatgggca accaagtaaa gttacctctg tatccgtctg aactggtttt
     6241 tgaggtatct tacgagtttt gaaaataggt gttatttgct tatttaagga acctacaacc
     6301 aggaagtaga atgaatgtgg aaatattatt cttctcttgc cgagcatggt ggctcacacc
     6361 tgtaatccca gcactttggg aggttgaggc agatggatca ctgaatgtca ggagttcaag
     6421 accagcctgg caccaacata gtgaaatcct gtctctactg aaaacacaaa aattagccag
     6481 gtgtgttggc aggcgcctgt aatcccagct acttgagagg ctgagacagg agaatcacat
     6541 gaacctggga ggcgaaggtt gcagtgagct gcgattgtgc cattgcactc taggctaggt
     6601 gacggtgcga gactccatct caaaaaaaaa agaaaaaaga aatattattc ttctaagggg
     6661 ccacattggc ttaacgaatt cagggttacc agtgaaggtc aatactttag atatgaagga
     6721 gctaatcaga gatagcttcc gtgaagattt tctcattaag aaagtgattt ctccaaaatc
     6781 cagtttatgt aattttttaa ggctgtaacc aaagttcaga aataaccatt tgcagaggaa
     6841 agctgctgct aagtattaac cttcttagta ctgaattcaa aatcttggtt tttcctgttg
     6901 tgtgttttgc tgttaagttg tggggagagg ttgctcccac ctacctcccc taacttctac
     6961 aacttacagc agccacagct gggtttgttt gtttgtttgt ttgtttgttt gtttgttttt
     7021 tgagactgag tctcactgtg tcacccaggt tggagtgcag tggcataatc tcagctcact
     7081 gcaacccctg cctcctgggt tcaagcaatt ctcatgcctc agcctcctga gtagctggaa
     7141 ttacagggga ccaccatgcc tggctaattt ttgtattttt agtagagatg agctttcaac
     7201 ggcgcggtgg ctcacgccag tagtcccatc actttgggag gctgaggcgg gtggatcacc
     7261 tgaggtcagg agtttaatac cagcctgggt ttatttataa ctaattgtat gaggatcctt
     7321 gtttgtggtt ctgaaatccc atatttctta ccctgagcag tttttgcatt agacagttgt
     7381 caaatgagta gccatacttt tctaggccct ttagaaatcc actgttctgt tcattctaat
     7441 gaacgatttt aagattttgt aaggaaggat actagtggag aagaaagaag agatttggga
     7501 ttaactgatt ttgaaagtgt tcctttgtga tgaagaaatc ccaattcccc agatctcaaa
     7561 ttgggatttt gtgtatgggg ggtggaagat tggaaggaga gtgggaattt ggcctgtcaa
     7621 tgccatgtat gttgactttg gaacactctt taccactttg gttctgtggc caagcctttt
     7681 cctctgttga tattacttga aataatactt atagggagat atataaaaga ccaaattttc
     7741 catgtaacaa ggcttttagg agcctaggtt tatgacattt gaaatgtaat gtatatttat
     7801 aatgtatgag aactgaggct ctcttgtaca tagtcagtga ccacccaaga cacctttctt
     7861 ctttcttcca ttttgcttta ataaattcag gatgaagccc agacatgtga taagcttact
     7921 gggtcaatat gatacagatc agcattggta tatttctcag ttttcacaag ttgattcctg
     7981 gctttgctct ttcttagctg tgtgtatgaa tttggacaag ttattaagtc taagactatg
     8041 tttactcttt gtaaattgat gataaaaata gtaccttcct cattgggttg ccatgcagat
     8101 taagtgaagt aatccatata aaattcttaa ctaagtcact gacctatagt gctcaataaa
     8161 tatgtgataa tgaaacaggt ttttaagtgt ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     8221 gtgtgtattg caaacacaat tcagacagct aattcactca acccccttgg attttttata
     8281 gaatgcaggg aaggctaact aacattttag tttaaagacc aagacctttt attgatagat
     8341 tgtagttttg tgttcattct ttcttagaca tatttatata tatttttacc aagtcaactc
     8401 tgaaagacca catactgaaa gaaaagtcag ggacaaaaag aaactattag gcttacaaat
     8461 ggcatttaaa aacctttgaa gatgatattg gaacctatgt ttgaatgtct ttgtatggac
     8521 tctcacttgg tttcaaaatg cagcgtagat ttatgtctag gataaagtaa agaaacactc
