LOCUS       NM_000094               9231 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens collagen type VII alpha 1 chain (COL7A1), mRNA.
ACCESSION   NM_000094 XM_011533337
VERSION     NM_000094.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9231)
  AUTHORS   Pironon,N., Bourrat,E., Prost,C., Chen,M., Woodley,D.T., Titeux,M.
            and Hovnanian,A.
  TITLE     Splice modulation strategy applied to deep intronic variants in
            COL7A1 causing recessive dystrophic epidermolysis bullosa
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2401781121 (2024)
   PUBMED   39159368
  REMARK    GeneRIF: Splice modulation strategy applied to deep intronic
            variants in COL7A1 causing recessive dystrophic epidermolysis
            bullosa.
REFERENCE   2  (bases 1 to 9231)
  AUTHORS   Ali,F.M., Zhou,J., Wang,M., Wang,Q., Sun,L., Mshenga,M.M. and Lu,H.
  TITLE     Epidermolysis Bullosa: Two rare case reports of COL7A1 and EBS-GEN
            SEV KRT14 variants with review of literature
  JOURNAL   BMC Pediatr 24 (1), 242 (2024)
   PUBMED   38580989
  REMARK    GeneRIF: Epidermolysis Bullosa: Two rare case reports of COL7A1 and
            EBS-GEN SEV KRT14 variants with review of literature.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9231)
  AUTHORS   Natale,M.I., Manzur,G.B., Lusso,S.B., Cella,E., Giovo,M.E.,
            Andrada,R., Goitia,J., Fernandez,M.F., Della Giovanna,P.S.,
            Guillamondegui,M.J., Dominguez,M., Gutierrez,O., Izquierdo,A.,
            Hernandez Herrera,H., Velazquez Perdomo,L.G., Mistchenko,A.S. and
            Valinotto,L.E.
  TITLE     Analysis of COL7A1 pathogenic variants in a large cohort of
            dystrophic epidermolysis bullosa patients from Argentina reveals a
            new genotype-phenotype correlation
  JOURNAL   Am J Med Genet A 188 (11), 3153-3161 (2022)
   PUBMED   35979658
  REMARK    GeneRIF: Analysis of COL7A1 pathogenic variants in a large cohort
            of dystrophic epidermolysis bullosa patients from Argentina reveals
            a new genotype-phenotype correlation.
REFERENCE   4  (bases 1 to 9231)
  AUTHORS   Chao,Y.C., Hong,J.B., Liu,C., Lee,M.S. and Lin,R.Y.
  TITLE     COL7A1 G2287R mutation with two clinical phenotypes in the same
            family: Bullous dermolysis of the newborn and dystrophic
            epidermolysis bullosa pruriginosa
  JOURNAL   J Dermatol 49 (9), e313-e314 (2022)
   PUBMED   35560343
  REMARK    GeneRIF: COL7A1 G2287R mutation with two clinical phenotypes in the
            same family: Bullous dermolysis of the newborn and dystrophic
            epidermolysis bullosa pruriginosa.
REFERENCE   5  (bases 1 to 9231)
  AUTHORS   Akasaka,E., Nakano,H. and Sawamura,D.
  TITLE     Two cases of the intermediate phenotype of recessive dystrophic
            epidermolysis bullosa harboring the novel COL7A1 mutation c.3570G>A
  JOURNAL   J Dermatol Sci 106 (3), 193-195 (2022)
   PUBMED   35527172
  REMARK    GeneRIF: Two cases of the intermediate phenotype of recessive
            dystrophic epidermolysis bullosa harboring the novel COL7A1
            mutation c.3570G>A.
            Erratum:[J Dermatol Sci. 2022 Oct;108(1):55. doi:
            10.1016/j.jdermsci.2022.11.002.. PMID: 36404218]
REFERENCE   6  (bases 1 to 9231)
  AUTHORS   Pfendner,E.G. and Lucky,A.W.
  TITLE     Dystrophic Epidermolysis Bullosa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301481
REFERENCE   7  (bases 1 to 9231)
  AUTHORS   Gammon,W.R., Abernethy,M.L., Padilla,K.M., Prisayanh,P.S.,
            Cook,M.E., Wright,J., Briggaman,R.A. and Hunt,S.W. 3rd.
  TITLE     Noncollagenous (NC1) domain of collagen VII resembles multidomain
            adhesion proteins involved in tissue-specific organization of
            extracellular matrix
  JOURNAL   J Invest Dermatol 99 (6), 691-696 (1992)
   PUBMED   1469284
REFERENCE   8  (bases 1 to 9231)
  AUTHORS   Christiano,A.M., Rosenbaum,L.M., Chung-Honet,L.C., Parente,M.G.,
            Woodley,D.T., Pan,T.C., Zhang,R.Z., Chu,M.L., Burgeson,R.E. and
            Uitto,J.
