LOCUS       XM_017002059           20618 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript
            variant X1, mRNA.
ACCESSION   XM_017002059
VERSION     XM_017002059.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017002059.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..20618
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 13 ESTs, 504 long SRA reads, 2 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     CDS             309..2636
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform X1"
                     /protein_id="XP_016857548.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSA
                     AALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGS
                     SSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCI
                     HQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHR
                     WQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKR
                     EQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSLEFSSDMHRIF
                     VNGILIISIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFST
                     RMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRD
                     CDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSD
                     YEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNS
                     VASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAK
                     FVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSL
                     YLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGYPRIAWEKQRS
                     HLCHIQSWSHRWKFRSAKVFPTVAAANLFFLYRSD"
     polyA_site      20618
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gctcgcgcgc gcgcgcacgg ccggccacgg cgcgccgggg ttggctgcta cagggaccgc
       61 ggtggcggcg gcggcctcga cagcggtagt gccttctact ccgctttttt agtttcctcc
      121 gccccctccc gtgggacgct gttgtgtggc tgccttaaaa aaaaacgcaa ctttattgtt
      181 cctcagcccc acctccggct cggcgggcgt cctcaggatg cactgaggct gaggggaggg
      241 gaggcggcgg agggtcgagg tcgcggtccc tctcctccga gcgcccggct ggaggggagg
      301 gagtcacgat gtctggtagc cgccaggccg ggtcgggctc cgctgggaca agccccgggt
      361 cctcggcggc ctcctcggtg acttccgcct cctcgtcttt atcctcttcc ccgtcgccgc
      421 cttccgtggc ggtttcggcg gcagcgctgg tgtccggcgg ggtggcccag gccgccggct
      481 cgggcggcct cgggggcccg gtgcggcctg tgttggtggc gcccgccgta tcgggtagcg
      541 gcggcggggc ggtgtccacg ggcctgtccc ggcacagctg cgcggccagg cccagcgccg
      601 gcgtaggagg cagcagctcc agcctaggca gcggcagcag gaagcgacct ctcctcgccc
      661 ccctctgcaa cgggctcatc aactcctacg aggacaaaag caacgacttc gtatgcccca
      721 tctgctttga tatgattgaa gaagcataca tgacaaaatg tggccacagc ttttgctaca
      781 agtgtattca tcagagtttg gaggacaata atagatgtcc caagtgtaac tatgttgtgg
      841 acaatattga ccatctgtat cctaatttct tggtgaatga actcattctt aaacagaagc
      901 aaagatttga ggaaaagagg ttcaaattgg accactcagt gagtagcacc aatggccaca
      961 ggtggcagat atttcaagat tggttgggaa ctgaccaaga taaccttgat ttggccaatg
     1021 tcaatcttat gttggagtta ctagtgcaga agaagaaaca actggaagca gaatcacatg
     1081 cagcccaact acagattctt atggaattcc tcaaggttgc aagaagaaat aagagagagc
     1141 aactggaaca gatccagaag gagctaagtg ttttggaaga ggatattaag agagtggaag
     1201 aaatgagtgg cttatactct cctgtcagtg aggatagcac agtgcctcaa tttgaagctc
     1261 cttctccatc acacagcctt gaattcagtt ctgatatgca caggatcttt gtcaatggaa
     1321 tacttattat tagtattatt gattccacag aatacagcca acctccaggt ttcagtggca
