LOCUS       NM_001287759            6613 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens collagen type IV alpha 6 chain (COL4A6), transcript
            variant 4, mRNA.
ACCESSION   NM_001287759 XM_005262074
VERSION     NM_001287759.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6613)
  AUTHORS   O'Brien,A., Aw,W.Y., Tee,H.Y., Naegeli,K.M., Bademci,G., Tekin,M.,
            Arnos,K. and Pandya,A.
  TITLE     Confirmation of COL4A6 variants in X-linked nonsyndromic hearing
            loss and its clinical implications
  JOURNAL   Eur J Hum Genet 30 (1), 7-12 (2022)
   PUBMED   33840813
  REMARK    GeneRIF: Confirmation of COL4A6 variants in X-linked nonsyndromic
            hearing loss and its clinical implications.
REFERENCE   2  (bases 1 to 6613)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6613)
  AUTHORS   Komori,T., Ono,M., Hara,E.S., Ueda,J., Nguyen,H.T.T., Nguyen,H.T.,
            Yonezawa,T., Maeba,T., Kimura-Ono,A., Takarada,T., Momota,R.,
            Maekawa,K., Kuboki,T. and Oohashi,T.
  TITLE     Type IV collagen alpha6 chain is a regulator of keratin 10 in
            keratinization of oral mucosal epithelium
  JOURNAL   Sci Rep 8 (1), 2612 (2018)
   PUBMED   29422532
  REMARK    GeneRIF: These findings indicate that alpha112:alpha556 (IV)
            network, which is the only network that includes the alpha6(IV)
            chain, is one regulator of KRT10 expression in keratinization of
            oral mucosal epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6613)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   5  (bases 1 to 6613)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   6  (bases 1 to 6613)
  AUTHORS   Ghebrehiwet,B., Peerschke,E.I., Hong,Y., Munoz,P. and Gorevic,P.D.
  TITLE     Short amino acid sequences derived from C1q receptor (C1q-R) show
            homology with the alpha chains of fibronectin and vitronectin
            receptors and collagen type IV
  JOURNAL   J Leukoc Biol 51 (6), 546-556 (1992)
   PUBMED   1377218
REFERENCE   7  (bases 1 to 6613)
  AUTHORS   Gupta,S., Batchu,R.B. and Datta,K.
  TITLE     Purification, partial characterization of rat kidney hyaluronic
            acid binding protein and its localization on the cell surface
  JOURNAL   Eur J Cell Biol 56 (1), 58-67 (1991)
   PUBMED   1724753
REFERENCE   8  (bases 1 to 6613)
  AUTHORS   Hernandez,M.R., Igoe,F. and Neufeld,A.H.
  TITLE     Extracellular matrix of the human optic nerve head
  JOURNAL   Am J Ophthalmol 102 (2), 139-148 (1986)
   PUBMED   2426947
REFERENCE   9  (bases 1 to 6613)
  AUTHORS   Glant,T.T., Hadhazy,C., Mikecz,K. and Sipos,A.
  TITLE     Appearance and persistence of fibronectin in cartilage. Specific
            interaction of fibronectin with collagen type II
  JOURNAL   Histochemistry 82 (2), 149-158 (1985)
   PUBMED   3997552
REFERENCE   10 (bases 1 to 6613)
  AUTHORS   Matsubara,T., Trueb,B., Fehr,K., Ruttner,J.R. and Odermatt,B.F.
  TITLE     The localization and secretion of type IV collagen in synovial
            capillaries by immunohistochemistry using a monoclonal antibody
            against human type IV collagen
  JOURNAL   Exp Cell Biol 52 (3), 159-169 (1984)
   PUBMED   6386565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN313347.1, BC000874.1,
            BC144669.1, CN313332.1, AL136080.6, EU182215.1, DB260304.1 and
            CB050016.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001287759.1.
            
            Summary: This gene encodes one of the six subunits of type IV
            collagen, the major structural component of basement membranes.