  TITLE     The large non-collagenous domain (NC-1) of type VII collagen is
            amino-terminal and chimeric. Homology to cartilage matrix protein,
            the type III domains of fibronectin and the A domains of von
            Willebrand factor
  JOURNAL   Hum Mol Genet 1 (7), 475-481 (1992)
   PUBMED   1307247
REFERENCE   9  (bases 1 to 9231)
  AUTHORS   Tanaka,T., Takahashi,K., Furukawa,F. and Imamura,S.
  TITLE     Molecular cloning and characterization of type VII collagen cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (3), 958-963 (1992)
   PUBMED   1567409
REFERENCE   10 (bases 1 to 9231)
  AUTHORS   Parente,M.G., Chung,L.C., Ryynanen,J., Woodley,D.T., Wynn,K.C.,
            Bauer,E.A., Mattei,M.G., Chu,M.L. and Uitto,J.
  TITLE     Human type VII collagen: cDNA cloning and chromosomal mapping of
            the gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 6931-6935 (1991)
   PUBMED   1871109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121252.4.
            
            On or before Feb 25, 2020 this sequence version replaced
            XM_011533337.1, NM_000094.3.
            
            Summary: This gene encodes the alpha chain of type VII collagen.
            The type VII collagen fibril, composed of three identical alpha
            collagen chains, is restricted to the basement zone beneath
            stratified squamous epithelia. It functions as an anchoring fibril
            between the external epithelia and the underlying stroma. Mutations
            in this gene are associated with all forms of dystrophic
            epidermolysis bullosa. In the absence of mutations, however, an
            acquired form of this disease can result from an autoimmune
            response made to type VII collagen. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.19427.1,
                                           SRR18074969.701241.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681320.1/ ENSP00000506558.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC121252.4         33716-33777         c
            63-148              AC121252.4         33523-33608         c
            149-329             AC121252.4         32816-32996         c
            330-489             AC121252.4         31985-32144         c
            490-583             AC121252.4         31804-31897         c
            584-745             AC121252.4         31550-31711         c
            746-909             AC121252.4         31223-31386         c
            910-1039            AC121252.4         31018-31147         c
            1040-1156           AC121252.4         30799-30915         c
            1157-1303           AC121252.4         30550-30696         c
            1304-1420           AC121252.4         30346-30462         c
            1421-1570           AC121252.4         30121-30270         c
            1571-1699           AC121252.4         29912-30040         c
            1700-1843           AC121252.4         29121-29264         c
            1844-1969           AC121252.4         28907-29032         c
            1970-2113           AC121252.4         28661-28804         c
            2114-2233           AC121252.4         28047-28166         c
            2234-2377           AC121252.4         27775-27918         c
            2378-2503           AC121252.4         27318-27443         c
            2504-2650           AC121252.4         27090-27236         c
            2651-2773           AC121252.4         26730-26852         c
            2774-2920           AC121252.4         26241-26387         c
            2921-3055           AC121252.4         25868-26002         c
            3056-3202           AC121252.4         25638-25784         c
            3203-3339           AC121252.4         25420-25556         c
            3340-3466           AC121252.4         25011-25137         c
            3467-3613           AC121252.4         24780-24926         c
            3614-3786           AC121252.4         24522-24694         c
            3787-3822           AC121252.4         24388-24423         c
            3823-3849           AC121252.4         24278-24304         c
            3850-3894           AC121252.4         24138-24182         c
            3895-3957           AC121252.4         24005-24067         c
            3958-4038           AC121252.4         23484-23564         c
            4039-4074           AC121252.4         23358-23393         c
            4075-4110           AC121252.4         23182-23217         c
            4111-4182           AC121252.4         22933-23004         c
            4183-4260           AC121252.4         22746-22823         c
            4261-4287           AC121252.4         22483-22509         c
            4288-4341           AC121252.4         22348-22401         c
            4342-4404           AC121252.4         22166-22228         c
            4405-4464           AC121252.4         22004-22063         c
            4465-4500           AC121252.4         21841-21876         c
