LOCUS       NM_001846               6446 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens collagen type IV alpha 2 chain (COL4A2), mRNA.
ACCESSION   NM_001846
VERSION     NM_001846.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6446)
  AUTHORS   Wang,H., Zhu,Y., Zheng,L., Chen,M., Hao,Z., Guo,R., Feng,L. and
            Wang,D.
  TITLE     Association of the COL4A2 Gene Polymorphisms with Primary
            Intracerebral Hemorrhage Risk and Outcome in Chinese Han Population
  JOURNAL   Mol Neurobiol 61 (11), 8787-8796 (2024)
   PUBMED   38565785
  REMARK    GeneRIF: Association of the COL4A2 Gene Polymorphisms with Primary
            Intracerebral Hemorrhage Risk and Outcome in Chinese Han
            Population.
REFERENCE   2  (bases 1 to 6446)
  AUTHORS   McNeilly,S., Thomson,C.R., Gonzalez-Trueba,L., Sin,Y.Y.,
            Granata,A., Hamilton,G., Lee,M., Boland,E., McClure,J.D.,
            Lumbreras-Perales,C., Aman,A., Kumar,A.A., Cantini,M., Gok,C.,
            Graham,D., Tomono,Y., Anderson,C.D., Lu,Y., Smith,C., Markus,H.S.,
            Abramowicz,M., Vilain,C., Al-Shahi Salman,R., Salmeron-Sanchez,M.,
            Hainsworth,A.H., Fuller,W., Kadler,K.E., Bulleid,N.J. and Van
            Agtmael,T.
  TITLE     Collagen IV deficiency causes hypertrophic remodeling and
            endothelium-dependent hyperpolarization in small vessel disease
            with intracerebral hemorrhage
  JOURNAL   EBioMedicine 107, 105315 (2024)
   PUBMED   39216230
  REMARK    GeneRIF: Collagen IV deficiency causes hypertrophic remodeling and
            endothelium-dependent hyperpolarization in small vessel disease
            with intracerebral hemorrhage.
REFERENCE   3  (bases 1 to 6446)
  AUTHORS   He,L., Han,W., Yue,K. and Wang,X.
  TITLE     COL4A2 enhances thyroid cancer cell proliferation through the AKT
            pathway
  JOURNAL   Oncol Res 32 (9), 1467-1478 (2024)
   PUBMED   39220121
  REMARK    GeneRIF: COL4A2 enhances thyroid cancer cell proliferation through
            the AKT pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6446)
  AUTHORS   Hu,C., Liu,D. and Wang,H.
  TITLE     Col4a2 Mutations Contribute to Infantile Epileptic Spasm Syndrome
            and Neuroinflammation
  JOURNAL   Int J Med Sci 21 (9), 1756-1768 (2024)
   PUBMED   39006838
  REMARK    GeneRIF: Col4a2 Mutations Contribute to Infantile Epileptic Spasm
            Syndrome and Neuroinflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6446)
  AUTHORS   Oh,J.K., Levi,S.R., de Carvalho,J.R.L. Jr., Abdelhakim,A.H.,
            Hirano,M., Maumenee,I.H. and Tsang,S.H.
  TITLE     Venous Tortuosity in COL4A2-Associated Gould Syndrome
  JOURNAL   Ophthalmic Surg Lasers Imaging Retina 54 (9), 536-539 (2023)
   PUBMED   37642429
  REMARK    GeneRIF: Venous Tortuosity in COL4A2-Associated Gould Syndrome.
REFERENCE   6  (bases 1 to 6446)
  AUTHORS   Ghebrehiwet,B., Peerschke,E.I., Hong,Y., Munoz,P. and Gorevic,P.D.
  TITLE     Short amino acid sequences derived from C1q receptor (C1q-R) show
            homology with the alpha chains of fibronectin and vitronectin
            receptors and collagen type IV
  JOURNAL   J Leukoc Biol 51 (6), 546-556 (1992)
   PUBMED   1377218
REFERENCE   7  (bases 1 to 6446)
  AUTHORS   Gupta,S., Batchu,R.B. and Datta,K.
