LOCUS       NM_001848               4203 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens collagen type VI alpha 1 chain (COL6A1), mRNA.
ACCESSION   NM_001848
VERSION     NM_001848.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4203)
  AUTHORS   Maksiutenko,E.M., Merkureva,V., Barbitoff,Y.A., Tsay,V.V.,
            Aseev,M.V., Glotov,A.S. and Glotov,O.S.
  TITLE     Exome sequencing in extreme altitude mountaineers identifies
            pathogenic variants in RTEL1 and COL6A1 previously associated with
            respiratory failure
  JOURNAL   Physiol Rep 12 (8), e16015 (2024)
   PUBMED   38653581
  REMARK    GeneRIF: Exome sequencing in extreme altitude mountaineers
            identifies pathogenic variants in RTEL1 and COL6A1 previously
            associated with respiratory failure.
REFERENCE   2  (bases 1 to 4203)
  AUTHORS   Barington,M., Duno,M., Birkedal,U., Vissing,J., Born,A.P., Krag,T.,
            Hansen,T.V.O. and Ostergaard,E.
  TITLE     Homozygous splice variant (c.1741-6G>A) of the COL6A1 gene in three
            patients with Ullrich congenital muscular dystrophy
  JOURNAL   Neuromuscul Disord 33 (7), 539-545 (2023)
   PUBMED   37315421
  REMARK    GeneRIF: Homozygous splice variant (c.1741-6G>A) of the COL6A1 gene
            in three patients with Ullrich congenital muscular dystrophy.
REFERENCE   3  (bases 1 to 4203)
  AUTHORS   Zanotti,S., Magri,F., Salani,S., Napoli,L., Ripolone,M., Ronchi,D.,
            Fortunato,F., Ciscato,P., Velardo,D., D'Angelo,M.G., Gualandi,F.,
            Nigro,V., Sciacco,M., Corti,S., Comi,G.P. and Piga,D.
  TITLE     Extracellular Matrix Disorganization and Sarcolemmal Alterations in
            COL6-Related Myopathy Patients with New Variants of COL6 Genes
  JOURNAL   Int J Mol Sci 24 (6), 5551 (2023)
   PUBMED   36982625
  REMARK    GeneRIF: Extracellular Matrix Disorganization and Sarcolemmal
            Alterations in COL6-Related Myopathy Patients with New Variants of
            COL6 Genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4203)
  AUTHORS   Shi,T.T., Liu,H.Y., Zhu,X.R., Xin,Z., Hua,L., Xie,R.R., Sun,R.,
            Cao,X. and Yang,J.K.
  TITLE     Integrated Proteomics and Metabolomics Analyses of Serum in Chinese
            Patients with Severe and Active Graves' Orbitopathy: A
            Cross-sectional Study
  JOURNAL   Endocr Metab Immune Disord Drug Targets 23 (9), 1151-1161 (2023)
   PUBMED   36809953
  REMARK    GeneRIF: Integrated Proteomics and Metabolomics Analyses of Serum
            in Chinese Patients with Severe and Active Graves' Orbitopathy: A
            Cross-sectional Study.
REFERENCE   5  (bases 1 to 4203)
  AUTHORS   Foley,A.R., Mohassel,P., Donkervoort,S., Bolduc,V. and
            Bonnemann,C.G.
  TITLE     Collagen VI-Related Dystrophies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301676
REFERENCE   6  (bases 1 to 4203)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   7  (bases 1 to 4203)
  AUTHORS   Bidanset,D.J., Guidry,C., Rosenberg,L.C., Choi,H.U., Timpl,R. and
            Hook,M.
  TITLE     Binding of the proteoglycan decorin to collagen type VI
  JOURNAL   J Biol Chem 267 (8), 5250-5256 (1992)
   PUBMED   1544908
REFERENCE   8  (bases 1 to 4203)
  AUTHORS   Saitta,B., Wang,Y.M., Renkart,L., Zhang,R.Z., Pan,T.C., Timpl,R.
            and Chu,M.L.
  TITLE     The exon organization of the triple-helical coding regions of the
            human alpha 1(VI) and alpha 2(VI) collagen genes is highly similar
  JOURNAL   Genomics 11 (1), 145-153 (1991)
   PUBMED   1765372
REFERENCE   9  (bases 1 to 4203)
  AUTHORS   Chu,M.L., Pan,T.C., Conway,D., Kuo,H.J., Glanville,R.W., Timpl,R.,
            Mann,K. and Deutzmann,R.
  TITLE     Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human
            type VI collagen reveals internal triplication of globular domains
            similar to the A domains of von Willebrand factor and two alpha
            2(VI) chain variants that differ in the carboxy terminus
  JOURNAL   EMBO J 8 (7), 1939-1946 (1989)
   PUBMED   2551668
REFERENCE   10 (bases 1 to 4203)
  AUTHORS   Chu,M.L., Conway,D., Pan,T.C., Baldwin,C., Mann,K., Deutzmann,R.
            and Timpl,R.