            Like the other members of the type IV collagen gene family, this
            gene is organized in a head-to-head conformation with another type
            IV collagen gene, alpha 5 type IV collagen, so that the gene pair
            shares a common promoter. Deletions in the alpha 5 gene that extend
            into the alpha 6 gene result in diffuse leiomyomatosis accompanying
            the X-linked Alport syndrome caused by the deletion in the alpha 5
            gene. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (4) lacks several alternate
            in-frame exons compared to variant 3. The resulting protein
            (isoform 4) is shorter compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144669.1, SRR14038195.242265.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CN313347.1         12-83
            73-96               BC000874.1         15-38
            97-1585             BC144669.1         1-1489
            1586-1927           CN313332.1         132-473
            1928-3033           BC144669.1         1832-2937
            3034-3034           AL136080.6         5360-5360           c
            3035-4588           BC144669.1         2939-4492
            4589-5043           EU182215.1         52-506
            5044-6182           BC144669.1         4948-6086
            6183-6186           DB260304.1         564-567
            6187-6613           CB050016.1         36-462              c
FEATURES             Location/Qualifiers
     source          1..6613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..6613
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="collagen type IV alpha 6 chain"
                     /db_xref="GeneID:1288"
                     /db_xref="HGNC:HGNC:2208"
                     /db_xref="MIM:303631"
     exon            1..237
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..5227
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; collagen of basement membrane, alpha-6;
                     collagen IV, alpha-6 polypeptide; collagen alpha-6(IV)
                     chain; dJ889N15.4 (Collagen Alpha 6(IV)); collagen, type
                     IV, alpha 6"
                     /codon_start=1
                     /product="collagen alpha-6(IV) chain isoform 4 precursor"
                     /protein_id="NP_001274688.1"
                     /db_xref="CCDS:CCDS76009.1"
                     /db_xref="GeneID:1288"
                     /db_xref="HGNC:HGNC:2208"
                     /db_xref="MIM:303631"
                     /translation="MHPGLWLLLVTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPE
                     KGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFL
                     GINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPV
                     LAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNM
                     GLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPG
                     FPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIE
                     GQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPAL
                     SGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLH
                     NKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLP
                     GLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQG
                     FRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPG
                     LPGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPGPKGSRGL
                     PGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKDGLPGMIGSP
                     GLPGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGE
                     RGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSI
                     VKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPG
                     IPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGS
                     QGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGL
                     KGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGE
