LOCUS       NM_000393               6829 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens collagen type V alpha 2 chain (COL5A2), mRNA.
ACCESSION   NM_000393
VERSION     NM_000393.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6829)
  AUTHORS   Li,X., Zhang,Q., Yu,S.M. and Li,Y.
  TITLE     The Chemistry and Biology of Collagen Hybridization
  JOURNAL   J Am Chem Soc 145 (20), 10901-10916 (2023)
   PUBMED   37158802
  REMARK    Review article
REFERENCE   2  (bases 1 to 6829)
  AUTHORS   Guo,X., Bu,X., Yuan,L. and Ji,L.
  TITLE     Collagen type V alpha 2 promotes the development of gastric cancer
            via M2 macrophage polarization
  JOURNAL   Chin J Physiol 66 (2), 93-102 (2023)
   PUBMED   37082997
  REMARK    GeneRIF: Collagen type V alpha 2 promotes the development of
            gastric cancer via M2 macrophage polarization.
REFERENCE   3  (bases 1 to 6829)
  AUTHORS   Kempers,M.J., Wessels,M., Van Berendoncks,A., van de Laar,I.M., de
            Leeuw,N. and Loeys,B.
  TITLE     Phenotype of COL3A1/COL5A2 deletion patients
  JOURNAL   Eur J Med Genet 65 (10), 104593 (2022)
   PUBMED   35964930
  REMARK    GeneRIF: Phenotype of COL3A1/COL5A2 deletion patients.
REFERENCE   4  (bases 1 to 6829)
  AUTHORS   Zhu,J., Tu,S. and Qu,Q.
  TITLE     lncRNA BZRAP1-AS1 alleviates rheumatoid arthritis by regulating
            miR-1286/COL5A2 axis
  JOURNAL   Immun Inflamm Dis 10 (2), 163-174 (2022)
   PUBMED   34766472
  REMARK    GeneRIF: lncRNA BZRAP1-AS1 alleviates rheumatoid arthritis by
            regulating miR-1286/COL5A2 axis.
REFERENCE   5  (bases 1 to 6829)
  AUTHORS   Urbizu,A., Garrett,M.E., Soldano,K., Drechsel,O., Loth,D.,
            Marce-Grau,A., Mestres I Soler,O., Poca,M.A., Ossowski,S.,
            Macaya,A., Loth,F., Labuda,R. and Ashley-Koch,A.
  TITLE     Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and
            COL5A2 frequently occur in Chiari Malformation Type 1
  JOURNAL   PLoS One 16 (5), e0251289 (2021)
   PUBMED   33974636
  REMARK    GeneRIF: Rare functional genetic variants in COL7A1, COL6A5, COL1A2
            and COL5A2 frequently occur in Chiari Malformation Type 1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6829)
  AUTHORS   Malfait,F., Symoens,S. and Syx,D.
  TITLE     Classic Ehlers-Danlos Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301422
REFERENCE   7  (bases 1 to 6829)
  AUTHORS   Mann,K.
  TITLE     Isolation of the alpha 3-chain of human type V collagen and
            characterization by partial sequencing
  JOURNAL   Biol Chem Hoppe Seyler 373 (2), 69-75 (1992)
   PUBMED   1571108
REFERENCE   8  (bases 1 to 6829)
  AUTHORS   Greenspan,D.S., Lee,S.T., Lee,B.S. and Hoffman,G.G.
  TITLE     Homology between alpha 2(V) and alpha 1(III) collagen promoters and
            evidence for negatively acting elements in the alpha 2(V) first
            intron and 5' flanking sequences
  JOURNAL   Gene Expr 1 (1), 29-39 (1991)
   PUBMED   1820205
REFERENCE   9  (bases 1 to 6829)
  AUTHORS   Greenspan,D.S., Hoffman,G.G. and Lee,B.S.
  TITLE     High levels of expression of full length human pro-alpha 2(V)
            collagen cDNA in pro-alpha 2(V)-deficient hamster cells
  JOURNAL   J Biol Chem 264 (34), 20683-20687 (1989)
   PUBMED   2584236
REFERENCE   10 (bases 1 to 6829)
  AUTHORS   Myers,J.C., Loidl,H.R., Seyer,J.M. and Dion,A.S.
  TITLE     Complete primary structure of the human alpha 2 type V procollagen
            COOH-terminal propeptide
  JOURNAL   J Biol Chem 260 (20), 11216-11222 (1985)
   PUBMED   2411731
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL552427.3, AC133106.3,
            J04478.1 and AB209045.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000393.4.
            
            Summary: This gene encodes an alpha chain for one of the low
            abundance fibrillar collagens. Fibrillar collagen molecules are
            trimers that can be composed of one or more types of alpha chains.
