LOCUS       NM_015101               5179 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens collagen beta(1-O)galactosyltransferase 2 (COLGALT2),
            transcript variant 1, mRNA.
ACCESSION   NM_015101
VERSION     NM_015101.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Kehayova,Y.S., Wilkinson,J.M., Rice,S.J. and Loughlin,J.
  TITLE     Mediation of the Same Epigenetic and Transcriptional Effect by
            Independent Osteoarthritis Risk-Conferring Alleles on a Shared
            Target Gene, COLGALT2
  JOURNAL   Arthritis Rheumatol 75 (6), 910-922 (2023)
   PUBMED   36538011
  REMARK    GeneRIF: Mediation of the Same Epigenetic and Transcriptional
            Effect by Independent Osteoarthritis Risk-Conferring Alleles on a
            Shared Target Gene, COLGALT2.
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Kehayova,Y.S., Wilkinson,J.M., Rice,S.J. and Loughlin,J.
  TITLE     Osteoarthritis genetic risk acting on the galactosyltransferase
            gene COLGALT2 has opposing functional effects in articulating joint
            tissues
  JOURNAL   Arthritis Res Ther 25 (1), 83 (2023)
   PUBMED   37208701
  REMARK    GeneRIF: Osteoarthritis genetic risk acting on the
            galactosyltransferase gene COLGALT2 has opposing functional effects
            in articulating joint tissues.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   Kehayova,Y.S., Watson,E., Wilkinson,J.M., Loughlin,J. and Rice,S.J.
  TITLE     Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer
            Associated With Osteoarthritis
  JOURNAL   Arthritis Rheumatol 73 (10), 1856-1865 (2021)
   PUBMED   33760386
  REMARK    GeneRIF: Genetic and Epigenetic Interplay Within a COLGALT2
            Enhancer Associated With Osteoarthritis.
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Guo,T., Li,B., Kang,Y., Gu,C., Fang,F., Chen,X., Liu,X., Lu,G.,
            Feng,C. and Xu,C.
  TITLE     COLGALT2 is overexpressed in ovarian cancer and interacts with
            PLOD3
  JOURNAL   Clin Transl Med 11 (3), e370 (2021)
   PUBMED   33783989
  REMARK    GeneRIF: COLGALT2 is overexpressed in ovarian cancer and interacts
            with PLOD3.
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Okada,Y., Kamatani,Y., Takahashi,A., Matsuda,K., Hosono,N.,
            Ohmiya,H., Daigo,Y., Yamamoto,K., Kubo,M., Nakamura,Y. and
            Kamatani,N.
  TITLE     A genome-wide association study in 19 633 Japanese subjects
            identified LHX3-QSOX2 and IGF1 as adult height loci
  JOURNAL   Hum Mol Genet 19 (11), 2303-2312 (2010)
   PUBMED   20189936
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Schegg,B., Hulsmeier,A.J., Rutschmann,C., Maag,C. and Hennet,T.
  TITLE     Core glycosylation of collagen is initiated by two
            beta(1-O)galactosyltransferases
  JOURNAL   Mol Cell Biol 29 (4), 943-952 (2009)
   PUBMED   19075007
  REMARK    GeneRIF: Two collagen beta(1-O)galactosyltransferases corresponding
            to the GLT25D1 and GLT25D2 proteins were identified.
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035672.1, AB011156.1 and BQ477485.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015101.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288389.1, AB011156.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361927.9/ ENSP00000354960.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2329              BC035672.1         25-2353
            2330-4488           AB011156.1         2297-4455
            4489-5176           AB011156.1         4457-5144
            5177-5179           BQ477485.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..5179
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /note="collagen beta(1-O)galactosyltransferase 2"
                     /db_xref="GeneID:23127"
                     /db_xref="HGNC:HGNC:16790"
                     /db_xref="MIM:617533"
     exon            1..634
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2252
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /EC_number="2.4.1.50"
                     /note="isoform 1precursor is encoded by transcript variant
                     1; procollagen galactosyltransferase 2; hydroxylysine
                     galactosyltransferase 2; glycosyltransferase 25 family
                     member 2; glycosyltransferase 25 domain containing 2"
                     /codon_start=1
