LOCUS       NM_016144               1435 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens COMM domain containing 10 (COMMD10), transcript
            variant 1, mRNA.
ACCESSION   NM_016144
VERSION     NM_016144.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Zhao,W., Lin,J., Cheng,S., Li,H., Shu,Y. and Xu,C.
  TITLE     Comprehensive analysis of COMMD10 as a novel prognostic biomarker
            for gastric cancer
  JOURNAL   PeerJ 11, e14645 (2023)
   PUBMED   36919165
  REMARK    GeneRIF: Comprehensive analysis of COMMD10 as a novel prognostic
            biomarker for gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Yang,M., Wu,X., Hu,J., Wang,Y., Wang,Y., Zhang,L., Huang,W.,
            Wang,X., Li,N., Liao,L., Chen,M., Xiao,N., Dai,Y., Liang,H.,
            Huang,W., Yuan,L., Pan,H., Li,L., Chen,L., Liu,L., Liang,L. and
            Guan,J.
  TITLE     COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and
            radiosensitivity by disrupting Cu-Fe balance in hepatocellular
            carcinoma
  JOURNAL   J Hepatol 76 (5), 1138-1150 (2022)
   PUBMED   35101526
  REMARK    GeneRIF: COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis
            and radiosensitivity by disrupting Cu-Fe balance in hepatocellular
            carcinoma.
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Yang,M., Wu,X., Li,L., Li,S., Li,N., Mao,M., Pan,S., Du,R.,
            Wang,X., Chen,M., Xiao,N., Zhu,X., He,G., Zhang,L., Huang,W.,
            Pan,H., Deng,L., Chen,L., Liang,L. and Guan,J.
  TITLE     COMMD10 inhibits tumor progression and induces apoptosis by
            blocking NF-kappaB signal and values up BCLC staging in predicting
            overall survival in hepatocellular carcinoma
  JOURNAL   Clin Transl Med 11 (5), e403 (2021)
   PUBMED   34047468
  REMARK    GeneRIF: COMMD10 inhibits tumor progression and induces apoptosis
            by blocking NF-kappaB signal and values up BCLC staging in
            predicting overall survival in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Starokadomskyy,P., Gluck,N., Li,H., Chen,B., Wallis,M., Maine,G.N.,
            Mao,X., Zaidi,I.W., Hein,M.Y., McDonald,F.J., Lenzner,S., Zecha,A.,
            Ropers,H.H., Kuss,A.W., McGaughran,J., Gecz,J. and Burstein,E.
  TITLE     CCDC22 deficiency in humans blunts activation of proinflammatory
            NF-kappaB signaling
  JOURNAL   J Clin Invest 123 (5), 2244-2256 (2013)
   PUBMED   23563313
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Bergen,S.E., O'Dushlaine,C.T., Ripke,S., Lee,P.H., Ruderfer,D.M.,
            Akterin,S., Moran,J.L., Chambert,K.D., Handsaker,R.E., Backlund,L.,
            Osby,U., McCarroll,S., Landen,M., Scolnick,E.M., Magnusson,P.K.,
            Lichtenstein,P., Hultman,C.M., Purcell,S.M., Sklar,P. and
            Sullivan,P.F.
  TITLE     Genome-wide association study in a Swedish population yields
            support for greater CNV and MHC involvement in schizophrenia
            compared with bipolar disorder
  JOURNAL   Mol Psychiatry 17 (9), 880-886 (2012)
   PUBMED   22688191
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Aslibekyan,S., Kabagambe,E.K., Irvin,M.R., Straka,R.J.,
            Borecki,I.B., Tiwari,H.K., Tsai,M.Y., Hopkins,P.N., Shen,J.,
            Lai,C.Q., Ordovas,J.M. and Arnett,D.K.
  TITLE     A genome-wide association study of inflammatory biomarker changes
            in response to fenofibrate treatment in the Genetics of Lipid
            Lowering Drug and Diet Network
  JOURNAL   Pharmacogenet Genomics 22 (3), 191-197 (2012)
   PUBMED   22228203
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Mao,X., Gluck,N., Chen,B., Starokadomskyy,P., Li,H., Maine,G.N. and
            Burstein,E.