     1381 gttctcagac aaagaaacag ccttggtata atagcacgtt agcatcaaga cgaaaacgac
     1441 ttactgctca ttttgaagac ttggagcagt gttacttttc tacaaggatg tctcgtatct
     1501 cagatgacag tcgaactgca agccagttgg atgaatttca ggaatgcttg tccaagttta
     1561 ctcgatataa ttcagtacga cctttagcca cattgtcata tgctagtgat ctctataatg
     1621 gttccagtat agtctctagt attgaatttg accgggattg tgactatttt gcgattgctg
     1681 gagttacaaa gaagattaaa gtctatgaat atgacactgt catccaggat gcagtggata
     1741 ttcattaccc tgagaatgaa atgacctgca attcgaaaat cagctgtatc agttggagta
     1801 gttaccataa gaacctgtta gctagcagtg attatgaagg cactgttatt ttatgggatg
     1861 gattcacagg acagaggtca aaggtctatc aggagcatga gaagaggtgt tggagtgttg
     1921 actttaattt gatggatcct aaactcttgg cttcaggttc tgatgatgca aaagtgaagc
     1981 tgtggtctac caatctagac aactcagtgg caagcattga ggcaaaggct aatgtgtgct
     2041 gtgttaaatt cagcccctct tccagatacc atttggcttt cggctgtgca gatcactgtg
     2101 tccactacta tgatcttcgt aacactaaac agccaatcat ggtattcaaa ggacaccgta
     2161 aagcagtctc ttatgcaaag tttgtgagtg gtgaggaaat tgtctctgcc tcaacagaca
     2221 gtcagctaaa actgtggaat gtagggaaac catactgcct acgttccttc aagggtcata
     2281 tcaatgaaaa aaactttgta ggcctggctt ccaatggaga ttatatagct tgtggaagtg
     2341 aaaataactc tctctacctg tactataaag gactttctaa gactttgcta acttttaagt
     2401 ttgatacagt caaaagtgtt ctcgacaaag accgaaaaga agatgataca aatgaatttg
     2461 ttagtgctgt gtgctggagg gcactaccag atgggtatcc tagaattgca tgggagaagc
     2521 aaagatccca tctctgtcac atccaatctt ggagccaccg gtggaaattt agaagtgcca
     2581 aagtgtttcc aacagtcgct gccgcaaacc tattctttct ttacaggagt gattaggtac
     2641 tgtctcaaac cctcctgagt gccacatcag gaggctctct atggtctgtt ggtcactttg
     2701 gaagatgtag agactaaatc caagggagac attagataat aagccagggt tctcatcagt
     2761 ctcctcagta gcaaaagcaa aggctagaac attctggtag tgctcattat taattggaac
     2821 attacagctg gagtcaaaga tctgcctcct gaaaggtact gtgttctgat gtttacagcc
     2881 aaattccatt aaacattgac tgatttatta caatggatac aactcagaaa tagctcatgg
     2941 gaagagatgc atagggcaag gtattggaga gtggcgggtg gagtacacag aataggtctg
     3001 tgctggtgac tcttggaaac actttggcat tttcttccca gatgggtacc ctcctagtac
     3061 ctcaatgttt tcaccaacct ggaggccctg gaacctccat tttcaacaaa ctccctttgg
     3121 gatttatata taataaaatg ctataaaata tcagtttttg agctcttttc tgtttgtata
     3181 tttgcttaat aagaatttgc taaatgaata aattttatct gattaagttt tcaaggaccc
     3241 aaatgaccaa aataagaact tactgtaaga ctcaaaatat aacaaatgag gttaatttaa
     3301 atcaggcagt gagtttttgg agaatatgtt ctgtacaaca aaaaaaaagt tactacaaaa
     3361 tacccttcca actttgacat attaacatcc ttatttcctt ctggctttat cagtctttct
     3421 aagtcattta agtctaaaac cccagaatca ttattgttgc atctctttat tttccatcta
     3481 attattcatc aaatagcagt aatgctttct ttgaaatgtc ttctatatat ctttgttttc
     3541 gtttctgctt ttcatctcct catttctgtt ccttcccctt ccccttctct cgatttactt
     3601 ctaacagctt tatgtccctt tcagtcggcc tttatgcact accaaatatt catctttata
     3661 cagagataat caatcaaaca ttgcttgtta cctttagttg acccaggtct ttcagaaaag
     3721 tttttttcaa attcagcatt tgcatgtacc tctatctggt atattttggc caacactaaa
     3781 aataagggga aattttgata aatatattac ctgaacttgt tagttattta atctatttca
     3841 cttcagatat ctgtatctaa ttttaaaatt atatttaccc ttactattaa atatgatcct
     3901 taagaaaatt ataggaaaaa gtacaataga aaaaaatact caaaggtaac tcagatttca
     3961 aaatttacta gtatttagaa aattagcctt tataataagt atagaacaat gtcgttccta
     4021 tatctacttc ttaactgctc tatttcctga tctcatgtgt ttgcacttag actatcgtat
     4081 ctaaactatt acattcaaga ttttcaataa tctaatataa tgctatccat ctaactttat
