LOCUS       NM_006438               3133 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens collectin subfamily member 10 (COLEC10), transcript
            variant 1, mRNA.
ACCESSION   NM_006438
VERSION     NM_006438.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Zhang,M., Jing,Y., Xu,W., Shi,X., Zhang,W., Chen,P., Cao,X.,
            Han,X., Duan,X. and Ren,J.
  TITLE     The C-type lectin COLEC10 is predominantly produced by hepatic
            stellate cells and involved in the pathogenesis of liver fibrosis
  JOURNAL   Cell Death Dis 14 (11), 785 (2023)
   PUBMED   38036508
  REMARK    GeneRIF: The C-type lectin COLEC10 is predominantly produced by
            hepatic stellate cells and involved in the pathogenesis of liver
            fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Cai,M.N., Chen,D.M., Xiao,L.X., Li,S.S., Liao,C.H., Li,J.,
            Huang,Z.X., Wang,J.L., Gu,Y.R., Gu,L., Huang,Y.H. and Lian,Y.F.
  TITLE     COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and
            Inhibits Hepatocellular Carcinoma
  JOURNAL   Lab Invest 103 (7), 100130 (2023)
   PUBMED   36925047
  REMARK    GeneRIF: COLEC10 Induces Endoplasmic Reticulum Stress by Occupying
            GRP78 and Inhibits Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Migliorero,M., Kalantari,S., Bracciama,V., Sorbini,M., Arruga,F.,
            Peruzzi,L., Biamino,E., Amoroso,A., Vaisitti,T. and Deaglio,S.
  TITLE     A novel COLEC10 mutation in a child with 3MC syndrome
  JOURNAL   Eur J Med Genet 64 (12), 104374 (2021)
   PUBMED   34740859
  REMARK    GeneRIF: A novel COLEC10 mutation in a child with 3MC syndrome.
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   Gajek,G., Swierzko,A.S. and Cedzynski,M.
  TITLE     Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes
            with 3MC Syndrome
  JOURNAL   Int J Mol Sci 21 (15), 5483 (2020)
   PUBMED   32751929
  REMARK    GeneRIF: Association of Polymorphisms of MASP1/3, COLEC10, and
            COLEC11 Genes with 3MC Syndrome.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3133)
  AUTHORS   Hansen,S.W.K., Aagaard,J.B., Bjerrum,K.B., Hejbol,E.K., Nielsen,O.,
            Schroder,H.D., Skjoedt,K., Sorensen,A.L., Graversen,J.H. and
            Henriksen,M.L.
  TITLE     CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High
            and Co-Localized Expression in Secretory Epithelia and Mucosa
  JOURNAL   Front Immunol 9, 1757 (2018)
   PUBMED   30108587
  REMARK    GeneRIF: Collectin liver 1 (CL-L1, collectin 10) and collectin
            kidney 1 (CL-K1, collectin 11) were found widespread and almost
            identical tissue with a high expression in epithelial cells in
            endo-/exocrine secretory tissues and mucosa.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3133)
  AUTHORS   Rivadeneira,F., Styrkarsdottir,U., Estrada,K., Halldorsson,B.V.,
            Hsu,Y.H., Richards,J.B., Zillikens,M.C., Kavvoura,F.K., Amin,N.,
            Aulchenko,Y.S., Cupples,L.A., Deloukas,P., Demissie,S.,
            Grundberg,E., Hofman,A., Kong,A., Karasik,D., van Meurs,J.B.,
            Oostra,B., Pastinen,T., Pols,H.A., Sigurdsson,G., Soranzo,N.,
            Thorleifsson,G., Thorsteinsdottir,U., Williams,F.M., Wilson,S.G.,
            Zhou,Y., Ralston,S.H., van Duijn,C.M., Spector,T., Kiel,D.P.,
            Stefansson,K., Ioannidis,J.P. and Uitterlinden,A.G.
  CONSRTM   Genetic Factors for Osteoporosis (GEFOS) Consortium
  TITLE     Twenty bone-mineral-density loci identified by large-scale
            meta-analysis of genome-wide association studies
  JOURNAL   Nat Genet 41 (11), 1199-1206 (2009)
   PUBMED   19801982
REFERENCE   7  (bases 1 to 3133)
  AUTHORS   Styrkarsdottir,U., Halldorsson,B.V., Gretarsdottir,S.,
            Gudbjartsson,D.F., Walters,G.B., Ingvarsson,T., Jonsdottir,T.,
            Saemundsdottir,J., Center,J.R., Nguyen,T.V., Bagger,Y.,
            Gulcher,J.R., Eisman,J.A., Christiansen,C., Sigurdsson,G., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Multiple genetic loci for bone mineral density and fractures
  JOURNAL   N Engl J Med 358 (22), 2355-2365 (2008)
   PUBMED   18445777
REFERENCE   8  (bases 1 to 3133)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3133)
  AUTHORS   Kawai,T., Suzuki,Y., Eda,S., Kase,T., Ohtani,K., Sakai,Y.,
            Keshi,H., Fukuoh,A., Sakamoto,T., Nozaki,M., Copeland,N.G.,
            Jenkins,N.A. and Wakamiya,N.
