LOCUS       NM_001851               3697 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens collagen type IX alpha 1 chain (COL9A1), transcript
            variant 1, mRNA.
ACCESSION   NM_001851
VERSION     NM_001851.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Zhao,J., Cai,F., Liu,P., Wei,J. and Chen,Q.
  TITLE     Gene Environment Interactions Between the COL9A1 Gene and Maternal
            Drinking of Alcohol Contribute to the Risk of Congenital Talipes
            Equinovarus
  JOURNAL   Genet Test Mol Biomarkers 25 (1), 48-54 (2021)
   PUBMED   33372835
  REMARK    GeneRIF: Gene Environment Interactions Between the COL9A1 Gene and
            Maternal Drinking of Alcohol Contribute to the Risk of Congenital
            Talipes Equinovarus.
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Liu,H., Zhao,H., Lin,H., Li,Z., Xue,H., Zhang,Y. and Lu,J.
  TITLE     Relationship of COL9A1 and SOX9 Genes with Genetic Susceptibility
            of Postmenopausal Osteoporosis
  JOURNAL   Calcif Tissue Int 106 (3), 248-255 (2020)
   PUBMED   31732751
  REMARK    GeneRIF: Relationship of COL9A1 and SOX9 Genes with Genetic
            Susceptibility of Postmenopausal Osteoporosis.
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Mortier,G.
  TITLE     Stickler Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301479
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Briggs,M.D., Wright,M.J. and Mortier,G.R.
  TITLE     Multiple Epiphyseal Dysplasia, Autosomal Dominant
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301302
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   Muragaki,Y., Kimura,T., Ninomiya,Y. and Olsen,B.R.
  TITLE     The complete primary structure of two distinct forms of human alpha
            1 (IX) collagen chains
  JOURNAL   Eur J Biochem 192 (3), 703-708 (1990)
   PUBMED   2209617
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Muragaki,Y., Nishimura,I., Henney,A., Ninomiya,Y. and Olsen,B.R.
  TITLE     The alpha 1 (IX) collagen gene gives rise to two different
            transcripts in both mouse embryonic and human fetal RNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2400-2404 (1990)
   PUBMED   1690886
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   Kimura,T., Mattei,M.G., Stevens,J.W., Goldring,M.B., Ninomiya,Y.
            and Olsen,B.R.
  TITLE     Molecular cloning of rat and human type IX collagen cDNA and
            localization of the alpha 1(IX) gene on the human chromosome 6
  JOURNAL   Eur J Biochem 179 (1), 71-78 (1989)
   PUBMED   2465149
REFERENCE   10 (bases 1 to 3697)
  AUTHORS   McCormick,D., van der Rest,M., Goodship,J., Lozano,G., Ninomiya,Y.
            and Olsen,B.R.
  TITLE     Structure of the glycosaminoglycan domain in the type IX
            collagen-proteoglycan
  JOURNAL   Proc Natl Acad Sci U S A 84 (12), 4044-4048 (1987)
   PUBMED   3473493
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL080275.20 and AL160262.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 10, 2020 this sequence version replaced NM_001851.5.