     4141 ttctgttttc taacacagtt cacctacttc attaagaaag tttcttcatt gtcccatact
     4201 attcccattc cggcttctaa actcgtattc atgttgttct tcatattgcc ttatcctctt
     4261 atttctgctt aactaagttc tcatcatttt ttagcccaat cactgcttct ctttccctct
     4321 tttaaccatt ttatctcctt ggtttctggt ttctcacagc tattgatgaa cctatagaat
     4381 gcagtctacc aactgatgtt cacattcatc ttgaattgtt tgttatgctt cattagtgtt
     4441 gccccaggta cattccttgc ttcaacttgg agagcaaaaa aatacaaaca ccagcagcta
     4501 ccagagtaag agctacttag ttttctagga aagaggagtt aaagattgag tgagaataaa
     4561 atttaagtct gcctaaccca gagagcctac ttttatcaat ttcataagat cataaatata
     4621 ctgactagaa taatacacta gtattattac tactagtaca ctgtgatact gacagtacta
     4681 atatgatact aatagtacta tcattgcttg agataactac cctttaactg taaagaaatt
     4741 aaggttatat agtattttag taaaagcaac taccattcat ttgtttagtg cctatagtgt
     4801 gccagttact ctttggttac atgctgtaag ggagaaaaga tttttctcac ctgttggctt
     4861 gattcatgac ggagacctct gtaagtttta catgacatag aagttttacg tgacacagaa
     4921 ggcttcagaa atgaagaccc aaagaatggg taaacttgta tatgtttatg cttaggtttg
     4981 atgaagaaat gaatagtctc atggagaagt atgattggag gacaaagggg tatgatctaa
     5041 tggtaataaa ctgggggcaa cttagcaaga cctgtttgtt gagcttcttc tctgtgtctc
     5101 tgtctccaga gataagggca ttcctttcct caggtaagga taggcaactc tggaatgaga
     5161 gtcttatgac ctgcttcagt ggaagggcag agaattcttt tatgacctgc ttcagaggag
     5221 aagtgtggga gaaggtcttc ctgcttctgc tgttttttca aataccaagg tgactatttg
     5281 gaggtagtgt gttctggtcc ctaacaatgc tctactgtgt tttccttgaa tcttcataca
     5341 gattctacct aagagtatct gctttatatt tggagaaatt gaatgtctaa aaggattaag
     5401 cagaaccaaa attcagatcc aggtttccat gccttgaatg tattgctttt tctgttaaca
     5461 tggtattccc caaatagtac tgaattctag aatcagcttt accagagtag tctggaggaa
     5521 atttgcgaat agctctctta aatatgcacg gttctatgct cagaggagct cttctcagta
     5581 ttaatcagca atccagtcat ttttttcccc tcatacttgt cattgtaagc acatttttct
     5641 caagctttac tcagaagatc atccagagat attaactgtt aacatgtgct gcaagttgaa
     5701 agtgtttaga gagaatattt gagtgcagtg tgacaaggat aatcaagttg tttagggcca
     5761 gttggcgaga agactttgga aagcattgag aaaggaatga tgaatgtatg tgttgttttg
     5821 tatctaaatc cttcttccct tgtgtatgtt cttcacagcc ttttctccct gaataaggat
     5881 cactttgact ttgtatgcta agtgtgcctt cttaatggtt cttttcctgt tatctgaatc
     5941 ctgaagtata tttaaatgag aatttgatgc agttagttaa ttggaatata aaagactggt
     6001 taacaaaagt cttcttaata atgaagcaca ccagaaatgg aagctgctgg aaccagccat
     6061 gtggacaaat gaaaaaatgc cttttgtcta cagattgcag cgatcctaca taaatatatg
     6121 gaggtctctg tctggcttag gacagctggc taagtctgat cgttcccctc cgtacagcct
     6181 ttaaaactgc cactctaaat acttggtttc cttgccattt tattcagtat ctgctggtta
     6241 tgagtactgt attatttttt aaatgggcaa ccaagtaaag ttacctctgt atccgtctga
     6301 actggttttt gaggtatctt acgagttttg aaaataggtg ttatttgctt atttaaggaa
     6361 cctacaacca ggaagtagaa tgaatgtgga aatattattc ttctcttgcc gagcatggtg
     6421 gctcacacct gtaatcccag cactttggga ggttgaggca gatggatcac tgaatgtcag
     6481 gagttcaaga ccagcctggc accaacatag tgaaatcctg tctctactga aaacacaaaa
     6541 attagccagg tgtgttggca ggcgcctgta atcccagcta cttgagaggc tgagacagga
     6601 gaatcacatg aacctgggag gcgaaggttg cagtgagctg cgattgtgcc attgcactct
     6661 aggctaggtg acggtgcgag actccatctc aaaaaaaaaa gaaaaaagaa atattattct
     6721 tctaaggggc cacattggct taacgaattc agggttacca gtgaaggtca atactttaga
     6781 tatgaaggag ctaatcagag atagcttccg tgaagatttt ctcattaaga aagtgatttc
     6841 tccaaaatcc agtttatgta attttttaag gctgtaacca aagttcagaa ataaccattt