                     /product="procollagen galactosyltransferase 2 isoform
                     1precursor"
                     /protein_id="NP_055916.1"
                     /db_xref="CCDS:CCDS1360.1"
                     /db_xref="GeneID:23127"
                     /db_xref="HGNC:HGNC:16790"
                     /db_xref="MIM:617533"
                     /translation="MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVV
                     FPESPLQSPTVLVAVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIF
                     REWLKNVQRLYHYVEWRPMDEPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWS
                     DYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDY
                     VQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTFYPPHQDYTWTFDDIIVFAFSSRQ
                     AGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQYVSVVPK
                     YPDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKALNIE
                     MLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLM
                     KLMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQ
                     KLVGANPFGKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQP
                     GYLSDTETSTIWDNETVATDWDRTHAWKSRKQSRIYSNAKNTEALPPPTSLDTVPSRD
                     EL"
     exon            635..745
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..863
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..998
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1203
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1323
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1400
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1507
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1640
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1768
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1975
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..5179
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5157..5162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /note="hexamer: ATTAAA"
     polyA_site      5179
                     /gene="COLGALT2"
                     /gene_synonym="C1orf17; ColGalT 2; GLT25D2"
                     /note="major polyA site"
ORIGIN      
        1 acaactcgcg gctctaggga aggccacaga cctcagctgt acgagcggaa cctggactag
       61 aggaactttc ctcaggactc agggcacaca gcccctcggc cactactgtc tgcgagcccg
      121 aggcgcaggg gagcgccagc ggctgcaggt acgctgcgca cccgcactgg ggcctgggcg
      181 gtgcagcggc ggcgggaggg tcctgggaac cgcagccgcc gaggccagtg tgtgagccgg
      241 ccggccgcgg caagccgcat cccccggccg cccctcgcag ccccttgctc cccggcagcc
      301 gccgccgccc tcaggcagcc cagccgggcg ctcgcgccag gacttccccg ccgcccgcct
      361 cggcccggaa catggctgcg cgccctgctg ccaccctcgc ctggtcgcta ctgctcctct
      421 cctcagccct gctccgcgaa ggctgccgag cgcgcttcgt cgccgagcgg gactcggagg
      481 acgacggaga ggagccggtg gttttcccgg agtcgcccct gcagagcccc acggtgctcg
      541 tggcggtcct cgcccgcaac gcggcgcaca cgctgccgca cttcctcggc tgcctggagc
      601 ggctggacta ccccaagagc aggatggcca tctgggcagc cactgatcac aatgtggata
      661 atacaacaga aatattcagg gagtggttga aaaatgtaca gagactctat cactatgtgg
      721 agtggaggcc tatggatgaa ccagagtctt accctgatga aattggacca aagcactggc
      781 caacctcccg gtttgcccat gtgatgaaac tacgacaggc agcccttcga actgcgaggg
      841 aaaaatggtc agactacatt ctgttcatag atgttgacaa tttcctgact aatccacaga
      901 ccctcaatct actgattgca gaaaacaaaa ctattgtggc ccccatgctg gagtctcggg
      961 gcctgtattc taatttctgg tgcggaatca cccctaaggg cttctataag aggaccccag
     1021 actacgttca gattcgagaa tggaagagga caggctgctt ccccgtcccc atggtccact
     1081 ccaccttcct aattgacctc aggaaggagg cctcggacaa gctgactttc taccccccac
     1141 accaggacta cacctggacc tttgatgaca tcattgtctt tgccttctcc agcaggcaag
     1201 caggcatcca gatgtacctc tgcaacagag agcactatgg ctacctgccc atccccctga
     1261 agccccatca gacactgcag gaagacatcg agaacctcat ccatgtgcag attgaagcaa
     1321 tgattgaccg tcctccaatg gaaccctccc agtatgtctc agttgtccct aaatatccag
     1381 acaagatggg atttgatgag attttcatga taaacctcaa acgcagaaag gacaggcggg
     1441 accggatgct gcgcacactg tatgaacagg agattgaggt caagattgtc gaggctgtgg
     1501 atggaaaggc actcaacaca agccagctga aggcactgaa tattgaaatg ctgcctggct
     1561 atcgagatcc ctattcctcc aggcctctaa caaggggtga aatcggctgc tttctcagcc
     1621 actactcagt ctggaaagag gtaattgatc gagagctaga gaagactctt gtaattgaag
