LOCUS       NM_017828                895 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens COMM domain containing 4 (COMMD4), transcript variant
            1, mRNA.
ACCESSION   NM_017828
VERSION     NM_017828.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 895)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 895)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 895)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 895)
  AUTHORS   Suraweera,A., Gandhi,N.S., Beard,S., Burgess,J.T., Croft,L.V.,
            Bolderson,E., Naqi,A., Ashton,N.W., Adams,M.N., Savage,K.I.,
            Zhang,S.D., O'Byrne,K.J. and Richard,D.J.
  TITLE     COMMD4 functions with the histone H2A-H2B dimer for the timely
            repair of DNA double-strand breaks
  JOURNAL   Commun Biol 4 (1), 484 (2021)
   PUBMED   33875784
  REMARK    GeneRIF: COMMD4 functions with the histone H2A-H2B dimer for the
            timely repair of DNA double-strand breaks.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 895)
  AUTHORS   Suraweera,A., Duff,A., Adams,M.N., Jekimovs,C., Duijf,P.H.G.,
            Liu,C., McTaggart,M., Beard,S., O'Byrne,K.J. and Richard,D.J.
  TITLE     Defining COMMD4 as an anti-cancer therapeutic target and prognostic
            factor in non-small cell lung cancer
  JOURNAL   Br J Cancer 123 (4), 591-603 (2020)
   PUBMED   32439936
  REMARK    GeneRIF: Defining COMMD4 as an anti-cancer therapeutic target and
            prognostic factor in non-small cell lung cancer.
            Erratum:[Br J Cancer. 2021 Apr;124(9):1612. doi:
            10.1038/s41416-020-01242-4.. PMID: 33500542]
REFERENCE   6  (bases 1 to 895)
  AUTHORS   Phillips-Krawczak,C.A., Singla,A., Starokadomskyy,P., Deng,Z.,
            Osborne,D.G., Li,H., Dick,C.J., Gomez,T.S., Koenecke,M.,
            Zhang,J.S., Dai,H., Sifuentes-Dominguez,L.F., Geng,L.N.,
            Kaufmann,S.H., Hein,M.Y., Wallis,M., McGaughran,J., Gecz,J.,
            Sluis,Bv., Billadeau,D.D. and Burstein,E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   7  (bases 1 to 895)
  AUTHORS   Starokadomskyy,P., Gluck,N., Li,H., Chen,B., Wallis,M., Maine,G.N.,
            Mao,X., Zaidi,I.W., Hein,M.Y., McDonald,F.J., Lenzner,S., Zecha,A.,
            Ropers,H.H., Kuss,A.W., McGaughran,J., Gecz,J. and Burstein,E.
  TITLE     CCDC22 deficiency in humans blunts activation of proinflammatory
            NF-kappaB signaling
  JOURNAL   J Clin Invest 123 (5), 2244-2256 (2013)
   PUBMED   23563313
REFERENCE   8  (bases 1 to 895)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   9  (bases 1 to 895)
  AUTHORS   Uys,G.M., Ramburan,A., Loos,B., Kinnear,C.J., Korkie,L.J.,
            Mouton,J., Riedemann,J. and Moolman-Smook,J.C.
  TITLE     Myomegalin is a novel A-kinase anchoring protein involved in the
            phosphorylation of cardiac myosin binding protein C
  JOURNAL   BMC Cell Biol 12, 18 (2011)
   PUBMED   21569246
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 895)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI829484.1 and BC068998.1.
            
            On May 17, 2019 this sequence version replaced NM_017828.4.
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.16500.1,
                                           SRR5189661.153514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267935.13/ ENSP00000267935.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BI829484.1         68-78
            12-895              BC068998.1         1-884
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..895
                     /gene="COMMD4"
                     /note="COMM domain containing 4"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
     exon            1..30
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..627
                     /gene="COMMD4"
                     /note="isoform 1 is encoded by transcript variant 1; COMM
                     domain-containing protein 4"
                     /codon_start=1
                     /product="COMM domain-containing protein 4 isoform 1"
                     /protein_id="NP_060298.2"
                     /db_xref="CCDS:CCDS10277.1"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
                     /translation="MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQ
                     GIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEH
                     AASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLE
                     VAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG"
     exon            31..102
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            103..168
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            169..208
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            209..328
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..409
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..586
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            587..895
                     /gene="COMMD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      874..879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD4"
                     /note="hexamer: AATAAA"
     polyA_site      895
                     /gene="COMMD4"
                     /note="major polyA site"
ORIGIN      
        1 attcccgggc cctggcttct tggcgcgatg aggttccggt tctgtggtga tctggactgt
       61 cccgactggg tcctggcaga aatcagcacg ctggccaaga tgtcctctgt gaagttgcgg
      121 ctgctctgca gccaggtact aaaggagctg ctgggacagg ggattgatta tgagaagatc
      181 ctgaagctca cggctgacgc caagtttgag tcaggcgatg tgaaggccac agtggcagtg
      241 ctgagtttca tcctctccag tgcggccaag cacagtgtcg atggcgaatc cttgtccagt
      301 gaactgcagc agctggggct gcccaaagag cacgcggcca gcctgtgccg ctgttatgag
      361 gagaagcaaa gccccttgca gaagcacttg cgggtctgca gcctacgcat gaataggttg
      421 gcaggtgtgg gctggcgggt ggactacacc ctgagctcca gcctgctgca atccgtggaa
      481 gagcccatgg tgcacctgcg gctggaggtg gcagctgccc cagggacccc agcccagcct
      541 gttgccatgt ccctctcagc agacaagttc caggtcctcc tggcagaact gaagcaggcc
      601 cagaccctga tgagctccct gggctgagga gaagggtgtt ccaggcctgt gtggagccgc
      661 cctgcccgta tggagtcacg ccctctgaac tgctcttcgg gaggcagccc tggttctagg
      721 atgctgaggc cctggcccgg actctggcct cccagatccc cagctgcctc acttctctct
      781 tgagaacttg gctcagggct cctgaggacc tttcccagca ttaccttccc ttcccttgaa
      841 aggcaattgt tggctgtttt cataagcagg aaaaataaac agaagtataa aggaa
//