  TITLE     Molecular cloning of mouse collectin liver 1
  JOURNAL   Biosci Biotechnol Biochem 66 (10), 2134-2145 (2002)
   PUBMED   12450124
REFERENCE   10 (bases 1 to 3133)
  AUTHORS   Ohtani,K., Suzuki,Y., Eda,S., Kawai,T., Kase,T., Yamazaki,H.,
            Shimada,T., Keshi,H., Sakai,Y., Fukuoh,A., Sakamoto,T. and
            Wakamiya,N.
  TITLE     Molecular cloning of a novel human collectin from liver (CL-L1)
  JOURNAL   J Biol Chem 274 (19), 13681-13689 (1999)
   PUBMED   10224141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291791.1, AC080033.10 and
            AI417503.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006438.4.
            
            Summary: This gene encodes a member of the C-lectin family,
            proteins that possess collagen-like sequences and carbohydrate
            recognition domains. The other members of this family are secreted
            proteins and bind to carbohydrate antigens on microorganisms
            facilitating their recognition and removal. This gene product is a
            cytosolic protein, a characteristic that suggests that it may have
            different biological functions than other C-lectins. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002631.1, BC103816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332843.3/ ENSP00000332723.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1020              AK291791.1         63-1082
            1021-3106           AC080033.10        56479-58564
            3107-3133           AI417503.1         6-32                c
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..3133
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="collectin subfamily member 10"
                     /db_xref="GeneID:10584"
                     /db_xref="HGNC:HGNC:2220"
                     /db_xref="MIM:607620"
     exon            1..183
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..869
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collectin liver 1; collectin-10; collectin-34;
                     collectin liver protein 1; collectin sub-family member 10
                     (C-type lectin)"
                     /codon_start=1
                     /product="collectin-10 isoform 1 precursor"
                     /protein_id="NP_006429.2"
                     /db_xref="CCDS:CCDS6327.1"
                     /db_xref="GeneID:10584"
                     /db_xref="HGNC:HGNC:2220"
                     /db_xref="MIM:607620"
                     /translation="MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTI
                     SPGPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGE
                     KGLLGIPGEKGKAGTVCDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFY
                     YIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREG
                     QYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKK
                     K"
     exon            184..255
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..327
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..381
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..477
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..3133
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="hexamer: ATTACA"
     polyA_site      930
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="major polyA site"
     polyA_site      994
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="major polyA site"
     regulatory      3114..3119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="hexamer: AATAAT"
     polyA_site      3133
                     /gene="COLEC10"
                     /gene_synonym="3MC3; CL-10; CL-34; CLL1"
                     /note="major polyA site"
ORIGIN      
        1 atttctggga gacccttttc tgaggaacca cagcaatgaa tggctttgca tccttgcttc