                     SGFKGTKGRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSS
                     GHQGAIGPLGSPGLIGPKGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKG
                     DRGFPGLQGPAGLPGAPGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSN
                     QGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDP
                     GFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPV
                     GLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPG
                     QSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRF
                     STMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYISRCSVCEAPSQA
                     IAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIE
                     CSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQVCMKSL"
     exon            238..289
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            290..370
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..505
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            506..550
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..667
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            668..736
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            737..772
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            773..835
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            836..871
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            872..913
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1006
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1060
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1129
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1174
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1228
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1298
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1406
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1547
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1652
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1813
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1993
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2177
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2249
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2357
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2579
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2741
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2912
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3056
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3182
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3364
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3428
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3503
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3611
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3719
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3845
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3962
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4124
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4223
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4370
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4371..4487
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4679
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4966
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..6613
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6597..6602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="hexamer: AATAAA"
     polyA_site      6613
                     /gene="COL4A6"
                     /gene_synonym="CXDELq22.3; DELXq22.3; DFNX6"
                     /note="major polyA site"
ORIGIN      
        1 atctcctgag tgctgcaagt tgtaacgggc accgctgagc ctgtttccct ttggagcact
       61 tcttatctag aagcagtgtt tagtttcttc caaactgggc cacttcgtcc acctactctg
      121 ttctgagtaa ggaaacagcc tccaagcatc agcagagccc agatgagcac gggccgcgga
      181 gccgcttagc agtctcccgg gacccagctc cggaggagcc gcaagcatgc accctgggtt
