LOCUS       XM_017002061           20564 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript
            variant X3, mRNA.
ACCESSION   XM_017002061
VERSION     XM_017002061.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017002061.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..20564
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 20 ESTs, 586 long SRA reads, 6 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 9 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     CDS             309..2582
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform X3"
                     /protein_id="XP_016857550.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSA
                     AALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGS
                     SSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCI
                     HQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHR
                     WQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKR
                     EQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQP
                     PGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEF
                     QECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEY
                     DTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV
                     YQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPS
                     SRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKL
                     WNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT
                     VKSVLDKDRKEDDTNEFVSAVCWRALPDGYPRIAWEKQRSHLCHIQSWSHRWKFRSAK
                     VFPTVAAANLFFLYRSD"
     polyA_site      20564
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gctcgcgcgc gcgcgcacgg ccggccacgg cgcgccgggg ttggctgcta cagggaccgc
       61 ggtggcggcg gcggcctcga cagcggtagt gccttctact ccgctttttt agtttcctcc
      121 gccccctccc gtgggacgct gttgtgtggc tgccttaaaa aaaaacgcaa ctttattgtt
      181 cctcagcccc acctccggct cggcgggcgt cctcaggatg cactgaggct gaggggaggg
      241 gaggcggcgg agggtcgagg tcgcggtccc tctcctccga gcgcccggct ggaggggagg
      301 gagtcacgat gtctggtagc cgccaggccg ggtcgggctc cgctgggaca agccccgggt
      361 cctcggcggc ctcctcggtg acttccgcct cctcgtcttt atcctcttcc ccgtcgccgc
      421 cttccgtggc ggtttcggcg gcagcgctgg tgtccggcgg ggtggcccag gccgccggct
      481 cgggcggcct cgggggcccg gtgcggcctg tgttggtggc gcccgccgta tcgggtagcg
      541 gcggcggggc ggtgtccacg ggcctgtccc ggcacagctg cgcggccagg cccagcgccg
      601 gcgtaggagg cagcagctcc agcctaggca gcggcagcag gaagcgacct ctcctcgccc
      661 ccctctgcaa cgggctcatc aactcctacg aggacaaaag caacgacttc gtatgcccca
      721 tctgctttga tatgattgaa gaagcataca tgacaaaatg tggccacagc ttttgctaca
      781 agtgtattca tcagagtttg gaggacaata atagatgtcc caagtgtaac tatgttgtgg
      841 acaatattga ccatctgtat cctaatttct tggtgaatga actcattctt aaacagaagc
      901 aaagatttga ggaaaagagg ttcaaattgg accactcagt gagtagcacc aatggccaca
      961 ggtggcagat atttcaagat tggttgggaa ctgaccaaga taaccttgat ttggccaatg
     1021 tcaatcttat gttggagtta ctagtgcaga agaagaaaca actggaagca gaatcacatg
     1081 cagcccaact acagattctt atggaattcc tcaaggttgc aagaagaaat aagagagagc
     1141 aactggaaca gatccagaag gagctaagtg ttttggaaga ggatattaag agagtggaag
     1201 aaatgagtgg cttatactct cctgtcagtg aggatagcac agtgcctcaa tttgaagctc
     1261 cttctccatc acacagtagt attattgatt ccacagaata cagccaacct ccaggtttca
     1321 gtggcagttc tcagacaaag aaacagcctt ggtataatag cacgttagca tcaagacgaa