  TITLE     COMMD1 (copper metabolism MURR1 domain-containing protein 1)
            regulates Cullin RING ligases by preventing CAND1
            (Cullin-associated Nedd8-dissociated protein 1) binding
  JOURNAL   J Biol Chem 286 (37), 32355-32365 (2011)
   PUBMED   21778237
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Burstein,E., Hoberg,J.E., Wilkinson,A.S., Rumble,J.M., Csomos,R.A.,
            Komarck,C.M., Maine,G.N., Wilkinson,J.C., Mayo,M.W. and
            Duckett,C.S.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY139221.1, BC005179.1 and AW662195.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016144.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.985282.1,
                                           SRR5189655.73216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274458.9/ ENSP00000274458.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 HY139221.1         51-55
            6-942               BC005179.1         1-937
            943-1435            AW662195.1         9-501               c
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..1435
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /note="COMM domain containing 10"
                     /db_xref="GeneID:51397"
                     /db_xref="HGNC:HGNC:30201"
                     /db_xref="MIM:616704"
     exon            1..69
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..637
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /note="isoform a is encoded by transcript variant 1; COMM
                     domain-containing protein 10"
                     /codon_start=1
                     /product="COMM domain-containing protein 10 isoform a"
                     /protein_id="NP_057228.1"
                     /db_xref="CCDS:CCDS34215.1"
                     /db_xref="GeneID:51397"
                     /db_xref="HGNC:HGNC:30201"
                     /db_xref="MIM:616704"
                     /translation="MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLK
                     AESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLR
                     QDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVL
                     QLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQAQLDSLT"
     exon            70..160
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     exon            161..271
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     exon            272..427
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     exon            428..538
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     exon            539..598
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     exon            599..1435
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1413..1418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /note="hexamer: AATAAA"
     polyA_site      1435
                     /gene="COMMD10"
                     /gene_synonym="PTD002"
                     /note="major polyA site"
ORIGIN      
        1 agacggcggc agtgcgagaa agccgaagat ggcggtcccc gcggcgctga tcctacggga
       61 gagccccagc atgaagaaag cagtgtcact gataaatgca atagatacag gaagatttcc
      121 acggttgctc actcggattc ttcaaaaact tcacctgaag gctgagagca gtttcagtga
      181 agaagaggaa gaaaaacttc aagcggcatt ttctctagag aaacaagatc ttcacctagt
      241 tcttgaaaca atatcattta ttttagaaca ggcagtgtat cacaatgtga agccagcagc
      301 tttgcagcag caattagaga acattcatct tagacaagac aaagctgaag catttgtcaa
      361 tacgtggtct tctatgggtc aagaaacagt tgaaaagttc cggcagagaa ttctggctcc
      421 ctgtaagcta gagaccgttg gatggcagct taaccttcag atggctcact ctgctcaagc
      481 aaaactaaaa tctcctcaag ctgtgttaca actcggagtg aacaatgaag attcaaagag
      541 cctggagaaa gttcttgtgg aattcagtca caaggagttg tttgatttct ataacaagct
      601 agagactata caagcacagc tggattccct tacatgatgt tttcgaagac tgtttttttc
      661 atcacgctcc tgccacctca ttattttgca ttgaagatac attgccaggt tgtgttttct
      721 gaaggattca gtgacttgct ttctgtaaat tatatggctt atcacttctt agacaaataa
      781 caaccaatag agatcattgt taagaatact gaggttctaa tatactttct ttagttctgt
      841 gagccaacag taattattaa gaacactttc cctttaaagg aaacaaaagt gaataccata
      901 ttgtttttac tgtcatagtg ttgctttctt gcctgtcctg cttagttttt acttgctgga
      961 tgataccata atgtatcaag gagcgtccat ggatacaaga taagatgtgt accttagtag
     1021 aatacagagc tttggtaatt acatgaataa aattaagaaa atagccatat acaatcaaat
     1081 acactatggc atttttattt gaatatgatg agtatatttt gcttcggaaa taatatagga
     1141 aggaaatgta aaatagtgag tagtatggta tcagttaatt ccagtctgag cttctctgtc
     1201 aacttcagtt tctctctcag tttaatgatt taataatagt ccaggttttt gtgtgttttt
     1261 ctttatactg caaattaata atgattcact ttatagtttg ggagacagaa tcaggtcttg
     1321 aataaaataa ttgtaatgag tgctaaatgg gcaccattat tcgaatcaga taccttttat
     1381 attctctttc cataaatacg ttgatttctg tcaataaaat ttttgtgtct tagga
//