      241 gtggctgctc ctggttacgt tgtgcctgac cgaggaactg gcagcagcgg gagagaagtc
      301 ttatggaaag ccatgtgggg gccaggactg cagtgggagc tgtcagtgtt ttcctgagaa
      361 aggagcgaga ggacgacctg gaccaattgg aattcaaggc ccaacaggtc ctcaaggatt
      421 cactggctct actggtttat cgggattgaa aggagaaagg ggtttcccag gccttctggg
      481 accttatgga ccaaaaggag ataagggtcc catgggagtt cctggctttc ttggcatcaa
      541 tgggattccg ggccaccctg gacaaccagg ccccagaggc ccacctggtc tggatggctg
      601 taatggaact caaggagctg ttggatttcc aggccctgat ggctatcctg ggcttctcgg
      661 accacccggg cttcctggtc agaaaggatc aaaaggtgac cctgtccttg ctccaggtag
      721 tttcaaagga atgaaggggg atcctgggct gcctggactg gatggaatca ctggcccaca
      781 aggagcaccc ggatttcctg gagctgtagg acctgcagga ccaccaggat tacaaggtcc
      841 tccagggcct cctggtcctc ttggtcctga tgggaatatg gggctaggtt ttcaaggaga
      901 gaaaggagtc aagggggatg ttggcctccc tggcccagca ggacctccac catctactgg
      961 agagctggaa ttcatgggat tccccaaagg gaagaaagga tccaagggtg aaccagggcc
     1021 taagggtttt ccaggcataa gtggccctcc aggcttcccg ggccttggaa ctactggaga
     1081 aaagggagaa aagggagaaa agggaatccc tggtttgcca ggacctaggg gtcccatggg
     1141 ttcagaagga gtccaaggcc ctccagggca acagggcaag aaagggaccc tgggatttcc
     1201 tgggcttaat ggattccaag gaattgaggg tcaaaagggt gacattggcc tgccaggccc
     1261 agatgttttc atcgatatag atggtgctgt gatctcaggt aatcctggag atcctggtgt
     1321 acctggcctc ccaggcctta aaggagatga aggcatccaa ggcctacgtg gcccttctgg
     1381 tgtccctgga ttgccagcat tatcaggtgt cccaggagcc ctagggcctc agggatttcc
     1441 agggctgaag ggggaccaag gaaacccagg ccgtaccaca attggagcag ctggcctccc
     1501 tggcagagat ggtttgccag gcccaccagg tccaccaggc ccacctagtc cagaatttga
     1561 gactgaaact ctacacaaca aagagtcagg gttccctggt ctccgaggag aacaaggtcc
     1621 aaaaggaaac ctaggcctca aaggaataaa aggagactca ggtttctgtg cttgtgacgg
     1681 tggtgttccc aacactggac cacccgggga accaggccca cctggtccat ggggtctcat
     1741 aggccttcca ggccttaaag gagccagagg agatcgaggc tctgggggtg cacagggccc
     1801 agcaggggct ccaggcttag ttgggcctct gggtccttca ggacccaaag gaaagaaggg
     1861 ggaaccaatt ctcagtacaa tccaaggaat gccaggagat cggggtgatt ctggctccca
     1921 gggcttccgt ggtgtaatag gagaaccagg caaggacgga gtaccaggtt taccaggtct
     1981 gccaggcctt ccgggtgatg gtggacaggg cttcccaggt gaaaaggggt tacctggact
     2041 tcctggtgaa aaaggccatc ctggtccacc tggcctccca ggaaatgggt taccaggact
     2101 tcctggaccc cgtgggcttc ctggagataa aggcaaggat ggattaccgg gacaacaagg
     2161 ccttcccgga tctaagggaa tcaccctgcc ctgtattatt cctgggtcat acggtccatc
     2221 aggatttcca ggcactcccg gattcccagg ccctaaaggg tctcgaggcc tccctgggac
     2281 cccaggccag cctgggtcaa gtggaagtaa aggagagcca gggagtccag gattggttca
     2341 tcttcctgaa ttaccaggat ttcctggacc tcgtggggag aagggcttgc ctgggtttcc
     2401 tgggctccct ggaaaagatg gcttgcctgg gatgattggc agtccaggct tacctggttc
     2461 caagggagcc actggtgaca tctttggtgc tgaaaatggt gctccggggg aacaaggcct
     2521 acaaggatta acagggcaca aaggatttct tggagactct ggccttccag gactcaaggg
     2581 tgtgcacggg aagcctggct tactaggccc caaaggtgag cggggcagcc ctgggacacc
     2641 aggacaggtg ggacagccag gcaccccagg atctagtggt ccatatggca tcaagggcaa
     2701 atctgggctc ccaggagcac caggcttccc aggcatctca ggacatcctg gaaagaaagg
     2761 aacaagaggc aagaaaggtc ctcctggatc aattgtaaag aaagggctgc cagggctaaa
     2821 aggccttcct ggaaatccag gcctagtagg actgaaagga agcccaggct ctccaggggt
     2881 cgctgggttg ccagccctct ctggacccaa gggagagaag gggtctgttg gattcgtagg
     2941 ttttccagga ataccaggtc tgcctggtat tcctggaaca agaggattaa aaggaattcc
     3001 aggatcaact ggaaaaatgg gaccatctgg acgtgctggt actcctggtg aaaagggaga
     3061 cagaggcaat ccggggccag tcggaatacc tagtccaaga cgtccaatgt caaacctttg
     3121 gctcaaagga gacaaaggct ctcaaggctc agccggatcc aatggatttc ctgggccaag
     3181 aggtgacaaa ggagaggctg gtcgacctgg accaccaggc ctacctggag ctcctggcct
     3241 cccaggcatt atcaaaggag ttagtggaaa gccagggccc cctggcttca tgggaatccg
     3301 gggcttacct ggcctgaagg ggtcctctgg gatcacaggt ttcccaggaa tgccaggaga
     3361 aagtggttca caaggtatca gagggtcgcc tggactccca ggagcatctg gtctcccagg