     6901 gcagaggaaa gctgctgcta agtattaacc ttcttagtac tgaattcaaa atcttggttt
     6961 ttcctgttgt gtgttttgct gttaagttgt ggggagaggt tgctcccacc tacctcccct
     7021 aacttctaca acttacagca gccacagctg ggtttgtttg tttgtttgtt tgtttgtttg
     7081 tttgtttttt gagactgagt ctcactgtgt cacccaggtt ggagtgcagt ggcataatct
     7141 cagctcactg caacccctgc ctcctgggtt caagcaattc tcatgcctca gcctcctgag
     7201 tagctggaat tacaggggac caccatgcct ggctaatttt tgtattttta gtagagatga
     7261 gctttcaacg gcgcggtggc tcacgccagt agtcccatca ctttgggagg ctgaggcggg
     7321 tggatcacct gaggtcagga gtttaatacc agcctgggtt tatttataac taattgtatg
     7381 aggatccttg tttgtggttc tgaaatccca tatttcttac cctgagcagt ttttgcatta
     7441 gacagttgtc aaatgagtag ccatactttt ctaggccctt tagaaatcca ctgttctgtt
     7501 cattctaatg aacgatttta agattttgta aggaaggata ctagtggaga agaaagaaga
     7561 gatttgggat taactgattt tgaaagtgtt cctttgtgat gaagaaatcc caattcccca
     7621 gatctcaaat tgggattttg tgtatggggg gtggaagatt ggaaggagag tgggaatttg
     7681 gcctgtcaat gccatgtatg ttgactttgg aacactcttt accactttgg ttctgtggcc
     7741 aagccttttc ctctgttgat attacttgaa ataatactta tagggagata tataaaagac
     7801 caaattttcc atgtaacaag gcttttagga gcctaggttt atgacatttg aaatgtaatg
     7861 tatatttata atgtatgaga actgaggctc tcttgtacat agtcagtgac cacccaagac
     7921 acctttcttc tttcttccat tttgctttaa taaattcagg atgaagccca gacatgtgat
     7981 aagcttactg ggtcaatatg atacagatca gcattggtat atttctcagt tttcacaagt
     8041 tgattcctgg ctttgctctt tcttagctgt gtgtatgaat ttggacaagt tattaagtct
     8101 aagactatgt ttactctttg taaattgatg ataaaaatag taccttcctc attgggttgc
     8161 catgcagatt aagtgaagta atccatataa aattcttaac taagtcactg acctatagtg
     8221 ctcaataaat atgtgataat gaaacaggtt tttaagtgtt tgtgtgtgtg tgtgtgtgtg
     8281 tgtgtgtgtg tgtgtattgc aaacacaatt cagacagcta attcactcaa cccccttgga
     8341 ttttttatag aatgcaggga aggctaacta acattttagt ttaaagacca agacctttta
     8401 ttgatagatt gtagttttgt gttcattctt tcttagacat atttatatat atttttacca
     8461 agtcaactct gaaagaccac atactgaaag aaaagtcagg gacaaaaaga aactattagg
     8521 cttacaaatg gcatttaaaa acctttgaag atgatattgg aacctatgtt tgaatgtctt
     8581 tgtatggact ctcacttggt ttcaaaatgc agcgtagatt tatgtctagg ataaagtaaa
     8641 gaaacactcc ggtcaaataa ggggattctt atgatgaatc aaacccagat aagtggctgg
     8701 gtgcggtggc tcacgcttgt aatcccaaca ctttaggagg ctgaggcggg tgggtcacga
     8761 ggtcaggagt tcgagaccag cctgaccaac atgatgaaac cccgtctcca aatacaaaaa
     8821 ttagctgggt ttggtggcac gcacatgtaa tcccagctac tcaggaggct gaagcaggag
     8881 gatcacttga acccgggaag cggaggttgc agtgagccga gactgcacca ctgcagtcca
     8941 gcctgagcga cagagcgaga ctccatctca aaaacaaaca aacaaacaaa aacaaaacaa
     9001 aaaaaaaacc cagataagtg aaatgaattt ctctgagctc caaaaacaaa agaaatttga
     9061 attttaaaag atgtactaga aagtgcttta aataaaagaa tgattctgcg tgtcaggaaa
     9121 tcaacagtgg cccaatagga tgaagtaaca aaatgtcagc acgagtgatg aaattggaca
     9181 attgaatagt atcacttaac aaggcgttga acaaagaaaa atttaagaat ccctatatct
     9241 tatatctgta tttcttctca agggcaaggg agaggatgtt cataaggcaa ctatagatca
     9301 tgcatcaaaa gaagggcaaa tttatttgaa attgttctgt ggctgtagga tcctgagtga
     9361 aaatcagatt tgactataca cagagtccat gacctcctac atgaggagag aagctatttt
     9421 agttttcagg atgcaattgc agtacaaata gtaacagccc accctgaaga cagaaaaaaa
     9481 aaatggagca aaagcccatt cttttatgtt tataatcttg gtatgaaaaa gagcttaagg
     9541 caggtatggt cttttatttt cagtgacatg aaatcatctt tgtatgagtg caaattaaca
     9601 ctctcttttc tggcaatgag aaaacaagac atttgtgttc ataaagagaa tgcctttgtc
