LOCUS       NM_001204062            3382 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens COMMD3-BMI1 readthrough (COMMD3-BMI1), mRNA.
ACCESSION   NM_001204062
VERSION     NM_001204062.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3382)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158211.29 and AK313235.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001204062.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring COMM domain-containing
            protein 3 and polycomb complex protein BMI-1 genes on chromosome
            10. The read-through transcript produces a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313235.1, SRR14372079.1444793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 648, 23412
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL158211.29        71395-71415
            22-74               AK313235.1         1-53
            75-1440             AK313235.1         55-1420
            1441-3382           AL158211.29        84550-86491
FEATURES             Location/Qualifiers
     source          1..3382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3382
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="COMMD3-BMI1 readthrough"
                     /db_xref="GeneID:100532731"
                     /db_xref="HGNC:HGNC:48326"
     exon            1..169
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1440
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="Polycomb complex protein BMI-1; Polycomb group RING
                     finger protein 4; RING finger protein 51"
                     /codon_start=1
                     /product="COMMD3-BMI1 read-through protein"
                     /protein_id="NP_001190991.1"
                     /db_xref="GeneID:100532731"
                     /db_xref="HGNC:HGNC:48326"
                     /translation="MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEA
                     VLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCT
                     EYQNNKNSLEILLGRTLIPHPIQRLVLVAAWNNYRIFYQAEMHRTTRIKITELNPHLM
                     CVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTL
                     QDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEDKRIITDDEIISL
                     SIEFFDQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQI
                     DVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGEL
                     ESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQSS
                     FANRPRKSSVNGSSATSSG"
     exon            170..281
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            282..345
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            346..380
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            381..440
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            441..571
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            572..668
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            669..724
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            725..775
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            776..884
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            885..930
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1029
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1110
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..3382
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="hexamer: ATTAAA"
     polyA_site      2966
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="major polyA site"
     regulatory      3358..3363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="hexamer: AGTAAA"
     polyA_site      3382
                     /gene="COMMD3-BMI1"
                     /gene_synonym="BMI1; PCGF4; RNF51"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtgtcg aaggtcacgg cgcgctcaca atggagctct cggagtctgt gcagaaaggc
       61 ttccagatgc tggcggatcc ccgctccttc gactccaacg ccttcacgct tctcctccgg
      121 gcggcattcc agagtctgct ggacgcccag gcggacgagg ccgtgttaga tcatccagac
