LOCUS       NM_022457               2826 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript variant 1,
            mRNA.
ACCESSION   NM_022457
VERSION     NM_022457.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Liu,P. and Xie,N.
  TITLE     RFWD2 increases proliferation and CDDP resistance of osteosarcoma
            cells
  JOURNAL   Gene 933, 148973 (2025)
   PUBMED   39349111
  REMARK    GeneRIF: RFWD2 increases proliferation and CDDP resistance of
            osteosarcoma cells.
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Li,X., Shao,L.Z., Li,Z.H., Wang,Y.H., Cai,Q.Y., Wang,S., Chen,H.,
            Sheng,J., Luo,X., Chen,X.M., Wang,Y.X., Ding,Y.B. and Liu,T.H.
  TITLE     STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination
            to degrade P57Kip2
  JOURNAL   J Transl Med 22 (1), 852 (2024)
   PUBMED   39304928
  REMARK    GeneRIF: STK40 inhibits trophoblast fusion by mediating COP1
            ubiquitination to degrade P57[Kip2].
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Cao,K., Liu,Z., Liu,J., Hu,Q., Shan,W., Hu,B., Shi,H. and Zhang,B.
  TITLE     Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1
            receptor accessory protein in human liver cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (18), 16247-16260 (2023)
   PUBMED   37700160
  REMARK    GeneRIF: Constitutive photomorphogenic protein 1 ubiquitinates
            interleukin-1 receptor accessory protein in human liver cancer.
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Zhao,B., Wu,J., Cha,X., Mao,G., Shi,H., Fei,S. and Miao,B.
  TITLE     Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by
            Down-Regulation of CDH18 via PI3K/AKT Signal Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2023, 5617875 (2023)
   PUBMED   37025097
  REMARK    GeneRIF: Effect of COP1 in Promoting the Tumorigenesis of Gastric
            Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Shen,T., Dong,B., Meng,Y., Moore,D.D. and Yang,F.
  TITLE     A COP1-GATA2 axis suppresses AR signaling and prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2205350119 (2022)
   PUBMED   36251994
  REMARK    GeneRIF: A COP1-GATA2 axis suppresses AR signaling and prostate
            cancer.
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Wertz,I.E., O'Rourke,K.M., Zhang,Z., Dornan,D., Arnott,D.,
            Deshaies,R.J. and Dixit,V.M.
  TITLE     Human De-etiolated-1 regulates c-Jun by assembling a CUL4A
            ubiquitin ligase
  JOURNAL   Science 303 (5662), 1371-1374 (2004)
   PUBMED   14739464
  REMARK    GeneRIF: DET1 promotes ubiquitination and degradation of c-Jun by
            assembling a multisubunit ubiquitin ligase containing DNA Damage
            Binding Protein-1 (DDB1), cullin 4A (CUL4A), Regulator of Cullins-1
            (ROC1), and constitutively photomorphogenic-1
REFERENCE   7  (bases 1 to 2826)
  AUTHORS   Bianchi,E., Denti,S., Catena,R., Rossetti,G., Polo,S.,
            Gasparian,S., Putignano,S., Rogge,L. and Pardi,R.
  TITLE     Characterization of human constitutive photomorphogenesis protein
            1, a RING finger ubiquitin ligase that interacts with Jun
            transcription factors and modulates their transcriptional activity
  JOURNAL   J Biol Chem 278 (22), 19682-19690 (2003)
   PUBMED   12615916
REFERENCE   8  (bases 1 to 2826)
  AUTHORS   Yi,C., Wang,H., Wei,N. and Deng,X.W.
  TITLE     An initial biochemical and cell biological characterization of the
            mammalian homologue of a central plant developmental switch, COP1
  JOURNAL   BMC Cell Biol 3, 30 (2002)
   PUBMED   12466024
REFERENCE   9  (bases 1 to 2826)
  AUTHORS   Hoecker,U. and Quail,P.H.