            4501-4545           AC121252.4         21575-21619         c
            4546-4581           AC121252.4         21461-21496         c
            4582-4626           AC121252.4         21057-21101         c
            4627-4662           AC121252.4         20926-20961         c
            4663-4698           AC121252.4         20771-20806         c
            4699-4731           AC121252.4         20359-20391         c
            4732-4785           AC121252.4         20154-20207         c
            4786-4845           AC121252.4         20021-20080         c
            4846-4881           AC121252.4         19896-19931         c
            4882-4962           AC121252.4         19708-19788         c
            4963-4998           AC121252.4         19570-19605         c
            4999-5043           AC121252.4         19330-19374         c
            5044-5115           AC121252.4         19029-19100         c
            5116-5160           AC121252.4         18748-18792         c
            5161-5187           AC121252.4         18479-18505         c
            5188-5217           AC121252.4         18233-18262         c
            5218-5298           AC121252.4         18036-18116         c
            5299-5334           AC121252.4         17928-17963         c
            5335-5370           AC121252.4         17817-17852         c
            5371-5451           AC121252.4         17645-17725         c
            5452-5487           AC121252.4         17367-17402         c
            5488-5550           AC121252.4         16901-16963         c
            5551-5595           AC121252.4         16769-16813         c
            5596-5631           AC121252.4         15440-15475         c
            5632-5667           AC121252.4         15332-15367         c
            5668-5763           AC121252.4         15124-15219         c
            5764-5799           AC121252.4         14970-15005         c
            5800-5835           AC121252.4         14848-14883         c
            5836-5883           AC121252.4         14697-14744         c
            5884-5919           AC121252.4         14315-14350         c
            5920-6042           AC121252.4         14074-14196         c
            6043-6243           AC121252.4         13787-13987         c
            6244-6279           AC121252.4         13655-13690         c
            6280-6342           AC121252.4         13512-13574         c
            6343-6411           AC121252.4         13245-13313         c
            6412-6456           AC121252.4         13125-13169         c
            6457-6519           AC121252.4         12936-12998         c
            6520-6564           AC121252.4         12710-12754         c
            6565-6600           AC121252.4         12303-12338         c
            6601-6636           AC121252.4         12138-12173         c
            6637-6681           AC121252.4         11961-12005         c
            6682-6714           AC121252.4         11764-11796         c
            6715-6777           AC121252.4         11622-11684         c
            6778-6813           AC121252.4         11469-11504         c
            6814-6894           AC121252.4         11310-11390         c
            6895-6963           AC121252.4         11119-11187         c
            6964-6999           AC121252.4         10951-10986         c
            7000-7041           AC121252.4         10828-10869         c
            7042-7086           AC121252.4         10575-10619         c
            7087-7131           AC121252.4         10449-10493         c
            7132-7167           AC121252.4         9691-9726           c
            7168-7227           AC121252.4         9549-9608           c
            7228-7335           AC121252.4         9309-9416           c
            7336-7407           AC121252.4         9087-9158           c
            7408-7443           AC121252.4         8913-8948           c
            7444-7503           AC121252.4         8723-8782           c
            7504-7548           AC121252.4         8582-8626           c
            7549-7584           AC121252.4         8328-8363           c
            7585-7620           AC121252.4         8173-8208           c
            7621-7677           AC121252.4         8040-8096           c
            7678-7749           AC121252.4         7823-7894           c
            7750-7821           AC121252.4         7232-7303           c
            7822-7857           AC121252.4         6947-6982           c
            7858-7938           AC121252.4         6538-6618           c
            7939-7992           AC121252.4         6286-6339           c
            7993-8046           AC121252.4         6158-6211           c
            8047-8109           AC121252.4         6022-6084           c
            8110-8172           AC121252.4         5576-5638           c
            8173-8289           AC121252.4         5355-5471           c
