LOCUS       NM_033641               6685 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens collagen type IV alpha 6 chain (COL4A6), transcript
            variant B, mRNA.
ACCESSION   NM_033641
VERSION     NM_033641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6685)
  AUTHORS   O'Brien,A., Aw,W.Y., Tee,H.Y., Naegeli,K.M., Bademci,G., Tekin,M.,
            Arnos,K. and Pandya,A.
  TITLE     Confirmation of COL4A6 variants in X-linked nonsyndromic hearing
            loss and its clinical implications
  JOURNAL   Eur J Hum Genet 30 (1), 7-12 (2022)
   PUBMED   33840813
  REMARK    GeneRIF: Confirmation of COL4A6 variants in X-linked nonsyndromic
            hearing loss and its clinical implications.
REFERENCE   2  (bases 1 to 6685)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6685)
  AUTHORS   Komori,T., Ono,M., Hara,E.S., Ueda,J., Nguyen,H.T.T., Nguyen,H.T.,
            Yonezawa,T., Maeba,T., Kimura-Ono,A., Takarada,T., Momota,R.,
            Maekawa,K., Kuboki,T. and Oohashi,T.
  TITLE     Type IV collagen alpha6 chain is a regulator of keratin 10 in
            keratinization of oral mucosal epithelium
  JOURNAL   Sci Rep 8 (1), 2612 (2018)
   PUBMED   29422532
  REMARK    GeneRIF: These findings indicate that alpha112:alpha556 (IV)
            network, which is the only network that includes the alpha6(IV)
            chain, is one regulator of KRT10 expression in keratinization of
            oral mucosal epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6685)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   5  (bases 1 to 6685)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   6  (bases 1 to 6685)
  AUTHORS   Ghebrehiwet,B., Peerschke,E.I., Hong,Y., Munoz,P. and Gorevic,P.D.
  TITLE     Short amino acid sequences derived from C1q receptor (C1q-R) show
            homology with the alpha chains of fibronectin and vitronectin
            receptors and collagen type IV
  JOURNAL   J Leukoc Biol 51 (6), 546-556 (1992)
   PUBMED   1377218
REFERENCE   7  (bases 1 to 6685)
  AUTHORS   Gupta,S., Batchu,R.B. and Datta,K.
  TITLE     Purification, partial characterization of rat kidney hyaluronic
            acid binding protein and its localization on the cell surface
  JOURNAL   Eur J Cell Biol 56 (1), 58-67 (1991)
   PUBMED   1724753
REFERENCE   8  (bases 1 to 6685)
  AUTHORS   Hernandez,M.R., Igoe,F. and Neufeld,A.H.
  TITLE     Extracellular matrix of the human optic nerve head
  JOURNAL   Am J Ophthalmol 102 (2), 139-148 (1986)
   PUBMED   2426947
REFERENCE   9  (bases 1 to 6685)
  AUTHORS   Glant,T.T., Hadhazy,C., Mikecz,K. and Sipos,A.
  TITLE     Appearance and persistence of fibronectin in cartilage. Specific
            interaction of fibronectin with collagen type II
  JOURNAL   Histochemistry 82 (2), 149-158 (1985)
   PUBMED   3997552
REFERENCE   10 (bases 1 to 6685)
  AUTHORS   Matsubara,T., Trueb,B., Fehr,K., Ruttner,J.R. and Odermatt,B.F.
  TITLE     The localization and secretion of type IV collagen in synovial
            capillaries by immunohistochemistry using a monoclonal antibody
            against human type IV collagen
  JOURNAL   Exp Cell Biol 52 (3), 159-169 (1984)
   PUBMED   6386565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN313347.1, D21337.1,
            AL136080.6, U04845.1, BF726518.1, BQ331638.1 and CB050016.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_033641.3.
            
            Summary: This gene encodes one of the six subunits of type IV
            collagen, the major structural component of basement membranes.
