LOCUS       NM_015719               6207 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens collagen type V alpha 3 chain (COL5A3), mRNA.
ACCESSION   NM_015719
VERSION     NM_015719.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6207)
  AUTHORS   Li,X., Zhang,Q., Yu,S.M. and Li,Y.
  TITLE     The Chemistry and Biology of Collagen Hybridization
  JOURNAL   J Am Chem Soc 145 (20), 10901-10916 (2023)
   PUBMED   37158802
  REMARK    Review article
REFERENCE   2  (bases 1 to 6207)
  AUTHORS   Margaritte-Jeannin,P., Babron,M.C., Laprise,C., Lavielle,N.,
            Sarnowski,C., Brossard,M., Moffatt,M., Gagne-Ouellet,V.,
            Etcheto,A., Lathrop,M., Just,J., Cookson,W.O., Bouzigon,E.,
            Demenais,F. and Dizier,M.H.
  TITLE     The COL5A3 and MMP9 genes interact in eczema susceptibility
  JOURNAL   Clin Exp Allergy 48 (3), 297-305 (2018)
   PUBMED   29168291
  REMARK    GeneRIF: This study identified significant interaction between two
            new genes, COL5A3 and MMP9, which may be accounted for by a
            degradation of COL5A3 by MMP9 influencing eczema susceptibility
REFERENCE   3  (bases 1 to 6207)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   4  (bases 1 to 6207)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   5  (bases 1 to 6207)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 6207)
  AUTHORS   Mann,K.
  TITLE     Isolation of the alpha 3-chain of human type V collagen and
            characterization by partial sequencing
  JOURNAL   Biol Chem Hoppe Seyler 373 (2), 69-75 (1992)
   PUBMED   1571108
REFERENCE   7  (bases 1 to 6207)
  AUTHORS   van der Rest,M. and Garrone,R.
  TITLE     Collagen family of proteins
  JOURNAL   FASEB J 5 (13), 2814-2823 (1991)
   PUBMED   1916105
  REMARK    Review article
REFERENCE   8  (bases 1 to 6207)
  AUTHORS   Niyibizi,C., Fietzek,P.P. and van der Rest,M.
  TITLE     Human placenta type V collagens. Evidence for the existence of an
            alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule
  JOURNAL   J Biol Chem 259 (22), 14170-14174 (1984)
   PUBMED   6501291
REFERENCE   9  (bases 1 to 6207)
  AUTHORS   Abedin,M.Z., Ayad,S. and Weiss,J.B.
  TITLE     Isolation and native characterization of cysteine-rich collagens
            from bovine placental tissues and uterus and their relationship to
            types IV and V collagens
  JOURNAL   Biosci Rep 2 (7), 493-502 (1982)
   PUBMED   7115902
REFERENCE   10 (bases 1 to 6207)
  AUTHORS   Rhodes,R.K. and Miller,E.J.
  TITLE     Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V)
            collagen molecule in human placental tissue
  JOURNAL   Coll Relat Res 1 (4), 337-343 (1981)
   PUBMED   7346227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008742.9, AF177941.1 and
            BQ006883.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015719.3.
            
            Summary: This gene encodes an alpha chain for one of the low
            abundance fibrillar collagens. Fibrillar collagen molecules are
            trimers that can be composed of one or more types of alpha chains.