            8290-8367           AC121252.4         5108-5185           c
            8368-8421           AC121252.4         4958-5011           c
            8422-8470           AC121252.4         4715-4763           c
            8471-8503           AC121252.4         4084-4116           c
            8504-8590           AC121252.4         3858-3944           c
            8591-8683           AC121252.4         3557-3649           c
            8684-8881           AC121252.4         3231-3428           c
            8882-9231           AC121252.4         2521-2870           c
FEATURES             Location/Qualifiers
     source          1..9231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..9231
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /note="collagen type VII alpha 1 chain"
                     /db_xref="GeneID:1294"
                     /db_xref="HGNC:HGNC:2214"
                     /db_xref="MIM:120120"
     exon            1..62
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            63..148
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..8898
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /note="LC collagen; collagen VII, alpha-1 polypeptide;
                     collagen alpha-1(VII) chain; long-chain collagen;
                     collagen, type VII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(VII) chain precursor"
                     /protein_id="NP_000085.1"
                     /db_xref="CCDS:CCDS2773.1"
                     /db_xref="GeneID:1294"
                     /db_xref="HGNC:HGNC:2214"
                     /db_xref="MIM:120120"
                     /translation="MTLRLLVAALCAGILAEAPRVRAQHRERVTCTRLYAADIVFLLD
                     GSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGD
                     VIRAIRELSYKGGNTRTGAAILHVADHVFLPQLARPGVPKVCILITDGKSQDLVDTAA
                     QRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRVCTT
                     AGGVPVTRPPDDSTSAPRDLVLSEPSSQSLRVQWTAASGPVTGYKVQYTPLTGLGQPL
                     PSERQEVNVPAGETSVRLRGLRPLTEYQVTVIALYANSIGEAVSGTARTTALEGPELT
                     IQNTTAHSLLVAWRSVPGATGYRVTWRVLSGGPTQQQELGPGQGSVLLRDLEPGTDYE
                     VTVSTLFGRSVGPATSLMARTDASVEQTLRPVILGPTSILLSWNLVPEARGYRLEWRR
                     ETGLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTLYTLLEGHEVATPATVVPTGPELPV
                     SPVTDLQATELPGQRVRVSWSPVPGATQYRIIVRSTQGVERTLVLPGSQTAFDLDDVQ
                     AGLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVVSDATRVRVAWGPVPGA
                     SGFRISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQVAVSVLRGREEGPAAVIVAR
                     TDPLGPVRTVHVTQASSSSVTITWTRVPGATGYRVSWHSAHGPEKSQLVSGEATVAEL
                     DGLEPDTEYTVHVRAHVAGVDGPPASVVVRTAPEPVGRVSRLQILNASSDVLRITWVG
                     VTGATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPV
                     SIVVTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQGFLLHWQPEGGQEQSRVLGP
                     ELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPSIELRVVDTSIDSV
                     TLAWTPVSRASSYILSWRPLRGPGQEVPGSPQTLPGISSSQRVTGLEPGVSYIFSLTP
                     VLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEATRRVLERLVLALGPLGP
                     QAVQVGLLSYSHRPSPLFPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYML
                     APDAPGRRQHVPGVMVLLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQLRRLA
                     PGMDSVQTFFAVDDGPSLDQAVSGLATALCQASFTTQPRPEPCPVYCPKGQKGEPGEM
                     GLRGQVGPPGDPGLPGRTGAPGPQGPPGSATAKGERGFPGADGRPGSPGRAGNPGTPG
                     APGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGP
                     RGPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQG
                     PVGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEAGEK
                     GERGPPGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGEPGRPGDPAVVGPAVAGP
                     KGEKGDVGPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSG
                     PPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGP
                     VGEKGDQGDPGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQ
                     EGPRGPKGDPGLPGAPGERGIEGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLD
                     GKPGAAGPSGPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNG
                     KNGEPGDPGEDGRKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQ
                     GFPGVPGGTGPKGDRGETGSKGEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALRE
                     IVETWDESSGSFLPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGP
                     PGLALGERGPPGPSGLAGEPGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGR
                     DGPPGLPGTPGPPGPPGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQGPKGDRG
                     VPGIKGDRGEPGPRGQDGNPGLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDPGPPGA
                     PGLAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPGLPG
                     QVGETGKPGAPGRDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAVVGLP
                     GAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKGAPGP
                     KGFKGDPGVGVPGSPGPPGPPGVKGDLGLPGLPGAPGVVGFPGQTGPRGEMGQPGPSG
                     ERGLAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIR
                     GEDGRPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGAKGDM
                     GERGPRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLPGLRGLLGPQGQPGAAGIPG
                     DPGSPGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAGPPGRPGL
                     AGHKGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQGEKGERGTPGIGGFP
                     GPSGNDGSAGPPGPPGSVGPRGPEGLQGQKGERGPPGERVVGAPGVPGAPGERGEQGR
                     PGPAGPRGEKGEAALTEDDIRGFVRQEMSQHCACQGQFIASGSRPLPSYAADTAGSQL
                     HAVPVLRVSHAEEEERVPPEDDEYSEYSEYSVEEYQDPEAPWDSDDPCSLPLDEGSCT
                     AYTLRWYHRAVTGSTEACHPFVYGGCGGNANRFGTREACERRCPPRVVQSQGTGTAQD
                     "
     exon            149..329
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            330..489
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            490..583
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            584..745
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            746..909
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1039
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1156
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1303
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1420
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1570
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1699
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1843
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1969
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2113
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2233
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2377
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2503
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2650
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2773
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2920
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3055
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3202
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3339
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3466
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3613
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3786
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3822
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3849
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3894
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..3957
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4038
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4074
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4075..4110
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4182
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4260
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4287
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4341
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4404
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4464
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4500
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4545
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4546..4581
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4582..4626
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4627..4662
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4698
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4731
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..4785
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..4845
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..4881
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4962
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..4998
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5043
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5044..5115
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5160
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5161..5187
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5188..5217
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5298
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5334
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5370
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5371..5451
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5452..5487
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5550
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..5595
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5596..5631
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5667
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5668..5763
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5764..5799
