LOCUS       NM_024027               1425 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens collectin subfamily member 11 (COLEC11), transcript
            variant 1, mRNA.
ACCESSION   NM_024027
VERSION     NM_024027.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Wang,J.X., Cao,B., Ma,N., Wu,K.Y., Chen,W.B., Wu,W., Dong,X.,
            Liu,C.F., Gao,Y.F., Diao,T.Y., Min,X.Y., Yong,Q., Li,Z.F., Zhou,W.
            and Li,K.
  TITLE     Collectin-11 promotes cancer cell proliferation and tumor growth
  JOURNAL   JCI Insight 8 (5), e159452 (2023)
   PUBMED   36883567
  REMARK    GeneRIF: Collectin-11 promotes cancer cell proliferation and tumor
            growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Wei,M., Guo,W.Y., Xu,B.Y., Shi,S.F., Liu,L.J., Zhou,X.J., Lv,J.C.,
            Zhu,L. and Zhang,H.
  TITLE     Collectin11 and Complement Activation in IgA Nephropathy
  JOURNAL   Clin J Am Soc Nephrol 16 (12), 1840-1850 (2021)
   PUBMED   34615657
  REMARK    GeneRIF: Collectin11 and Complement Activation in IgA Nephropathy.
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Gajek,G., Swierzko,A.S. and Cedzynski,M.
  TITLE     Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes
            with 3MC Syndrome
  JOURNAL   Int J Mol Sci 21 (15), 5483 (2020)
   PUBMED   32751929
  REMARK    GeneRIF: Association of Polymorphisms of MASP1/3, COLEC10, and
            COLEC11 Genes with 3MC Syndrome.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Gong,K., Xia,M., Wang,Y., Bai,L., Ying,W., Zhu,F. and Chen,Y.
  TITLE     Importance of glycosylation in the interaction of Tamm-Horsfall
            protein with collectin-11 and acute kidney injury
  JOURNAL   J Cell Mol Med 24 (6), 3572-3581 (2020)
   PUBMED   32045104
  REMARK    GeneRIF: Importance of glycosylation in the interaction of
            Tamm-Horsfall protein with collectin-11 and acute kidney injury.
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Ma,Y.J., Skjoedt,M.O. and Garred,P.
  TITLE     Collectin-11/MASP complex formation triggers activation of the
            lectin complement pathway--the fifth lectin pathway initiation
            complex
  JOURNAL   J Innate Immun 5 (3), 242-250 (2013)
   PUBMED   23220946
  REMARK    GeneRIF: collectin-11 associates with all the known MBL-associated
            serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin
            complement pathway regulator MAP-1.
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Yoshizaki,T., Ohtani,K., Motomura,W., Jang,S.J., Mori,K.,
            Kitamoto,N., Yoshida,I., Suzuki,Y. and Wakamiya,N.
  TITLE     Comparison of human blood concentrations of collectin kidney 1 and
            mannan-binding lectin
  JOURNAL   J Biochem 151 (1), 57-64 (2012)
   PUBMED   21893516
  REMARK    GeneRIF: Data show that the concentration of collectin kidney 1
            (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in
            mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml.
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Degn,S.E., Jensenius,J.C. and Thiel,S.
  TITLE     Disease-causing mutations in genes of the complement system
  JOURNAL   Am J Hum Genet 88 (6), 689-705 (2011)
   PUBMED   21664996
  REMARK    Review article
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Rooryck,C., Diaz-Font,A., Osborn,D.P., Chabchoub,E.,
            Hernandez-Hernandez,V., Shamseldin,H., Kenny,J., Waters,A.,
            Jenkins,D., Kaissi,A.A., Leal,G.F., Dallapiccola,B., Carnevale,F.,
            Bitner-Glindzicz,M., Lees,M., Hennekam,R., Stanier,P., Burns,A.J.,
            Peeters,H., Alkuraya,F.S. and Beales,P.L.
  TITLE     Mutations in lectin complement pathway genes COLEC11 and MASP1
            cause 3MC syndrome
  JOURNAL   Nat Genet 43 (3), 197-203 (2011)
   PUBMED   21258343
  REMARK    GeneRIF: these findings demonstrate a role for complement pathway
            factors in fundamental developmental processes and in the etiology
            of 3MC syndrome.
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Hansen,S., Selman,L., Palaniyar,N., Ziegler,K., Brandt,J.,
            Kliem,A., Jonasson,M., Skjoedt,M.O., Nielsen,O., Hartshorn,K.,
            Jorgensen,T.J., Skjodt,K. and Holmskov,U.
  TITLE     Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma
            collectin with microbial-binding activity
  JOURNAL   J Immunol 185 (10), 6096-6104 (2010)
   PUBMED   20956340
  REMARK    GeneRIF: CL-11 plays a role in activation of the complement system
            and in the defense against invading microorganisms
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Keshi,H., Sakamoto,T., Kawai,T., Ohtani,K., Katoh,T., Jang,S.J.,
            Motomura,W., Yoshizaki,T., Fukuda,M., Koyama,S., Fukuzawa,J.,
            Fukuoh,A., Yoshida,I., Suzuki,Y. and Wakamiya,N.