     3421 cctgaaagga gacaacggcc agacagttga aatttccggt agcccaggac ccaagggaca
     3481 gcctggcgaa tctggtttta aaggcacaaa aggaagagat ggactaatag gcaatatagg
     3541 cttccctgga aacaaaggtg aagatggaaa agttggtgtt tctggagatg ttggccttcc
     3601 tggagctcca ggatttccag gagttgccgg catgagagga gaaccaggac ttccaggttc
     3661 ttctggtcac caaggggcaa ttgggcctct aggatccccc ggattaatag gacccaaagg
     3721 acctagtatc accggtgtgc ctgggcctgc tggtctccct ggacccaaag gagaaaaagg
     3781 atatccagga attggcatcg gagctccagg gaagccgggc ctgagagggc aaaaaggtga
     3841 tcgaggtttc ccaggtctcc agggccctgc tggtctcccc ggtgccccag gcatctcctt
     3901 gccctcactc atagcaggac agcctggtga ccccgggcga ccaggcctag atggagaacg
     3961 aggccgccca ggccccgctg gacccccagg tccccctggg ccatcctcga atcaaggcga
     4021 caccggagac cctggcttcc ctggaattcc tggacctaaa gggcctaagg gagaccaagg
     4081 aattccaggt ttttctggcc tccctggaga gctaggactg aaaggcatga gaggtgagcc
     4141 tggcttcatg gggactccag gcaaggttgg gccacctgga gacccaggat ttcccggaat
     4201 gaaggggaag gcagggccaa gaggctcttc tggcctccaa ggtgatcctg gacaaacacc
     4261 aactgcagaa gctgtccagg ttcctcctgg acccttgggt ctaccaggga tcgatggcat
     4321 ccctggcctc actggggacc ctggggctca aggccctgta ggcctacaag gctccaaagg
     4381 tttacctggc atccccggta aagatggccc cagtgggctc ccaggcccac ctggggctct
     4441 tggtgatcct ggtctgcctg gactgcaagg ccctccagga tttgaaggag ctccagggca
     4501 gcaaggcccc ttcgggatgc ctggaatgcc tggccagagc atgagagtgg gctacacgtt
     4561 ggtaaagcac agccagtcgg aacaggtgcc cccgtgtccc atcgggatga gccagctgtg
     4621 ggtggggtac agcttactgt ttgtggaggg gcaagagaaa gcccacaacc aggacctggg
     4681 ctttgctggc tcctgtctgc cccgcttcag caccatgccc ttcatctact gcaacatcaa
     4741 cgaggtgtgc cactatgcca ggcgcaatga taaatcttac tggctctcca ctaccgcccc
     4801 tatccccatg atgcccgtca gccagaccca gattccccag tacatcagcc gctgctctgt
     4861 gtgtgaggca ccctcgcaag ccattgctgt gcacagccag gacatcacca tcccgcagtg
     4921 ccccctgggc tggcgcagcc tctggattgg gtactctttc ctcatgcaca ctgccgctgg
     4981 tgccgagggt ggaggccagt ccctggtctc acctggctcc tgcctagagg actttcgggc
     5041 cactcctttc atcgaatgca gtggtgcccg aggcacctgc cactactttg caaacaagta
     5101 cagtttctgg ttgaccacag tggaggagag gcagcagttt ggggagttgc ctgtgtctga
     5161 aacgctgaaa gctgggcagc tccacactcg agtcagtcgc tgccaggtgt gtatgaaaag
     5221 cctgtagggt ggcacctgcc actctgcccc ttgccctccc ctgcccctca caacagtcac
     5281 ctcacaaacc tgaatggtct gaagaaggaa ggcctgagcc cctttgcctg tcaagttgta
     5341 cattggagtc tcatttgggc tagactaccg gacactcgtc accccagccc tcgggtccat
     5401 agagatgagc ccaccctgct gagatctgct gtcctgtttc tgtcaagctg gtgctactgt
     5461 ttgatttgga tgattgtgtg actattcatg gctacctcag aaagatttga tgggccacaa
     5521 ctgtcttaga ctgctagctt tctccttacc gtcttgatcg gaaagctctt cctaatcgct
     5581 aatcagtcat ttcttcatgt acagaggtca gcacacatta tttggcttaa accagaaccc
     5641 agtgtttcca cacttaaatt ctctaaccga atattcatgg atggctcaag tctgcacaga
     5701 gcaagtcctc actcttcaag gaggcccact gtgtctaggc aggcaagaga attgaaatga
     5761 ggtgccaccc agtagcccag agtgagcttt agctctctct agaatgagca agactgggcc
     5821 ccacatggct tagagaggct tgaaggccag cagctgggtt gggggtggtg gtcattaatg
     5881 gcatatggtc ctagacaaac catctcctcc ttgccggctc cccctccagc cagagacaga
     5941 ggatgtggcc tggttcaaag taaagcagag gatgcaacaa atgtggccaa gcctatcaaa
     6001 ggaaatgaga atgacagcct tttttcctgg gccagaagta gaggggtggg tgcgtaagga
     6061 tgtgtgagtt ttgcttttga ctccaggaac aaaaaggtaa atcccacatc ccagtttctc
     6121 agaagtccct gtttattcca aatgccatcc agatgtgtgc aatgtggcaa actgaagctg
     6181 cacagtgttg gtttccttgt attctgagga tgttaaagac tttgttaaat ggttatccaa
     6241 ttgctctttc acaggtagcc tattaaacta ttttaatatg tttttttaaa cctcataaaa
     6301 atctagcaca ctcttctctt gagcagttag cagacctaaa gcaagcctga attggctatg
     6361 cagtacattg tattctgttt gggggaattt gttttagcca ttttctttaa ttaccagttt
     6421 tccagaacac tcttagctat gttgacatga ggcagttcct tccaggtgat tctgtttcct
     6481 taagtattat ataaactgtg ccaatacaga caaagcataa tcaatataat ctgaattatt
     6541 gttatcttta cctcctgagt aataagcatg gtgtcagttt tgtacatagc aaataaaata
     6601 aatgaaatct gaa
//