  TITLE     Amino acid sequence of the triple-helical domain of human collagen
            type VI
  JOURNAL   J Biol Chem 263 (35), 18601-18606 (1988)
   PUBMED   3198591
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU100220.1, CN369026.1,
            BC052575.1, BI769554.1, CN369002.1, CN369041.1, BM686857.1 and
            BM707144.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001848.2.
            
            Summary: The collagens are a superfamily of proteins that play a
            role in maintaining the integrity of various tissues. Collagens are
            extracellular matrix proteins and have a triple-helical domain as
            their common structural element. Collagen VI is a major structural
            component of microfibrils. The basic structural unit of collagen VI
            is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI)
            chains. The alpha2(VI) and alpha3(VI) chains are encoded by the
            COL6A2 and COL6A3 genes, respectively. The protein encoded by this
            gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain).
            Mutations in the genes that code for the collagen VI subunits
            result in the autosomal dominant disorder, Bethlem myopathy.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052575.1, GQ891373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361866.8/ ENSP00000355180.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AU100220.1         34-108
            76-79               CN369026.1         95-98
            80-1173             BC052575.1         81-1174
            1174-1178           BI769554.1         50-54               c
            1179-1388           BC052575.1         1180-1389
            1389-1396           CN369002.1         418-425
            1397-3257           BC052575.1         1398-3258
            3258-3628           CN369041.1         140-510
            3629-4128           BM686857.1         58-557
            4129-4203           BM707144.1         400-474
FEATURES             Location/Qualifiers
     source          1..4203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..4203
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /note="collagen type VI alpha 1 chain"
                     /db_xref="GeneID:1291"
                     /db_xref="HGNC:HGNC:2211"
                     /db_xref="MIM:120220"
     exon            1..178
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            179..308
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            309..509
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            510..669
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            670..798
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            799..819
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            820..840
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            841..885
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            886..939
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            940..984
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1011
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1038
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1083
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1137
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1200
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1263
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1317
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1353
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1416
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1479
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1542
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1605
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1656
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1692
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1755
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1821
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1857
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1894
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1903
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2037
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2147
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2331
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2515
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2545
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..4203
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4184..4189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /note="hexamer: AATAAA"
     polyA_site      4203
                     /gene="COL6A1"
                     /gene_synonym="BTHLM1; BTHLM1A; OPLL; UCHMD1; UCHMD1A"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcagc ctcggtctct gggcggcggc ggcggcccac tctgccctgg ccgcgctgtg
       61 tggtgaccgc aggccccaga catgagggcg gcccgtgctc tgctgcccct gctgctgcag
      121 gcctgctgga cagccgcgca ggatgagccg gagaccccga gggccgtggc cttccaggac