     8581 cggtcaaata aggggattct tatgatgaat caaacccaga taagtggctg ggtgcggtgg
     8641 ctcacgcttg taatcccaac actttaggag gctgaggcgg gtgggtcacg aggtcaggag
     8701 ttcgagacca gcctgaccaa catgatgaaa ccccgtctcc aaatacaaaa attagctggg
     8761 tttggtggca cgcacatgta atcccagcta ctcaggaggc tgaagcagga ggatcacttg
     8821 aacccgggaa gcggaggttg cagtgagccg agactgcacc actgcagtcc agcctgagcg
     8881 acagagcgag actccatctc aaaaacaaac aaacaaacaa aaacaaaaca aaaaaaaaac
     8941 ccagataagt gaaatgaatt tctctgagct ccaaaaacaa aagaaatttg aattttaaaa
     9001 gatgtactag aaagtgcttt aaataaaaga atgattctgc gtgtcaggaa atcaacagtg
     9061 gcccaatagg atgaagtaac aaaatgtcag cacgagtgat gaaattggac aattgaatag
     9121 tatcacttaa caaggcgttg aacaaagaaa aatttaagaa tccctatatc ttatatctgt
     9181 atttcttctc aagggcaagg gagaggatgt tcataaggca actatagatc atgcatcaaa
     9241 agaagggcaa atttatttga aattgttctg tggctgtagg atcctgagtg aaaatcagat
     9301 ttgactatac acagagtcca tgacctccta catgaggaga gaagctattt tagttttcag
     9361 gatgcaattg cagtacaaat agtaacagcc caccctgaag acagaaaaaa aaaatggagc
     9421 aaaagcccat tcttttatgt ttataatctt ggtatgaaaa agagcttaag gcaggtatgg
     9481 tcttttattt tcagtgacat gaaatcatct ttgtatgagt gcaaattaac actctctttt
     9541 ctggcaatga gaaaacaaga catttgtgtt cataaagaga atgcctttgt ccaaataaga
     9601 caagaggctc ttatggagag aatattaagg aattaacaga tatagtatag attgtgagtt
     9661 tttttgtgtg aagcctagtt acctcaaatt tttattcttt atatttactt aaggaaggat
     9721 atttaaattc agccatgttt ctcactgttc tgtgccctcc agggagctgt atttgcagat
     9781 actgtatgtt gttcatagtg atttaccatt tccatttaat caaatgcttg ttaaaggact
     9841 taaatggaca tacaatttaa acttagtggg cacactttaa gaagaaaatt cagtgattat
     9901 aggacaaatt gtttaaggca gaactgctta taactttgct agccatctca gctgcagttt
     9961 ctgcttttag aggacaaatg taaatagtat ttcagtgtac tttacatttt ctgtgtcact
    10021 aatagtgttc taccacttga aaggggaact aaaattaaaa atcatcttct gggctttttt
    10081 tccccagtaa aattttcaag gaacttacct tcctttgtca tgaagttgtt ttaggggaga
    10141 aaacatttct gatttttgtt ggcttttttt tgtttttgtt ttgtttttag atccttattt
    10201 agcaaggtta tgcttttaaa catctaaggg tagagggtgg gatatgtgtc atttattacc
    10261 ttctgtcttg gggtaatgtt ctgattgaga gtgctggagc caagttgcca ggtttgcctc
    10321 ctatcaccat taagtattag ctgtaagact ttgggaaagt tatttaacct ttctgtgcct
    10381 cagtttcctc ttctgtgaaa ttagattaat agtatcttgc atgtaatatt ctgaaataaa
    10441 attagaaaat acatggaaag tactaagaaa atagttggca caagataaat gatcaatcag
    10501 taaatgttgc tgtcatcttt aacattttat atacgaatcc acataactgg acaactgtac
    10561 ttgtttttag ttcatcaaat attgtgcaat atgaaaatat attctctgca tttaagtgat
    10621 ttacaaccta gtaaatagaa atattcataa ataactatag tatgaaccca aatgaaagaa
    10681 atctttataa gatcattacc cctgaaatta ttgaccctag agggaagacg ttacttctaa
    10741 cttggagaat gatggaatac tttatgaaga taggggcttt tgagctgggc ttcataaaga
    10801 tataaagggt ttcagaagtc taaagacaaa gggaaaggaa ggtacctgga caaaagacca
    10861 taaacaaaca catctattaa gtaccaacca ggcagtatac taagtgctat cttaatttaa
    10921 aatcatcatc atcaatcttt taaggcatat atgcttgagt tcctttaaaa gtgaaattga