  TITLE     Purification, partial characterization of rat kidney hyaluronic
            acid binding protein and its localization on the cell surface
  JOURNAL   Eur J Cell Biol 56 (1), 58-67 (1991)
   PUBMED   1724753
REFERENCE   8  (bases 1 to 6446)
  AUTHORS   Paralkar,V.M., Nandedkar,A.K., Pointer,R.H., Kleinman,H.K. and
            Reddi,A.H.
  TITLE     Interaction of osteogenin, a heparin binding bone morphogenetic
            protein, with type IV collagen
  JOURNAL   J Biol Chem 265 (28), 17281-17284 (1990)
   PUBMED   2211625
REFERENCE   9  (bases 1 to 6446)
  AUTHORS   Myers,J.C., Howard,P.S., Jelen,A.M., Dion,A.S. and Macarak,E.J.
  TITLE     Duplication of type IV collagen COOH-terminal repeats and
            species-specific expression of alpha 1(IV) and alpha 2(IV) collagen
            genes
  JOURNAL   J Biol Chem 262 (19), 9231-9238 (1987)
   PUBMED   2439508
  REMARK    Erratum:[J Biol Chem 1987 Oct 15;262(29):14372]
REFERENCE   10 (bases 1 to 6446)
  AUTHORS   Hernandez,M.R., Igoe,F. and Neufeld,A.H.
  TITLE     Extracellular matrix of the human optic nerve head
  JOURNAL   Am J Ophthalmol 102 (2), 139-148 (1986)
   PUBMED   2426947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161773.21, AL159153.17 and
            AL139385.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001846.3.
            
            Summary: This gene encodes one of the six subunits of type IV
            collagen, the major structural component of basement membranes. The
            C-terminal portion of the protein, known as canstatin, is an
            inhibitor of angiogenesis and tumor growth. Like the other members
            of the type IV collagen gene family, this gene is organized in a
            head-to-head conformation with another type IV collagen gene so
            that each gene pair shares a common promoter. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360467.7/ ENSP00000353654.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AL161773.21        73329-73573
            246-333             AL161773.21        73905-73992
            334-388             AL161773.21        74114-74168
            389-469             AL161773.21        123517-123597
            470-604             AL159153.17        38584-38718
            605-649             AL159153.17        38803-38847
            650-766             AL159153.17        42317-42433
            767-838             AL159153.17        43735-43806
            839-874             AL159153.17        44251-44286
            875-937             AL159153.17        44395-44457
            938-973             AL159153.17        46175-46210
            974-1015            AL159153.17        48251-48292
            1016-1114           AL159153.17        50119-50217
            1115-1150           AL159153.17        51852-51887
            1151-1201           AL159153.17        52468-52518
            1202-1246           AL159153.17        53639-53683
            1247-1300           AL159153.17        59679-59732
            1301-1367           AL159153.17        60648-60714
            1368-1478           AL159153.17        63529-63639
            1479-1628           AL159153.17        64155-64304
            1629-1721           AL159153.17        71193-71285
            1722-1885           AL159153.17        72621-72784
            1886-1958           AL159153.17        75964-76036
            1959-2065           AL159153.17        76128-76234
            2066-2267           AL159153.17        79255-79456
            2268-2327           AL159153.17        79853-79912
            2328-2384           AL159153.17        80890-80946
            2385-2492           AL159153.17        83067-83174
            2493-2714           AL159153.17        86779-87000
            2715-2876           AL159153.17        91853-92014
            2877-3047           AL159153.17        94070-94240
            3048-3191           AL159153.17        96366-96509
            3192-3314           AL159153.17        98755-98877
            3315-3496           AL159153.17        99505-99686