            Type V collagen is found in tissues containing type I collagen and
            appears to regulate the assembly of heterotypic fibers composed of
            both type I and type V collagen. This gene product is closely
            related to type XI collagen and it is possible that the collagen
            chains of types V and XI constitute a single collagen type with
            tissue-specific chain combinations. Mutations in this gene are
            thought to be responsible for the symptoms of a subset of patients
            with Ehlers-Danlos syndrome type III. Messages of several sizes can
            be detected in northern blots but sequence information cannot
            confirm the identity of the shorter messages. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264828.4/ ENSP00000264828.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC008742.9         177912-177944       c
            34-1082             AF177941.1         1-1049
            1083-1083           AC008742.9         169110-169110       c
            1084-3124           AF177941.1         1051-3091
            3125-3125           AC008742.9         146026-146026       c
            3126-5177           AF177941.1         3093-5144
            5178-5178           AC008742.9         128123-128123       c
            5179-5380           AF177941.1         5146-5347
            5381-6139           AC008742.9         127069-127827       c
            6140-6207           BQ006883.1         19-86               c
FEATURES             Location/Qualifiers
     source          1..6207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6207
                     /gene="COL5A3"
                     /note="collagen type V alpha 3 chain"
                     /db_xref="GeneID:50509"
                     /db_xref="HGNC:HGNC:14864"
                     /db_xref="MIM:120216"
     exon            1..207
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..5357
                     /gene="COL5A3"
                     /note="pro-(alpha)3(V) collagen; collagen alpha-3(V)
                     chain; collagen, type V, alpha 3"
                     /codon_start=1
                     /product="collagen alpha-3(V) chain preproprotein"
                     /protein_id="NP_056534.2"
                     /db_xref="CCDS:CCDS12222.1"
                     /db_xref="GeneID:50509"
                     /db_xref="HGNC:HGNC:14864"
                     /db_xref="MIM:120216"
                     /translation="MGNRRDLGQPRAGLCLLLAALQLLPGTQADPVDVLKALGVQGGQ
                     AGVPEGPGFCPQRTPEGDRAFRIGQASTLGIPTWELFPEGHFPENFSLLITLRGQPAN
                     QSVLLSIYDERGARQLGLALGPALGLLGDPFRPLPQQVNLTDGRWHRVAVSIDGEMVT
                     LVADCEAQPPVLGHGPRFISIAGLTVLGTQDLGEKTFEGDIQELLISPDPQAAFQACE
                     RYLPDCDNLAPAATVAPQGEPETPRPRRKGKGKGRKKGRGRKGKGRKKNKEIWTSSPP
                     PDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTELGT
                     LETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEG
                     PPGAPGPQGVVGPSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFA
                     GGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAE
                     GPQGPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRG
                     DFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGA
                     PGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPL
                     GHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKG
                     DVGLKGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGR
                     PGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDV
                     GQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPG
                     PAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGP
                     AGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSE
                     GPVGPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKG
                     SKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGP
                     PGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEK
                     GERGDAGDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTG
                     LPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPPGKRGPSGHMGR
                     EGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQM
                     GPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKG
                     DPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGPPGAPAELHG
                     LRRRRRFVPVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHP
                     HLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKKFEIVKLASWSKEKPGGWYS
                     TFRRGKKFSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDYSHS
                     ARFLGTNGEELSFNQTTAATVSVPQDGCRLRKGQTKTLFEFSSSRAGFLPLWDVAATD
                     FGQTNQKFGFELGPVCFSS"
     exon            208..366
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            367..556
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..713
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..818
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            819..968
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1082
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1229
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1277
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1319
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1382
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1457
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1541
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1598
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1652
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1706
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1760
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1814
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1868
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1913
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1967
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2012
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2066
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2111
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2165
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2210
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2264
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2309
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2363
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2471
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2525
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2579
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2624
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2678
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2723
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2777
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2831
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2885
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2993
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3083
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3137
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3245
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3353
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3407
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3461
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3569
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3623
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3677
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3731
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3785
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3893
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..3947
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4001
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4055
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4109
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4217
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..4271
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4325
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4433
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4487
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4523
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4577
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..4788
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4789..4901
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..4970
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            4971..5210
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     exon            5211..6207
                     /gene="COL5A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6189..6194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL5A3"
                     /note="hexamer: AATAAA"
     polyA_site      6207
                     /gene="COL5A3"
                     /note="major polyA site"
ORIGIN      
        1 agtttcccgc ggaccctgag aggagcggcc gccgcgagtg actgcaccga gcccgagaag
       61 tcgccgcgcc ccgcagccgc cccgactggt tccccgcctt gcccgtgggc cccgccggga
      121 tggggaaccg ccgggacctg ggccagccgc gggccggtct ctgcctgctc ctggccgcgc
      181 tgcagcttct gccggggacg caggccgatc ctgtggatgt cctgaaggcc ctgggtgtgc
      241 agggaggcca ggctggggtc cccgaggggc ctggcttctg tccccagagg actccagagg
      301 gtgaccgggc attcagaatt ggccaggcca gcacgctcgg catccccacg tgggaactct
      361 ttccagaagg ccactttcct gagaacttct ccttgctgat caccttgcgg ggacagccag
      421 ccaatcagtc tgtcctgctg tccatttatg atgaaagggg tgcccggcag ttgggcctgg
      481 cactggggcc agcgctgggt ctcctaggtg accccttccg ccccctcccc cagcaggtca
      541 acctcacaga tggcaggtgg caccgtgtgg ccgtcagcat agatggtgag atggtgaccc
      601 tggtagctga ctgtgaagct cagccccctg ttttgggcca tggcccccgc ttcatcagca
      661 tagctggact cactgtgctg gggacccagg accttgggga aaagactttc gagggagaca
      721 ttcaggagct gctgataagc ccagatcctc aggctgcctt ccaggcttgt gagcggtacc
      781 tccccgactg tgacaacctg gcaccggcag ccacagtggc tccccagggt gaaccagaaa
      841 cccctcgtcc tcggcggaag gggaagggaa aagggaggaa gaaagggcga ggtcgcaagg
      901 ggaagggcag gaaaaagaac aaggaaattt ggacctcaag tccacctcct gactccgcag
      961 agaaccagac ctccactgac atccccaaga cagagactcc agctccaaat ctgcctccga
     1021 cccccacgcc tttggtcgtc acctccactg tgactactgg actcaatgcc acgatcctag
     1081 agaggagctt ggaccctgac agtggaaccg agctggggac cctggagacc aaggcagcca
     1141 gggaggatga agaaggagat gattccacca tgggccctga cttccgggca gcagaatatc
     1201 catctcggac tcagttccag atctttcctg gtgctggaga gaaaggagca aaaggagagc
     1261 ccgcagtgat tgaaaagggg cagcagtttg agggacctcc aggagcccca ggaccccaag
     1321 gggtggttgg cccctcaggc cctcccggcc ccccaggatt ccctggcgac cctggtccac
     1381 cgggccctgc tggcctccca ggaatccccg gcattgatgg gatccgaggc ccaccgggca
     1441 ctgtgatcat gatgccgttc cagtttgcag gcggctcctt taaaggcccc ccagtctcat
     1501 tccagcaggc ccaggctcag gcagttctgc agcagactca gctctctatg aaaggccccc
     1561 ctggtccagt ggggctcact gggcgcccag gccctgtggg tctccccggg catccaggtc
     1621 tgaaaggaga ggagggagca gaagggccac agggtccccg aggcctgcag ggacctcatg
     1681 gaccccctgg ccgagtgggc aagatgggcc gccctggagc agatggagct cggggcctcc
     1741 caggggacac tggacctaag ggtgatcgtg gcttcgatgg cctccctggg ctgcctggtg
     1801 agaagggcca aaggggtgac tttggccatg tggggcaacc cggtccccca ggagaggatg
     1861 gtgagagggg agcagaggga cctccagggc ccactggcca ggctggggag ccgggtccac
     1921 gaggactgct tggccccaga ggctctcctg gccccacggg tcgcccgggt gtgactggaa
     1981 ttgatggtgc tcctggtgcc aaaggcaatg tgggtcctcc aggagaacca ggccctccgg
     2041 gacagcaggg aaaccatggg tcccagggac tccccggtcc ccagggactc attggcactc
     2101 ctggggagaa gggtccccct ggaaacccag gaattccagg cctcccagga tccgatggcc
     2161 ctctgggtca cccaggacat gagggcccca cgggagagaa aggggctcag ggtccaccag
     2221 ggtcggcagg ccctccgggc tatcctggac ctcggggagt gaagggcact tcaggcaacc
     2281 ggggcctcca gggggagaaa ggcgagaagg gagaggacgg cttcccaggc ttcaagggcg
     2341 atgtggggct caaaggtgat caggggaaac ccggagctcc aggtccccgg ggagaggatg
     2401 gtcctgaggg gccgaagggg caggcggggc aggctggcga ggaggggccc ccaggctcag
     2461 ctggggagaa gggcaagctt ggggtgccag gcctcccagg ttatccagga cgccctggac
     2521 ctaagggatc tattggattt cccggtcccc tgggacccat aggagagaaa gggaagtcgg
     2581 gaaagacagg gcagccaggc ctggaaggag agcggggacc accaggttcc cgtggagaga
     2641 gggggcaacc gggtgccaca gggcaaccag gccccaaggg cgatgtgggc caggatggag
     2701 cccctgggat ccctggagaa aagggcctcc ctggtctgca aggccctcca ggattccctg
     2761 ggccaaaggg cccccctggt caccaaggta aagatgggcg accagggcac cctggacaga