    10981 cgctcagatt tgcccaagat tacacagcta aataagggat acagttggaa ttagaaccca
    11041 ggtcgggctg gctgtaaaac gtacaccctt tctgctatac tgcagaaagc tagagaacag
    11101 tgtaaacaaa ggcgcagatg agggaaagtg caatagatgt ttaagaaact tctaataaag
    11161 tgtctaagta ggatggtgga gtagggactt tattgagaga tgaggccaga gagtgtgcta
    11221 gatattatag tcttgaatgc catactgaga gaaaaaaaaa aagtttagac cttcttctgt
    11281 aggcattaaa tgcctaaagc ccactgtgaa gataatccca tgagagtatt atcatagcag
    11341 tgggtatagt gcattgtaat gagagattaa aagtagagag tctactcagg taggttatta
    11401 aataatttaa ttattcaggg tttttttttt ctgtgttcag tttccttctg gggaataaga
    11461 ataacagaaa acacccacat gtaacattca tgtttttcaa gatgttaagt ttgccctcac
    11521 atattaaaaa aaatgtttat ttgacgatgt ttcattatat tcacttcaaa caataaatct
    11581 tgaactatgt ttgcggatat aatcattaac ttctaccttc tagtacacaa cttaattttt
    11641 tttctgcttt tccaagaatt cacttattta acttaacaca tgtgaattga agagttttgt
    11701 taagagatag gattaaagga gatgactcta ggtgcccagg gagggggagg tgcggtgaga
    11761 gatggctgaa ggaatagaac actggtggga agcaaagttc ttttctaccc tcttaggttc
    11821 tctggctagg tctgtgaaat aaactgacaa ctgatggatt aacagaaaag gcatacaaat
    11881 ttatttgata ttcaaagttt tacatgaatc agctgccagg ggtgggttgg aatagtgggg
    11941 gatatctcgt agaaagaaaa cccccaatga aaaggctcgg tttggaggtt tttataccat
    12001 ttagacaaga agacaaattt aaagggaagc gacaagacaa aggaaaggga ctttgagctt
    12061 ctaggagtga tgaacaatag gaaggcaaat attaatatat aagaaactaa tggtagataa
    12121 gggctagtta gtgaggtttg tgcagatttt ttctcagtac catctcatct ttggtaataa
    12181 taataaggtt gttatccctt tcctggtaca ggaagtaact ggggtacagg gaattcctct
    12241 ctttcacaag aggaatttat tgtctgtttt caggcagata gaaggagagc agaaagctct
    12301 cctcagttgc tttcagctca aaataatctt tccaccagag tagcatattt tgggatggca
    12361 tattctgatc tacaacacca aagaaaaact gctcctatct attttttgca taaaggcagt
    12421 cactgacttt tgttatccat aaataaaatt cacagataaa ttaatcttac ttattttcta
    12481 accctggtat gctacagttt acatgcttac cccacctcat attttcatct cgttaactaa
    12541 tacataagct gctttctcca cacaatttgt catcattcca aaaccatttt tttttttcaa
    12601 atttattcca tgtgcatgac cgtgtccctt tgcctaacat atccatcttt tctcctgtga
    12661 aatttcaagt tttattcttc cattgttcca tttgtgacct aatctgtgaa gcctttctta
    12721 tcttttccaa gtaaaggatc actctcttct tacttcttca gttgcccctt tgagctctat
    12781 aatatattct tttttttttt tttttttttt tgagacaggg tctcactctg ttacccaggc
    12841 tggaatgcag tggcccaatt caggcccatt gcagccttga cctcccaggc tcaggtgatc
    12901 ctcccgcctc agcctcccaa agtgctggga ttacaggcat gagccaccac acccagccta
    12961 tttctttctg ttaaaagtcc atttcccctg ttggcctatg gtcttaagat cagacatcat
    13021 gtcttattct cctttgaaat tccaggaccc agcacaatta tctggcatgt gatatctacc
    13081 ctaatggacg gataatgatg gatgaataaa gtggcatgaa attaataaac ttcatgccaa
    13141 agtcactact gtataatgaa acgactgtga tgattgaaag ttattctctc tgtgaatcaa
    13201 tttgggagcg tttctttatg tcttagtcag ggttctccaa agggacagaa gtaataggac
    13261 atgtatagtt agatctatga cagggttttt atttggggta ttagctcaca tgattacaga
    13321 gggtgagaca taccatgata tgccagggag gccagtagca tggcagaatc ttaggctaaa