     1381 aacgacttac tgctcatttt gaagacttgg agcagtgtta cttttctaca aggatgtctc
     1441 gtatctcaga tgacagtcga actgcaagcc agttggatga atttcaggaa tgcttgtcca
     1501 agtttactcg atataattca gtacgacctt tagccacatt gtcatatgct agtgatctct
     1561 ataatggttc cagtatagtc tctagtattg aatttgaccg ggattgtgac tattttgcga
     1621 ttgctggagt tacaaagaag attaaagtct atgaatatga cactgtcatc caggatgcag
     1681 tggatattca ttaccctgag aatgaaatga cctgcaattc gaaaatcagc tgtatcagtt
     1741 ggagtagtta ccataagaac ctgttagcta gcagtgatta tgaaggcact gttattttat
     1801 gggatggatt cacaggacag aggtcaaagg tctatcagga gcatgagaag aggtgttgga
     1861 gtgttgactt taatttgatg gatcctaaac tcttggcttc aggttctgat gatgcaaaag
     1921 tgaagctgtg gtctaccaat ctagacaact cagtggcaag cattgaggca aaggctaatg
     1981 tgtgctgtgt taaattcagc ccctcttcca gataccattt ggctttcggc tgtgcagatc
     2041 actgtgtcca ctactatgat cttcgtaaca ctaaacagcc aatcatggta ttcaaaggac
     2101 accgtaaagc agtctcttat gcaaagtttg tgagtggtga ggaaattgtc tctgcctcaa
     2161 cagacagtca gctaaaactg tggaatgtag ggaaaccata ctgcctacgt tccttcaagg
     2221 gtcatatcaa tgaaaaaaac tttgtaggcc tggcttccaa tggagattat atagcttgtg
     2281 gaagtgaaaa taactctctc tacctgtact ataaaggact ttctaagact ttgctaactt
     2341 ttaagtttga tacagtcaaa agtgttctcg acaaagaccg aaaagaagat gatacaaatg
     2401 aatttgttag tgctgtgtgc tggagggcac taccagatgg gtatcctaga attgcatggg
     2461 agaagcaaag atcccatctc tgtcacatcc aatcttggag ccaccggtgg aaatttagaa
     2521 gtgccaaagt gtttccaaca gtcgctgccg caaacctatt ctttctttac aggagtgatt
     2581 aggtactgtc tcaaaccctc ctgagtgcca catcaggagg ctctctatgg tctgttggtc
     2641 actttggaag atgtagagac taaatccaag ggagacatta gataataagc cagggttctc
     2701 atcagtctcc tcagtagcaa aagcaaaggc tagaacattc tggtagtgct cattattaat
     2761 tggaacatta cagctggagt caaagatctg cctcctgaaa ggtactgtgt tctgatgttt
     2821 acagccaaat tccattaaac attgactgat ttattacaat ggatacaact cagaaatagc
     2881 tcatgggaag agatgcatag ggcaaggtat tggagagtgg cgggtggagt acacagaata
     2941 ggtctgtgct ggtgactctt ggaaacactt tggcattttc ttcccagatg ggtaccctcc
     3001 tagtacctca atgttttcac caacctggag gccctggaac ctccattttc aacaaactcc
     3061 ctttgggatt tatatataat aaaatgctat aaaatatcag tttttgagct cttttctgtt
     3121 tgtatatttg cttaataaga atttgctaaa tgaataaatt ttatctgatt aagttttcaa
     3181 ggacccaaat gaccaaaata agaacttact gtaagactca aaatataaca aatgaggtta
     3241 atttaaatca ggcagtgagt ttttggagaa tatgttctgt acaacaaaaa aaaagttact
     3301 acaaaatacc cttccaactt tgacatatta acatccttat ttccttctgg ctttatcagt
     3361 ctttctaagt catttaagtc taaaacccca gaatcattat tgttgcatct ctttattttc
     3421 catctaatta ttcatcaaat agcagtaatg ctttctttga aatgtcttct atatatcttt
     3481 gttttcgttt ctgcttttca tctcctcatt tctgttcctt ccccttcccc ttctctcgat
     3541 ttacttctaa cagctttatg tccctttcag tcggccttta tgcactacca aatattcatc
     3601 tttatacaga gataatcaat caaacattgc ttgttacctt tagttgaccc aggtctttca
     3661 gaaaagtttt tttcaaattc agcatttgca tgtacctcta tctggtatat tttggccaac
     3721 actaaaaata aggggaaatt ttgataaata tattacctga acttgttagt tatttaatct
     3781 atttcacttc agatatctgt atctaatttt aaaattatat ttacccttac tattaaatat
     3841 gatccttaag aaaattatag gaaaaagtac aatagaaaaa aatactcaaa ggtaactcag
     3901 atttcaaaat ttactagtat ttagaaaatt agcctttata ataagtatag aacaatgtcg
     3961 ttcctatatc tacttcttaa ctgctctatt tcctgatctc atgtgtttgc acttagacta
     4021 tcgtatctaa actattacat tcaagatttt caataatcta atataatgct atccatctaa