            
            Summary: This gene encodes one of the three alpha chains of type IX
            collagen, which is a minor (5-20%) collagen component of hyaline
            cartilage. Type IX collagen is usually found in tissues containing
            type II collagen, a fibrillar collagen. Studies in knockout mice
            have shown that synthesis of the alpha 1 chain is essential for
            assembly of type IX collagen molecules, a heterotrimeric molecule,
            and that lack of type IX collagen is associated with early onset
            osteoarthritis. Mutations in this gene are associated with
            osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a
            form of chondrodysplasia, and with Stickler syndrome, a disease
            characterized by ophthalmic, orofacial, articular, and auditory
            defects. Two transcript variants that encode different isoforms
            have been identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as the long form).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357250.11/ ENSP00000349790.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL080275.20        61827-62000         c
            175-248             AL080275.20        60917-60990         c
            249-326             AL080275.20        59225-59302         c
            327-459             AL080275.20        58959-59091         c
            460-856             AL080275.20        53083-53479         c
            857-940             AL080275.20        42653-42736         c
            941-961             AL080275.20        41814-41834         c
            962-1036            AL080275.20        40306-40380         c
            1037-1072           AL080275.20        39920-39955         c
            1073-1135           AL080275.20        39728-39790         c
            1136-1189           AL080275.20        33635-33688         c
            1190-1225           AL080275.20        32963-32998         c
            1226-1249           AL080275.20        30981-31004         c
            1250-1303           AL080275.20        30571-30624         c
            1304-1357           AL080275.20        29230-29283         c
            1358-1390           AL080275.20        28549-28581         c
            1391-1447           AL080275.20        27720-27776         c
            1448-1501           AL080275.20        25633-25686         c
            1502-1555           AL080275.20        22160-22213         c
            1556-1609           AL080275.20        19573-19626         c
            1610-1663           AL080275.20        15684-15737         c
            1664-1717           AL080275.20        14253-14306         c
            1718-1771           AL080275.20        14066-14119         c
            1772-1825           AL080275.20        13879-13932         c
            1826-1879           AL080275.20        13392-13445         c
            1880-1924           AL080275.20        12301-12345         c
            1925-1978           AL080275.20        11178-11231         c
            1979-2032           AL080275.20        11036-11089         c
            2033-2086           AL080275.20        1578-1631           c
            2087-2158           AL080275.20        880-951             c
            2159-2194           AL080275.20        335-370             c
            2195-2239           AL160262.12        53101-53145         c
            2240-2272           AL160262.12        51666-51698         c
            2273-2419           AL160262.12        47206-47352         c
            2420-2474           AL160262.12        46951-47005         c
            2475-2663           AL160262.12        44995-45183         c
            2664-2741           AL160262.12        38344-38421         c
            2742-3697           AL160262.12        28538-29493         c
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..3697
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /note="collagen type IX alpha 1 chain"
                     /db_xref="GeneID:1297"
                     /db_xref="HGNC:HGNC:2217"
                     /db_xref="MIM:120210"
     exon            1..174
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2926
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cartilage-specific short collagen; collagen,
                     type IX, alpha 1; collagen IX, alpha-1 polypeptide;