            3497-3560           AL139385.12        2976-3039
            3561-3635           AL139385.12        3242-3316
            3636-3743           AL139385.12        4764-4871
            3744-3851           AL139385.12        5601-5708
            3852-3923           AL139385.12        6742-6813
            3924-4049           AL139385.12        8873-8998
            4050-4166           AL139385.12        15199-15315
            4167-4328           AL139385.12        16652-16813
            4329-4427           AL139385.12        16914-17012
            4428-4574           AL139385.12        17378-17524
            4575-4691           AL139385.12        17679-17795
            4692-4883           AL139385.12        19946-20137
            4884-5170           AL139385.12        21466-21752
            5171-6446           AL139385.12        25465-26740
FEATURES             Location/Qualifiers
     source          1..6446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..6446
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /note="collagen type IV alpha 2 chain"
                     /db_xref="GeneID:1284"
                     /db_xref="HGNC:HGNC:2203"
                     /db_xref="MIM:120090"
     exon            1..245
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..333
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..388
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..469
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..604
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..649
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..766
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..838
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..874
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..937
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..973
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1015
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1114
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1150
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1201
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1246
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1300
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1367
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1478
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1628
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1721
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1885
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1958
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2065
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2267
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2327
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2384
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2492
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2714
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2876
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3047
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3191
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3314
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3496
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3560
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3635
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3743
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3851
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3923
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4049
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4166
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4328
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4427
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4574
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4691
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..4883
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..5170
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..6446