     4081 ctttatttct gttttctaac acagttcacc tacttcatta agaaagtttc ttcattgtcc
     4141 catactattc ccattccggc ttctaaactc gtattcatgt tgttcttcat attgccttat
     4201 cctcttattt ctgcttaact aagttctcat cattttttag cccaatcact gcttctcttt
     4261 ccctctttta accattttat ctccttggtt tctggtttct cacagctatt gatgaaccta
     4321 tagaatgcag tctaccaact gatgttcaca ttcatcttga attgtttgtt atgcttcatt
     4381 agtgttgccc caggtacatt ccttgcttca acttggagag caaaaaaata caaacaccag
     4441 cagctaccag agtaagagct acttagtttt ctaggaaaga ggagttaaag attgagtgag
     4501 aataaaattt aagtctgcct aacccagaga gcctactttt atcaatttca taagatcata
     4561 aatatactga ctagaataat acactagtat tattactact agtacactgt gatactgaca
     4621 gtactaatat gatactaata gtactatcat tgcttgagat aactaccctt taactgtaaa
     4681 gaaattaagg ttatatagta ttttagtaaa agcaactacc attcatttgt ttagtgccta
     4741 tagtgtgcca gttactcttt ggttacatgc tgtaagggag aaaagatttt tctcacctgt
     4801 tggcttgatt catgacggag acctctgtaa gttttacatg acatagaagt tttacgtgac
     4861 acagaaggct tcagaaatga agacccaaag aatgggtaaa cttgtatatg tttatgctta
     4921 ggtttgatga agaaatgaat agtctcatgg agaagtatga ttggaggaca aaggggtatg
     4981 atctaatggt aataaactgg gggcaactta gcaagacctg tttgttgagc ttcttctctg
     5041 tgtctctgtc tccagagata agggcattcc tttcctcagg taaggatagg caactctgga
     5101 atgagagtct tatgacctgc ttcagtggaa gggcagagaa ttcttttatg acctgcttca
     5161 gaggagaagt gtgggagaag gtcttcctgc ttctgctgtt ttttcaaata ccaaggtgac
     5221 tatttggagg tagtgtgttc tggtccctaa caatgctcta ctgtgttttc cttgaatctt
     5281 catacagatt ctacctaaga gtatctgctt tatatttgga gaaattgaat gtctaaaagg
     5341 attaagcaga accaaaattc agatccaggt ttccatgcct tgaatgtatt gctttttctg
     5401 ttaacatggt attccccaaa tagtactgaa ttctagaatc agctttacca gagtagtctg
     5461 gaggaaattt gcgaatagct ctcttaaata tgcacggttc tatgctcaga ggagctcttc
     5521 tcagtattaa tcagcaatcc agtcattttt ttcccctcat acttgtcatt gtaagcacat
     5581 ttttctcaag ctttactcag aagatcatcc agagatatta actgttaaca tgtgctgcaa
     5641 gttgaaagtg tttagagaga atatttgagt gcagtgtgac aaggataatc aagttgttta
     5701 gggccagttg gcgagaagac tttggaaagc attgagaaag gaatgatgaa tgtatgtgtt
     5761 gttttgtatc taaatccttc ttcccttgtg tatgttcttc acagcctttt ctccctgaat
     5821 aaggatcact ttgactttgt atgctaagtg tgccttctta atggttcttt tcctgttatc
     5881 tgaatcctga agtatattta aatgagaatt tgatgcagtt agttaattgg aatataaaag
     5941 actggttaac aaaagtcttc ttaataatga agcacaccag aaatggaagc tgctggaacc
     6001 agccatgtgg acaaatgaaa aaatgccttt tgtctacaga ttgcagcgat cctacataaa
     6061 tatatggagg tctctgtctg gcttaggaca gctggctaag tctgatcgtt cccctccgta
     6121 cagcctttaa aactgccact ctaaatactt ggtttccttg ccattttatt cagtatctgc
     6181 tggttatgag tactgtatta ttttttaaat gggcaaccaa gtaaagttac ctctgtatcc
     6241 gtctgaactg gtttttgagg tatcttacga gttttgaaaa taggtgttat ttgcttattt
     6301 aaggaaccta caaccaggaa gtagaatgaa tgtggaaata ttattcttct cttgccgagc
     6361 atggtggctc acacctgtaa tcccagcact ttgggaggtt gaggcagatg gatcactgaa
     6421 tgtcaggagt tcaagaccag cctggcacca acatagtgaa atcctgtctc tactgaaaac
     6481 acaaaaatta gccaggtgtg ttggcaggcg cctgtaatcc cagctacttg agaggctgag
     6541 acaggagaat cacatgaacc tgggaggcga aggttgcagt gagctgcgat tgtgccattg
     6601 cactctaggc taggtgacgg tgcgagactc catctcaaaa aaaaaagaaa aaagaaatat
     6661 tattcttcta aggggccaca ttggcttaac gaattcaggg ttaccagtga aggtcaatac
     6721 tttagatatg aaggagctaa tcagagatag cttccgtgaa gattttctca ttaagaaagt
     6781 gatttctcca aaatccagtt tatgtaattt tttaaggctg taaccaaagt tcagaaataa