            Like the other members of the type IV collagen gene family, this
            gene is organized in a head-to-head conformation with another type
            IV collagen gene, alpha 5 type IV collagen, so that the gene pair
            shares a common promoter. Deletions in the alpha 5 gene that extend
            into the alpha 6 gene result in diffuse leiomyomatosis accompanying
            the X-linked Alport syndrome caused by the deletion in the alpha 5
            gene. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (B) utilizes the same 5' exon as
            variant 3 (exon 1B) but lacks several alternate in-frame exons. The
            resulting protein (isoform B) is shorter compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2146982
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334504.12/ ENSP00000334733.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-726               CN313347.1         12-737
            727-2971            D21337.1           735-2979
            2972-3034           AL136080.6         5360-5422           c
            3035-3303           D21337.1           3043-3311
            3304-3304           AL136080.6         4184-4184           c
            3305-4479           U04845.1           3191-4365
            4480-5644           D21337.1           4452-5616
            5645-6015           BF726518.1         97-467
            6016-6188           BQ331638.1         146-318             c
            6189-6685           CB050016.1         36-532              c
FEATURES             Location/Qualifiers
     source          1..6685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..6685
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="collagen type IV alpha 6 chain"
                     /db_xref="GeneID:1288"
                     /db_xref="HGNC:HGNC:2208"
                     /db_xref="MIM:303631"
     exon            1..237
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            238..289
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            290..370
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..505
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            506..550
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..667
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            668..736
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            737..772
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            773..835
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            836..871
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            872..913
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1006
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1060
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1129
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1174
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1228
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1298
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1406
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1547
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1652
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1813
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1993
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2177
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2249
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2357
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2579
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2741
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2912
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3056
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3182
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3364
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3428
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3503
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3611
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3719
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3791
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3917
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4034
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4196
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4295
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4442
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4559