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6236..6241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /note="hexamer: AATAAA"
     polyA_site      6264
                     /gene="COL4A2"
                     /gene_synonym="BSVD2; ICH; POREN2"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtggct gcagtgcgcc gggacaccag ggctccgcgc tccgcactca agaggctccc
       61 gcgtcccaac ccctcgcgcc cgcgcgttcg cggatccagg ccgaggaccg aaaggggccg
      121 cccgagcccc cggggccggc gcccagagag cccagcaagg ccggccgccc tgccggtgtg
      181 ccgccggcgg gtgcttctgg aagggccaat gcgttcgggc agcagcccct gaagccgagc
      241 ccgaggctaa gtgggactga ccggggccca gagtggacga accgccagca tggggagaga
      301 ccagcgcgcg gtggccggcc ctgccctacg gcggtggctg ctgctgggga cagtgaccgt
      361 ggggttcctc gcccagagcg tcttggcggg tgtgaagaag tttgatgtgc cgtgtggagg
      421 aagagattgc agtgggggct gccagtgcta ccctgagaaa ggtggacgtg gtcagcctgg
      481 gccagtgggc ccccaggggt acaatgggcc accaggatta caaggattcc cgggactgca
      541 gggacgtaaa ggagacaagg gtgaaagggg agcccccgga gtaacgggac ccaagggcga
      601 cgtgggagca agaggcgttt ctggattccc tggtgccgat ggaattcctg gacacccggg
      661 gcaaggtggg cccaggggaa ggccgggcta cgatggctgc aacggaaccc agggagactc
      721 aggtccacag gggccccccg gctctgaggg gttcaccggg cctcccgggc cccaaggacc
      781 aaaagggcag aaaggtgagc cttatgcact gcctaaagag gagcgcgaca gatatcgggg
      841 tgaacctgga gagcctggat tggtcggttt ccagggacct cccggccgcc ctgggcatgt
      901 gggacagatg ggtccagttg gagctccagg gagaccagga ccacctggac cccctggacc
      961 aaaaggacag caaggcaaca gaggacttgg tttctacgga gttaagggtg aaaagggtga
     1021 cgtagggcag ccgggaccca acgggattcc atcagacacc ctccacccca tcatcgcgcc
     1081 cacaggagtc accttccacc cagatcagta caagggtgaa aaaggcagtg agggggaacc
     1141 aggaataaga ggcatttcct tgaagggaga agaaggaatc atgggctttc ctggactgag
     1201 gggttaccct ggcttgagtg gtgaaaaagg atcaccagga cagaagggaa gccgaggcct
     1261 ggatggctat caagggcctg atggaccccg gggacccaag ggagaagccg gagacccagg
     1321 gccccctgga ctacctgcct actcccctca cccttcccta gcaaaaggtg ccagaggtga
     1381 cccgggattc ccaggggccc aaggggagcc aggaagccag ggtgagccag gagacccggg
     1441 cctcccaggt ccccctggcc tctccatcgg agatggagat cagaggagag gcctgccggg
     1501 tgagatggga cccaagggct tcatcggaga ccccggcatc cctgcgctct acgggggccc
     1561 acctggacct gatggaaagc gagggcctcc aggacccccc gggctccctg gaccacctgg
     1621 acctgatggc ttcctgtttg ggctgaaagg agcaaaagga agagcaggct tccctgggct
     1681 tcccggctcc cctggagccc gcggaccaaa ggggtggaaa ggtgacgctg gggaatgcag
     1741 atgtacagaa ggcgacgaag ctatcaaagg tcttccggga ctgccaggac ccaagggctt
     1801 cgcaggcatc aacggggagc cggggaggaa aggggacaga ggagaccccg gccaacacgg
     1861 cctccctggg ttcccagggc tcaagggagt gcctggcaac attggtgctc ccggacccaa
     1921 aggagcaaaa ggagattcca gaacaatcac aaccaaaggt gagcggggac agcccggcgt
     1981 cccaggtgtg cccgggatga aaggtgacga tggcagccca ggccgcgatg ggctcgatgg
     2041 attccccggc ctcccaggcc ctcccggtga tggcatcaag ggccctccag gggacccagg
     2101 ctatccagga atacctggaa cgaagggtac tccaggagaa atgggccccc caggactggg
     2161 ccttcccggc ctcaaaggcc aacgtggttt ccctggagac gccggcttac ctggaccacc
     2221 aggcttcctg ggccctcctg gccccgcagg gaccccagga caaatagatt gtgacacaga
     2281 tgtgaaaagg gccgttggag gtgacagaca ggaggccatc cagccaggtt gcataggagg
     2341 gcccaaggga ttgccaggcc tgccaggacc cccaggcccc acaggtgcca aaggcctccg
     2401 aggaatccca ggcttcgcag gagctgatgg aggaccaggg cccaggggct tgccaggaga
     2461 cgcaggtcgt gaagggttcc caggaccccc agggttcata ggaccccgag gatccaaagg
     2521 tgcagtgggc ctccctggcc cagatggatc cccaggtccc atcggcctgc cagggccaga
     2581 tgggccccct ggggaaaggg gcctccctgg agaagtcctg ggagctcagc ccgggccacg
     2641 gggagatgct ggtgtgcctg gacagcctgg gcttaaaggc cttcccggag acagaggccc
     2701 ccctggattc agaggaagcc aagggatgcc tgggatgcca gggctgaagg gccagccagg
     2761 cctcccagga ccttccggcc agccaggcct gtatgggcct ccaggactgc atggattccc
     2821 aggagctcct ggccaagagg ggcccttggg gctgccagga atcccaggcc gtgaaggtct
     2881 gcctggtgat agaggggacc ctggggacac aggcgctcct ggccctgtgg gcatgaaagg
     2941 tctctctggt gacagaggag atgctggctt cacaggggag caaggccatc caggaagccc