    13381 ggcctgagaa tttgagggcc cattgatgca agtcccagag tccaaaagct ggagaatctg
    13441 gacttctgat ggccaaggcc aggagaagag tgtcccagct ccaggagaga ggaagcaaat
    13501 tcacctttct gctccctttt tgtctatcca ggcccccagc tgattggatg gtgcctatcc
    13561 acattgaggg ctgaacttcc ccactcagtc aaccgactca cacaccagtc tcttctggaa
    13621 acaccctcac agacttaccc agaagtagtg ctttgccagt tctctaagta tccctttatc
    13681 cagtcaagtt gaaacctaaa attacccatc acactgttac cttggacatc aggagtagct
    13741 ttctggcgaa gcctctgtca aagccagttt ctaatggcta agttagccag ggacttataa
    13801 aggcccttta taatgcaaac ttgaccattt ggtggagttg cttttgatgt taccagtacc
    13861 atctaatgtc caaatccaat aacatattat tactaaacag tcttcatttc ctcatgattt
    13921 ttgacaattt tgacttgctt ctctttctta aactcttctt ttagcctcca taatagtctt
    13981 ctgttttgct tcctgcccct ttgttcattt tgggctcctt tgcttgcctt ccttgaactg
    14041 ctaagccaga agcaattttc cctcacttaa agatcactta taagatacat actttatgcc
    14101 aggcacttat gtatgtgtct gtttgatcat aaaaatggtt ctgttagctt agttttatta
    14161 gcattgtttt atagttatgg agactgagat tcagagaggt caagtaactt gcccataatg
    14221 aaaagtctag aagcgttaga gctttgaatt gaaatctttc agactccaaa gacatttaat
    14281 ctactctgtc actctgtcta tgttttgtcc acctgttaat ttgattttag gaatacagat
    14341 tgtcgtatat aaattctggt ccatttcctc ctgaaaacca gttactggca tttccatgaa
    14401 tatagaaaac tctgtaaaat tgttttttct ataagagaag cctacagacc tctcttaggt
    14461 gatgaagagg cttagaattg aatatcaaat ttggcttgcc acttaaaaca gaatggagtc
    14521 tcaagttgca agtagggttg tttgttaaac ctgaaacaca aaacaagata aagggaggat
    14581 ataaccacca aatagaaaac ttttgactct gtacattttg agaaagccct gaagatgtat
    14641 ttgatctatt atacaattca ggtttacatt aatgatggta atttacctag aaagatttca
    14701 cacctgataa tagtagttga ctctctaggg agatgagaga cactcagttt tcccctactc
    14761 ttttgtactg tgtgaatttt taccacatgt gtatattatc tattcaagtt aaccaataaa
    14821 catatttttc taaataagag aaaggtatct aggtagtcct taagggatcc attatttatt
    14881 atccccattt ttaatccaac catcttgcta aactctctta ttaattttaa ttattcattt
    14941 ctacgttcct tggatttttt tatgcacaca attaattcat ccacaaataa ttaaagttta
    15001 gtgtctgctt ttccagtact tataccttta tatctttatt catttgccgt attttgatgg
    15061 ccagaacatc taatgtaatg ttaaataaaa gtaatggtat ctggcatcgt tgacttgttc
    15121 ctcaccaaag ggaaagcttt taaagatgtt atcattaagt atgtctgctg taagagtttt
    15181 gtagatacat acccttacaa agaagtttcc ttcagttctc aatgtgctga gagttcttac
    15241 cataaatgaa tgctaaagta tattactgct tttttgtacc tatttaacat gatataatat
    15301 ttttctttca aatattgatc tagtaggtga aatttttttt taacctaata ttaaaccaac
    15361 tttacattcg ctggaataag cccaacttgg tcaagattta ttctccttat atattgttaa
    15421 aatcaacttg ctactatttt gtttaggatt ttttcatttg tctttatgaa taacattggc
    15481 ctataatctt ttcctttttt gcattgtcca tgtcaggttt tgatttcatg ggtatattaa
    15541 cttcataaag caaattaagg agttctttcc tcctttgatg tggaaaaatt tgtgtaatac
    15601 gaaattattt ctttcttgaa tattggctga actcgtagat gaagtcatgt aagcctgagg
    15661 tagaaatatt tttgactgtc gatttatgaa tttaatacct gtaggatgat tcttgctttc
    15721 tatttcttct tgattagttg ggtaagtttt tataggaatt tttccacttg gcttaaatat