     2821 gaggagaact gggcttccaa ggtcagacag gcccgcctgg accagctggt gtcttaggcc
     2881 ctcagggaaa gacaggagaa gtgggacctc taggtgaaag ggggcctcca ggcccccctg
     2941 gacctcctgg tgaacaaggt cttcctggcc tggaaggcag agagggggcc aagggggaac
     3001 tgggaccacc aggacccctt gggaaagaag ggccagctgg actcaggggc tttcccggcc
     3061 ccaaaggggg ccctggggac ccgggaccta ctggcttaaa gggtgataag ggccccccag
     3121 ggcccgtggg ggccaatggc tcccctggtg agcgcggtcc tttgggccca gcaggaggca
     3181 ttggacttcc tggccaaagt ggcagcgaag gccccgttgg ccctgcaggc aagaaggggt
     3241 cccggggaga acgtggcccc cctggcccca ctggcaaaga tgggatccca gggcccctgg
     3301 ggcctctggg accccctgga gctgctgggc cttctggcga ggaaggggac aagggggatg
     3361 tgggtgcccc cggacacaag gggagtaaag gcgataaagg agacgcgggc ccacctggac
     3421 aaccagggat acggggtcct gcaggacacc caggtccccc gggagcagac ggggctcagg
     3481 ggcgccgggg acccccaggc ctctttgggc agaaaggaga tgacggagtc agaggctttg
     3541 tgggggtgat tggccctcct ggactgcagg ggctgccagg ccctccggga gagaaagggg
     3601 aggtcggaga cgtcgggtcc atgggtcccc atggagctcc aggtcctcgg ggtccccaag
     3661 gccccactgg atcagagggc actccagggc tgcctggagg agttggtcag ccaggcgccg
     3721 tgggtgagaa gggtgagcga ggggacgctg gagacccagg gcctccagga gccccaggca
     3781 tcccggggcc caagggagac attggtgaaa agggggactc aggcccatct ggagctgctg
     3841 gacccccagg caagaaaggt ccccctggag aggatggagc caaagggagc gtgggcccca
     3901 cggggctgcc cggagatcta gggcccccag gagaccctgg agtttcaggc atagatggtt
     3961 ccccagggga gaagggagac cctggtgatg ttgggggacc gggtccgcct ggagcttctg
     4021 gggagcccgg cgcccccggg ccccccggca agaggggtcc ttcaggccac atgggtcgag
     4081 aaggcagaga aggggagaaa ggtgccaagg gggagccagg tcctgatggg cccccaggga
     4141 ggacgggtcc aatgggggct agagggcccc ctggacgtgt ggggcctgag ggtcttcgag
     4201 ggatccctgg ccctgtgggt gaaccaggcc tcctgggagc ccctggacag atgggccctc
     4261 ctggccccct ggggccctct ggcctcccag ggctgaaggg agacactggc cccaaggggg
     4321 aaaagggcca cattggattg atcggtctca ttggcccccc gggagaagct ggtgagaaag
     4381 gagatcaggg gttgccaggc gtgcagggac cccctggtcc caagggagac cctggtcccc
     4441 ctggtcccat tggctctctg ggccaccctg ggcccccagg tgtggcgggc cctctaggac
     4501 agaaaggctc aaaagggtct ccggggtcca tgggcccccg tggagacact ggacctgcag
     4561 gcccaccagg ccccccgggt gcccctgccg agctgcatgg gctgcgcagg cgccggcgct
     4621 tcgtcccagt cccgcttcca gtcgtggagg gcggcctgga ggaggtgctg gcctcgctca
     4681 catcgctgag cttggagctg gagcagctgc ggcgtcctcc cggcactgcg gagcgcccgg
     4741 gcctcgtgtg ccacgagctg caccgcaacc acccgcacct gcctgatggg gaatactgga
     4801 ttgaccccaa ccagggctgc gcgcgggact cgttcagggt tttttgcaac ttcacggcgg
     4861 gaggagagac ctgcctctat cccgacaaga agtttgagat cgtgaaattg gcctcctggt
     4921 ccaaggaaaa gcctggaggc tggtatagca cattccgtcg agggaagaag ttctcctacg
     4981 tggacgccga cgggtcccca gtgaatgtcg tgcagctgaa cttcctgaaa ctgctgagtg
     5041 ccacagctcg ccagaacttc acctactcct gccagaatgc agctgcctgg ctggacgaag
     5101 ccacgggtga ctacagccac tccgcccgct tccttggcac caatggagag gagctgtctt
     5161 tcaaccagac gacagcagcc actgtcagcg tcccccagga tggctgccgg ctccggaaag
     5221 gacagacgaa gacccttttc gaattcagct cttctcgagc gggatttctg cccctgtggg
     5281 atgtggcggc cactgacttt ggccagacga accaaaagtt tgggtttgaa ctgggccccg
     5341 tctgcttcag cagctgagag tgtccggggt gggagggacc atgagggagc cccagaatgg
     5401 ggtgcatttg gtgctgaggc tttgaagcca ccgtattttt cgttacctgt gactatggag
     5461 ccaatgggat gtgacttcgc tcatcacgga cagtcattcc ttctcctttc cagggtgctg
     5521 ggggctgggg ttccctggcc caagggtcca gcctcctctc accccattcc aggtggcata
     5581 ctgcagtctg gctctttctc ccctccctcc ccacccaagc ctcacctccc caccccttga
     5641 acccccatgc aatgagcttc taactcagag ctgatgaaca aaagcccccc cacccccaat
     5701 gcctgcctcc tcactcctcc gtcgctgccc ttcacacctt ttggtgctac ccctccccag
     5761 agttaagcac tggatgtctc ctgatcccag gctgggaccc ctacccccac cccctttgat
     5821 cctttctact tccacggtga aaggactgag gtcggactac agagggaaga gggacttccc
     5881 ttgactgggt tgtgtttctt ttcctgcctc agcccagctc tgcaaatccc ctccccctgc
     5941 cccccacctc cccaggctca ccttgccatg ccaggtggtt tggggaccaa gatgttgggg
     6001 gggtgaatca ggatcctaat ggtgctgccc tatttatacc tgggtctgta ttaaaaggga
     6061 aagtcccccc tgttgtagat ttcatctgct tcctccttag ggaaggctgg gatatgatga
     6121 gagattccag cccaagcctg gccccccacc gccaggccat agggcataat ttgcatctca
     6181 aatctgagaa taaactgatg aactgtg
//