                     collagen alpha-1(IX) chain; alpha-1(IX) collagen chain"
                     /codon_start=1
                     /product="collagen alpha-1(IX) chain isoform 1 precursor"
                     /protein_id="NP_001842.3"
                     /db_xref="CCDS:CCDS4971.1"
                     /db_xref="GeneID:1297"
                     /db_xref="HGNC:HGNC:2217"
                     /db_xref="MIM:120210"
                     /translation="MKTCWKIPVFFFVCSFLEPWASAAVKRRPRFPVNSNSNGGNELC
                     PKIRIGQDDLPGFDLISQFQVDKAASRRAIQRVVGSATLQVAYKLGNNVDFRIPTRNL
                     YPSGLPEEYSFLTTFRMTGSTLKKNWNIWQIQDSSGKEQVGIKINGQTQSVVFSYKGL
                     DGSLQTAAFSNLSSLFDSQWHKIMIGVERSSATLFVDCNRIESLPIKPRGPIDIDGFA
                     VLGKLADNPQVSVPFELQWMLIHCDPLRPRRETCHELPARITPSQTTDERGPPGEQGP
                     PGPPGPPGVPGIDGIDGDRGPKGPPGPPGPAGEPGKPGAPGKPGTPGADGLTGPDGSP
                     GSIGSKGQKGEPGVPGSRGFPGRGIPGPPGPPGTAGLPGELGRVGPVGDPGRRGPPGP
                     PGPPGPRGTIGFHDGDPLCPNACPPGRSGYPGLPGMRGHKGAKGEIGEPGRQGHKGEE
                     GDQGELGEVGAQGPPGAQGLRGITGIVGDKGEKGARGLDGEPGPQGLPGAPGDQGQRG
                     PPGEAGPKGDRGAEGARGIPGLPGPKGDTGLPGVDGRDGIPGMPGTKGEPGKPGPPGD
                     AGLQGLPGVPGIPGAKGVAGEKGSTGAPGKPGQMGNSGKPGQQGPPGEVGPRGPQGLP
                     GSRGELGPVGSPGLPGKLGSLGSPGLPGLPGPPGLPGMKGDRGVVGEPGPKGEQGASG
                     EEGEAGERGELGDIGLPGPKGSAGNPGEPGLRGPEGSRGLPGVEGPRGPPGPRGVQGE
                     QGATGLPGVQGPPGRAPTDQHIKQVCMRVIQEHFAEMAASLKRPDSGATGLPGRPGPP
                     GPPGPPGENGFPGQMGIRGLPGIKGPPGALGLRGPKGDLGEKGERGPPGRGPNGLPGA
                     IGLPGDPGPASYGRNGRDGERGPPGVAGIPGVPGPPGPPGLPGFCEPASCTMQAGQRA
                     FNKGPDP"
     exon            175..248
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            249..326
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            327..459
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            460..856
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            857..940
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            941..961
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1036
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1072
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1135
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1189
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1225
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1249
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1303
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1357
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1390
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1447
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1501
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1555
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1609
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1663
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1717
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1771
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1825
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1879
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1924
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1978
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2032
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2086
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2158
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2194
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2239
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2272
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2419
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2474
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2663
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2741
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..3697
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3679..3684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /note="hexamer: AATAAA"
     polyA_site      3697
                     /gene="COL9A1"
                     /gene_synonym="DJ149L1.1.2; EDM6; MED; STL4"
                     /note="major polyA site"
ORIGIN      
        1 ccctttgctt ttagccctca ccgggggcag gagggaccaa ggctgggccc agaacacata
       61 gtcctagggt aacagtgaag gggtcgtgag gggacagtga ctcccttcca accccttctt
      121 catagggact gttggcaaac aaagaaaatc aactgggaaa atgaagacct gctggaaaat
