LOCUS       NM_016094               3694 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COMM domain containing 2 (COMMD2), transcript variant
            1, mRNA.
ACCESSION   NM_016094
VERSION     NM_016094.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Tai,P., Wang,Z., Chen,X., Chen,A., Gong,L., Cheng,Y. and Cao,K.
  TITLE     Multi-omics analysis of the oncogenic value of copper
            Metabolism-Related protein COMMD2 in human cancers
  JOURNAL   Cancer Med 12 (10), 11941-11959 (2023)
   PUBMED   36205192
  REMARK    GeneRIF: Multi-omics analysis of the oncogenic value of copper
            Metabolism-Related protein COMMD2 in human cancers.
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Phillips-Krawczak,C.A., Singla,A., Starokadomskyy,P., Deng,Z.,
            Osborne,D.G., Li,H., Dick,C.J., Gomez,T.S., Koenecke,M.,
            Zhang,J.S., Dai,H., Sifuentes-Dominguez,L.F., Geng,L.N.,
            Kaufmann,S.H., Hein,M.Y., Wallis,M., McGaughran,J., Gecz,J.,
            Sluis,Bv., Billadeau,D.D. and Burstein,E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Starokadomskyy,P., Gluck,N., Li,H., Chen,B., Wallis,M., Maine,G.N.,
            Mao,X., Zaidi,I.W., Hein,M.Y., McDonald,F.J., Lenzner,S., Zecha,A.,
            Ropers,H.H., Kuss,A.W., McGaughran,J., Gecz,J. and Burstein,E.
  TITLE     CCDC22 deficiency in humans blunts activation of proinflammatory
            NF-kappaB signaling
  JOURNAL   J Clin Invest 123 (5), 2244-2256 (2013)
   PUBMED   23563313
REFERENCE   9  (bases 1 to 3694)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   10 (bases 1 to 3694)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA811158.1, BC022206.1, BC001228.1, AK055223.1 and BU633168.1.
            
            On Nov 24, 2018 this sequence version replaced NM_016094.3.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3471100.1,
                                           SRR11853561.21375.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000473414.6/ ENSP00000419475.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA811158.1         10-512
            504-1108            BC022206.1         498-1102
            1109-1227           BC001228.1         1098-1216
            1228-3664           AK055223.1         49-2485
            3665-3694           BU633168.1         21-50               c
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..3694
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /note="COMM domain containing 2"
                     /db_xref="GeneID:51122"
                     /db_xref="HGNC:HGNC:24993"
                     /db_xref="MIM:616699"
     exon            1..112
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..645
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /codon_start=1
                     /product="COMM domain-containing protein 2"
                     /protein_id="NP_057178.2"
                     /db_xref="CCDS:CCDS3145.1"
                     /db_xref="GeneID:51122"
                     /db_xref="HGNC:HGNC:24993"
                     /db_xref="MIM:616699"
                     /translation="MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIY
                     EGAARKLNVSSDTVQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQL
                     YLDNRKEIRTILSELAPSLPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDH
                     NTKVLQTDPATLLHLVQQLEQALEEMKTNHCRRVVRNIK"
     exon            113..190
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /inference="alignment:Splign:2.1.0"
     exon            191..273
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /inference="alignment:Splign:2.1.0"
     exon            274..447
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /inference="alignment:Splign:2.1.0"
     exon            448..3694
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /note="hexamer: AATAAA"
     polyA_site      1419
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /note="major polyA site"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /note="hexamer: AATAAA"
     polyA_site      3694
                     /gene="COMMD2"
                     /gene_synonym="HSPC042"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcgggg tcggcgctgc cgggtgaaat cgtaggacag tgaagatgct gctggaattg
       61 tccgaggagc ataaggaaca cctggccttc ctgcctcaag tggacagcgc ggtggtcgcc
      121 gagtttgggc ggattgctgt ggaattcctg agacgcggcg caaacccaaa aatctacgaa