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5800..5835
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5883
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..5919
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6042
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6043..6243
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6244..6279
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6280..6342
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6343..6411
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6456
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6457..6519
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6520..6564
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6565..6600
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6601..6636
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6637..6681
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6682..6714
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..6777
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6778..6813
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6814..6894
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6895..6963
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            6964..6999
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7000..7041
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7042..7086
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7087..7131
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7132..7167
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7168..7227
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7228..7335
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7336..7407
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7408..7443
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7444..7503
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7504..7548
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7549..7584
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7585..7620
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7621..7677
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7678..7749
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7750..7821
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7822..7857
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7858..7938
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7939..7992
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            7993..8046
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8047..8109
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8110..8172
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8173..8289
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8290..8367
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8368..8421
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8422..8470
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8471..8503
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8504..8590
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8591..8683
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8684..8881
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     exon            8882..9231
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9208..9213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /note="hexamer: ATTAAA"
     polyA_site      9231
                     /gene="COL7A1"
                     /gene_synonym="EBD1; EBDCT; EBR1; NDNC8"
                     /note="major polyA site"
ORIGIN      
        1 gacttttctc tgctctgccc gagagactgc agcggcggcg gcgggagcgg gcggacgcgc
       61 aggatgacgc tgcggcttct ggtggccgcg ctctgcgccg ggatcctggc agaggcgccc
      121 cgagtgcgag cccagcacag ggagagagtg acctgcacgc gcctttacgc cgctgacatt
      181 gtgttcttac tggatggctc ctcatccatt ggccgcagca atttccgcga ggtccgcagc
      241 tttctcgaag ggctggtgct gcctttctct ggagcagcca gtgcacaggg tgtgcgcttt
      301 gccacagtgc agtacagcga tgacccacgg acagagttcg gcctggatgc acttggctct
      361 gggggtgatg tgatccgcgc catccgtgag cttagctaca aggggggcaa cactcgcaca
      421 ggggctgcaa ttctccatgt ggctgaccat gtcttcctgc cccagctggc ccgacctggt
      481 gtccccaagg tctgcatcct gatcacagac gggaagtccc aggacctggt ggacacagct
      541 gcccaaaggc tgaaggggca gggggtcaag ctatttgctg tggggatcaa gaatgctgac
      601 cctgaggagc tgaagcgagt tgcctcacag cccaccagtg acttcttctt cttcgtcaat
      661 gacttcagca tcttgaggac actactgccc ctcgtttccc ggagagtgtg cacgactgct
      721 ggtggcgtgc ctgtgacccg acctccggat gactcgacct ctgctccacg agacctggtg
      781 ctgtctgagc caagcagcca atccttgaga gtacagtgga cagcggccag tggccctgtg
      841 actggctaca aggtccagta cactcctctg acggggctgg gacagccact gccgagtgag
      901 cggcaggagg tgaacgtccc agctggtgag accagtgtgc ggctgcgggg tctccggcca
      961 ctgaccgagt accaagtgac tgtgattgcc ctctacgcca acagcatcgg ggaggctgtg
     1021 agcgggacag ctcggaccac tgccctagaa gggccggaac tgaccatcca gaataccaca
     1081 gcccacagcc tcctggtggc ctggcggagt gtgccaggtg ccactggcta ccgtgtgaca
     1141 tggcgggtcc tcagtggtgg gcccacacag cagcaggagc tgggccctgg gcagggttca
     1201 gtgttgctgc gtgacttgga gcctggcacg gactatgagg tgaccgtgag caccctattt