     6841 ccatttgcag aggaaagctg ctgctaagta ttaaccttct tagtactgaa ttcaaaatct
     6901 tggtttttcc tgttgtgtgt tttgctgtta agttgtgggg agaggttgct cccacctacc
     6961 tcccctaact tctacaactt acagcagcca cagctgggtt tgtttgtttg tttgtttgtt
     7021 tgtttgtttg ttttttgaga ctgagtctca ctgtgtcacc caggttggag tgcagtggca
     7081 taatctcagc tcactgcaac ccctgcctcc tgggttcaag caattctcat gcctcagcct
     7141 cctgagtagc tggaattaca ggggaccacc atgcctggct aatttttgta tttttagtag
     7201 agatgagctt tcaacggcgc ggtggctcac gccagtagtc ccatcacttt gggaggctga
     7261 ggcgggtgga tcacctgagg tcaggagttt aataccagcc tgggtttatt tataactaat
     7321 tgtatgagga tccttgtttg tggttctgaa atcccatatt tcttaccctg agcagttttt
     7381 gcattagaca gttgtcaaat gagtagccat acttttctag gccctttaga aatccactgt
     7441 tctgttcatt ctaatgaacg attttaagat tttgtaagga aggatactag tggagaagaa
     7501 agaagagatt tgggattaac tgattttgaa agtgttcctt tgtgatgaag aaatcccaat
     7561 tccccagatc tcaaattggg attttgtgta tggggggtgg aagattggaa ggagagtggg
     7621 aatttggcct gtcaatgcca tgtatgttga ctttggaaca ctctttacca ctttggttct
     7681 gtggccaagc cttttcctct gttgatatta cttgaaataa tacttatagg gagatatata
     7741 aaagaccaaa ttttccatgt aacaaggctt ttaggagcct aggtttatga catttgaaat
     7801 gtaatgtata tttataatgt atgagaactg aggctctctt gtacatagtc agtgaccacc
     7861 caagacacct ttcttctttc ttccattttg ctttaataaa ttcaggatga agcccagaca
     7921 tgtgataagc ttactgggtc aatatgatac agatcagcat tggtatattt ctcagttttc
     7981 acaagttgat tcctggcttt gctctttctt agctgtgtgt atgaatttgg acaagttatt
     8041 aagtctaaga ctatgtttac tctttgtaaa ttgatgataa aaatagtacc ttcctcattg
     8101 ggttgccatg cagattaagt gaagtaatcc atataaaatt cttaactaag tcactgacct
     8161 atagtgctca ataaatatgt gataatgaaa caggttttta agtgtttgtg tgtgtgtgtg
     8221 tgtgtgtgtg tgtgtgtgtg tattgcaaac acaattcaga cagctaattc actcaacccc
     8281 cttggatttt ttatagaatg cagggaaggc taactaacat tttagtttaa agaccaagac
     8341 cttttattga tagattgtag ttttgtgttc attctttctt agacatattt atatatattt
     8401 ttaccaagtc aactctgaaa gaccacatac tgaaagaaaa gtcagggaca aaaagaaact
     8461 attaggctta caaatggcat ttaaaaacct ttgaagatga tattggaacc tatgtttgaa
     8521 tgtctttgta tggactctca cttggtttca aaatgcagcg tagatttatg tctaggataa
     8581 agtaaagaaa cactccggtc aaataagggg attcttatga tgaatcaaac ccagataagt
     8641 ggctgggtgc ggtggctcac gcttgtaatc ccaacacttt aggaggctga ggcgggtggg
     8701 tcacgaggtc aggagttcga gaccagcctg accaacatga tgaaaccccg tctccaaata
     8761 caaaaattag ctgggtttgg tggcacgcac atgtaatccc agctactcag gaggctgaag
     8821 caggaggatc acttgaaccc gggaagcgga ggttgcagtg agccgagact gcaccactgc
     8881 agtccagcct gagcgacaga gcgagactcc atctcaaaaa caaacaaaca aacaaaaaca
     8941 aaacaaaaaa aaaacccaga taagtgaaat gaatttctct gagctccaaa aacaaaagaa
     9001 atttgaattt taaaagatgt actagaaagt gctttaaata aaagaatgat tctgcgtgtc
     9061 aggaaatcaa cagtggccca ataggatgaa gtaacaaaat gtcagcacga gtgatgaaat
     9121 tggacaattg aatagtatca cttaacaagg cgttgaacaa agaaaaattt aagaatccct
     9181 atatcttata tctgtatttc ttctcaaggg caagggagag gatgttcata aggcaactat
     9241 agatcatgca tcaaaagaag ggcaaattta tttgaaattg ttctgtggct gtaggatcct
     9301 gagtgaaaat cagatttgac tatacacaga gtccatgacc tcctacatga ggagagaagc
     9361 tattttagtt ttcaggatgc aattgcagta caaatagtaa cagcccaccc tgaagacaga
     9421 aaaaaaaaat ggagcaaaag cccattcttt tatgtttata atcttggtat gaaaaagagc
     9481 ttaaggcagg tatggtcttt tattttcagt gacatgaaat catctttgta tgagtgcaaa
     9541 ttaacactct cttttctggc aatgagaaaa caagacattt gtgttcataa agagaatgcc