       61 gaagaaacca atttatcctc ctggtactat ttcttttgca aattcagagt ctgggtctgg
      121 atattgatag ccgtcctacc gctgaagtct gtgccacaca cacaatttca ccaggaccca
      181 aaggagatga tggtgaaaaa ggagatccag gagaagaggg aaagcatggc aaagtgggac
      241 gcatggggcc gaaaggaatt aaaggagaac tgggtgatat gggagatcag ggcaatattg
      301 gcaagactgg gcccattggg aagaagggtg acaaagggga aaaaggtttg cttggaatac
      361 ctggagaaaa aggcaaagca ggtactgtct gtgattgtgg aagataccgg aaatttgttg
      421 gacaactgga tattagtatt gctcggctca agacatctat gaagtttgtc aagaatgtga
      481 tagcagggat tagggaaact gaagagaaat tctactacat cgtgcaggaa gagaagaact
      541 acagggaatc cctaacccac tgcaggattc ggggtggaat gctagccatg cccaaggatg
      601 aagctgccaa cacactcatc gctgactatg ttgccaagag tggcttcttt cgggtgttca
      661 ttggcgtgaa tgaccttgaa agggagggac agtacatgtt cacagacaac actccactgc
      721 agaactatag caactggaat gagggggaac ccagcgaccc ctatggtcat gaggactgtg
      781 tggagatgct gagctctggc agatggaatg acacagagtg ccatcttacc atgtactttg
      841 tctgtgagtt catcaagaag aaaaagtaac ttccctcatc ctacgtattt gctattttcc
      901 tgtgaccgtc attacagtta ttgttatcca tccttttttt cctgattgta ctacatttga
      961 tctgagtcaa catagctaga aaatgctaaa ctgaggtatg gagcctccat catcatgctc
     1021 ttttgtgatg attttcatat tttcacacat ggtatattat tgacccaata actcgccagg
     1081 ttacatgggt cttgagagag aattttaatt actaattgtg cacgagatag ttggttgtct
     1141 atatgtcaaa tgagttgttc tcttggtatt tgctctacca tctctcccta gagcactctg
     1201 tgtctatccc agtggataat ttcccagttt actggtgatg attaggaagg ttgttgatgg
     1261 ttaggctaac ctgccctggc ccaaagccag acatgtacaa gggctttctg tgagcaatga
     1321 taagatcttt gaatccaaga tgcccagatc ttttaccagt cacaccctat ggccatggct
     1381 atacttggaa gttctccttg ttggcacaga catagaaatg ctttaacccc aaacctttat
     1441 atgggggact tctagctttg tgtcttgttt cagaccatgt ggaatgataa atactctttt
     1501 tgtgcttctg atctatcgat ttcactaaca tataccaagt aggtgctttg aacccctttc
     1561 tgtaggctca caccttaatc tcaggcccct atatagtcac actttgattt aagaaaaatg
     1621 gagctcttga aatcaaaaga aaaaaatggg gaattgttca caaacaatac tggttatagt
     1681 tctcttgcta aattgcccac tgctattaac ttaacttcat ttttatttat cttaggttta
     1741 cctgcatcaa ttttattcac cttaggcata gggaatgagg gaaggagttt gtgaagcctt
     1801 aagaaaattc tggaagcttc aaagtgctac caacatcatc tccaggcccc ctcatccttg
     1861 cctctaacat atcactaatg gtgacatttc atgggaggcc ttttactctt cataaatata
     1921 tgtcatagaa atcctactgg agatgtccct tctaatactc tggcatcaca gaaatgtgtg
     1981 aggcacagaa ttcggaacat gcttagaact cacatttact gagctggtaa aattctacct
     2041 tgaactgtag atcaaacctc aaagcagctt tcacttggaa tttaaaaata aacagttcaa
     2101 agatactcta gattatcacc ctataaactt ctactccagt tatggtttct gacatatgat
     2161 tagactgttt caaatgctgg caaaatggtt aatgaagtaa gagaaacaga tcaacaacat
     2221 atgttcacct taaaccatct gttcatgatt tcacccgtga ctaactggtt atgagatagg
     2281 acttaattag gttatttctg tgggttcaac aagggccata aactcagatc ctacaggggc
     2341 caggcagatg acttacctaa atgaagtgga acacgtgggg accctagtgc actgagcaca
     2401 gcttgccctt ccaaaggagc cagctgctcc tcagtggctg ctgctggtgc tagggaggac
     2461 ccaatcttgc taaatgtgct gatatttcaa gagaagtcag aaagctggga ctttgtaaca
     2521 taagctcata ttttaatatg ttggcaacta attaattttt aacccaaatt ttaagtgggt
     2581 taaaaattaa ttaaaattaa agatttgagg tcaaaagtct tctagctaaa gttgtgatca
     2641 tttcatttct tacttctgga ggaaggttca gaaggttcta accaaataga atgtcattag
     2701 gatatgatga catgaaagtc aagatatccc attaatacca tattcaattc agcttaataa
     2761 taggaatttg ttatatgttt gacatttatc aggttactag ttaaactctt ttgagatgat
     2821 agtacatgac actttaaagg cagaaaagct taataaaaat tacaaagtag gacatcaaac
     2881 gccagtatcc ttggatagaa agccatccca gatcatgagg aatgaaaacc tagaaacacc
     2941 tgtaggaaaa taaagctcat atgtaagaag agaggaagga gagacatgca gcaaatgttg
     3001 cctacgggca acttcatgtt aaggatccat gttctgattt gttctaagcc cccaaagtat
     3061 gagtatttat tgtgtgcact gttagtgcta ttattattta ctgtgaatgt tataataata
     3121 gttctctcaa tga
//