     1681 acgatgtgcg ttttgagcat cagtttaaga agaagctgat gaagctgatg gataacattg
     1741 accaggctca gctggactgg gaactgattt atattggtag gaagaggatg caagtaaagg
     1801 agccagagaa agcagtgccc aatgtggcaa acctggtcga agccgactat tcctactgga
     1861 ccctgggcta cgtcatctct ctggaaggag cacagaagct ggttggagcc aatccttttg
     1921 ggaagatgct gccagtggat gagtttctgc cagtcatgta caacaagcat cccgtagccg
     1981 agtacaagga gtattatgaa tccagggacc tgaaagcctt ctctgcagaa cccttgctca
     2041 tctaccctac gcactacaca ggccagccgg ggtacctgag tgacacggag acctccacca
     2101 tctgggacaa tgagacagtg gccaccgact gggataggac acatgcctgg aagtcccgga
     2161 agcaaagccg catctacagc aatgccaaga acacagaggc cctgccaccg ccaacctccc
     2221 tggacactgt gccttcaagg gatgagctat gaaggctccc tgggagtgtg gcccacatca
     2281 gttcaacatc ctctggtttt tctaaagggc tattcatctg tttgctccag ttttctgttt
     2341 tgttttgttc ttagtggtca cagtcatcta accaaagtga tctagtgtga tagatcgaaa
     2401 ttaacatatt tttgaccatg gaaggaaata aggaaattca acccaaattt cccaagacgg
     2461 ctgaaagaca ggttttttgg aaactgttaa gataaactgt aatccagaca cctaattctt
     2521 cagttcacta ctcatgtgat actgattccc acattaaggt tgaacaacat ggctcagagt
     2581 cttgttcaag agaaagtgat caccgagctg tcacatcagc aaatatgtag tcaaggcagc
     2641 caggccaact agaccacact tattggtcta gtttgtccgt tttatatgac attgaaaact
     2701 tgtgtgtgca acttttgggg gacaggaatc acttaaaatc atatttattt ggctttttat
     2761 ttaaaggatt ctgtcacaag tcttattgaa aagtagattt tttaaaaaaa aaaaatctta
     2821 gtccctgtta tccagtaggg gtgggtattt gggtccgact gagacttggc ctgtgaccat
     2881 catggcagtt ggagttctca tatagaggtg accagtttgc catgtggata taatttagta
     2941 gatatttgac agtttgtgta ggtatttgag ggaaaaaact caatgtttgg cttttttatt
     3001 atggccactc gagtcaggat gctctattta taaagataaa tgtaatatat aaagggtgag
     3061 gactggctgt gcatcctgcc ctgtcccggg tttgcgcgct gctacagagc ttcacgctct
     3121 ccgctccacc ccttagcctg ggaacccacc gcaggtgtga gttctgtgag tcactgctaa
     3181 gagacagagc acattttcag gccagcaact atccttgcca gagttttttc attatatttt
     3241 gaattattta ttttacaaaa tgggcgaaga tattgtcttt aggataaggc agagaaacag
     3301 atgttgcaga cttccacggc acccggggga gtggtgggtg tggacacatt ggttcggcaa
     3361 tctgattctc ctgaatttcc cagccaggct cttgtgggga ggcctgtgga tggggggatt
     3421 tgaactattt ggaaacaaat gattctctat ctcaggtgag aaacctggtc agaaacaaag
     3481 ggctggtcac ctgatttagg ccagcaacca gggaagctct tagaatccca ggcggacacc
     3541 ctttctcaaa agatatcccc taagagtcct ttctgctttc ttcacagatt gattttatgt
     3601 aaaatgcaga gttggactac acgatttctt cccactccac aatctgtcat cctagtatag
     3661 atcatggtgg tttccctcaa gtttatgttc tcatgccctc aatctgtaaa tttttgtctc
     3721 cagaaaaacc ctcccaggca tcccatacca gcaccgttcc tcatcactgt ccatgcacca
     3781 tgcagccata tggggggccg tgcacacccc aaaccctgag cttcacactt aaactcatgg
     3841 ggagggccct tcagagcaga gtccacaggc gggtggtgct acatacacaa gcttagtgta
     3901 cgagtgtaag atacacttta agccagacac ctaattcttc agttcactgc ccatgtgata
     3961 ctgattgcca cattaaggtt gaacagcatg gctcagagtc tagagaaagt gatcaccaag
     4021 ctgtctcatc accaaatagg tagtcaaggc agcctcatct ccccaggtga ggggcgggtc
     4081 cccactttag gacaagaggc agcttgcctt ccaccagacg ccagcctcgg ccttccttcc
     4141 cgactcactg tgggtaccct tctacactga ccagcaagct aggccgctgg aggaaaggga
     4201 actcacccaa ctctaaattg tgccgcttag acttagctgt cagtgtgact tcctttccca
     4261 cccaccccca gaaaaacaga aagagcatct ggggagcgag tgaaaattcc ttaggtgatt
     4321 cctaagattt ccttgggtat ctggtttttg ttttcatatt tgagtgtgtg catgtgtgca
     4381 tgactttaat gactttttta atggggtggg aggtggctgg ggtgctgggg ttgaaggaag
     4441 tttgggttga tttttgtggt gttttgttta atagagaatt ttttttttcc tgttcccctg
     4501 tcagctggtc tgacagattt aagaactctc attcttaaaa gactttggac ttaaattcta
     4561 gcattttaga ctaggactgt tctactgtga agaaagttct gtctccttta gcccggtttg
     4621 tttctccctg ctcaggtcta gaatcccaag cagtgttctt ttctggtgaa cactgtgagc
     4681 cgcagatgtg actttttttt taaagtcatc tcttcagcaa tccagaggtt ccttgacctc
     4741 attatttgtc ctatctctcc cttatagtcc taagccaaga catttgacct ttgacatttg
     4801 acctttgcag tgtcatgtga gggcgtcagt atagaggcct ttgcatctgg gcctggcacc
     4861 cgctctctgc ctctggaggc taaaccctgt ctggatttct cttgggatct aacgtgggat
     4921 cttctggaca gacaaccgtg acatcagcag tgctggtgct gctgtgtgtg gactgaacac
     4981 ctgcactttg cagaggacac gctgcatggg ccccgcttgc ggttcattca ggcctgctgc
     5041 aggagctctg agaacaagaa agagtggaca cccgttcccc tgcatcatct gtcttgcgtg
     5101 ctatttcaga gtggggaagt gataaactat ttgccttctg gagctctttg tgaaaaatta
     5161 aaaaaaaact tagctcaaa
//