     1261 ggccgcagtg tggggcccgc cacttccctg atggctcgca ctgacgcttc tgttgagcag
     1321 accctgcgcc cggtcatcct gggccccaca tccatcctcc tttcctggaa cttggtgcct
     1381 gaggcccgtg gctaccggtt ggaatggcgg cgtgagactg gcttggagcc accgcagaag
     1441 gtggtactgc cctctgatgt gacccgctac cagttggatg ggctgcagcc gggcactgag
     1501 taccgcctca cactctacac tctgctggag ggccacgagg tggccacccc tgcaaccgtg
     1561 gttcccactg gaccagagct gcctgtgagc cctgtaacag acctgcaagc caccgagctg
     1621 cccgggcagc gggtgcgagt gtcctggagc ccagtccctg gtgccaccca gtaccgcatc
     1681 attgtgcgca gcacccaggg ggttgagcgg accctggtgc ttcctgggag tcagacagca
     1741 ttcgacttgg atgacgttca ggctgggctt agctacactg tgcgggtgtc tgctcgagtg
     1801 ggtccccgtg agggcagtgc cagtgtcctc actgtccgcc gggagccgga aactccactt
     1861 gctgttccag ggctgcgggt tgtggtgtca gatgcaacgc gagtgagggt ggcctgggga
     1921 cccgtccctg gagccagtgg atttcggatt agctggagca caggcagtgg tccggagtcc
     1981 agccagacac tgcccccaga ctctactgcc acagacatca cagggctgca gcctggaacc
     2041 acctaccagg tggctgtgtc ggtactgcga ggcagagagg agggccctgc tgcagtcatc
     2101 gtggctcgaa cggacccact gggcccagtg aggacggtcc atgtgactca ggccagcagc
     2161 tcatctgtca ccattacctg gaccagggtt cctggcgcca caggatacag ggtttcctgg
     2221 cactcagccc acggcccaga gaaatcccag ttggtttctg gggaggccac ggtggctgag
     2281 ctggatggac tggagccaga tactgagtat acggtgcatg tgagggccca tgtggctggc
     2341 gtggatgggc cccctgcctc tgtggttgtg aggactgccc ctgagcctgt gggtcgtgtg
     2401 tcgaggctgc agatcctcaa tgcttccagc gacgttctac ggatcacctg ggtaggggtc
     2461 actggagcca cagcttacag actggcctgg ggccggagtg aaggcggccc catgaggcac
     2521 cagatactcc caggaaacac agactctgca gagatccggg gtctcgaagg tggagtcagc
     2581 tactcagtgc gagtgactgc acttgtcggg gaccgcgagg gcacacctgt ctccattgtt
     2641 gtcactacgc cgcctgaggc tccgccagcc ctggggacgc ttcacgtggt gcagcgcggg
     2701 gagcactcgc tgaggctgcg ctgggagccg gtgcccagag cgcagggctt ccttctgcac
     2761 tggcaacctg agggtggcca ggaacagtcc cgggtcctgg ggcccgagct cagcagctat
     2821 cacctggacg ggctggagcc agcgacacag taccgcgtga ggctgagtgt cctagggcca
     2881 gctggagaag ggccctctgc agaggtgact gcgcgcactg agtcacctcg tgttccaagc
     2941 attgaactac gtgtggtgga cacctcgatc gactcggtga ctttggcctg gactccagtg
     3001 tccagggcat ccagctacat cctatcctgg cggccactca gaggccctgg ccaggaagtg
     3061 cctgggtccc cgcagacact tccagggatc tcaagctccc agcgggtgac agggctagag
     3121 cctggcgtct cttacatctt ctccctgacg cctgtcctgg atggtgtgcg gggtcctgag
     3181 gcatctgtca cacagacgcc agtgtgcccc cgtggcctgg cggatgtggt gttcctacca
     3241 catgccactc aagacaatgc tcaccgtgcg gaggctacga ggagggtcct ggagcgtctg
     3301 gtgttggcac ttgggcctct tgggccacag gcagttcagg ttggcctgct gtcttacagt
     3361 catcggccct ccccactgtt cccactgaat ggctcccatg accttggcat tatcttgcaa
     3421 aggatccgtg acatgcccta catggaccca agtgggaaca acctgggcac agccgtggtc
     3481 acagctcaca gatacatgtt ggcaccagat gctcctgggc gccgccagca cgtaccaggg
     3541 gtgatggttc tgctagtgga tgaacccttg agaggtgaca tattcagccc catccgtgag
     3601 gcccaggctt ctgggcttaa tgtggtgatg ttgggaatgg ctggagcgga cccagagcag
     3661 ctgcgtcgct tggcgccggg tatggactct gtccagacct tcttcgccgt ggatgatggg
     3721 ccaagcctgg accaggcagt cagtggtctg gccacagccc tgtgtcaggc atccttcact
     3781 actcagcccc ggccagagcc ctgcccagtg tattgtccaa agggccagaa gggggaacct
     3841 ggagagatgg gcctgagagg acaagttggg cctcctggcg accctggcct cccgggcagg
     3901 accggtgctc ccggccccca ggggccccct ggaagtgcca ctgccaaggg cgagaggggc
     3961 ttccctggag cagatgggcg tccaggcagc cctggccgcg ccgggaatcc tgggacccct
     4021 ggagcccctg gcctaaaggg ctctccaggg ttgcctggcc ctcgtgggga cccgggagag
     4081 cgaggacctc gaggcccaaa gggggagccg ggggctcccg gacaagtcat cggaggtgaa
     4141 ggacctgggc ttcctgggcg gaaaggggac cctggaccat cgggcccccc tggacctcgt
     4201 ggaccactgg gggacccagg accccgtggc cccccagggc ttcctggaac agccatgaag
     4261 ggtgacaaag gcgatcgtgg ggagcggggt ccccctggac caggtgaagg tggcattgct
     4321 cctggggagc ctgggctgcc gggtcttccc ggaagccctg gaccccaagg ccccgttggc
     4381 ccccctggaa agaaaggaga aaaaggtgac tctgaggatg gagctccagg cctcccagga
     4441 caacctgggt ctccgggtga gcagggccca cggggacctc ctggagctat tggccccaaa
     4501 ggtgaccggg gctttccagg gcccctgggt gaggctggag agaagggcga acgtggaccc
     4561 ccaggcccag cgggatcccg ggggctgcca ggggttgctg gacgtcctgg agccaagggt
     4621 cctgaagggc caccaggacc cactggccgc caaggagaga agggggagcc tggtcgccct
     4681 ggggaccctg cagtggtggg acctgctgtt gctggaccca aaggagaaaa gggagatgtg
     4741 gggcccgctg ggcccagagg agctaccgga gtccaagggg aacggggccc acccggcttg
     4801 gttcttcctg gagaccctgg ccccaaggga gaccctggag accggggtcc cattggcctt
     4861 actggcagag caggaccccc aggtgactca gggcctcctg gagagaaggg agaccctggg
     4921 cggcctggcc ccccaggacc tgttggcccc cgaggacgag atggtgaagt tggagagaaa
     4981 ggtgacgagg gtcctccggg tgacccgggt ttgcctggaa aagcaggcga gcgtggcctt
     5041 cggggggcac ctggagttcg ggggcctgtg ggtgaaaagg gagaccaggg agatcctgga
     5101 gaggatggac gaaatggcag ccctggatca tctggaccca agggtgaccg tggggagccg
     5161 ggtcccccag gacccccggg acggctggta gacacaggac ctggagccag agagaaggga
