LOCUS       NM_053041               1362 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens COMM domain containing 7 (COMMD7), transcript variant
            1, mRNA.
ACCESSION   NM_053041 XM_097779
VERSION     NM_053041.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Cao,S., Fu,B., Cai,J., Zhang,D., Wang,C. and Wu,H.
  TITLE     Linc00852 from cisplatin-resistant gastric cancer cell-derived
            exosomes regulates COMMD7 to promote cisplatin resistance of
            recipient cells through microRNA-514a-5p
  JOURNAL   Cell Biol Toxicol 39 (2), 483-496 (2023)
   PUBMED   35088190
  REMARK    GeneRIF: Linc00852 from cisplatin-resistant gastric cancer
            cell-derived exosomes regulates COMMD7 to promote cisplatin
            resistance of recipient cells through microRNA-514a-5p.
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Shao,X., Zhong,L., Chu,X., Wan,P., Chen,S., Zhou,Z., Zhang,H.,
            Wang,M. and Liu,B.
  TITLE     ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia
            Proliferation Via the NF-kappaB Signaling Pathway
  JOURNAL   Int J Med Sci 20 (4), 520-529 (2023)
   PUBMED   37057209
  REMARK    GeneRIF: ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia
            Proliferation Via the NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1362)
  AUTHORS   Zheng,L., Liang,P., Li,J., Huang,X.B., Liu,S.C., Zhao,H.Z.,
            Han,K.Q. and Wang,Z.
  TITLE     ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth
  JOURNAL   PLoS One 7 (9), e45412 (2012)
   PUBMED   23049798
  REMARK    GeneRIF: COMMD7 contributes to hepatocellular carcinoma progression
            by reducing cell apoptosis and overcoming cell cycle arrest.
            Erratum:[PLoS One. 2019 Mar 18;14(3):e0214259. doi:
            10.1371/journal.pone.0214259.. PMID: 30883605]
REFERENCE   7  (bases 1 to 1362)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   8  (bases 1 to 1362)
  AUTHORS   Zheng,L., Liang,P., Li,J., Huang,X.B., Wang,W.W., Wang,L. and
            Feng,H.
  TITLE     Expression of BC047440 protein in hepatocellular carcinoma and its
            relationship to prognosis
  JOURNAL   Chin J Cancer 29 (11), 931-936 (2010)
   PUBMED   20979692
  REMARK    GeneRIF: BC047440 can promote the growth and invasion of
            hepatocellular carcinoma.
REFERENCE   9  (bases 1 to 1362)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
REFERENCE   10 (bases 1 to 1362)
  AUTHORS   Roperch,J.P., Lethrone,F., Prieur,S., Piouffre,L., Israeli,D.,
            Tuynder,M., Nemani,M., Pasturaud,P., Gendron,M.C., Dausset,J.,
            Oren,M., Amson,R.B. and Telerman,A.
  TITLE     SIAH-1 promotes apoptosis and tumor suppression through a network
            involving the regulation of protein folding, unfolding, and
            trafficking: identification of common effectors with p53 and
            p21(Waf1)
  JOURNAL   Proc Natl Acad Sci U S A 96 (14), 8070-8073 (1999)
   PUBMED   10393949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG715846.1, AK027893.1 and BQ006261.1.
            
            On May 21, 2020 this sequence version replaced NM_053041.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047440.1, AK096307.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278980.11/ ENSP00000278980.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BG715846.1         546-557
            13-1358             AK027893.1         1-1346
            1359-1362           BQ006261.1         26-29               c
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1362
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /note="COMM domain containing 7"
                     /db_xref="GeneID:149951"
                     /db_xref="HGNC:HGNC:16223"
                     /db_xref="MIM:616703"
     exon            1..160
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..679
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /note="isoform 1 is encoded by transcript variant 1; COMM
                     domain-containing protein 7"
                     /codon_start=1
                     /product="COMM domain-containing protein 7 isoform 1"
                     /protein_id="NP_444269.2"
                     /db_xref="CCDS:CCDS42864.1"
                     /db_xref="GeneID:149951"
                     /db_xref="HGNC:HGNC:16223"
                     /db_xref="MIM:616703"
                     /translation="MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEP
                     KEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLS
                     EEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQL
                     KLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFC"
     exon            161..214
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            215..317
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..374
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..412
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            413..503
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            504..553
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            554..602
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..1362
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="COMMD7"
                     /gene_synonym="C20orf92; dJ1085F17.3"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcagcg gcagcggagg aggaagctga gcagggcggc ggcggcggtg gaacctgcgg
       61 ggctggggcg cgcgccatgg gccgcctgca ctgcactgag gacccggtgc cggaggccgt
      121 gggcggcgac atgcagcagc tgaaccagct gggcgcgcag cagttctcag ccctgacaga
      181 ggtgcttttc cacttcctaa ctgagccaaa agaggtggaa agatttctgg ctcagctctc
      241 tgaatttgcc accaccaatc agatcagtct tggctccctc agaagcatcg tgaaaagcct
      301 ccttctggtt ccaaatggtg ctttgaagaa gagtctcaca gccaagcagg tccaggcgga
      361 tttcataact ctgggtctta gtgaggagaa agccacttac ttttctgaaa agtggaagca
      421 gaatgctccc acccttgctc gatgggccat aggtcagact ctgatgatta accagctcat
      481 agatatggag tggaaatttg gagtgacatc tgggagcagc gaattggaga aagtgggaag
      541 tatattttta caactaaagt tggtggttaa gaaaggaaat caaaccgaaa atgtgtatat
      601 agaattaacc ttgcctcagt tctacagctt cctgcacgag atggagcgag tcagaaccag
      661 catggagtgt ttctgctgat ttctgtccct gcatctcccc tggccccgtt ccctgccctc
      721 ctcccttccc tgggtgactg ctctgagagg cacttcactc acaggcctgt gggatgctcc
      781 atggggccct gctggctcca tggggcccag gtgcaaaggg tttctgaaaa acagcaggat
      841 taagtactga aagagcccaa cacaattacc ctgtaaactc tctgttaggg caaccaccac
      901 cacctgtctt ccaggacaca tttttagata ctctgacagg ccactgcatc tcagattcag
      961 gggagaaaat aagttgtcac ctccccttca aagttccaga gtaaacaaat ggtgccatca
     1021 ttcaagataa catgctgatc accctcctcc caaaaagcaa gagcttgttt atggctgagg
     1081 aatcggcgga ttgtctgaat gacacatata cagagccccc acggatttct gcacactctg
     1141 ggtctgtgct ggtggaacat tgccaatcag ttcttaatga ggcacctgtg tgtaaataca
     1201 tgcttggtct tctctgcaga gaactgaggc taaactctgt ccctacttct ggttttgccc
     1261 tgtcatgtcg taacgaggtg ggccttttga ggccatttta gtttgagttc gagccaacca
     1321 cctctgttgg ttagatgatg aataaaaagg ttctgaagaa aa
//
