LOCUS       NM_017845               1461 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens COMM domain containing 8 (COMMD8), transcript variant
            1, mRNA.
ACCESSION   NM_017845
VERSION     NM_017845.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1461)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 1461)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1461)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1461)
  AUTHORS   Zhang,R., Niu,Z., Pei,H. and Peng,Z.
  TITLE     Long noncoding RNA LINC00657 induced by SP1 contributes to the
            non-small cell lung cancer progression through targeting
            miR-26b-5p/COMMD8 axis
  JOURNAL   J Cell Physiol 235 (4), 3340-3349 (2020)
   PUBMED   31566716
  REMARK    GeneRIF: Long noncoding RNA LINC00657 induced by SP1 contributes to
            the non-small cell lung cancer progression through targeting
            miR-26b-5p/COMMD8 axis.
REFERENCE   6  (bases 1 to 1461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 1461)
  AUTHORS   Starokadomskyy,P., Gluck,N., Li,H., Chen,B., Wallis,M., Maine,G.N.,
            Mao,X., Zaidi,I.W., Hein,M.Y., McDonald,F.J., Lenzner,S., Zecha,A.,
            Ropers,H.H., Kuss,A.W., McGaughran,J., Gecz,J. and Burstein,E.
  TITLE     CCDC22 deficiency in humans blunts activation of proinflammatory
            NF-kappaB signaling
  JOURNAL   J Clin Invest 123 (5), 2244-2256 (2013)
   PUBMED   23563313
REFERENCE   8  (bases 1 to 1461)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   9  (bases 1 to 1461)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   10 (bases 1 to 1461)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107398.4.
            
            On Nov 23, 2018 this sequence version replaced NM_017845.4.
            
            Summary: The protein encoded by this gene binds coiled-coil
            domain-containing protein 22 (CCDC22), and this complex can
            regulate the turnover of I-kappa-B and the activation of
            NF-kappa-B. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2259041.1, BC008371.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381571.6/ ENSP00000370984.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC107398.4         31188-31304         c
            118-273             AC107398.4         27746-27901         c
            274-426             AC107398.4         24179-24331         c
            427-582             AC107398.4         20661-20816         c
            583-1461            AC107398.4         18389-19267         c
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..1461
                     /gene="COMMD8"
                     /note="COMM domain containing 8"
                     /db_xref="GeneID:54951"
                     /db_xref="HGNC:HGNC:26036"
                     /db_xref="MIM:616656"
     exon            1..117
                     /gene="COMMD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..603
                     /gene="COMMD8"
                     /note="isoform 1 is encoded by transcript variant 1; COMM
                     domain-containing protein 8"
                     /codon_start=1
                     /product="COMM domain-containing protein 8 isoform 1"
                     /protein_id="NP_060315.1"
                     /db_xref="CCDS:CCDS3475.1"
                     /db_xref="GeneID:54951"
                     /db_xref="HGNC:HGNC:26036"
                     /db_xref="MIM:616656"
                     /translation="MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHT
                     VWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIK
                     QALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEM
                     SREELQNLIQSLEAANKVVLQLK"
     exon            118..273
                     /gene="COMMD8"
                     /inference="alignment:Splign:2.1.0"
     exon            274..426
                     /gene="COMMD8"
                     /inference="alignment:Splign:2.1.0"
     exon            427..582
                     /gene="COMMD8"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1461
                     /gene="COMMD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD8"
                     /note="hexamer: AATAAA"
     polyA_site      1377
                     /gene="COMMD8"
                     /note="major polyA site"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD8"
                     /note="hexamer: AACAAG"
     polyA_site      1461
                     /gene="COMMD8"
                     /note="major polyA site"
ORIGIN      
        1 agacaagcgg ccagccttga cacgtgaccc aagccccagc ttcgcgcagg gatggagccg
       61 gaagagggga cgcccttgtg gcggctgcag aagctgccgg ccgagctggg cccgcagctt
      121 cttcacaaaa taattgatgg catttgtggt cgagcttatc ctgtgtacca agattatcac
      181 actgtttggg aatcagaaga atggatgcac gttttagaag atattgccaa atttttcaaa
      241 gccatagttg gtaaaaactt acctgatgaa gagatatttc agcagttgaa tcagttgaat
      301 tcacttcatc aagaaactat catgaaatgc gtgaaaagta ggaaagatga aatcaaacag
      361 gctctgtcaa gagaaatagt tgctatttcc tctgcacagc tacaggattt tgattggcag
      421 gtaaagcttg cactttccag tgacaagatt gctgcattac gaatgccact tttaagcctg
      481 catctagatg taaaagaaaa tggtgaagta aaaccttatt ctattgaaat gagtagagag
      541 gagctgcaga atctaataca gtccttggaa gcagcgaata aggtggtcct gcagttgaaa
      601 taactggaaa tgatgaatac cagtcctatc agattttatt gctccaactt atatggcaga
      661 gtgaatactg cgtgttcaga aaccttgtga tgtcttgact gttgcaccag gctgagaaag
      721 cagcaatatt gatattataa agataaaaat ttatcaacat tccttaacag gaaattacat
      781 ggttgagagg aaatgcataa aatgaaagat gaaaaatcta tagtagcagt ttatattttc
      841 atgattgttt tgcctcattt attaaatatt tgagaaatct ttggagatac atagttttat
      901 tgaaagctaa aaataggttc taaagtaatg taaaaatata aagcacaaat atacttgaat
      961 attgcttaaa gaattgtgtg aatagcaaca tatattatgg atatatactt tgtgatattt
     1021 ttaaaaaata attttttcaa agaatgtata agctgcatat ataactcagg agattccatg
     1081 tctttctcat atttcagagg aaagattata aaatataaaa tttcttagag aacacctctt
     1141 tgtcagagat aaacaagaac aaatactcta aacttatgtg aacagttttg agtttatgaa
     1201 ttctagaaac taaaatcaag aatacagaaa aatgaaaata acattttact tctgcgcttc
     1261 tatgtttggg aaacattgct ctgataaaaa atagctgtca ttatgcagtg tgtatattca
     1321 aatatgagat aagactatgt acacatccac ttttgttaat aaactcaata ttgaatactt
     1381 tgggatgtta aattcattgg aaaaacaaac catttgtaac ctcagttaac tttaacaaca
     1441 agcattctga gcaaatgaaa a
//