     9601 tttgtccaaa taagacaaga ggctcttatg gagagaatat taaggaatta acagatatag
     9661 tatagattgt gagttttttt gtgtgaagcc tagttacctc aaatttttat tctttatatt
     9721 tacttaagga aggatattta aattcagcca tgtttctcac tgttctgtgc cctccaggga
     9781 gctgtatttg cagatactgt atgttgttca tagtgattta ccatttccat ttaatcaaat
     9841 gcttgttaaa ggacttaaat ggacatacaa tttaaactta gtgggcacac tttaagaaga
     9901 aaattcagtg attataggac aaattgttta aggcagaact gcttataact ttgctagcca
     9961 tctcagctgc agtttctgct tttagaggac aaatgtaaat agtatttcag tgtactttac
    10021 attttctgtg tcactaatag tgttctacca cttgaaaggg gaactaaaat taaaaatcat
    10081 cttctgggct ttttttcccc agtaaaattt tcaaggaact taccttcctt tgtcatgaag
    10141 ttgttttagg ggagaaaaca tttctgattt ttgttggctt ttttttgttt ttgttttgtt
    10201 tttagatcct tatttagcaa ggttatgctt ttaaacatct aagggtagag ggtgggatat
    10261 gtgtcattta ttaccttctg tcttggggta atgttctgat tgagagtgct ggagccaagt
    10321 tgccaggttt gcctcctatc accattaagt attagctgta agactttggg aaagttattt
    10381 aacctttctg tgcctcagtt tcctcttctg tgaaattaga ttaatagtat cttgcatgta
    10441 atattctgaa ataaaattag aaaatacatg gaaagtacta agaaaatagt tggcacaaga
    10501 taaatgatca atcagtaaat gttgctgtca tctttaacat tttatatacg aatccacata
    10561 actggacaac tgtacttgtt tttagttcat caaatattgt gcaatatgaa aatatattct
    10621 ctgcatttaa gtgatttaca acctagtaaa tagaaatatt cataaataac tatagtatga
    10681 acccaaatga aagaaatctt tataagatca ttacccctga aattattgac cctagaggga
    10741 agacgttact tctaacttgg agaatgatgg aatactttat gaagataggg gcttttgagc
    10801 tgggcttcat aaagatataa agggtttcag aagtctaaag acaaagggaa aggaaggtac
    10861 ctggacaaaa gaccataaac aaacacatct attaagtacc aaccaggcag tatactaagt
    10921 gctatcttaa tttaaaatca tcatcatcaa tcttttaagg catatatgct tgagttcctt
    10981 taaaagtgaa attgacgctc agatttgccc aagattacac agctaaataa gggatacagt
    11041 tggaattaga acccaggtcg ggctggctgt aaaacgtaca ccctttctgc tatactgcag
    11101 aaagctagag aacagtgtaa acaaaggcgc agatgaggga aagtgcaata gatgtttaag
    11161 aaacttctaa taaagtgtct aagtaggatg gtggagtagg gactttattg agagatgagg
    11221 ccagagagtg tgctagatat tatagtcttg aatgccatac tgagagaaaa aaaaaaagtt
    11281 tagaccttct tctgtaggca ttaaatgcct aaagcccact gtgaagataa tcccatgaga
    11341 gtattatcat agcagtgggt atagtgcatt gtaatgagag attaaaagta gagagtctac
    11401 tcaggtaggt tattaaataa tttaattatt cagggttttt tttttctgtg ttcagtttcc
    11461 ttctggggaa taagaataac agaaaacacc cacatgtaac attcatgttt ttcaagatgt
    11521 taagtttgcc ctcacatatt aaaaaaaatg tttatttgac gatgtttcat tatattcact
    11581 tcaaacaata aatcttgaac tatgtttgcg gatataatca ttaacttcta ccttctagta
    11641 cacaacttaa ttttttttct gcttttccaa gaattcactt atttaactta acacatgtga
    11701 attgaagagt tttgttaaga gataggatta aaggagatga ctctaggtgc ccagggaggg
    11761 ggaggtgcgg tgagagatgg ctgaaggaat agaacactgg tgggaagcaa agttcttttc
    11821 taccctctta ggttctctgg ctaggtctgt gaaataaact gacaactgat ggattaacag
    11881 aaaaggcata caaatttatt tgatattcaa agttttacat gaatcagctg ccaggggtgg
    11941 gttggaatag tgggggatat ctcgtagaaa gaaaaccccc aatgaaaagg ctcggtttgg
    12001 aggtttttat accatttaga caagaagaca aatttaaagg gaagcgacaa gacaaaggaa
    12061 agggactttg agcttctagg agtgatgaac aataggaagg caaatattaa tatataagaa
    12121 actaatggta gataagggct agttagtgag gtttgtgcag attttttctc agtaccatct
    12181 catctttggt aataataata aggttgttat ccctttcctg gtacaggaag taactggggt
    12241 acagggaatt cctctctttc acaagaggaa tttattgtct gttttcaggc agatagaagg
    12301 agagcagaaa gctctcctca gttgctttca gctcaaaata atctttccac cagagtagca