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..4751
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..5038
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..6685
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6669..6674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="hexamer: AATAAA"
     polyA_site      6685
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="major polyA site"
ORIGIN      
        1 atctcctgag tgctgcaagt tgtaacgggc accgctgagc ctgtttccct ttggagcact
       61 tcttatctag aagcagtgtt tagtttcttc caaactgggc cacttcgtcc acctactctg
      121 ttctgagtaa ggaaacagcc tccaagcatc agcagagccc agatgagcac gggccgcgga
      181 gccgcttagc agtctcccgg gacccagctc cggaggagcc gcaagcatgc accctgggtt
      241 gtggctgctc ctggttacgt tgtgcctgac cgaggaactg gcagcagcgg gagagaagtc
      301 ttatggaaag ccatgtgggg gccaggactg cagtgggagc tgtcagtgtt ttcctgagaa
      361 aggagcgaga ggacgacctg gaccaattgg aattcaaggc ccaacaggtc ctcaaggatt
      421 cactggctct actggtttat cgggattgaa aggagaaagg ggtttcccag gccttctggg
      481 accttatgga ccaaaaggag ataagggtcc catgggagtt cctggctttc ttggcatcaa
      541 tgggattccg ggccaccctg gacaaccagg ccccagaggc ccacctggtc tggatggctg
      601 taatggaact caaggagctg ttggatttcc aggccctgat ggctatcctg ggcttctcgg
      661 accacccggg cttcctggtc agaaaggatc aaaaggtgac cctgtccttg ctccaggtag
      721 tttcaaagga atgaaggggg atcctgggct gcctggactg gatggaatca ctggcccaca
      781 aggagcaccc ggatttcctg gagctgtagg acctgcagga ccaccaggat tacaaggtcc
      841 tccagggcct cctggtcctc ttggtcctga tgggaatatg gggctaggtt ttcaaggaga
      901 gaaaggagtc aagggggatg ttggcctccc tggcccagca ggacctccac catctactgg
      961 agagctggaa ttcatgggat tccccaaagg gaagaaagga tccaagggtg aaccagggcc
     1021 taagggtttt ccaggcataa gtggccctcc aggcttcccg ggccttggaa ctactggaga
     1081 aaagggagaa aagggagaaa agggaatccc tggtttgcca ggacctaggg gtcccatggg
     1141 ttcagaagga gtccaaggcc ctccagggca acagggcaag aaagggaccc tgggatttcc
     1201 tgggcttaat ggattccaag gaattgaggg tcaaaagggt gacattggcc tgccaggccc
     1261 agatgttttc atcgatatag atggtgctgt gatctcaggt aatcctggag atcctggtgt
     1321 acctggcctc ccaggcctta aaggagatga aggcatccaa ggcctacgtg gcccttctgg
     1381 tgtccctgga ttgccagcat tatcaggtgt cccaggagcc ctagggcctc agggatttcc
     1441 agggctgaag ggggaccaag gaaacccagg ccgtaccaca attggagcag ctggcctccc
     1501 tggcagagat ggtttgccag gcccaccagg tccaccaggc ccacctagtc cagaatttga
     1561 gactgaaact ctacacaaca aagagtcagg gttccctggt ctccgaggag aacaaggtcc
     1621 aaaaggaaac ctaggcctca aaggaataaa aggagactca ggtttctgtg cttgtgacgg
     1681 tggtgttccc aacactggac cacccgggga accaggccca cctggtccat ggggtctcat
     1741 aggccttcca ggccttaaag gagccagagg agatcgaggc tctgggggtg cacagggccc
     1801 agcaggggct ccaggcttag ttgggcctct gggtccttca ggacccaaag gaaagaaggg
     1861 ggaaccaatt ctcagtacaa tccaaggaat gccaggagat cggggtgatt ctggctccca
     1921 gggcttccgt ggtgtaatag gagaaccagg caaggacgga gtaccaggtt taccaggtct
     1981 gccaggcctt ccgggtgatg gtggacaggg cttcccaggt gaaaaggggt tacctggact
     2041 tcctggtgaa aaaggccatc ctggtccacc tggcctccca ggaaatgggt taccaggact
     2101 tcctggaccc cgtgggcttc ctggagataa aggcaaggat ggattaccgg gacaacaagg
     2161 ccttcccgga tctaagggaa tcaccctgcc ctgtattatt cctgggtcat acggtccatc
     2221 aggatttcca ggcactcccg gattcccagg ccctaaaggg tctcgaggcc tccctgggac
     2281 cccaggccag cctgggtcaa gtggaagtaa aggagagcca gggagtccag gattggttca
     2341 tcttcctgaa ttaccaggat ttcctggacc tcgtggggag aagggcttgc ctgggtttcc
     2401 tgggctccct ggaaaagatg gcttgcctgg gatgattggc agtccaggct tacctggttc
     2461 caagggagcc actggtgaca tctttggtgc tgaaaatggt gctccggggg aacaaggcct
     2521 acaaggatta acagggcaca aaggatttct tggagactct ggccttccag gactcaaggg
     2581 tgtgcacggg aagcctggct tactaggccc caaaggtgag cggggcagcc ctgggacacc
     2641 aggacaggtg ggacagccag gcaccccagg atctagtggt ccatatggca tcaagggcaa
     2701 atctgggctc ccaggagcac caggcttccc aggcatctca ggacatcctg gaaagaaagg
     2761 aacaagaggc aagaaaggtc ctcctggatc aattgtaaag aaagggctgc cagggctaaa
     2821 aggccttcct ggaaatccag gcctagtagg actgaaagga agcccaggct ctccaggggt
     2881 cgctgggttg ccagccctct ctggacccaa gggagagaag gggtctgttg gattcgtagg
     2941 ttttccagga ataccaggtc tgcctggtat tcctggaaca agaggattaa aaggaattcc
     3001 aggatcaact ggaaaaatgg gaccatctgg acgtgctggt actcctggtg aaaagggaga
     3061 cagaggcaat ccggggccag tcggaatacc tagtccaaga cgtccaatgt caaacctttg
     3121 gctcaaagga gacaaaggct ctcaaggctc agccggatcc aatggatttc ctgggccaag
