LOCUS       NM_012071                926 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens COMM domain containing 3 (COMMD3), mRNA.
ACCESSION   NM_012071
VERSION     NM_012071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 926)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 926)
  AUTHORS   Hancock,J.L., Kalimutho,M., Straube,J., Lim,M., Gresshoff,I.,
            Saunus,J.M., Lee,J.S., Lakhani,S.R., Simpson,K.J., Bush,A.I.,
            Anderson,R.L. and Khanna,K.K.
  TITLE     COMMD3 loss drives invasive breast cancer growth by modulating
            copper homeostasis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 90 (2023)
   PUBMED   37072858
  REMARK    GeneRIF: COMMD3 loss drives invasive breast cancer growth by
            modulating copper homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 926)
  AUTHORS   Wang,S., Liu,Y., Li,S., Chen,Y., Liu,Y., Yan,J., Wu,J., Li,J.,
            Wang,L., Xiang,R., Shi,Y., Qin,X. and Yang,S.
  TITLE     COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the
            Progression of Ovarian Carcinoma
  JOURNAL   Mol Cancer Res 21 (3), 199-213 (2023)
   PUBMED   36445330
  REMARK    GeneRIF: COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the
            Progression of Ovarian Carcinoma.
REFERENCE   4  (bases 1 to 926)
  AUTHORS   Ambrosio,A.L., Febvre,H.P. and Di Pietro,S.M.
  TITLE     Syntaxin 12 and COMMD3 are new factors that function with VPS33B in
            the biogenesis of platelet alpha-granules
  JOURNAL   Blood 139 (6), 922-935 (2022)
   PUBMED   34905616
  REMARK    GeneRIF: Syntaxin 12 and COMMD3 are new factors that function with
            VPS33B in the biogenesis of platelet alpha-granules.
REFERENCE   5  (bases 1 to 926)
  AUTHORS   Wang,X., He,S., Zheng,X., Huang,S., Chen,H., Chen,H., Luo,W.,
            Guo,Z., He,X. and Zhao,Q.
  TITLE     Transcriptional analysis of the expression, prognostic value and
            immune infiltration activities of the COMMD protein family in
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 21 (1), 1001 (2021)
   PUBMED   34493238
  REMARK    GeneRIF: Transcriptional analysis of the expression, prognostic
            value and immune infiltration activities of the COMMD protein
            family in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 926)
  AUTHORS   Phillips-Krawczak,C.A., Singla,A., Starokadomskyy,P., Deng,Z.,
            Osborne,D.G., Li,H., Dick,C.J., Gomez,T.S., Koenecke,M.,
            Zhang,J.S., Dai,H., Sifuentes-Dominguez,L.F., Geng,L.N.,
            Kaufmann,S.H., Hein,M.Y., Wallis,M., McGaughran,J., Gecz,J.,
            Sluis,Bv., Billadeau,D.D. and Burstein,E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   7  (bases 1 to 926)
  AUTHORS   Starokadomskyy,P., Gluck,N., Li,H., Chen,B., Wallis,M., Maine,G.N.,
            Mao,X., Zaidi,I.W., Hein,M.Y., McDonald,F.J., Lenzner,S., Zecha,A.,
            Ropers,H.H., Kuss,A.W., McGaughran,J., Gecz,J. and Burstein,E.
  TITLE     CCDC22 deficiency in humans blunts activation of proinflammatory
            NF-kappaB signaling
  JOURNAL   J Clin Invest 123 (5), 2244-2256 (2013)
   PUBMED   23563313
REFERENCE   8  (bases 1 to 926)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   9  (bases 1 to 926)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   10 (bases 1 to 926)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF695081.1 and AF201948.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012071.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201948.1, SRR5189664.146551.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376836.8/ ENSP00000366032.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BF695081.1         7-7
            2-926               AF201948.1         1-925
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..926
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="COMM domain containing 3"
                     /db_xref="GeneID:23412"
                     /db_xref="HGNC:HGNC:23332"
                     /db_xref="MIM:616700"
     exon            1..169
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..618
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="protein Bup"
                     /codon_start=1
                     /product="COMM domain-containing protein 3"
                     /protein_id="NP_036203.1"
                     /db_xref="CCDS:CCDS7137.1"
                     /db_xref="GeneID:23412"
                     /db_xref="HGNC:HGNC:23332"
                     /db_xref="MIM:616700"
                     /translation="MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEA
                     VLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCT
                     EYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDS
                     PSYPEISFSCSMEQLQDLVGKLKDASKSLERATQL"
     exon            170..281
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            282..345
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            346..380
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            381..441
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            442..498
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            499..558
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     exon            559..926
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="hexamer: AATAAA"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="hexamer: AATAAG"
     polyA_site      922
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="major polyA site"
     polyA_site      926
                     /gene="COMMD3"
                     /gene_synonym="BUP; C10orf8"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtgtcg aaggtcacgg cgcgctcaca atggagctct cggagtctgt gcagaaaggc
       61 ttccagatgc tggcggatcc ccgctccttc gactccaacg ccttcacgct tctcctccgg
      121 gcggcattcc agagtctgct ggacgcccag gcggacgagg ccgtgttaga tcatccagac
      181 ttgaaacata tcgacccagt ggttttaaaa cattgtcatg cagcagctgc aacttacata
      241 ctagaggcag gaaagcaccg agctgacaag tcaactctaa gcacttatct agaagactgt
      301 aaatttgaca gagagcgaat agaactgttt tgcacggaat atcagaataa taagaattcc
      361 ctagaaatcc tactgggaag tataggcaga tctctccctc atataacgga tgtttcttgg
      421 cgcttggaat atcagataaa gaccaatcaa cttcatagga tgtacagacc tgcatatttg
      481 gtgaccttaa gtgtacagaa cactgattcc ccatcctatc cagagattag ttttagttgc
      541 agcatggaac aattacagga cttggtgggg aaacttaaag atgcttcgaa aagcctggaa
      601 agagcaactc agttgtaact tggggaagtt aacgatccgc ccgagtgcag aggaaaacca
      661 gaaacgcctt gccttcagct gaaccaccgt ttgtgcgagc tggatgtcct tttcagtaga
      721 aaagaatttt ccttttgaat ttataccatt catcaatttt gacactttaa aaacgtgtga
      781 aagggttaag agggaaagat actgcccaag tatttgaatc gtttagtagt aactgtccat
      841 ttatcctatt ttgatctttt tcaagtcttc tgaaaggaag tagacagtat tacaccctga
      901 ataaataagg tgttgttttc cacaaa
//
