LOCUS       NM_203495               1669 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens COMM domain containing 6 (COMMD6), transcript variant
            2, mRNA.
ACCESSION   NM_203495
VERSION     NM_203495.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Yang,M., Huang,W., Sun,Y., Liang,H., Chen,M., Wu,X., Wang,X.,
            Zhang,L., Cheng,X., Fan,Y., Pan,H., Chen,L. and Guan,J.
  TITLE     Prognosis and modulation mechanisms of COMMD6 in human tumours
            based on expression profiling and comprehensive bioinformatics
            analysis
  JOURNAL   Br J Cancer 121 (8), 699-709 (2019)
   PUBMED   31523056
  REMARK    GeneRIF: COMMD6 expression was widely observed in human tissues.
            COMMD6 may modulate the ubiquitination and degradation of NF-kappaB
            subunits and regulate ribonucleoprotein and spliceosome complex
            biogenesis in tumours. COMMD6 expression is increased in some
            cancers, and decreased in others, implying that different
            mechanisms are involved in the regulation of COMMD6 expression in
            the development of human tissues.
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   de Bie,P., van de Sluis,B., Burstein,E., Duran,K.J., Berger,R.,
            Duckett,C.S., Wijmenga,C. and Klomp,L.W.
  TITLE     Characterization of COMMD protein-protein interactions in NF-kappaB
            signalling
  JOURNAL   Biochem J 398 (1), 63-71 (2006)
   PUBMED   16573520
  REMARK    GeneRIF: These data support the significance of COMMD
            protein-protein interactions and provide new mechanistic insight
            into the function of this protein family in NF-kappaB signalling.
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
REFERENCE   9  (bases 1 to 1669)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 1669)
  AUTHORS   Kurihara,L.J., Semenova,E., Miller,W., Ingram,R.S., Guan,X.J. and
            Tilghman,S.M.
  TITLE     Candidate genes required for embryonic development: a comparative
            analysis of distal mouse chromosome 14 and human chromosome 13q22
  JOURNAL   Genomics 79 (2), 154-161 (2002)
   PUBMED   11829485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY105279.1, BC110837.1, DB574884.1, BX106312.1, AA425275.1 and
            AL137244.28.
            
            On Aug 14, 2020 this sequence version replaced NM_203495.3.
            
            Summary: COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM
            164014)-inhibiting proteins characterized by the presence of a COMM
            domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed
            16573520]).[supplied by OMIM, Mar 2009].
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon
            in the 3' region compared to variant 1. The resulting shorter
            isoform (b) lacks a 13 aa protein segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110837.1, AK000009.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682242.1/ ENSP00000506987.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                HY105279.1         33-64
            33-606              BC110837.1         1-574
            607-900             DB574884.1         174-467
            901-1214            BX106312.1         201-514
            1215-1664           AA425275.1         9-458               c
            1665-1669           AL137244.28        35362-35366         c
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.2"
     gene            1..1669
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="COMM domain containing 6"
                     /db_xref="GeneID:170622"
                     /db_xref="HGNC:HGNC:24015"
                     /db_xref="MIM:612377"
     exon            1..78
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..294
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="isoform b is encoded by transcript variant 2; Acrg
                     embryonic lethality minimal region ortholog; COMM
                     domain-containing protein 6"
                     /codon_start=1
                     /product="COMM domain-containing protein 6 isoform b"
                     /protein_id="NP_987091.1"
                     /db_xref="CCDS:CCDS9451.1"
                     /db_xref="GeneID:170622"
                     /db_xref="HGNC:HGNC:24015"
                     /db_xref="MIM:612377"
                     /translation="MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVA
                     VMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV"
     exon            79..90
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            91..243
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1669
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      425..430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="hexamer: AATAAA"
     polyA_site      447
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="major polyA site"
     polyA_site      472
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="hexamer: AATACA"
     polyA_site      903
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
     regulatory      990..995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="hexamer: CATAAA"
     polyA_site      1024
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
                     /note="hexamer: AATAAA"
     polyA_site      1669
                     /gene="COMMD6"
                     /gene_synonym="Acrg"
ORIGIN      
        1 ctctcgagtc cgggccgcaa gtcccagacg ctgcccatgg aggcgtccag cgagccgccg
       61 ctggatgcta agtccgatgt caccaaccag cttgtagatt ttcagtggaa actgggtatg
      121 gctgtgagct cagacacttg cagatctctt aagtatcctt acgttgcagt gatgctaaaa
      181 gtggcagatc attcaggcca agtaaagacc aagtgctttg aaatgacgat tccacagttt
      241 cagaatttct acagacagtt caaggaaatt gctgcagtta ttgaaacggt gtgaagacgg
      301 attctttggt tgataaattg ctatcattct aaagtcatgg acttcacttt cggcaacaaa
      361 actaaataag gatggaacat ttattgaatg aaaaatgcac ttttgttttt ccattttttt
      421 aaataataaa aatcagacaa acaggaactg ggtagtggtg atgaatgcaa aactttgtga
      481 atgtgcttta taaaagtgat aattagacac tttagaggat atacttggtg ataatgtgaa
      541 tgatgtaatc agactaacag ttgaatcatt gctgttggag gcagcacaaa tttatgtgtt
      601 acaacagtag tttaaaaact tgtactggat ggaacccatt ttataaacag tcttatttgg
      661 agtcatgtat ataaaaatat atataaatta gaaaagtagt atttgattag gataacttta
      721 caaattcaat agtatagcca tcacttatta taatggcaat cagaagagtg aggcttcttt
      781 tttcaaactt ttgtaatcag attaagattg accattgctc ctttacacag tattagtcta
      841 gcattcaatt atttctgtta ttaatggttg tagaaagttc aaatacatac gcagagttgg
      901 aaagacgagt tttagtctga gttctgtacg acggagttaa cccgttagca caagttattg
      961 cattagatga tctctgttga atttaaatac ataaacctgt tgttaaacgc ttttatacta
     1021 taaagccacc acattgtatg gcatttgttt agaagtaagc aaatagacca ccggaataga
     1081 atagatggcc tagaaataga tcaagacatt ctggtccgcc atattagaaa tttaaaccct
     1141 cttcacaccc tgtctgcatt tctgcaggtc tgtgtgagtc cactttcttt tttgttccct
     1201 gctaggtagc acacagctgt gaggagccca ggactgctgc ctgccgcagc ccacctgtgc
     1261 gctcagattc ctaccagctt gatgagttag ctgatgggcc atttgtgcat accaactacc
     1321 cacagacatt tctattaccc accctctgga tgccagtgca ttaatgattc tagaattagg
     1381 agaaaccaaa gatcccttct ctctccctcc cacaaccagt gtcgtcgtgt tcctagaaat
     1441 aagagtagaa acccctctat ctgggttaaa acagcaaacc tgccttctgt aactgtgcat
     1501 gaggttcctc tgtctcccac ttacttcgga ttaacacctt cctctttccc cttccctgtt
     1561 tgcagggtag catttctagg tttaaggcaa tatgcaaaaa gacccaaagt taggccctgg
     1621 ctcaaacact gtgggtagca gatttgaaat aaatttaaat tgcatgttt
//