    12361 tattttggga tggcatattc tgatctacaa caccaaagaa aaactgctcc tatctatttt
    12421 ttgcataaag gcagtcactg acttttgtta tccataaata aaattcacag ataaattaat
    12481 cttacttatt ttctaaccct ggtatgctac agtttacatg cttaccccac ctcatatttt
    12541 catctcgtta actaatacat aagctgcttt ctccacacaa tttgtcatca ttccaaaacc
    12601 attttttttt ttcaaattta ttccatgtgc atgaccgtgt ccctttgcct aacatatcca
    12661 tcttttctcc tgtgaaattt caagttttat tcttccattg ttccatttgt gacctaatct
    12721 gtgaagcctt tcttatcttt tccaagtaaa ggatcactct cttcttactt cttcagttgc
    12781 ccctttgagc tctataatat attctttttt tttttttttt ttttttgaga cagggtctca
    12841 ctctgttacc caggctggaa tgcagtggcc caattcaggc ccattgcagc cttgacctcc
    12901 caggctcagg tgatcctccc gcctcagcct cccaaagtgc tgggattaca ggcatgagcc
    12961 accacaccca gcctatttct ttctgttaaa agtccatttc ccctgttggc ctatggtctt
    13021 aagatcagac atcatgtctt attctccttt gaaattccag gacccagcac aattatctgg
    13081 catgtgatat ctaccctaat ggacggataa tgatggatga ataaagtggc atgaaattaa
    13141 taaacttcat gccaaagtca ctactgtata atgaaacgac tgtgatgatt gaaagttatt
    13201 ctctctgtga atcaatttgg gagcgtttct ttatgtctta gtcagggttc tccaaaggga
    13261 cagaagtaat aggacatgta tagttagatc tatgacaggg tttttatttg gggtattagc
    13321 tcacatgatt acagagggtg agacatacca tgatatgcca gggaggccag tagcatggca
    13381 gaatcttagg ctaaaggcct gagaatttga gggcccattg atgcaagtcc cagagtccaa
    13441 aagctggaga atctggactt ctgatggcca aggccaggag aagagtgtcc cagctccagg
    13501 agagaggaag caaattcacc tttctgctcc ctttttgtct atccaggccc ccagctgatt
    13561 ggatggtgcc tatccacatt gagggctgaa cttccccact cagtcaaccg actcacacac
    13621 cagtctcttc tggaaacacc ctcacagact tacccagaag tagtgctttg ccagttctct
    13681 aagtatccct ttatccagtc aagttgaaac ctaaaattac ccatcacact gttaccttgg
    13741 acatcaggag tagctttctg gcgaagcctc tgtcaaagcc agtttctaat ggctaagtta
    13801 gccagggact tataaaggcc ctttataatg caaacttgac catttggtgg agttgctttt
    13861 gatgttacca gtaccatcta atgtccaaat ccaataacat attattacta aacagtcttc
    13921 atttcctcat gatttttgac aattttgact tgcttctctt tcttaaactc ttcttttagc
    13981 ctccataata gtcttctgtt ttgcttcctg cccctttgtt cattttgggc tcctttgctt
    14041 gccttccttg aactgctaag ccagaagcaa ttttccctca cttaaagatc acttataaga
    14101 tacatacttt atgccaggca cttatgtatg tgtctgtttg atcataaaaa tggttctgtt
    14161 agcttagttt tattagcatt gttttatagt tatggagact gagattcaga gaggtcaagt
    14221 aacttgccca taatgaaaag tctagaagcg ttagagcttt gaattgaaat ctttcagact
    14281 ccaaagacat ttaatctact ctgtcactct gtctatgttt tgtccacctg ttaatttgat
    14341 tttaggaata cagattgtcg tatataaatt ctggtccatt tcctcctgaa aaccagttac
    14401 tggcatttcc atgaatatag aaaactctgt aaaattgttt tttctataag agaagcctac
    14461 agacctctct taggtgatga agaggcttag aattgaatat caaatttggc ttgccactta
    14521 aaacagaatg gagtctcaag ttgcaagtag ggttgtttgt taaacctgaa acacaaaaca
    14581 agataaaggg aggatataac caccaaatag aaaacttttg actctgtaca ttttgagaaa
    14641 gccctgaaga tgtatttgat ctattataca attcaggttt acattaatga tggtaattta
    14701 cctagaaaga tttcacacct gataatagta gttgactctc tagggagatg agagacactc
    14761 agttttcccc tactcttttg tactgtgtga atttttacca catgtgtata ttatctattc
    14821 aagttaacca ataaacatat ttttctaaat aagagaaagg tatctaggta gtccttaagg
    14881 gatccattat ttattatccc catttttaat ccaaccatct tgctaaactc tcttattaat
    14941 tttaattatt catttctacg ttccttggat ttttttatgc acacaattaa ttcatccaca
    15001 aataattaaa gtttagtgtc tgcttttcca gtacttatac ctttatatct ttattcattt