     9661 caaataagac aagaggctct tatggagaga atattaagga attaacagat atagtataga
     9721 ttgtgagttt ttttgtgtga agcctagtta cctcaaattt ttattcttta tatttactta
     9781 aggaaggata tttaaattca gccatgtttc tcactgttct gtgccctcca gggagctgta
     9841 tttgcagata ctgtatgttg ttcatagtga tttaccattt ccatttaatc aaatgcttgt
     9901 taaaggactt aaatggacat acaatttaaa cttagtgggc acactttaag aagaaaattc
     9961 agtgattata ggacaaattg tttaaggcag aactgcttat aactttgcta gccatctcag
    10021 ctgcagtttc tgcttttaga ggacaaatgt aaatagtatt tcagtgtact ttacattttc
    10081 tgtgtcacta atagtgttct accacttgaa aggggaacta aaattaaaaa tcatcttctg
    10141 ggcttttttt ccccagtaaa attttcaagg aacttacctt cctttgtcat gaagttgttt
    10201 taggggagaa aacatttctg atttttgttg gctttttttt gtttttgttt tgtttttaga
    10261 tccttattta gcaaggttat gcttttaaac atctaagggt agagggtggg atatgtgtca
    10321 tttattacct tctgtcttgg ggtaatgttc tgattgagag tgctggagcc aagttgccag
    10381 gtttgcctcc tatcaccatt aagtattagc tgtaagactt tgggaaagtt atttaacctt
    10441 tctgtgcctc agtttcctct tctgtgaaat tagattaata gtatcttgca tgtaatattc
    10501 tgaaataaaa ttagaaaata catggaaagt actaagaaaa tagttggcac aagataaatg
    10561 atcaatcagt aaatgttgct gtcatcttta acattttata tacgaatcca cataactgga
    10621 caactgtact tgtttttagt tcatcaaata ttgtgcaata tgaaaatata ttctctgcat
    10681 ttaagtgatt tacaacctag taaatagaaa tattcataaa taactatagt atgaacccaa
    10741 atgaaagaaa tctttataag atcattaccc ctgaaattat tgaccctaga gggaagacgt
    10801 tacttctaac ttggagaatg atggaatact ttatgaagat aggggctttt gagctgggct
    10861 tcataaagat ataaagggtt tcagaagtct aaagacaaag ggaaaggaag gtacctggac
    10921 aaaagaccat aaacaaacac atctattaag taccaaccag gcagtatact aagtgctatc
    10981 ttaatttaaa atcatcatca tcaatctttt aaggcatata tgcttgagtt cctttaaaag
    11041 tgaaattgac gctcagattt gcccaagatt acacagctaa ataagggata cagttggaat
    11101 tagaacccag gtcgggctgg ctgtaaaacg tacacccttt ctgctatact gcagaaagct
    11161 agagaacagt gtaaacaaag gcgcagatga gggaaagtgc aatagatgtt taagaaactt
    11221 ctaataaagt gtctaagtag gatggtggag tagggacttt attgagagat gaggccagag
    11281 agtgtgctag atattatagt cttgaatgcc atactgagag aaaaaaaaaa agtttagacc
    11341 ttcttctgta ggcattaaat gcctaaagcc cactgtgaag ataatcccat gagagtatta
    11401 tcatagcagt gggtatagtg cattgtaatg agagattaaa agtagagagt ctactcaggt
    11461 aggttattaa ataatttaat tattcagggt tttttttttc tgtgttcagt ttccttctgg
    11521 ggaataagaa taacagaaaa cacccacatg taacattcat gtttttcaag atgttaagtt
    11581 tgccctcaca tattaaaaaa aatgtttatt tgacgatgtt tcattatatt cacttcaaac
    11641 aataaatctt gaactatgtt tgcggatata atcattaact tctaccttct agtacacaac
    11701 ttaatttttt ttctgctttt ccaagaattc acttatttaa cttaacacat gtgaattgaa
    11761 gagttttgtt aagagatagg attaaaggag atgactctag gtgcccaggg agggggaggt
    11821 gcggtgagag atggctgaag gaatagaaca ctggtgggaa gcaaagttct tttctaccct
    11881 cttaggttct ctggctaggt ctgtgaaata aactgacaac tgatggatta acagaaaagg
    11941 catacaaatt tatttgatat tcaaagtttt acatgaatca gctgccaggg gtgggttgga
    12001 atagtggggg atatctcgta gaaagaaaac ccccaatgaa aaggctcggt ttggaggttt
    12061 ttataccatt tagacaagaa gacaaattta aagggaagcg acaagacaaa ggaaagggac
    12121 tttgagcttc taggagtgat gaacaatagg aaggcaaata ttaatatata agaaactaat
    12181 ggtagataag ggctagttag tgaggtttgt gcagattttt tctcagtacc atctcatctt
    12241 tggtaataat aataaggttg ttatcccttt cctggtacag gaagtaactg gggtacaggg
    12301 aattcctctc tttcacaaga ggaatttatt gtctgttttc aggcagatag aaggagagca