      181 ttgaaacata tcgacccagt ggttttaaaa cattgtcatg cagcagctgc aacttacata
      241 ctagaggcag gaaagcaccg agctgacaag tcaactctaa gcacttatct agaagactgt
      301 aaatttgaca gagagcgaat agaactgttt tgcacggaat atcagaataa taagaattcc
      361 ctagaaatcc tactgggaag aacactgatt ccccatccta tccagagatt agttttagtt
      421 gcagcatgga acaattacag gattttttat caagcagaaa tgcatcgaac aacgagaatc
      481 aagatcactg agctaaatcc ccacctgatg tgtgtgcttt gtggagggta cttcattgat
      541 gccacaacca taatagaatg tctacattcc ttctgtaaaa cgtgtattgt tcgttacctg
      601 gagaccagca agtattgtcc tatttgtgat gtccaagttc acaagaccag accactactg
      661 aatataaggt cagataaaac tctccaagat attgtataca aattagttcc agggcttttc
      721 aaaaatgaaa tgaagagaag aagggatttt tatgcagctc atccttctgc tgatgctgcc
      781 aatggctcta atgaagatag aggagaggtt gcagatgaag ataagagaat tataactgat
      841 gatgagataa taagcttatc cattgaattc tttgaccaga acagattgga tcggaaagta
      901 aacaaagaca aagagaaatc taaggaggag gtgaatgata aaagatactt acgatgccca
      961 gcagcaatga ctgtgatgca cttaagaaag tttctcagaa gtaaaatgga catacctaat
     1021 actttccaga ttgatgtcat gtatgaggag gaacctttaa aggattatta tacactaatg
     1081 gatattgcct acatttatac ctggagaagg aatggtccac ttccattgaa atacagagtt
     1141 cgacctactt gtaaaagaat gaagatcagt caccagagag atggactgac aaatgctgga
     1201 gaactggaaa gtgactctgg gagtgacaag gccaacagcc cagcaggagg tattccctcc
     1261 acctcttctt gtttgcctag ccccagtact ccagtgcagt ctcctcatcc acagtttcct
     1321 cacatttcca gtactatgaa tggaaccagc aacagcccca gcggtaacca ccaatcttct
     1381 tttgccaata gacctcgaaa atcatcagta aatgggtcat cagcaacttc ttctggttga
     1441 tacctgagac tgttaaggaa aaaaatttta aacccctgat ttatatagat atcttcatgc
     1501 cattacagct ttctagatgc taatacatgt gactatcgtc caatttgctt tcttttgtag
     1561 tgacattaaa tttggctata aaagatggac tacatgtgat actcctatgg acgttaattg
     1621 aaaagaaaga ttgttgttat aaagaattgg tttcttggaa agcaggcaag actttttctc
     1681 tgtgttagga aagatgggaa atggtttctg taaccattgt ttggatttgg aagtactctg
     1741 cagtggacat aagcattggg ccatagtttg ttaatctcaa ctaacgccta cattacattc
     1801 tccttgatcg ttcttgttat tacgctgttt tgtgaacctg tagaaaacaa gtgcttttta
     1861 tcttgaaatt caaccaacgg aaagaatatg catagaataa tgcattctat gtagccatgt
     1921 cactgtgaat aacgatttct tgcatattta gccattttga ttcctgtttg atttatactt
     1981 ctctgttgct acgcaaaacc gatcaaagaa aagtgaactt cagttttaca atctgtatgc
     2041 ctaaaagcgg gtactaccgt ttattttact gacttgttta aatgattcgc ttttgtaaga
     2101 atcagatggc attatgcttg ttgtacaatg ccatattggt atatgacata acaggaaaca
     2161 gtattgtatg atatatttat aaatgctata aagaaatatt gtgtttcatg cattcagaaa
     2221 tgattgttaa aattctccca actggttcga cctttgcaga tacccataac ctatgttgag
     2281 ccttgcttac cagcaaagaa tatttttaat gtggatatct aattctaaag tctgttccat
     2341 tagaagcaat tggcacatct ttctatactt tatatacttt tctccagtaa tacatgttta
     2401 ctttaaagat tgttgcagtg aagaaaaacc tttaactgag aaatatggaa accgtcttaa
     2461 ttttccattg gctatgatgg aattaatatt gtattttaaa aatgcatatt gatcactata
     2521 attctaaaac aattttttaa ataaaccagc aggttgctaa aagaaggcat tttatctaaa
     2581 gttattttaa taggtggtat agcagtaatt ttaaatttaa gagttgcttt tacagttaac
     2641 aatggaatat gccttctctg ctatgtctga aaatagaagc tatttattat gagcttctac
     2701 aggtattttt aaatagagca agcatgttga atttaaaata tgaataaccc cacccaacaa
     2761 ttttcagttt attttttgct ttggtcgaac ttggtgtgtg ttcatcaccc atcagttatt
     2821 tgtgagggtg tttattctat atgaatattg tttcatgttt gtatgggaaa attgtagcta
     2881 aacatttcat tgtccccagt ctgcaaaaga agcacaattc tattgctttg tcttgcttat
     2941 agtcattaaa tcattacttt tacatatatt gctgttactt ctgctttctt taaaaatata
     3001 gtaaaggatg ttttatgaag tcacaagata catatatttt tattttgacc taaatttgta
     3061 cagtcccatt gtaagtgttg tttctaatta tagatgtaaa atgaaatttc atttgtaatt
     3121 ggaaaaaatc caataaaaag gatattcatt tagaaaatag ctaagatctt taataaaaat
     3181 ttgatatgaa aagcacaatg tgcagaagtt atggaaaacc tatagaggat tacaacaggt
     3241 aaacgttaaa gagaatacat tgctgactta tagtgatgtg gctaagaagt acatgctttg
     3301 ttgtaaaatt gcttgaaagc ccattgaaag atgtatctgt ttatttacag tctttgaagt
     3361 aaaagttacc aatgtttgcc aa
//