    15061 gccgtatttt gatggccaga acatctaatg taatgttaaa taaaagtaat ggtatctggc
    15121 atcgttgact tgttcctcac caaagggaaa gcttttaaag atgttatcat taagtatgtc
    15181 tgctgtaaga gttttgtaga tacataccct tacaaagaag tttccttcag ttctcaatgt
    15241 gctgagagtt cttaccataa atgaatgcta aagtatatta ctgctttttt gtacctattt
    15301 aacatgatat aatatttttc tttcaaatat tgatctagta ggtgaaattt ttttttaacc
    15361 taatattaaa ccaactttac attcgctgga ataagcccaa cttggtcaag atttattctc
    15421 cttatatatt gttaaaatca acttgctact attttgttta ggattttttc atttgtcttt
    15481 atgaataaca ttggcctata atcttttcct tttttgcatt gtccatgtca ggttttgatt
    15541 tcatgggtat attaacttca taaagcaaat taaggagttc tttcctcctt tgatgtggaa
    15601 aaatttgtgt aatacgaaat tatttctttc ttgaatattg gctgaactcg tagatgaagt
    15661 catgtaagcc tgaggtagaa atatttttga ctgtcgattt atgaatttaa tacctgtagg
    15721 atgattcttg ctttctattt cttcttgatt agttgggtaa gtttttatag gaatttttcc
    15781 acttggctta aatattaaaa tttattaaca taaagtcttt tcagtttctt ttttctataa
    15841 cattatttat tctcattctg agggaagtca tcaatttaac gtaatgctta acatttggag
    15901 aaataaattt taaagaaggg ttatattctg attttgttta atagttatct tctggttaat
    15961 aaaaggagga gaaatgtagg gtggaaatgc ttatcatagt aaatagcaag gtttatatat
    16021 aaaaccatct atattgaaca gggagagagg aatgacaaaa atatttacct ttctttttga
    16081 taattcagtg ccttattttg ggggaaatat ttagcttcat agctgaaatg gctttgatat
    16141 tatacctgaa tggttacaga gatctcataa atatagtagt gataaggggt ttatatatta
    16201 tgttgggaaa tcagaaaata tttaaatcat gaataatgac ttttaattgt taaagaccaa
    16261 tattgagttt aaagttaact tataaaatac gtatttgttc ttgtgtgttt gttcccagct
    16321 ttttaaaatt gatattattg aaatataatt tacataaata taaactacat acattttaag
    16381 agtattcagt gaatttttac aagtgtatac atcagtataa ctactacctt aattcagtta
    16441 taacaacatt ttcatcaccc aaaaagttac cttgtgtcac tttgtaatca gtcccctccc
    16501 ttctccacta caagctactg ctaatccact ttatgttatc ataagttaag ttttgcttat
    16561 tctaggattt catataacag gaatgataca gtatgtaatt ttttgcacct ggctcctttt
    16621 atttagcatg atactttgaa atgcttgtgt tattgcctgt atctgtagtt ccttcttatt
    16681 agtaatccat tttataacta tgcaacaaat tttgtatcta ttcaccaatc tttaatattg
    16741 cccttgtttc cagttttgaa ctatttttaa taaagccgct gtaaacattc ataaataagt
    16801 gtttatgtga ctatatacca tcatttcttt tggataaata cctaggagtg gcattatgag
    16861 attgtagagt agttgtaagt ttagccttat aagaaactgt caaacctttt tccatagttg
    16921 ttgtattaca ttcattggtc acttaacaat ggggatacgt tttgagaaat gccattaggt
    16981 gatttgattt catcattgca caaacatcat agagtgtact tcccaaacct ggatggtata
    17041 gcctagtaca taccttagct atgtggtata gcctgttgct cctaggctac aaatttgtac
    17101 agcatgttac tacactgaat agtgtaggca gttgtaacac aatgggattt gtgtatctaa
    17161 acacagaaaa gctatagtaa aaatacaata taaaaggtaa aaaatggtac acctgcctag
    17221 ggcattacca tgaatggagc ttggtggagt agaagctgct ctcggtgagt cagggagtga
    17281 gtggtgagtg aacgtgaaga cccagacatt attgtacatt actgtagact ttatcaacac
    17341 tgtataccta agctacacta atttatttta aaatgttttc tttcttcaat aataaattaa
    17401 ctatagttta ctgtaacttt ttactttata attttaattt ttttcacttt ttgactcttt
    17461 tgtaataact tttagcttaa aacacaaaca cattgtacag ctgtacagat ttttccttat
    17521 tctgtaagct ttcttccatt tttaaatgta tttatttatt tttacttttt aaacattttt
    17581 tgttaagctc atcaacatca ctgtcttcta catcttgtcc catcggaatg tcttcaggga
    17641 caataacaca catagagctg tcatctccta tggtaacaat gctttcttct ggagtatctc
    17701 ctgaaggacc tgcctgagcc tattttacag taactttttt tgttaataag tagaaggagt
    17761 ataatctaaa ttaatgatta agaagtatag tacaataatc ttattggacc accatcatat