      181 tgccccgtgg acctgttctt tgtgctggac acctctgaga gcgtggccct gaggctgaag
      241 ccctacgggg ccctcgtgga caaagtcaag tccttcacca agcgcttcat cgacaacctg
      301 agggacaggt actaccgctg tgaccgaaac ctggtgtgga acgcaggcgc gctgcactac
      361 agtgacgagg tggagatcat ccaaggcctc acgcgcatgc ctggcggccg cgacgcactc
      421 aaaagcagcg tggacgcggt caagtacttt gggaagggca cctacaccga ctgcgctatc
      481 aagaaggggc tggagcagct cctcgtgggg ggctcccacc tgaaggagaa taagtacctg
      541 attgtggtga ccgacgggca ccccctggag ggctacaagg aaccctgtgg ggggctggag
      601 gatgctgtga acgaggccaa gcacctgggc gtcaaagtct tctcggtggc catcacaccc
      661 gaccacctgg agccgcgtct gagcatcatc gccacggacc acacgtaccg gcgcaacttc
      721 acggcggctg actggggcca gagccgcgac gcagaggagg ccatcagcca gaccatcgac
      781 accatcgtgg acatgatcaa aaataacgtg gagcaagtgt gctgctcctt cgaatgccag
      841 cctgcaagag gacctccggg gctccggggc gaccccggct ttgagggaga acgaggcaag
      901 ccggggctcc caggagagaa gggagaagcc ggagatcctg gaagacccgg ggacctcgga
      961 cctgttgggt accagggaat gaagggagaa aaagggagcc gtggggagaa gggctccagg
     1021 ggacccaagg gctacaaggg agagaagggc aagcgtggca tcgacggggt ggacggcgtg
     1081 aagggggaga tggggtaccc aggcctgcca ggctgcaagg gctcgcccgg gtttgacggc
     1141 attcaaggac cccctggccc caagggagac cccggtgcct ttggactgaa aggagaaaag
     1201 ggcgagcctg gagctgacgg ggaggcgggg agaccaggga gctcgggacc atctggagac
     1261 gagggccagc cgggagagcc tgggcccccc ggagagaaag gagaggcggg cgacgagggg
     1321 aacccaggac ctgacggtgc ccccggggag cggggtggcc ctggagagag aggaccacgg
     1381 gggaccccag gcacgcgggg accaagagga gaccctggtg aagctggccc gcagggtgat
     1441 cagggaagag aaggccccgt tggtgtccct ggagacccgg gcgaggctgg ccctatcgga
     1501 cctaaaggct accgaggcga tgagggtccc ccagggtccg agggtgccag aggagcccca
     1561 ggacctgccg gaccccctgg agacccgggg ctgatgggtg aaaggggaga agacggcccc
     1621 gctggaaatg gcaccgaggg cttccccggc ttccccgggt atccgggcaa caggggcgct
     1681 cccgggataa acggcacgaa gggctacccc ggcctcaagg gggacgaggg agaagccggg
     1741 gaccccggag acgataacaa cgacattgca ccccgaggag tcaaaggagc aaaggggtac
     1801 cggggtcccg agggccccca gggaccccca ggacaccaag gaccgcctgg gccggacgaa
     1861 tgcgagattt tggacatcat catgaaaatg tgctcttgct gtgaatgcaa gtgcggcccc
     1921 atcgacctcc tgttcgtgct ggacagctca gagagcattg gcctgcagaa cttcgagatt
     1981 gccaaggact tcgtcgtcaa ggtcatcgac cggctgagcc gggacgagct ggtcaagttc
     2041 gagccagggc agtcgtacgc gggtgtggtg cagtacagcc acagccagat gcaggagcac
     2101 gtgagcctgc gcagccccag catccggaac gtgcaggagc tcaaggaagc catcaagagc
     2161 ctgcagtgga tggcgggcgg caccttcacg ggggaggccc tgcagtacac gcgggaccag
     2221 ctgctgccgc ccagcccgaa caaccgcatc gccctggtca tcactgacgg gcgctcagac
     2281 actcagaggg acaccacacc gctcaacgtg ctctgcagcc ccggcatcca ggtggtctcc
     2341 gtgggcatca aagacgtgtt tgacttcatc ccaggctcag accagctcaa tgtcatttct
     2401 tgccaaggcc tggcaccatc ccagggccgg cccggcctct cgctggtcaa ggagaactat
     2461 gcagagctgc tggaggatgc cttcctgaag aatgtcaccg cccagatctg catagacaag
     2521 aagtgtccag attacacctg ccccatcacg ttctcctccc cggctgacat caccatcctg
     2581 ctggacggct ccgccagcgt gggcagccac aactttgaca ccaccaagcg cttcgccaag
     2641 cgcctggccg agcgcttcct cacagcgggc aggacggacc ccgcccacga cgtgcgggtg
     2701 gcggtggtgc agtacagcgg cacgggccag cagcgcccag agcgggcgtc gctgcagttc
     2761 ctgcagaact acacggccct ggccagtgcc gtcgatgcca tggactttat caacgacgcc
     2821 accgacgtca acgatgccct gggctatgtg acccgcttct accgcgaggc ctcgtccggc
     2881 gctgccaaga agaggctgct gctcttctca gatggcaact cgcagggcgc cacgcccgct
     2941 gccatcgaga aggccgtgca ggaagcccag cgggcaggca tcgagatctt cgtggtggtc
     3001 gtgggccgcc aggtgaatga gccccacatc cgcgtcctgg tcaccggcaa gacggccgag
     3061 tacgacgtgg cctacggcga gagccacctg ttccgtgtcc ccagctacca ggccctgctc
     3121 cgcggtgtct tccaccagac agtctccagg aaggtggcgc tgggctagcc caccctgcac
     3181 gccggcacca aaccctgtcc tcccacccct ccccactcat cactaaacag agtaaaatgt
     3241 gatgcgaatt ttcccgacca acctgattcg ctagattttt tttaaggaaa agcttggaaa
     3301 gccaggacac aacgctgctg cctgctttgt gcagggtcct ccggggctca gccctgagtt
     3361 ggcatcacct gcgcagggcc ctctggggct cagccctgag ctagtgtcac ctgcacaggg
     3421 ccctctgagg ctcagccctg agctggcgtc acctgtgcag ggccctctgg ggctcagccc
     3481 tgagctggcc tcacctgggt tccccacccc gggctctcct gccctgccct cctgcccgcc
     3541 ctccctcctg cctgcgcagc tccttcccta ggcacctctg tgctgcatcc caccagcctg
     3601 agcaagacgc cctctcgggg cctgtgccgc actagcctcc ctctcctctg tccccatagc
     3661 tggtttttcc caccaatcct cacctaacag ttactttaca attaaactca aagcaagctc
     3721 ttctcctcag cttggggcag ccattggcct ctgtctcgtt ttgggaaacc aaggtcagga
     3781 ggccgttgca gacataaatc tcggcgactc ggccccgtct cctgagggtc ctgctggtga
     3841 ccggcctgga ccttggccct acagccctgg aggccgctgc tgaccagcac tgaccccgac
     3901 ctcagagagt actcgcaggg gcgctggctg cactcaagac cctcgagatt aacggtgcta
     3961 accccgtctg ctcctccctc ccgcagagac tggggcctgg actggacatg agagcccctt
     4021 ggtgccacag agggctgtgt cttactagaa acaacgcaaa cctctccttc ctcagaatag
     4081 tgatgtgttc gacgttttat caaaggcccc ctttctatgt tcatgttagt tttgctcctt
     4141 ctgtgttttt ttctgaacca tatccatgtt gctgactttt ccaaataaag gttttcactc
     4201 ctc
//