    12361 gaaagctctc ctcagttgct ttcagctcaa aataatcttt ccaccagagt agcatatttt
    12421 gggatggcat attctgatct acaacaccaa agaaaaactg ctcctatcta ttttttgcat
    12481 aaaggcagtc actgactttt gttatccata aataaaattc acagataaat taatcttact
    12541 tattttctaa ccctggtatg ctacagttta catgcttacc ccacctcata ttttcatctc
    12601 gttaactaat acataagctg ctttctccac acaatttgtc atcattccaa aaccattttt
    12661 ttttttcaaa tttattccat gtgcatgacc gtgtcccttt gcctaacata tccatctttt
    12721 ctcctgtgaa atttcaagtt ttattcttcc attgttccat ttgtgaccta atctgtgaag
    12781 cctttcttat cttttccaag taaaggatca ctctcttctt acttcttcag ttgccccttt
    12841 gagctctata atatattctt tttttttttt tttttttttt gagacagggt ctcactctgt
    12901 tacccaggct ggaatgcagt ggcccaattc aggcccattg cagccttgac ctcccaggct
    12961 caggtgatcc tcccgcctca gcctcccaaa gtgctgggat tacaggcatg agccaccaca
    13021 cccagcctat ttctttctgt taaaagtcca tttcccctgt tggcctatgg tcttaagatc
    13081 agacatcatg tcttattctc ctttgaaatt ccaggaccca gcacaattat ctggcatgtg
    13141 atatctaccc taatggacgg ataatgatgg atgaataaag tggcatgaaa ttaataaact
    13201 tcatgccaaa gtcactactg tataatgaaa cgactgtgat gattgaaagt tattctctct
    13261 gtgaatcaat ttgggagcgt ttctttatgt cttagtcagg gttctccaaa gggacagaag
    13321 taataggaca tgtatagtta gatctatgac agggttttta tttggggtat tagctcacat
    13381 gattacagag ggtgagacat accatgatat gccagggagg ccagtagcat ggcagaatct
    13441 taggctaaag gcctgagaat ttgagggccc attgatgcaa gtcccagagt ccaaaagctg
    13501 gagaatctgg acttctgatg gccaaggcca ggagaagagt gtcccagctc caggagagag
    13561 gaagcaaatt cacctttctg ctcccttttt gtctatccag gcccccagct gattggatgg
    13621 tgcctatcca cattgagggc tgaacttccc cactcagtca accgactcac acaccagtct
    13681 cttctggaaa caccctcaca gacttaccca gaagtagtgc tttgccagtt ctctaagtat
    13741 ccctttatcc agtcaagttg aaacctaaaa ttacccatca cactgttacc ttggacatca
    13801 ggagtagctt tctggcgaag cctctgtcaa agccagtttc taatggctaa gttagccagg
    13861 gacttataaa ggccctttat aatgcaaact tgaccatttg gtggagttgc ttttgatgtt
    13921 accagtacca tctaatgtcc aaatccaata acatattatt actaaacagt cttcatttcc
    13981 tcatgatttt tgacaatttt gacttgcttc tctttcttaa actcttcttt tagcctccat
    14041 aatagtcttc tgttttgctt cctgcccctt tgttcatttt gggctccttt gcttgccttc
    14101 cttgaactgc taagccagaa gcaattttcc ctcacttaaa gatcacttat aagatacata
    14161 ctttatgcca ggcacttatg tatgtgtctg tttgatcata aaaatggttc tgttagctta
    14221 gttttattag cattgtttta tagttatgga gactgagatt cagagaggtc aagtaacttg
    14281 cccataatga aaagtctaga agcgttagag ctttgaattg aaatctttca gactccaaag
    14341 acatttaatc tactctgtca ctctgtctat gttttgtcca cctgttaatt tgattttagg
    14401 aatacagatt gtcgtatata aattctggtc catttcctcc tgaaaaccag ttactggcat
    14461 ttccatgaat atagaaaact ctgtaaaatt gttttttcta taagagaagc ctacagacct
    14521 ctcttaggtg atgaagaggc ttagaattga atatcaaatt tggcttgcca cttaaaacag
    14581 aatggagtct caagttgcaa gtagggttgt ttgttaaacc tgaaacacaa aacaagataa
    14641 agggaggata taaccaccaa atagaaaact tttgactctg tacattttga gaaagccctg
    14701 aagatgtatt tgatctatta tacaattcag gtttacatta atgatggtaa tttacctaga
    14761 aagatttcac acctgataat agtagttgac tctctaggga gatgagagac actcagtttt
    14821 cccctactct tttgtactgt gtgaattttt accacatgtg tatattatct attcaagtta
    14881 accaataaac atatttttct aaataagaga aaggtatcta ggtagtcctt aagggatcca
    14941 ttatttatta tccccatttt taatccaacc atcttgctaa actctcttat taattttaat
    15001 tattcatttc tacgttcctt ggattttttt atgcacacaa ttaattcatc cacaaataat
    15061 taaagtttag tgtctgcttt tccagtactt atacctttat atctttattc atttgccgta