    17821 atgtgaccca tcgttgacca aaatgtcatt gtgcagtgca tgactatatt ttgcactcct
    17881 gccagcatcc taaaatcatt ccatttgtta catatttttg ccaacacttg atattgtcac
    17941 tttaagaaaa agatttagtt gttctagtaa gtgtggatgg tattttaaaa tttttgatga
    18001 agtccaattt atcagggttt tttttttcct ttattgtaca tgttttttgc atcctaaaaa
    18061 atagttgcca acccaaagat tttctctgat tttttttctt gaagttttat tgtttcagct
    18121 tttacatgta tgtcttagat ctatttagaa ttaattttgg gaatggtatg atagaaggat
    18181 tgaagtttac ttttttctgt atatacagtt gttttagcac acatatggtt gtttcacata
    18241 cctgcagttg tttcaacagc atttgtaaaa attactctat ttttttttta acttgccaag
    18301 ttgttttgaa attcagttga ttatggatgg atctgtttct ggaatttctt ttctgtgcct
    18361 ttgatttata tgtctatcct aataatacta cactgtattg attcctaatg cttttattaa
    18421 cagtagaact tcaaatcatg ttgtgtaagt ccctagtttt attttttctt tttcaaaatt
    18481 attttaacta ttataatgtc tttgcttttt catttaaatt tttgaatcac tttgccagtt
    18541 tctactagaa aagtttgtat gattttaatt ggaattgcat tgagcctata gataatgtaa
    18601 gaagaattgg cattgtgaca ctattgagtc tctggtctat gaacatggta taactgtcaa
    18661 tttatttagg tattctttaa catctctaag cattgtttgg taatttttag tatgtaggcc
    18721 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtttg tctctaaatg attcatgctt
    18781 tttatggtac tataaatggt attttttaaa ttctatttgc ttatcattta ttgttagttt
    18841 atggaagtga actgattttg gtataattga ctttgtgtct gacaatcttg ctgaagacaa
    18901 tttatttatt ctagtggctt atttttaagg tacattagga ttttccacat aggccatcat
    18961 ctcttttgca aatgaagaca gttttctttt ttcagatcca tatgcttttt ccttttcttg
    19021 actgtcgcac tgggttgtac ctctaataca gtgttgaata caaatggtga gagaaagcat
    19081 gttcaccttg ttcctagtct gagagagaaa gggttcagta tttcaccact aagtatgatg
    19141 ttagttgtaa gtttttcata ggtattcctt atcaccttga agaagttcct ttctattctt
    19201 agtttgctga agggatgatg aatgctctca agtgcatttt ctgtgttgtg attacattac
    19261 tttttctttt ttttgttttg aggcagggtc tcactcctgt cacccaggcg agagtacagt
    19321 gacacaatca cagctcacta cagccttccc aggctcaggt gattctccca cctcaacctt
    19381 ctgggtagct gggactacag gtgcatgcca ccacacccat ctaatttttt gtgtttttga
    19441 tagagagggt ttcgccatat tgcccaggct ggtctcacac tcctggactc aagcaatcca
    19501 cctgccttag cttcccagag tgctatcaca ggcatgagcc accctacctg gccttttcta
    19561 ttctctttac atagtgaatt atatatatat attttttaat gttgaaaacc aattttaata
    19621 tctggatgaa ttccatttag acatgatgca ttattctttt tgtatatgac tgaattatct
    19681 ttacttgtat tttgttaagg ttttttacat ctgtttataa aagtagttgg taattttatt
    19741 tgtttttgta atgtctttct ctggttttgt ttgatttaca agctgagttt ggaaatgttc
    19801 cttagtcttc atttttaaca actttttctt tcttctgtca taattgggaa tttgtatctt
    19861 tcatagaatt tgttcatttc attacctgtc agttttattg acatacaatt gttcatgttt
    19921 attttctaat tattctttta atatctatag aatatctagt gatatcccat aatttattac
    19981 tgatattgtt aacttacatt ttctttttgt taaggcgtat caattttatt gatttttttc
    20041 aatgaattaa cttttcattt caatactttt ttaccttttt ctggttttat tttgatttct
    20101 gctcttcatg actgtcattc ttgtacttac gtcatgtgta acttgctctt ttcctagctt
    20161 cttaaggtgc aagttactat atcattaatg ttcaaccttc ctgctttact aataagtatt
    20221 ggaagctata actttctagg cattgtttta ggtgcattac acaaattttg atatgttgca
    20281 tttttattat cttttagttc aaaatggttt ctcatttcca tccctgggtt atttgggagt
    20341 atatttttaa atttgcaaat acttgtggat ttttccagat ttctttttgt tattcttttc
    20401 tactttagtt ctgtttcttc agagaacata cttgtatgat tttagccctt taaatttact
    20461 gtgatttgtt ttatggtctg acacatcttt gttggggact agtacgcatg catttgaaaa
    20521 gaatgtgtat tctgtcattt aaataaaact ttctgtaaat gtca
//