            Type V collagen is found in tissues containing type I collagen and
            appears to regulate the assembly of heterotypic fibers composed of
            both type I and type V collagen. This gene product is closely
            related to type XI collagen and it is possible that the collagen
            chains of types V and XI constitute a single collagen type with
            tissue-specific chain combinations. Mutations in this gene are
            associated with Ehlers-Danlos syndrome, types I and II. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209045.1, SRR14038196.2911509.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374866.9/ ENSP00000364000.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               AL552427.3         119-589
            472-472             AC133106.3         96811-96811         c
            473-596             AL552427.3         591-714
            597-1444            J04478.1           578-1425
            1445-1467           AB209045.1         1425-1447
            1468-1468           AC133106.3         54684-54684         c
            1469-3567           AB209045.1         1449-3547
            3568-3568           AC133106.3         29790-29790         c
            3569-6212           AB209045.1         3549-6192
            6213-6829           AC133106.3         18477-19093         c
FEATURES             Location/Qualifiers
     source          1..6829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..6829
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="collagen type V alpha 2 chain"
                     /db_xref="GeneID:1290"
                     /db_xref="HGNC:HGNC:2210"
                     /db_xref="MIM:120190"
     exon            1..254
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..4657
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="AB collagen; collagen, fetal membrane, A
                     polypeptide; collagen alpha-2(V) chain; type V
                     preprocollagen alpha 2 chain"
                     /codon_start=1
                     /product="collagen alpha-2(V) chain preproprotein"
                     /protein_id="NP_000384.2"
                     /db_xref="CCDS:CCDS33350.1"
                     /db_xref="GeneID:1290"
                     /db_xref="HGNC:HGNC:2210"
                     /db_xref="MIM:120190"
                     /translation="MMANWAEARPLLILIVLLGQFVSIKAQEEDEDEGYGEEIACTQN
                     GQMYLNRDIWKPAPCQICVCDNGAILCDKIECQDVLDCADPVTPPGECCPVCSQTPGG
                     GNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGI
                     DGEPGVPGQPGAPGPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPV
                     GPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNPG
                     EVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGP
                     LGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPT
                     GARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAGPPG
                     SPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGD
                     PGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGSQGDPGRPGEP
                     GLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSG
                     DPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGP
                     PGPPGEGGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPD
                     GPKGSPGPSGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARG
                     LPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQ
                     PGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSA
                     GRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPG
                     EDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGP
                     PGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTP
                     GPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRG
                     FTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGS
                     VGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDESMPDPLPEFTEDQAAPDDKN
                     KTDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHSAKQSGEYWIDPNQGSV
                     EDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDMNRGSQFAYGDHQ
                     SPNTAITQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVLKGANDLDIKAE
                     GNIRFRYIVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDLAPVDVGGTDQEFGVEIG
                     PVCFV"
     exon            255..479
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..493
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..526
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..559
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..613
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..724
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..802
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..847
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..901
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..955
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1009
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1063
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1117
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1162
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1216
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1261
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1315
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1414
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1459
