LOCUS       NM_014066               1430 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COMM domain containing 5 (COMMD5), transcript variant
            1, mRNA.
ACCESSION   NM_014066
VERSION     NM_014066.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Ikeda,J., Matsuda,H., Ogasawara,M., Ishii,Y., Yamaguchi,K.,
            Takahashi,S., Fukuda,N., Masuhiro,Y., Endo,M., Soma,M., Hamet,P.
            and Tremblay,J.
  TITLE     COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells
  JOURNAL   Anticancer Res 41 (6), 2805-2815 (2021)
   PUBMED   34083270
  REMARK    GeneRIF: COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells.
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Chen,B.L., Yu,J., Zeng,Z.R., Chu,W.K., Wong,C.Y., Cheng,Y.Y.,
            Sung,J.J., Hu,P.J. and Leung,W.K.
  TITLE     Rosiglitazone suppresses gastric carcinogenesis by up-regulating
            HCaRG expression
  JOURNAL   Oncol Rep 20 (5), 1093-1097 (2008)
   PUBMED   18949406
  REMARK    GeneRIF: The up-regulation of HCaRG may be one of the mechanisms
            underlying the chemopreventive effect of rosiglitazone in gastric
            cancer.
REFERENCE   7  (bases 1 to 1430)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
REFERENCE   8  (bases 1 to 1430)
  AUTHORS   Solban,N., Dumas,P., Gossard,F., Sun,Y., Pravenec,M., Kren,V.,
            Lewanczuk,R., Hamet,P. and Tremblay,J.
  TITLE     Chromosomal mapping of HCaRG, a novel hypertension-related,
            calcium-regulated gene
  JOURNAL   Folia Biol (Praha) 48 (1), 9-14 (2002)
   PUBMED   11871861
  REMARK    GeneRIF: The gene for human HCaRG is located on chromosome 8q24.3.
REFERENCE   9  (bases 1 to 1430)
  AUTHORS   Solban,N., Jia,H.P., Richard,S., Tremblay,S., Devlin,A.M., Peng,J.,
            Gossard,F., Guo,D.F., Morel,G., Hamet,P., Lewanczuk,R. and
            Tremblay,J.
  TITLE     HCaRG, a novel calcium-regulated gene coding for a nuclear protein,
            is potentially involved in the regulation of cell proliferation
  JOURNAL   J Biol Chem 275 (41), 32234-32243 (2000)
   PUBMED   10918053
REFERENCE   10 (bases 1 to 1430)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG705627.1, BC065729.1 and AW137480.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014066.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 4. Variants 1 through 4 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.437782.1,
                                           SRR5189658.209035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305103.4/ ENSP00000304544.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BG705627.1         22-38
            18-1153             BC065729.1         5-1140
            1154-1430           AW137480.1         27-303              c
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1430
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="COMM domain containing 5"
                     /db_xref="GeneID:28991"
                     /db_xref="HGNC:HGNC:17902"
                     /db_xref="MIM:608216"
     exon            1..210
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1430
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..942
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="hypertension-related calcium-regulated gene
                     protein"
                     /codon_start=1
                     /product="COMM domain-containing protein 5"
                     /protein_id="NP_054785.2"
                     /db_xref="CCDS:CCDS6436.1"
                     /db_xref="GeneID:28991"
                     /db_xref="HGNC:HGNC:17902"
                     /db_xref="MIM:608216"
                     /translation="MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLD
                     RSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPT
                     SLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVD
                     VAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRC
                     ERRLQD"
     regulatory      1133..1138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="hexamer: AGTAAA"
     polyA_site      1151
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="major polyA site"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="hexamer: AATAAA"
     regulatory      1413..1418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
                     /note="hexamer: CATAAA"
     polyA_site      1424
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
     polyA_site      1430
                     /gene="COMMD5"
                     /gene_synonym="HCARG; HT002"
ORIGIN      
        1 gcttccgggg accaggcccg cttttggctg catcagccgg ggattgccgg cgccaggtgc
       61 tgggggcgac tcggacagcg ggagcgtggg gtggagtagg atggagtctc cctcccgagc
      121 tgggggtgtg ggcctaggaa aggctgcttc gccgctgtgt tcggagagct ctggatactg
      181 cggggctttt ccgcggagga gcgcccgccg gcatctgcat ctgggaccga cctcctgggc
      241 tggctgatca aagaggaagc agcagcaatg tctgctgtgg gggctgcaac tccatacctg
      301 catcatcctg gtgatagtca cagtggccga gtgagtttct tgggggccca gcttcctcca
      361 gaggtggcag caatggcccg gctactaggg gacctagaca ggagcacgtt cagaaagttg
      421 ctgaagtttg tggtcagcag cctgcagggg gaggactgcc gagaggctgt gcagcgtctt
      481 ggggtcagcg ccaacctgcc ggaggagcag ctgggtgccc tgctggcagg catgcacaca
      541 ctgctccagc aggccctccg tctgcccccc accagcctga agcctgacac cttcagggac
      601 cagctccagg agctctgcat cccccaagac ctggtcgggg acttggccag cgtggtattt
      661 gggagccagc ggcccctcct tgattctgtg gcccagcagc agggggcctg gctgccgcat
      721 gttgctgact ttcggtggcg ggtggatgta gcaatctcca ccagtgccct ggctcgctcc
      781 ctgcagccga gcgtcctgat gcagctgaag ctttcagatg ggtcagcata ccgctttgag
      841 gtccccacag ccaagttcca ggagctgcgg tacagcgtgg ccctggtcct aaaggagatg
      901 gcagatctgg agaagaggtg tgagcgcaga ctgcaggact gacccctcac ttgaccagtc
      961 ccattcagat ccggcttgga caggcacctg agatggtgcc aaagtgcagc tgactcttcc
     1021 cacgacagcc ctgcccttcc catgaggcag gctcttcagt gagtgtttga acgtaattat
     1081 gtagttttct gtttaattga aaaagagagc tatgcctttt tttctttttg gaagtaaagc
     1141 agctaaaaac atgtttctat aggtgagtgt tggacctcac accctcccct tccctgtaca
     1201 tttgtctttg gtgctggacg tggccatgtg aggccaggtt gaggcccttt gtagacaaca
     1261 tacagttgct cagcctggcc ccatgtagcc aggtgctttt gtagatcttg tgttttaggt
     1321 tgggcatttt cactcttctg ccttaaatcc ctgaccccat ggagctgaca ttctagtgcg
     1381 gctgagggga ggggaaacat tgtaaaataa atcataaaaa ttaactggaa
//