    15781 taaaatttat taacataaag tcttttcagt ttcttttttc tataacatta tttattctca
    15841 ttctgaggga agtcatcaat ttaacgtaat gcttaacatt tggagaaata aattttaaag
    15901 aagggttata ttctgatttt gtttaatagt tatcttctgg ttaataaaag gaggagaaat
    15961 gtagggtgga aatgcttatc atagtaaata gcaaggttta tatataaaac catctatatt
    16021 gaacagggag agaggaatga caaaaatatt tacctttctt tttgataatt cagtgcctta
    16081 ttttggggga aatatttagc ttcatagctg aaatggcttt gatattatac ctgaatggtt
    16141 acagagatct cataaatata gtagtgataa ggggtttata tattatgttg ggaaatcaga
    16201 aaatatttaa atcatgaata atgactttta attgttaaag accaatattg agtttaaagt
    16261 taacttataa aatacgtatt tgttcttgtg tgtttgttcc cagcttttta aaattgatat
    16321 tattgaaata taatttacat aaatataaac tacatacatt ttaagagtat tcagtgaatt
    16381 tttacaagtg tatacatcag tataactact accttaattc agttataaca acattttcat
    16441 cacccaaaaa gttaccttgt gtcactttgt aatcagtccc ctcccttctc cactacaagc
    16501 tactgctaat ccactttatg ttatcataag ttaagttttg cttattctag gatttcatat
    16561 aacaggaatg atacagtatg taattttttg cacctggctc cttttattta gcatgatact
    16621 ttgaaatgct tgtgttattg cctgtatctg tagttccttc ttattagtaa tccattttat
    16681 aactatgcaa caaattttgt atctattcac caatctttaa tattgccctt gtttccagtt
    16741 ttgaactatt tttaataaag ccgctgtaaa cattcataaa taagtgttta tgtgactata
    16801 taccatcatt tcttttggat aaatacctag gagtggcatt atgagattgt agagtagttg
    16861 taagtttagc cttataagaa actgtcaaac ctttttccat agttgttgta ttacattcat
    16921 tggtcactta acaatgggga tacgttttga gaaatgccat taggtgattt gatttcatca
    16981 ttgcacaaac atcatagagt gtacttccca aacctggatg gtatagccta gtacatacct
    17041 tagctatgtg gtatagcctg ttgctcctag gctacaaatt tgtacagcat gttactacac
    17101 tgaatagtgt aggcagttgt aacacaatgg gatttgtgta tctaaacaca gaaaagctat
    17161 agtaaaaata caatataaaa ggtaaaaaat ggtacacctg cctagggcat taccatgaat
    17221 ggagcttggt ggagtagaag ctgctctcgg tgagtcaggg agtgagtggt gagtgaacgt
    17281 gaagacccag acattattgt acattactgt agactttatc aacactgtat acctaagcta
    17341 cactaattta ttttaaaatg ttttctttct tcaataataa attaactata gtttactgta
    17401 actttttact ttataatttt aatttttttc actttttgac tcttttgtaa taacttttag
    17461 cttaaaacac aaacacattg tacagctgta cagatttttc cttattctgt aagctttctt
    17521 ccatttttaa atgtatttat ttatttttac tttttaaaca ttttttgtta agctcatcaa
    17581 catcactgtc ttctacatct tgtcccatcg gaatgtcttc agggacaata acacacatag
    17641 agctgtcatc tcctatggta acaatgcttt cttctggagt atctcctgaa ggacctgcct
    17701 gagcctattt tacagtaact ttttttgtta ataagtagaa ggagtataat ctaaattaat
    17761 gattaagaag tatagtacaa taatcttatt ggaccaccat catatatgtg acccatcgtt
    17821 gaccaaaatg tcattgtgca gtgcatgact atattttgca ctcctgccag catcctaaaa
    17881 tcattccatt tgttacatat ttttgccaac acttgatatt gtcactttaa gaaaaagatt
    17941 tagttgttct agtaagtgtg gatggtattt taaaattttt gatgaagtcc aatttatcag
    18001 ggtttttttt ttcctttatt gtacatgttt tttgcatcct aaaaaatagt tgccaaccca
    18061 aagattttct ctgatttttt ttcttgaagt tttattgttt cagcttttac atgtatgtct
    18121 tagatctatt tagaattaat tttgggaatg gtatgataga aggattgaag tttacttttt