  TITLE     The phytochrome A-specific signaling intermediate SPA1 interacts
            directly with COP1, a constitutive repressor of light signaling in
            Arabidopsis
  JOURNAL   J Biol Chem 276 (41), 38173-38178 (2001)
   PUBMED   11461903
REFERENCE   10 (bases 1 to 2826)
  AUTHORS   Wang,H., Kang,D., Deng,X.W. and Wei,N.
  TITLE     Evidence for functional conservation of a mammalian homologue of
            the light-responsive plant protein COP1
  JOURNAL   Curr Biol 9 (13), 711-714 (1999)
   PUBMED   10395541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359265.8, BG717002.1 and BC094728.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022457.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094728.1, AF527539.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367669.8/ ENSP00000356641.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL359265.8         58210-58251         c
            43-54               BG717002.1         6-17
            55-2826             BC094728.1         1-2772
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1-q25.2"
     gene            1..2826
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="COP1 E3 ubiquitin ligase"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
     exon            1..715
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2504
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RFWD2; putative ubiquitin ligase
                     COP1; RING finger protein 200; constitutive
                     photomorphogenesis protein 1 homolog; constitutive
                     photomorphogenic protein 1; ring finger and WD repeat
                     domain 2, E3 ubiquitin protein ligase; RING-type E3
                     ubiquitin transferase RFWD2; E3 ubiquitin-protein ligase
                     COP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1 isoform a"
                     /protein_id="NP_071902.2"
                     /db_xref="CCDS:CCDS30944.1"
                     /db_xref="GeneID:64326"
                     /db_xref="HGNC:HGNC:17440"
                     /db_xref="MIM:608067"
                     /translation="MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSA
                     AALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGS
                     SSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCI
                     HQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHR
                     WQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKR
                     EQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQP
                     PGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEF
                     QECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEY
                     DTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV
                     YQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPS
                     SRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKL
                     WNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT
                     VKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV"
     exon            716..775
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            776..873
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            874..950
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1070
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1139
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1199
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1276
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1334
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1449
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1585
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1729
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1838
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1920
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2037
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2155
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2280