    15121 ttttgatggc cagaacatct aatgtaatgt taaataaaag taatggtatc tggcatcgtt
    15181 gacttgttcc tcaccaaagg gaaagctttt aaagatgtta tcattaagta tgtctgctgt
    15241 aagagttttg tagatacata cccttacaaa gaagtttcct tcagttctca atgtgctgag
    15301 agttcttacc ataaatgaat gctaaagtat attactgctt ttttgtacct atttaacatg
    15361 atataatatt tttctttcaa atattgatct agtaggtgaa attttttttt aacctaatat
    15421 taaaccaact ttacattcgc tggaataagc ccaacttggt caagatttat tctccttata
    15481 tattgttaaa atcaacttgc tactattttg tttaggattt tttcatttgt ctttatgaat
    15541 aacattggcc tataatcttt tccttttttg cattgtccat gtcaggtttt gatttcatgg
    15601 gtatattaac ttcataaagc aaattaagga gttctttcct cctttgatgt ggaaaaattt
    15661 gtgtaatacg aaattatttc tttcttgaat attggctgaa ctcgtagatg aagtcatgta
    15721 agcctgaggt agaaatattt ttgactgtcg atttatgaat ttaatacctg taggatgatt
    15781 cttgctttct atttcttctt gattagttgg gtaagttttt ataggaattt ttccacttgg
    15841 cttaaatatt aaaatttatt aacataaagt cttttcagtt tcttttttct ataacattat
    15901 ttattctcat tctgagggaa gtcatcaatt taacgtaatg cttaacattt ggagaaataa
    15961 attttaaaga agggttatat tctgattttg tttaatagtt atcttctggt taataaaagg
    16021 aggagaaatg tagggtggaa atgcttatca tagtaaatag caaggtttat atataaaacc
    16081 atctatattg aacagggaga gaggaatgac aaaaatattt acctttcttt ttgataattc
    16141 agtgccttat tttgggggaa atatttagct tcatagctga aatggctttg atattatacc
    16201 tgaatggtta cagagatctc ataaatatag tagtgataag gggtttatat attatgttgg
    16261 gaaatcagaa aatatttaaa tcatgaataa tgacttttaa ttgttaaaga ccaatattga
    16321 gtttaaagtt aacttataaa atacgtattt gttcttgtgt gtttgttccc agctttttaa
    16381 aattgatatt attgaaatat aatttacata aatataaact acatacattt taagagtatt
    16441 cagtgaattt ttacaagtgt atacatcagt ataactacta ccttaattca gttataacaa
    16501 cattttcatc acccaaaaag ttaccttgtg tcactttgta atcagtcccc tcccttctcc
    16561 actacaagct actgctaatc cactttatgt tatcataagt taagttttgc ttattctagg
    16621 atttcatata acaggaatga tacagtatgt aattttttgc acctggctcc ttttatttag
    16681 catgatactt tgaaatgctt gtgttattgc ctgtatctgt agttccttct tattagtaat
    16741 ccattttata actatgcaac aaattttgta tctattcacc aatctttaat attgcccttg
    16801 tttccagttt tgaactattt ttaataaagc cgctgtaaac attcataaat aagtgtttat
    16861 gtgactatat accatcattt cttttggata aatacctagg agtggcatta tgagattgta
    16921 gagtagttgt aagtttagcc ttataagaaa ctgtcaaacc tttttccata gttgttgtat
    16981 tacattcatt ggtcacttaa caatggggat acgttttgag aaatgccatt aggtgatttg
    17041 atttcatcat tgcacaaaca tcatagagtg tacttcccaa acctggatgg tatagcctag
    17101 tacatacctt agctatgtgg tatagcctgt tgctcctagg ctacaaattt gtacagcatg
    17161 ttactacact gaatagtgta ggcagttgta acacaatggg atttgtgtat ctaaacacag
    17221 aaaagctata gtaaaaatac aatataaaag gtaaaaaatg gtacacctgc ctagggcatt
    17281 accatgaatg gagcttggtg gagtagaagc tgctctcggt gagtcaggga gtgagtggtg
    17341 agtgaacgtg aagacccaga cattattgta cattactgta gactttatca acactgtata
    17401 cctaagctac actaatttat tttaaaatgt tttctttctt caataataaa ttaactatag
    17461 tttactgtaa ctttttactt tataatttta atttttttca ctttttgact cttttgtaat
    17521 aacttttagc ttaaaacaca aacacattgt acagctgtac agatttttcc ttattctgta
    17581 agctttcttc catttttaaa tgtatttatt tatttttact ttttaaacat tttttgttaa
    17641 gctcatcaac atcactgtct tctacatctt gtcccatcgg aatgtcttca gggacaataa
    17701 cacacataga gctgtcatct cctatggtaa caatgctttc ttctggagta tctcctgaag
    17761 gacctgcctg agcctatttt acagtaactt tttttgttaa taagtagaag gagtataatc
    17821 taaattaatg attaagaagt atagtacaat aatcttattg gaccaccatc atatatgtga