    18181 tctgtatata cagttgtttt agcacacata tggttgtttc acatacctgc agttgtttca
    18241 acagcatttg taaaaattac tctatttttt ttttaacttg ccaagttgtt ttgaaattca
    18301 gttgattatg gatggatctg tttctggaat ttcttttctg tgcctttgat ttatatgtct
    18361 atcctaataa tactacactg tattgattcc taatgctttt attaacagta gaacttcaaa
    18421 tcatgttgtg taagtcccta gttttatttt ttctttttca aaattatttt aactattata
    18481 atgtctttgc tttttcattt aaatttttga atcactttgc cagtttctac tagaaaagtt
    18541 tgtatgattt taattggaat tgcattgagc ctatagataa tgtaagaaga attggcattg
    18601 tgacactatt gagtctctgg tctatgaaca tggtataact gtcaatttat ttaggtattc
    18661 tttaacatct ctaagcattg tttggtaatt tttagtatgt aggccgtgtg tgtgtgtgtg
    18721 tgtgtgtgtg tgtgtgtgtg gtttgtctct aaatgattca tgctttttat ggtactataa
    18781 atggtatttt ttaaattcta tttgcttatc atttattgtt agtttatgga agtgaactga
    18841 ttttggtata attgactttg tgtctgacaa tcttgctgaa gacaatttat ttattctagt
    18901 ggcttatttt taaggtacat taggattttc cacataggcc atcatctctt ttgcaaatga
    18961 agacagtttt cttttttcag atccatatgc tttttccttt tcttgactgt cgcactgggt
    19021 tgtacctcta atacagtgtt gaatacaaat ggtgagagaa agcatgttca ccttgttcct
    19081 agtctgagag agaaagggtt cagtatttca ccactaagta tgatgttagt tgtaagtttt
    19141 tcataggtat tccttatcac cttgaagaag ttcctttcta ttcttagttt gctgaaggga
    19201 tgatgaatgc tctcaagtgc attttctgtg ttgtgattac attacttttt cttttttttg
    19261 ttttgaggca gggtctcact cctgtcaccc aggcgagagt acagtgacac aatcacagct
    19321 cactacagcc ttcccaggct caggtgattc tcccacctca accttctggg tagctgggac
    19381 tacaggtgca tgccaccaca cccatctaat tttttgtgtt tttgatagag agggtttcgc
    19441 catattgccc aggctggtct cacactcctg gactcaagca atccacctgc cttagcttcc
    19501 cagagtgcta tcacaggcat gagccaccct acctggcctt ttctattctc tttacatagt
    19561 gaattatata tatatatttt ttaatgttga aaaccaattt taatatctgg atgaattcca
    19621 tttagacatg atgcattatt ctttttgtat atgactgaat tatctttact tgtattttgt
    19681 taaggttttt tacatctgtt tataaaagta gttggtaatt ttatttgttt ttgtaatgtc
    19741 tttctctggt tttgtttgat ttacaagctg agtttggaaa tgttccttag tcttcatttt
    19801 taacaacttt ttctttcttc tgtcataatt gggaatttgt atctttcata gaatttgttc
    19861 atttcattac ctgtcagttt tattgacata caattgttca tgtttatttt ctaattattc
    19921 ttttaatatc tatagaatat ctagtgatat cccataattt attactgata ttgttaactt
    19981 acattttctt tttgttaagg cgtatcaatt ttattgattt ttttcaatga attaactttt
    20041 catttcaata cttttttacc tttttctggt tttattttga tttctgctct tcatgactgt
    20101 cattcttgta cttacgtcat gtgtaacttg ctcttttcct agcttcttaa ggtgcaagtt
    20161 actatatcat taatgttcaa ccttcctgct ttactaataa gtattggaag ctataacttt
    20221 ctaggcattg ttttaggtgc attacacaaa ttttgatatg ttgcattttt attatctttt
    20281 agttcaaaat ggtttctcat ttccatccct gggttatttg ggagtatatt tttaaatttg
    20341 caaatacttg tggatttttc cagatttctt tttgttattc ttttctactt tagttctgtt
    20401 tcttcagaga acatacttgt atgattttag ccctttaaat ttactgtgat ttgttttatg
    20461 gtctgacaca tctttgttgg ggactagtac gcatgcattt gaaaagaatg tgtattctgt
    20521 catttaaata aaactttctg taaatgtca
//