  TITLE     Identification and characterization of a novel human collectin
            CL-K1
  JOURNAL   Microbiol Immunol 50 (12), 1001-1013 (2006)
   PUBMED   17179669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE259985.1, AB119525.1 and
            BF740034.1.
            
            On Aug 31, 2019 this sequence version replaced NM_024027.4.
            
            Summary: This gene encodes a member of the collectin family of
            C-type lectins that possess collagen-like sequences and
            carbohydrate recognition domains. Collectins are secreted proteins
            that play important roles in the innate immune system by binding to
            carbohydrate antigens on microorganisms, facilitating their
            recognition and removal. The encoded protein binds to multiple
            sugars with a preference for fucose and mannose. Mutations in this
            gene are a cause of 3MC syndrome-2. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358439.1, BC000078.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349077.9/ ENSP00000339168.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BE259985.1         257-284
            29-1227             AB119525.1         195-1393
            1228-1425           BF740034.1         4-201               c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..1425
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /note="collectin subfamily member 11"
                     /db_xref="GeneID:78989"
                     /db_xref="HGNC:HGNC:17213"
                     /db_xref="MIM:612502"
     exon            1..57
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..213
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..899
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; Collectin K1; collectin kidney protein 1;
                     collectin sub-family member 11"
                     /codon_start=1
                     /product="collectin-11 isoform a precursor"
                     /protein_id="NP_076932.1"
                     /db_xref="CCDS:CCDS1649.1"
                     /db_xref="GeneID:78989"
                     /db_xref="HGNC:HGNC:17213"
                     /db_xref="MIM:612502"
                     /translation="MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKG
                     DAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGP
                     PGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEE
                     KRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSD
                     HSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM"
     exon            214..285
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..357
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..411
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..507
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..1425
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /note="major polyA site"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
                     /note="hexamer: AACAAA"
     polyA_site      1425
                     /gene="COLEC11"
                     /gene_synonym="3MC2; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa;
                     CL-K1-IIb; CLK1"
ORIGIN      
        1 agtgtcctcg cgggccagcg acgggcagga cgccccgttc gcctagcgcg tgctcaggag
       61 ttggtgtcct gcctgcgctc aggatgaggg ggaatctggc cctggtgggc gttctaatca
      121 gcctggcctt cctgtcactg ctgccatctg gacatcctca gccggctggc gatgacgcct
      181 gctctgtgca gatcctcgtc cctggcctca aaggggatgc gggagagaag ggagacaaag
      241 gcgcccccgg acggcctgga agagtcggcc ccacgggaga aaaaggagac atgggggaca
      301 aaggacagaa aggcagtgtg ggtcgtcatg gaaaaattgg tcccattggc tctaaaggtg
      361 agaaaggaga ttccggtgac ataggacccc ctggtcctaa tggagaacca ggcctcccat
      421 gtgagtgcag ccagctgcgc aaggccatcg gggagatgga caaccaggtc tctcagctga
      481 ccagcgagct caagttcatc aagaatgctg tcgccggtgt gcgcgagacg gagagcaaga
      541 tctacctgct ggtgaaggag gagaagcgct acgcggacgc ccagctgtcc tgccagggcc
      601 gcgggggcac gctgagcatg cccaaggacg aggctgccaa tggcctgatg gccgcatacc
      661 tggcgcaagc cggcctggcc cgtgtcttca tcggcatcaa cgacctggag aaggagggcg
      721 ccttcgtgta ctctgaccac tcccccatgc ggaccttcaa caagtggcgc agcggtgagc
      781 ccaacaatgc ctacgacgag gaggactgcg tggagatggt ggcctcgggc ggctggaacg
      841 acgtggcctg ccacaccacc atgtacttca tgtgtgagtt tgacaaggag aacatgtgag
      901 cctcaggctg gggctgccca ttgggggccc cacatgtccc tgcagggttg gcagggacag
      961 agcccagacc atggtgccag ccagggagct gtccctctgt gaagggtgga ggctcactga
     1021 gtagagggct gttgtctaaa ctgagaaaat ggcctatgct taagaggaaa atgaaagtgt
     1081 tcctggggtg ctgtctctga agaagcagag tttcattacc tgtattgtag ccccaatgtc
     1141 attatgtaat tattacccag aattgctctt ccataaagct tgtgcctttg tccaagctat
     1201 acaataaaat ctttaagtag tgcagtagtt aagtccaaat agtggcaatg gggtcttgaa
     1261 ttactacctt ttaatttcta tatggaaaag aactcacttt gaccaacact tctgtaaatt
     1321 acattacaat ataggttcct tcacactatt atccatgtaa aaacaatttt gctttgcttc
     1381 aaacccagat ttcaggaaaa caacaacaaa attctccaaa cttta
//