    17881 cccatcgttg accaaaatgt cattgtgcag tgcatgacta tattttgcac tcctgccagc
    17941 atcctaaaat cattccattt gttacatatt tttgccaaca cttgatattg tcactttaag
    18001 aaaaagattt agttgttcta gtaagtgtgg atggtatttt aaaatttttg atgaagtcca
    18061 atttatcagg gttttttttt tcctttattg tacatgtttt ttgcatccta aaaaatagtt
    18121 gccaacccaa agattttctc tgattttttt tcttgaagtt ttattgtttc agcttttaca
    18181 tgtatgtctt agatctattt agaattaatt ttgggaatgg tatgatagaa ggattgaagt
    18241 ttactttttt ctgtatatac agttgtttta gcacacatat ggttgtttca catacctgca
    18301 gttgtttcaa cagcatttgt aaaaattact ctattttttt tttaacttgc caagttgttt
    18361 tgaaattcag ttgattatgg atggatctgt ttctggaatt tcttttctgt gcctttgatt
    18421 tatatgtcta tcctaataat actacactgt attgattcct aatgctttta ttaacagtag
    18481 aacttcaaat catgttgtgt aagtccctag ttttattttt tctttttcaa aattatttta
    18541 actattataa tgtctttgct ttttcattta aatttttgaa tcactttgcc agtttctact
    18601 agaaaagttt gtatgatttt aattggaatt gcattgagcc tatagataat gtaagaagaa
    18661 ttggcattgt gacactattg agtctctggt ctatgaacat ggtataactg tcaatttatt
    18721 taggtattct ttaacatctc taagcattgt ttggtaattt ttagtatgta ggccgtgtgt
    18781 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg tttgtctcta aatgattcat gctttttatg
    18841 gtactataaa tggtattttt taaattctat ttgcttatca tttattgtta gtttatggaa
    18901 gtgaactgat tttggtataa ttgactttgt gtctgacaat cttgctgaag acaatttatt
    18961 tattctagtg gcttattttt aaggtacatt aggattttcc acataggcca tcatctcttt
    19021 tgcaaatgaa gacagttttc ttttttcaga tccatatgct ttttcctttt cttgactgtc
    19081 gcactgggtt gtacctctaa tacagtgttg aatacaaatg gtgagagaaa gcatgttcac
    19141 cttgttccta gtctgagaga gaaagggttc agtatttcac cactaagtat gatgttagtt
    19201 gtaagttttt cataggtatt ccttatcacc ttgaagaagt tcctttctat tcttagtttg
    19261 ctgaagggat gatgaatgct ctcaagtgca ttttctgtgt tgtgattaca ttactttttc
    19321 ttttttttgt tttgaggcag ggtctcactc ctgtcaccca ggcgagagta cagtgacaca
    19381 atcacagctc actacagcct tcccaggctc aggtgattct cccacctcaa ccttctgggt
    19441 agctgggact acaggtgcat gccaccacac ccatctaatt ttttgtgttt ttgatagaga
    19501 gggtttcgcc atattgccca ggctggtctc acactcctgg actcaagcaa tccacctgcc
    19561 ttagcttccc agagtgctat cacaggcatg agccacccta cctggccttt tctattctct
    19621 ttacatagtg aattatatat atatattttt taatgttgaa aaccaatttt aatatctgga
    19681 tgaattccat ttagacatga tgcattattc tttttgtata tgactgaatt atctttactt
    19741 gtattttgtt aaggtttttt acatctgttt ataaaagtag ttggtaattt tatttgtttt
    19801 tgtaatgtct ttctctggtt ttgtttgatt tacaagctga gtttggaaat gttccttagt
    19861 cttcattttt aacaactttt tctttcttct gtcataattg ggaatttgta tctttcatag
    19921 aatttgttca tttcattacc tgtcagtttt attgacatac aattgttcat gtttattttc
    19981 taattattct tttaatatct atagaatatc tagtgatatc ccataattta ttactgatat
    20041 tgttaactta cattttcttt ttgttaaggc gtatcaattt tattgatttt tttcaatgaa
    20101 ttaacttttc atttcaatac ttttttacct ttttctggtt ttattttgat ttctgctctt
    20161 catgactgtc attcttgtac ttacgtcatg tgtaacttgc tcttttccta gcttcttaag
    20221 gtgcaagtta ctatatcatt aatgttcaac cttcctgctt tactaataag tattggaagc
    20281 tataactttc taggcattgt tttaggtgca ttacacaaat tttgatatgt tgcattttta
    20341 ttatctttta gttcaaaatg gtttctcatt tccatccctg ggttatttgg gagtatattt
    20401 ttaaatttgc aaatacttgt ggatttttcc agatttcttt ttgttattct tttctacttt
    20461 agttctgttt cttcagagaa catacttgta tgattttagc cctttaaatt tactgtgatt
    20521 tgttttatgg tctgacacat ctttgttggg gactagtacg catgcatttg aaaagaatgt
    20581 gtattctgtc atttaaataa aactttctgt aaatgtca
//