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1558
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1612
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1720
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1774
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1873
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1927
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2026
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2080
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2134
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2188
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2242
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2287
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2386
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2494
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2548
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2602
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2656
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2710
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2818
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2872
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2926
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3088
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3196
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3304
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3358
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3466
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3520
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3628
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3682
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3790
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..4082
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4083..4270
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4510
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..6829
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6188..6193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="hexamer: ATTAAA"
     polyA_site      6213
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="major polyA site"
     regulatory      6485..6490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="hexamer: AATAAA"
     regulatory      6498..6503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="hexamer: AATAAA"
     polyA_site      6504
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
     polyA_site      6522
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
     regulatory      6809..6814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
                     /note="hexamer: AATAAA"
     polyA_site      6829
                     /gene="COL5A2"
                     /gene_synonym="EDSC; EDSCL2"
ORIGIN      
        1 gcagactgtg ctggagctgg tgctgaaaaa gggggtttgc agaggctgcc ctggggctgg
       61 tgctgaaaga agagcccaca gctgacttca tggtgctaca ataacctcag aatctacttt
      121 tcactctcag gagaacccac atgtctaata tttagacatg atggcaaact gggcggaagc
      181 aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga
      241 agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta
      301 cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc
      361 cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc
      421 ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata ccaattttgg
      481 tagaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg
      541 tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc
      601 aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg
      661 tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag
      721 caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt
      781 aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg
      841 acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat
      901 gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga
      961 acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg
     1021 atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga
     1081 aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc
     1141 aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg
     1201 gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat
     1261 gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga
     1321 agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg
     1381 gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc
     1441 tggtgccaaa ggcccaacgg gctctccagg tacctctggt cctcctggct cagcagggcc
     1501 tcctggatct ccaggacctc agggtagcac tggtcctcag ggaattcgag gccaaccggg
     1561 tgatccagga gttccaggtt tcaaaggaga agctggccca aaaggggaac cagggccaca
     1621 tggtattcag ggtccgatag gcccacccgg tgaagaaggc aaaagaggtc ccagaggtga
     1681 cccaggaaca gttggtcctc cagggccagt gggagaaagg ggtgctcctg gcaatcgtgg
     1741 ttttccaggc tctgatggtt tacctgggcc aaagggtgct caaggagaac ggggtcctgt
     1801 aggttcttca ggacccaaag gaagccaggg ggatccagga cgtccagggg aacctgggct
     1861 tccaggtgct cggggtttga caggaaatcc tggtgttcaa ggtcctgaag gaaaacttgg
     1921 acctttgggt gcgccagggg aagatggccg tccaggtcct ccaggctcca taggaatcag
     1981 agggcagccc gggagcatgg gccttccagg ccccaaaggt agcagtggtg accctgggaa
     2041 acctggagaa gcaggaaatg ctggagttcc tgggcagagg ggagctcctg gaaaagatgg
     2101 tgaagttggt ccttctggtc ctgtgggccc gccgggtcta gctggtgaaa gaggagaaca
     2161 aggacctcca ggccccacag gttttcaggg gcttcctggt cctccagggc ctcctggaga
     2221 aggtggaaaa ccaggtgatc aaggtgttcc tggagatccc ggagcagttg gcccgttagg
     2281 acctagagga gaacgaggaa atcctgggga aagaggagaa cctgggataa ctggactccc
     2341 tggtgagaag ggaatggctg gaggacatgg tcctgatggc ccaaaaggca gtccaggtcc