      181 tccagttttc ttctttgtgt gcagtttcct ggaaccctgg gcatctgcag ctgtcaagcg
      241 tcgccccaga ttccctgtca attccaattc taatggtgga aatgaactct gtccaaagat
      301 caggattggc caagatgact taccagggtt tgatctgatc tctcagttcc aggtagataa
      361 agcagcatct agaagagcta tccagagagt agtgggatca gctacattgc aggtggctta
      421 caagttggga aataatgtag acttcaggat tccaactagg aatttatatc ccagtggact
      481 gcctgaagaa tactccttct tgacgacgtt tcgaatgact ggaagcactc tcaaaaagaa
      541 ctggaacatt tggcagattc aggattcctc tgggaaggag caagttggca taaagattaa
      601 tggccaaaca caatctgttg tattttcata caagggactg gatggaagtc tccaaacagc
      661 agccttttcg aatttgtcct ccttgtttga ttcccagtgg cataagatca tgattggcgt
      721 ggagaggagt agtgctactc tttttgttga ctgcaacagg attgaatctt tacctataaa
      781 gccaagaggc ccaattgaca ttgatggctt tgctgtgctg ggaaaacttg cagataatcc
      841 tcaagtttct gttccatttg aacttcaatg gatgctgatc cattgtgacc ccctgcggcc
      901 caggagagaa acttgccatg agctgccagc cagaataacg cccagccaga ccaccgacga
      961 gagaggtccc ccgggtgagc agggtcctcc cgggcctccg ggcccccctg gagttccagg
     1021 catcgatggc atcgacggtg accgaggtcc taagggcccc ccgggccccc cgggtcctgc
     1081 aggtgaaccg ggaaagccag gagctccagg caagcctggc acacctggcg ctgatggatt
     1141 aacaggacct gatggatccc ctggctccat tgggtcaaag ggacaaaaag gagaacctgg
     1201 tgtgcctgga tcgcgtggat ttccaggccg tggtattcct ggaccccctg gtcctcctgg
     1261 gacagcagga ctccctggag agcttggccg tgtaggacct gttggtgacc ctgggagaag
     1321 aggaccacct ggcccccctg gccccccagg acccagagga acaattggct ttcatgatgg
     1381 agatccattg tgtcccaatg cctgtccacc aggtcgctca ggatatccag gcctaccagg
     1441 catgaggggt cataaagggg ctaaaggaga aattggtgaa ccaggaagac aaggacacaa
     1501 gggtgaagaa ggtgaccagg gagaactcgg agaagttgga gctcaaggac ctccaggagc
     1561 ccagggtttg cgaggcatca ccggcatagt tggggacaaa ggggaaaaag gtgctcgggg
     1621 cttagatggt gaacctgggc ctcagggtct tcctggtgca cctggtgatc aaggacagcg
     1681 aggacctcca ggagaagcag gtcccaaagg agatagaggg gctgaaggtg ctagaggaat
     1741 tcctggtctc cctgggccca aaggagacac gggtttgcca ggtgtggatg gccgtgatgg
     1801 gatccctgga atgcctggaa caaagggtga accaggaaaa cctgggcctc ctggtgatgc
     1861 aggattgcag gggttaccag gtgtacctgg aattcctggt gcaaagggtg ttgctggtga
     1921 aaagggtagc acaggtgctc cagggaagcc tggtcagatg ggaaattcag gcaaaccggg
     1981 ccaacagggg cctccaggag aggtgggacc ccgaggaccc caggggcttc ctggcagtag
     2041 aggagaatta ggaccagtgg gatccccagg cctaccaggt aaactgggtt ctctgggtag
     2101 ccctggcctc cctggcttgc ctgggccccc tggacttcct ggaatgaaag gtgacagggg
     2161 tgtagtcggt gaaccgggtc caaagggtga acagggtgcc tctggtgaag aaggtgaagc
     2221 aggagaaagg ggggaacttg gagatatagg attacctggc ccaaagggat ctgcaggtaa
     2281 tcctggggaa cctggcttga gagggcctga gggaagtcgg gggcttcctg gagtggaagg
     2341 accaagagga ccacctggac cccggggtgt gcagggagaa cagggtgcca ccggcctgcc
     2401 tggtgtccag ggccctccgg gtagagcacc gacagatcag cacattaagc aggtttgcat
     2461 gagagtcata caagaacatt ttgctgagat ggctgccagt cttaagcgtc cagactcagg
     2521 tgccactggg cttcctggaa ggcctggccc tcctggtccc cccggccctc ctggagagaa
     2581 tggtttccca ggccagatgg gaattcgtgg ccttccgggc attaaggggc cccctggtgc
     2641 tcttggtttg aggggaccta aaggtgactt gggagaaaag ggggagcgtg gccctccagg
     2701 aagaggtccc aacggtttgc ctggagctat aggtctccca ggtgacccag gccctgccag
     2761 ctatggcaga aatggccgag acggtgagcg aggcccccca ggggtggcag gaattcctgg
     2821 agtgcctgga cccccgggac ctcctgggct tcccggtttc tgtgagccag cctcctgcac
     2881 catgcaggct ggtcagcgag catttaacaa agggcctgac ccttgaaagg cttactgctg
     2941 catggctgtc tgcatgaacc acgcctggtg aaggagcctg ggtgagaaac accatccaaa
     3001 gctggggcaa agatgattac cttcagcatg attacaatgt attaccttca gtatgattac
     3061 agaagtccta cttgacaatc acatatagaa gaacggtgct attcagtaag ttctctttcc
     3121 tttcccttgg agggaagaca gcagagtcat cagttaaaaa aaaaaaaaga aaaccaaaca
     3181 cctcccttga ataaatttat actcctgttc ccaggatctt gagctttagt gtgctatacc
     3241 tatgtgtctt atcgtgggcc actgtgccaa taaacaaaaa caactgtttg gtttacctca
     3301 gttgcagtag ttattttcat ttagaagttg ttctcagatt attgtttcag ttatatagag
     3361 gattactaga ctagttatga agaaacccca ctacattcaa tggaattggt gcttaaaatc
     3421 tcatcgatgt gctgtctctg gagtgataag aaagggctac atctcccgaa atgatttctt
     3481 tacgtcatgt attggtttcc ttcttcacct tgaacttttg ttgaactgta tgtactttac
     3541 cccaaacctg ttaatatttt gagcgcttct atgtgaaagc aaagaaataa ttttaatact
     3601 ctggcattca taaattttat tgatgagatt atttatttta aaggtttgag gtaacatctc
     3661 tggttgtacc aaagaagaaa taaatatggt ttcttaa
//