     5221 gagcctgggg accgcggaca agagggtcct cgagggccca agggtgatcc tggcctccct
     5281 ggagcccctg gggaaagggg cattgaaggg tttcggggac ccccaggccc acagggggac
     5341 ccaggtgtcc gaggcccagc aggagaaaag ggtgaccggg gtccccctgg gctggatggc
     5401 cggagcggac tggatgggaa accaggagcc gctgggccct ctgggccgaa tggtgctgca
     5461 ggcaaagctg gggacccagg gagagacggg cttccaggcc tccgtggaga acagggcctc
     5521 cctggcccct ctggtccccc tggattaccg ggaaagccag gcgaggatgg caaacctggc
     5581 ctgaatggaa aaaacggaga acctggggac cctggagaag acgggaggaa gggagagaaa
     5641 ggagattcag gcgcctctgg gagagaaggt cgtgatggcc ccaagggtga gcgtggagct
     5701 cctggtatcc ttggacccca ggggcctcca ggcctcccag ggccagtggg ccctcctggc
     5761 cagggttttc ctggtgtccc aggaggcacg ggccccaagg gtgaccgtgg ggagactgga
     5821 tccaaagggg agcagggcct ccctggagag cgtggcctgc gaggagagcc tggaagtgtg
     5881 ccgaatgtgg atcggttgct ggaaactgct ggcatcaagg catctgccct gcgggagatc
     5941 gtggagacct gggatgagag ctctggtagc ttcctgcctg tgcccgaacg gcgtcgaggc
     6001 cccaaggggg actcaggcga acagggcccc ccaggcaagg agggccccat cggctttcct
     6061 ggagaacgcg ggctgaaggg cgaccgtgga gaccctggcc ctcaggggcc acctggtctg
     6121 gcccttgggg agaggggccc ccccgggcct tccggccttg ccggggagcc tggaaagcct
     6181 ggtattcccg ggctcccagg cagggctggg ggtgtgggag aggcaggaag gccaggagag
     6241 aggggagaac ggggagagaa aggagaacgt ggagaacagg gcagagatgg ccctcctgga
     6301 ctccctggaa cccctgggcc ccccggaccc cctggcccca aggtgtctgt ggatgagcca
     6361 ggtcctggac tctctggaga acagggaccc cctggactca agggtgctaa gggggagccg
     6421 ggcagcaatg gtgaccaagg tcccaaagga gacaggggtg tgccaggcat caaaggagac
     6481 cggggagagc ctggaccgag gggtcaggac ggcaacccgg gtctaccagg agagcgtggt
     6541 atggctgggc ctgaagggaa gccgggtctg cagggtccaa gaggcccccc tggcccagtg
     6601 ggtggtcatg gagaccctgg accacctggt gccccgggtc ttgctggccc tgcaggaccc
     6661 caaggacctt ctggcctgaa gggggagcct ggagagacag gacctccagg acggggcctg
     6721 actggaccta ctggagctgt gggacttcct ggaccccccg gcccttcagg ccttgtgggt
     6781 ccacaggggt ctccaggttt gcctggacaa gtgggggaga cagggaagcc gggagcccca
     6841 ggtcgagatg gtgccagtgg aaaagatgga gacagaggga gccctggtgt gccagggtca
     6901 ccaggtctgc ctggccctgt cggacctaaa ggagaacctg gccccacggg ggcccctgga
     6961 caggctgtgg tcgggctccc tggagcaaag ggagagaagg gagcccctgg aggccttgct
     7021 ggagacctgg tgggtgagcc gggagccaaa ggtgaccgag gactgccagg gccgcgaggc
     7081 gagaagggtg aagctggccg tgcaggggag cccggagacc ctggggaaga tggtcagaaa
     7141 ggggctccag gacccaaagg tttcaagggt gacccaggag tcggggtccc gggctcccct
     7201 gggcctcctg gccctccagg tgtgaaggga gatctgggcc tccctggcct gcccggtgct
     7261 cctggtgttg ttgggttccc gggtcagaca ggccctcgag gagagatggg tcagccaggc
     7321 cctagtggag agcggggtct ggcaggcccc ccagggagag aaggaatccc aggacccctg
     7381 gggccacctg gaccaccggg gtcagtggga ccacctgggg cctctggact caaaggagac
     7441 aagggagacc ctggagtagg gctgcctggg ccccgaggcg agcgtgggga gccaggcatc
     7501 cggggtgaag atggccgccc cggccaggag ggaccccgag gactcacggg gccccctggc
     7561 agcaggggag agcgtgggga gaagggtgat gttgggagtg caggactaaa gggtgacaag
     7621 ggagactcag ctgtgatcct ggggcctcca ggcccacggg gtgccaaggg ggacatgggt
     7681 gaacgagggc ctcggggctt ggatggtgac aaaggacctc ggggagacaa tggggaccct
     7741 ggtgacaagg gcagcaaggg agagcctggt gacaagggct cagccgggtt gccaggactg
     7801 cgtggactcc tgggacccca gggtcaacct ggtgcagcag ggatccctgg tgacccggga
     7861 tccccaggaa aggatggagt gcctggtatc cgaggagaaa aaggagatgt tggcttcatg
     7921 ggtccccggg gcctcaaggg tgaacgggga gtgaagggag cctgtggcct tgatggagag
     7981 aagggagaca agggagaagc tggtccccca ggccgccccg ggctggcagg acacaaagga
     8041 gagatggggg agcctggtgt gccgggccag tcgggggccc ctggcaagga gggcctgatc
     8101 ggtcccaagg gtgaccgagg ctttgacggg cagccaggcc ccaagggtga ccagggcgag
     8161 aaaggggagc ggggaacccc aggaattggg ggcttcccag gccccagtgg aaatgatggc
     8221 tctgctggtc ccccagggcc acctggcagt gttggtccca gaggccccga aggacttcag
     8281 ggccagaagg gtgagcgagg tccccccgga gagagagtgg tgggggctcc tggggtccct
     8341 ggagctcctg gcgagagagg ggagcagggg cggccagggc ctgccggtcc tcgaggcgag
     8401 aagggagaag ctgcactgac ggaggatgac atccggggct ttgtgcgcca agagatgagt
     8461 cagcactgtg cctgccaggg ccagttcatc gcatctggat cacgacccct ccctagttat
     8521 gctgcagaca ctgccggctc ccagctccat gctgtgcctg tgctccgcgt ctctcatgca
     8581 gaggaggaag agcgggtacc ccctgaggat gatgagtact ctgaatactc cgagtattct
     8641 gtggaggagt accaggaccc tgaagctcct tgggatagtg atgacccctg ttccctgcca
     8701 ctggatgagg gctcctgcac tgcctacacc ctgcgctggt accatcgggc tgtgacaggc
     8761 agcacagagg cctgtcaccc ttttgtctat ggtggctgtg gagggaatgc caaccgtttt
     8821 gggacccgtg aggcctgcga gcgccgctgc ccaccccggg tggtccagag ccaggggaca
     8881 ggtactgccc aggactgagg cccagataat gagctgagat tcagcatccc ctggaggagt
     8941 cggggtctca gcagaacccc actgtccctc cccttggtgc tagaggcttg tgtgcacgtg
     9001 agcgtgcgtg tgcacgtccg ttatttcagt gacttggtcc cgtgggtcta gccttccccc
     9061 ctgtggacaa acccccattg tggctcctgc caccctggca gatgactcac tgtggggggg
     9121 tggctgtggg cagtgagcgg atgtgactgg cgtctgaccc gccccttgac ccaagcctgt
     9181 gatgacatgg tgctgattct ggggggcatt aaagctgctg ttttaaaagg c
//