      181 ggcgccgcca gaaaactcaa tgtgagtagt gacactgtcc agcatggtgt ggaaggatta
      241 acgtatctcc tcactgagag ctcaaagctc atgatttctg aactggattt ccaagactct
      301 gtttttgttc tgggattctc tgaagaatta aacaaattgt tgcttcagct ttatctggac
      361 aacagaaaag agatcagaac gattctgagt gaattggcac caagccttcc cagttatcat
      421 aaccttgaat ggcgactaga tgtacagctt gcaagtagaa gtctcaggca acagattaaa
      481 ccagcagtga ctataaagct acaccttaat caaaatggag atcacaacac caaagttctg
      541 cagacagacc cagccaccct gctccatttg gttcaacaac tggaacaagc attggaagag
      601 atgaagacaa atcactgtag gagagttgtt cgcaacatca agtagtacca gttttaaggt
      661 tttaattcat ttgaatcact tatgaattga tgatatacag caattacttt tcaaaattaa
      721 ttttttatta attcatgatg ataaatacat agtattcctc agtatctatt ccaagatact
      781 gaggtcataa tcagaagcta agctgggtgc agtggctcat gccagttatc ccagcacttt
      841 gggaggccga ggtgggcaaa tcatgaggtc aggagattga gaccttcctg gctaacatgg
      901 tgaaacccca tctctactaa aaatataaaa aattagccag gtgtggtggc acgcatctat
      961 cagagtccca gctactcagg aggctgaggc aggagaatcg cttgaacctg ggaggtggag
     1021 gttgcagtga gctgagattg tgccactgca ctccagcctg ggtgacagag tgagactcca
     1081 tctcaaaaat aataataata ataataaagt aaaaataaaa ataaaaaagt aatcagaagc
     1141 taaagtaaag ttcctttcct ggtgctaact gtggtcttct tgacacatta agatgtattt
     1201 tgtattttaa gagtctcatg ctctaccgtt ggaactagcc agatggccat tattttgtat
     1261 tttaaataca taaataggat tgaatcaact agaaatgaat ctatatgttc tgtatatatg
     1321 aatgactatc ttgtttttgc tacttctttt gactgcttaa ttttattatt ttcatcttta
     1381 ttgatcaaat ttgaaaataa aattcacaat gtaatactac tactatgcag aattttctaa
     1441 acagttcagt atttttgact tttaaaaaca ccccacagtg ttaatagcca cagaatattg
     1501 aacatcaata ggatttttaa tgctatattg ttataggcag tttattcatt tttctttgta
     1561 tatgaagatg ataagtatca tattgcctaa gtttgagtga tcatggttaa ttaattggct
     1621 taaatagtac tcaaatttgt gtggtcgtat attgtatttt atcaaggact aattcttcca
     1681 ccatacccaa agcatctagg agacactctg tcatttacat ttacaaataa tggatgcaga
     1741 gaaatataat caattcttga ttgtcctgga tacaaattat agtcactttt tataatttga
     1801 ataaactatg atgagggaag gaaggccatg tttattacat tataggcaac tatcccttct
     1861 caaaacataa cttgatttat gttttgtttt attttttagt agggaaccaa aagcttttgg
     1921 tctgaaaaac tcaggtgctg atttgtcagg tcagcctgag agagtgcaga gatactgagg
     1981 tcagcttagg gagaagaatt gtatggaagg gtggaaatga gggttcagtc ttaactatgt
     2041 gtccaagacc ttatcctgag agtcttcatg gaataatcta gaaagggctg tagaagcaat
     2101 caaactctaa actgcgctct agactttgtc aatactttgc ttcgtaagaa ttagggattt
     2161 tcatatcaga gtgataccat gttgcaatct ctttagagaa gagagagcct agcagggaat
     2221 aggctagtgg aagaaaaaca tacttgagat ggttacccat tggtccctgc aggcatctgg
     2281 gccacccttt tcctgtaggt atatattctg ccgttgtgaa acaactatat tattagatgt
     2341 cagcaaacta taatcagaaa taatttttaa ttatagtggc aacttgatta atgaagctct
     2401 catatacaac ctcacaaaca aaaagaaact ttattacgtg aaatagtagc atatgtcatt
     2461 gggtttaaaa gcaacatgcc tgcaaaacat atgataaaaa atacctctgt aagggttttt
     2521 atttgtccac cttcgatgga aggtaaacat ggctgatccc agccaagatg aaacaatagc
     2581 cctttgtctc ctcagaacaa cctatctcca actctttgtc cactgttctt accccaatta
     2641 aaacaagaaa gcatgtgcta atcctttttt aatttttatc aacctgcctt ggcctccttt
     2701 cactgtactc cattattcct tctgtgatgt tctaccttct tcaccttttg agaccagggt
     2761 gagttgggag cagtttgcct accttctttt agaatctggg gcttatcttt tagtacaagc
     2821 cattgaataa gcctcttcct tttttttgct caaacattcc acatccttgt ggattcccct
     2881 gcattgtttg ttttatataa catttgatat ttgttgtagc ttgtatatga acataatttt
     2941 ctttagaggt agtcactgtt ctctccagta tgacccaggt ttcttgactc tgagtaatgc
     3001 accttctata actatctaaa tttctattga agctttttgg attatgagta tgctgacttt
     3061 tcacgattgg ctggtgcatg tttagactta aatgtcatat ccttcatgtc tcaaagccaa
     3121 aatagtaaca tctcatctca gaacagagct gtgaccacat gccaatatat gtgtcacaaa
     3181 gtctacatat gttacattcc ttggaagtct ccttaaatgt ttcacaaaat gtcaacaagc
     3241 ttgttttgtt attgatattt ccgagattgg gcacatttaa gacagtaaac gggaaaggtg
     3301 gtgaagatgc tataagaaga tgctgtatct tgagaattga aaaatgagaa tctgacatgg
     3361 tttgaaaaat catgaagggt atatataaag gatgcatgtg taggagccat taaaattcat
     3421 aacagtatgt gccccttcag cgttttaatc ttatgaagtg gttaagagat aagtcttcgg
     3481 agttggacaa aaggatttga atttaggttc tgtggattat tatgggtcct tgataaattc
     3541 tcaaagcctt tttttttgtt catctctaaa ataggaatat aggattacct accacattga
     3601 ctcgtaagga ctatatgaga ccatgtatat agaatgttta acatagtacc aggctttaca
     3661 aagaactcaa taaatgttta ccattattga aata
//