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2441
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2486
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2826
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2805..2810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="hexamer: AATAAA"
     polyA_site      2826
                     /gene="COP1"
                     /gene_synonym="CFAP78; FAP78; RFWD2; RNF200"
                     /note="major polyA site"
ORIGIN      
        1 gctcgcgcgc gcgcgcacgg ccggccacgg cgcgccgggg ttggctgcta cagggaccgc
       61 ggtggcggcg gcggcctcga cagcggtagt gccttctact ccgctttttt agtttcctcc
      121 gccccctccc gtgggacgct gttgtgtggc tgccttaaaa aaaaacgcaa ctttattgtt
      181 cctcagcccc acctccggct cggcgggcgt cctcaggatg cactgaggct gaggggaggg
      241 gaggcggcgg agggtcgagg tcgcggtccc tctcctccga gcgcccggct ggaggggagg
      301 gagtcacgat gtctggtagc cgccaggccg ggtcgggctc cgctgggaca agccccgggt
      361 cctcggcggc ctcctcggtg acttccgcct cctcgtcttt atcctcttcc ccgtcgccgc
      421 cttccgtggc ggtttcggcg gcagcgctgg tgtccggcgg ggtggcccag gccgccggct
      481 cgggcggcct cgggggcccg gtgcggcctg tgttggtggc gcccgccgta tcgggtagcg
      541 gcggcggggc ggtgtccacg ggcctgtccc ggcacagctg cgcggccagg cccagcgccg
      601 gcgtaggagg cagcagctcc agcctaggca gcggcagcag gaagcgacct ctcctcgccc
      661 ccctctgcaa cgggctcatc aactcctacg aggacaaaag caacgacttc gtatgcccca
      721 tctgctttga tatgattgaa gaagcataca tgacaaaatg tggccacagc ttttgctaca
      781 agtgtattca tcagagtttg gaggacaata atagatgtcc caagtgtaac tatgttgtgg
      841 acaatattga ccatctgtat cctaatttct tggtgaatga actcattctt aaacagaagc
      901 aaagatttga ggaaaagagg ttcaaattgg accactcagt gagtagcacc aatggccaca
      961 ggtggcagat atttcaagat tggttgggaa ctgaccaaga taaccttgat ttggccaatg
     1021 tcaatcttat gttggagtta ctagtgcaga agaagaaaca actggaagca gaatcacatg
     1081 cagcccaact acagattctt atggaattcc tcaaggttgc aagaagaaat aagagagagc
     1141 aactggaaca gatccagaag gagctaagtg ttttggaaga ggatattaag agagtggaag
     1201 aaatgagtgg cttatactct cctgtcagtg aggatagcac agtgcctcaa tttgaagctc
     1261 cttctccatc acacagtagt attattgatt ccacagaata cagccaacct ccaggtttca
     1321 gtggcagttc tcagacaaag aaacagcctt ggtataatag cacgttagca tcaagacgaa
     1381 aacgacttac tgctcatttt gaagacttgg agcagtgtta cttttctaca aggatgtctc
     1441 gtatctcaga tgacagtcga actgcaagcc agttggatga atttcaggaa tgcttgtcca
     1501 agtttactcg atataattca gtacgacctt tagccacatt gtcatatgct agtgatctct
     1561 ataatggttc cagtatagtc tctagtattg aatttgaccg ggattgtgac tattttgcga
     1621 ttgctggagt tacaaagaag attaaagtct atgaatatga cactgtcatc caggatgcag
     1681 tggatattca ttaccctgag aatgaaatga cctgcaattc gaaaatcagc tgtatcagtt
     1741 ggagtagtta ccataagaac ctgttagcta gcagtgatta tgaaggcact gttattttat
     1801 gggatggatt cacaggacag aggtcaaagg tctatcagga gcatgagaag aggtgttgga
     1861 gtgttgactt taatttgatg gatcctaaac tcttggcttc aggttctgat gatgcaaaag
     1921 tgaagctgtg gtctaccaat ctagacaact cagtggcaag cattgaggca aaggctaatg
     1981 tgtgctgtgt taaattcagc ccctcttcca gataccattt ggctttcggc tgtgcagatc
     2041 actgtgtcca ctactatgat cttcgtaaca ctaaacagcc aatcatggta ttcaaaggac
     2101 accgtaaagc agtctcttat gcaaagtttg tgagtggtga ggaaattgtc tctgcctcaa
     2161 cagacagtca gctaaaactg tggaatgtag ggaaaccata ctgcctacgt tccttcaagg
     2221 gtcatatcaa tgaaaaaaac tttgtaggcc tggcttccaa tggagattat atagcttgtg
     2281 gaagtgaaaa taactctctc tacctgtact ataaaggact ttctaagact ttgctaactt
     2341 ttaagtttga tacagtcaaa agtgttctcg acaaagaccg aaaagaagat gatacaaatg
     2401 aatttgttag tgctgtgtgc tggagggcac taccagatgg ggagtccaat gtgctgattg
     2461 ctgctaacag tcagggtaca attaaggtgc tagaattggt atgaagggtt aactcaagtc
     2521 aaattgtact tgatcctgct gaaatacatc tgcagctgac aatgagagaa gaaacagaaa
     2581 atgtcatgtg atgtctctcc ccaaagtcat catgggtttt ggatttgttt tgaatatttt
     2641 tttctttttt tcttttccct cctttatgac ctttgggaca ttgggaatac ccagccaact
     2701 ctccaccatc aatgtaactc catggacatt gctgctcttg gtggtgttat ctaatttttg
     2761 tgatagggaa acaaattctt ttgaataaaa ataaataaca aaacaataaa agtttattga
     2821 gccaca
//