     2401 atctgggacc cctggagata caggcccacc aggtcttcaa ggtatgccgg gagaaagagg
     2461 aattgcagga actcctggcc ccaagggtga cagaggtggc ataggagaaa aaggtgctga
     2521 aggcacagct ggaaatgatg gtgcaagagg tcttccaggt cctttgggcc ctccaggtcc
     2581 ggcaggtcct actggagaaa agggtgaacc tggtcctcga ggtttagttg gccctcctgg
     2641 ctcccggggc aatcctggtt ctcgaggtga aaatgggcca actggagctg ttggttttgc
     2701 cggaccccag ggtcctgacg gacagcctgg agtaaaaggt gaacctggag agccaggaca
     2761 gaagggagat gctggttctc ctggaccaca aggtttagca ggatcccctg gccctcatgg
     2821 tcctaatggt gttcctggac taaaaggtgg tcgaggaacc caaggtccgc ctggtgctac
     2881 aggatttcct ggttctgcgg gcagagttgg acctccaggc cctgctggag ctccaggacc
     2941 tgcgggaccc ctaggggaac ccgggaagga gggacctcca ggtcttcgtg gggaccctgg
     3001 ctctcatggg cgtgtgggag atcgaggacc agctggcccc cctggtggcc caggagacaa
     3061 aggggaccca ggagaagatg ggcaacctgg tccagatggc ccccctggtc cagctggaac
     3121 gaccgggcag agaggaattg ttggcatgcc tgggcaacgt ggagagagag gcatgcccgg
     3181 cctaccaggc ccagcgggaa caccaggaaa agtaggacca actggtgcaa caggagataa
     3241 aggtccacct ggacctgtgg ggcccccagg ctccaatggt cctgtagggg aacctggacc
     3301 agaaggtcca gctggcaatg atggtacccc aggacgggat ggtgctgttg gagaacgtgg
     3361 tgatcgtgga gaccctgggc ctgcaggtct gccaggctct cagggtgccc ctggaactcc
     3421 tggccctgtg ggtgctccag gagatgcagg acaaagagga gatccgggtt ctcggggtcc
     3481 tataggacca cctggtcgag ctgggaaacg tggattacct ggaccccaag gacctcgtgg
     3541 tgacaaaggt gatcatggag accgaggtga cagaggtcag aagggccaca gaggctttac
     3601 tggtcttcag ggtcttcctg gccctcctgg tccaaatggt gaacaaggaa gtgctggaat
     3661 ccctggacca tttggcccaa gaggtcctcc aggcccagtt ggtccttcag gtaaagaagg
     3721 aaaccctggg ccacttgggc caattggacc tccaggtgta cgaggcagtg taggagaagc
     3781 aggacctgag ggccctcctg gtgagcctgg cccacctggc cctccgggtc cccctggcca
     3841 ccttacagct gctcttgggg atatcatggg gcactatgat gaaagcatgc cagatccact
     3901 tcctgagttt actgaagatc aggcggctcc tgatgacaaa aacaaaacgg acccaggggt
     3961 tcatgctacc ctgaagtcac tcagtagtca gattgaaacc atgcgcagcc ccgatggctc
     4021 gaaaaagcac ccagcccgca cgtgtgatga cctaaagctt tgccattccg caaagcagag
     4081 tggtgaatac tggattgatc ctaaccaagg atctgttgaa gatgcaatca aagtttactg
     4141 caacatggaa acaggagaaa catgtatttc agcaaaccca tccagtgtac cacgtaaaac
     4201 ctggtgggcc agtaaatctc ctgacaataa acctgtttgg tatggtcttg atatgaacag
     4261 agggtctcag ttcgcttatg gagaccacca atcacctaat acagccatta ctcagatgac
     4321 ttttttgcgc cttttatcaa aagaagcctc ccagaacatc acttacatct gtaaaaacag
     4381 tgtaggatac atggacgatc aagctaagaa cctcaaaaaa gctgtggttc tcaaaggggc
     4441 aaatgactta gatatcaaag cagagggaaa tattagattc cggtatatcg ttcttcaaga
     4501 cacttgctct aagcggaatg gaaatgtggg caagactgtc tttgaatata gaacacagaa
     4561 tgtggcacgc ttgcccatca tagatcttgc tcctgtggat gttggcggca cagaccagga
     4621 attcggcgtt gaaattgggc cagtttgttt tgtgtaaagt aagccaagac acatcgacaa
     4681 tgagcaccac catcaatgac caccgccatt cacaagaact ttgactgttt gaagttgatc
     4741 ctgagactct tgaagtaatg gctgatcctg catcagcatt gtatatatgg tcttaagtgc
     4801 ctggcctcct tatccttcag aatatttatt ttacttacaa tcctcaagtt ttaattgatt
     4861 ttaaatattt ttcaatacaa cagtttaggt ttaagatgac caatgacaat gaccaccttt
     4921 gcagaaagta aactgattga ataaataaat ctccgttttc ttcaatttat ttcagtgtaa
     4981 tgaaaaagtt gcttagtatt tatgaggaaa ttcttcttcc tggcaggtag cttaaagagt
     5041 ggggtatata gagccacaac acatgtttat tttgcttggc tgcagttgaa aaatagaaat
     5101 tagtgccctt ttgtgacctc tcattccaag attgtcaatt aaaaatgagt ttaaaatgtt
     5161 taacttgtga tcgagaccta catgcatgtc ttgatattgt gtaactataa tagagactct
     5221 ttaaggagaa tcttaaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat
     5281 agtatatatt cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt
     5341 tgtaaaagac tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc
     5401 ttgatcaatc tatcaatatt gatagaagtc acactagtat ataccattta atacatttac
     5461 actttcttat ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca
     5521 tatgtccaag gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc
     5581 tataatgaag aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg
     5641 attggaatta gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta
     5701 gcatgagcta cctcatctct agaagctggg atggacttac tattcttgtt tatattttag
     5761 atactgaaag gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa
     5821 aggtattatt atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa
     5881 aataaagatg gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg
     5941 aaagaaagag catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat
     6001 gctttgtaat acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata
     6061 cttttttttt cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac
     6121 agctgggacc atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa
     6181 gcatcaaatt aaatgcacgc ttttgtcatg tcagtggttt ttgttttgtg aaattccttt
     6241 gaccatatta gatctatttc atttccaata gtgaaaagga gatgtggtgg tatactttgt
     6301 ttgccatttg tttaaaagat acaacggata ccttctatca tgtatgtact ggcttataaa
     6361 tgaaaatcta tctacaacat tacccacaaa ggcaacatga caccaattat cactgcctct
     6421 gcccttaaaa atgtcagagt agtattattg ataaaaaggg caagcaatag atttttcatg
     6481 actgaataaa ctgtaataat aaaacatatg tctcaaagtg tatcacatat gaatttagcc
     6541 taattgtttt cagtttcatt ctcaatattt agtttacaac atcattttcc cctaaactgg
     6601 ttatattttg acctgtatat cttaaatttg agtatttata tgcctaaata catgtgtgag
     6661 ttttgtttga cttccaagtc caaactataa gattatataa gttcatatag atgaatcaga
     6721 aatatgtggt aatactatta agtcacaaac actaacaatt tccaactata gaaataacag
     6781 ttcttatttg gattttggga atgctaccaa taaaagcctg cccagacca
//