     3181 aggtgacaaa ggagaggctg gtcgacctgg accaccaggc ctacctggag ctcctggcct
     3241 cccaggcatt atcaaaggag ttagtggaaa gccagggccc cctggcttca tgggaatccg
     3301 gggcttacct ggcctgaagg ggtcctctgg gatcacaggt ttcccaggaa tgccaggaga
     3361 aagtggttca caaggtatca gagggtcgcc tggactccca ggagcatctg gtctcccagg
     3421 cctgaaagga gacaacggcc agacagttga aatttccggt agcccaggac ccaagggaca
     3481 gcctggcgaa tctggtttta aaggcacaaa aggaagagat ggactaatag gcaatatagg
     3541 cttccctgga aacaaaggtg aagatggaaa agttggtgtt tctggagatg ttggccttcc
     3601 tggagctcca ggatttccag gagttgccgg catgagagga gaaccaggac ttccaggttc
     3661 ttctggtcac caaggggcaa ttgggcctct aggatccccc ggattaatag gacccaaagg
     3721 cttccctgga tttcctggtt tacatggact gaatgggctt ccgggcacca agggtaccca
     3781 tggcactcca ggacctagta tcaccggtgt gcctgggcct gctggtctcc ctggacccaa
     3841 aggagaaaaa ggatatccag gaattggcat cggagctcca gggaagccgg gcctgagagg
     3901 gcaaaaaggt gatcgaggtt tcccaggtct ccagggccct gctggtctcc ccggtgcccc
     3961 aggcatctcc ttgccctcac tcatagcagg acagcctggt gaccccgggc gaccaggcct
     4021 agatggagaa cgaggccgcc caggccccgc tggaccccca ggtccccctg ggccatcctc
     4081 gaatcaaggc gacaccggag accctggctt ccctggaatt cctggaccta aagggcctaa
     4141 gggagaccaa ggaattccag gtttttctgg cctccctgga gagctaggac tgaaaggcat
     4201 gagaggtgag cctggcttca tggggactcc aggcaaggtt gggccacctg gagacccagg
     4261 atttcccgga atgaagggga aggcagggcc aagaggctct tctggcctcc aaggtgatcc
     4321 tggacaaaca ccaactgcag aagctgtcca ggttcctcct ggacccttgg gtctaccagg
     4381 gatcgatggc atccctggcc tcactgggga ccctggggct caaggccctg taggcctaca
     4441 aggctccaaa ggtttacctg gcatccccgg taaagatggc cccagtgggc tcccaggccc
     4501 acctggggct cttggtgatc ctggtctgcc tggactgcaa ggccctccag gatttgaagg
     4561 agctccaggg cagcaaggcc ccttcgggat gcctggaatg cctggccaga gcatgagagt
     4621 gggctacacg ttggtaaagc acagccagtc ggaacaggtg cccccgtgtc ccatcgggat
     4681 gagccagctg tgggtggggt acagcttact gtttgtggag gggcaagaga aagcccacaa
     4741 ccaggacctg ggctttgctg gctcctgtct gccccgcttc agcaccatgc ccttcatcta
     4801 ctgcaacatc aacgaggtgt gccactatgc caggcgcaat gataaatctt actggctctc
     4861 cactaccgcc cctatcccca tgatgcccgt cagccagacc cagattcccc agtacatcag
     4921 ccgctgctct gtgtgtgagg caccctcgca agccattgct gtgcacagcc aggacatcac
     4981 catcccgcag tgccccctgg gctggcgcag cctctggatt gggtactctt tcctcatgca
     5041 cactgccgct ggtgccgagg gtggaggcca gtccctggtc tcacctggct cctgcctaga
     5101 ggactttcgg gccactcctt tcatcgaatg cagtggtgcc cgaggcacct gccactactt
     5161 tgcaaacaag tacagtttct ggttgaccac agtggaggag aggcagcagt ttggggagtt
     5221 gcctgtgtct gaaacgctga aagctgggca gctccacact cgagtcagtc gctgccaggt
     5281 gtgtatgaaa agcctgtagg gtggcacctg ccactctgcc ccttgccctc ccctgcccct
     5341 cacaacagtc acctcacaaa cctgaatggt ctgaagaagg aaggcctgag cccctttgcc
     5401 tgtcaagttg tacattggag tctcatttgg gctagactac cggacactcg tcaccccagc
     5461 cctcgggtcc atagagatga gcccaccctg ctgagatctg ctgtcctgtt tctgtcaagc
     5521 tggtgctact gtttgatttg gatgattgtg tgactattca tggctacctc agaaagattt
     5581 gatgggccac aactgtctta gactgctagc tttctcctta ccgtcttgat cggaaagctc
     5641 ttcctaatcg ctaatcagtc atttcttcat gtacagaggt cagcacacat tatttggctt
     5701 aaaccagaac ccagtgtttc cacacttaaa ttctctaacc gaatattcat ggatggctca
     5761 agtctgcaca gagcaagtcc tcactcttca aggaggccca ctgtgtctag gcaggcaaga
     5821 gaattgaaat gaggtgccac ccagtagccc agagtgagct ttagctctct ctagaatgag
     5881 caagactggg ccccacatgg cttagagagg cttgaaggcc agcagctggg ttgggggtgg
     5941 tggtcattaa tggcatatgg tcctagacaa accatctcct ccttgccggc tccccctcca
     6001 gccagagaca gaggatgtgg cctggttcaa agtaaagcag aggatgcaac aaatgtggcc
     6061 aagcctatca aaggaaatga gaatgacagc cttttttcct gggccagaag tagaggggtg
     6121 ggtgcgtaag gatgtgtgag ttttgctttt gactccagga acaaaaaggt aaatcccaca
     6181 tcccagtttc tcagaagtcc ctgtttattc caaatgccat ccagatgtgt gcaatgtggc
     6241 aaactgaagc tgcacagtgt tggtttcctt gtattctgag gatgttaaag actttgttaa
     6301 atggttatcc aattgctctt tcacaggtag cctattaaac tattttaata tgttttttta
     6361 aacctcataa aaatctagca cactcttctc ttgagcagtt agcagaccta aagcaagcct
     6421 gaattggcta tgcagtacat tgtattctgt ttgggggaat ttgttttagc cattttcttt
     6481 aattaccagt tttccagaac actcttagct atgttgacat gaggcagttc cttccaggtg
     6541 attctgtttc cttaagtatt atataaactg tgccaataca gacaaagcat aatcaatata
     6601 atctgaatta ttgttatctt tacctcctga gtaataagca tggtgtcagt tttgtacata
     6661 gcaaataaaa taaatgaaat ctgaa
//