     3001 tggatttaaa ggaattgatg gaatgcctgg gacccccggg ctaaaaggag atagaggctc
     3061 acctgggatg gatggtttcc aaggcatgcc tggactcaaa gggagacccg ggtttccagg
     3121 gagcaaaggc gaggctggat ttttcggaat acccggtctg aagggtctgg ctggtgagcc
     3181 aggttttaaa ggcagccgag gggaccctgg gcccccagga ccacctcctg tcatcctgcc
     3241 aggaatgaaa gacattaaag gagagaaagg agatgaaggg cctatggggc tgaaaggata
     3301 cctgggcgca aaaggtatcc aaggaatgcc aggcatccca gggctgtcag gaatccctgg
     3361 gctgcctggg aggcccggcc acatcaaagg agtcaaggga gacatcggag tccccggcat
     3421 ccccggtttg ccaggattcc ctggggtggc tggcccccct ggaattacgg gattcccagg
     3481 attcatagga agccggggtg acaaaggtgc cccagggaga gcaggcctgt atggcgagat
     3541 tggcgcgact ggtgatttcg gtgacatcgg ggacactata aatttaccag gaagaccagg
     3601 cctgaagggg gagcggggca ccactggaat accaggtctg aagggattct ttggagagaa
     3661 gggaacagaa ggtgacatcg gcttccctgg gataacaggc gtgactggag tccaaggccc
     3721 tcctggactt aaaggacaaa caggctttcc agggctgact gggcctccag ggtcgcaggg
     3781 agagctgggg cggattggac tgcctggtgg caaaggagat gatggctggc cgggagctcc
     3841 gggcttacca ggttttccgg gactccgtgg gatccgcggc ttacacggct tgccaggcac
     3901 caagggcttt ccaggatccc caggttctga catccacgga gacccaggct tcccaggccc
     3961 tcctggggaa agaggtgacc caggagaggc caacaccctt ccaggccctg tgggagtccc
     4021 aggacagaaa ggagaccaag gagctccagg ggaacgaggc ccacctggga gcccaggact
     4081 tcaggggttc cctggtatca cacccccttc caacatctct ggggcacctg gtgacaaagg
     4141 ggcgccaggg atatttggcc tgaaaggtta tcggggccca ccagggccac caggttctgc
     4201 tgctcttcct ggaagcaaag gtgacacagg gaacccagga gctccaggaa ccccagggac
     4261 caaaggatgg gccggggact ccgggcccca gggcaggcct ggtgtgtttg gtctcccagg
     4321 agaaaaaggg cccaggggtg aacaaggctt catggggaac actggaccca ctggggcggt
     4381 gggcgacaga ggccccaagg gacccaaggg agacccagga ttccctggtg cccccgggac
     4441 tgtgggagcc cccgggattg caggaatccc ccagaagatt gccgtccaac cagggacagt
     4501 gggtccccag gggaggcgag gcccccctgg ggcaccgggg gagatggggc cccagggccc
     4561 ccccggagaa ccaggtttcc gtggggctcc agggaaagct gggccccaag gaagaggtgg
     4621 tgtgtctgct gttcccggct tccggggaga tgaaggaccc ataggccacc aggggccgat
     4681 tggccaagaa ggtgcaccag gccgtccagg gagcccgggc ctgccgggta tgccaggccg
     4741 cagcgtcagc atcggctacc tcctggtgaa gcacagccag acggaccagg agcccatgtg
     4801 cccagtgggc atgaacaaac tctggagtgg atacagcctg ctgtacttcg agggccagga
     4861 gaaggcgcac aaccaggacc tggggctggc gggctcctgc ctggcgcggt tcagcaccat
     4921 gcccttcctg tactgcaacc ctggtgatgt ctgctactat gccagccgga acgacaagtc
     4981 ctactggctc tctaccactg cgccgctgcc catgatgccc gtggccgagg acgagatcaa
     5041 gccctacatc agccgctgtt ctgtgtgtga ggccccggcc atcgccatcg cggtccacag
     5101 tcaggatgtc tccatcccac actgcccagc tgggtggcgg agtttgtgga tcggatattc
     5161 cttcctcatg cacacggcgg cgggagacga aggcggtggc caatcactgg tgtcaccggg
     5221 cagctgtcta gaggacttcc gcgccacacc attcatcgaa tgcaatggag gccgcggcac
     5281 ctgccactac tacgccaaca agtacagctt ctggctgacc accattcccg agcagagctt
     5341 ccagggctcg ccctccgccg acacgctcaa ggccggcctc atccgcacac acatcagccg
     5401 ctgccaggtg tgcatgaaga acctgtgagc cggcgcgtgc caggaagggc cattttggtg
     5461 cttattctta acttattacc tcaggtgcca acccaaaaat tggttttatt tttttcttaa
     5521 aaaaaaaaaa gtctaccaaa ggaatttgca tccagcagca gcacttagac ctgccagcca
     5581 ctgtcaccga gcgggtgcaa gcactcgggg tccctggagg gcaagccctg cccacagaaa
     5641 gccaggagca gccctggccc ccatcagccc tgctagacgc accgcctgaa ggcacagcta
     5701 accacttcgc acacacccat gtaaccactg cactttccaa tgccacagac aactcacatt
     5761 gttcaactcc cttctcgggg tgggacagac gagacaacag cacacaggca gccagccgtg
     5821 gccagaggct cgaggggctc agggcctcag gcacccgtcc ccacacgagg gccccgtggg
     5881 tgggcctggc cctgctttct acgccaatgt tatgccagct ccatgttctc ccaaataccg
     5941 ttgatgtgaa ttattttaaa ggcaaaaccg tgctctttat tttaaaaaac actgataatc
     6001 acactgcggt aggtcattct tttgccacat ccctatagac cactgggttt ggcaaaactc
     6061 aggcagaagt ggagaccttt ctagacatca ttgtcagcct tgctacttga aggtacaccc
     6121 catagggtcg gaggtgctgt ccccactgcc ccacgttgtc cctgagattt aacccctcca
     6181 ctgctggggg tgagctgtac tcttctgact gccccctcct gtgtaacgac tacaaaataa
     6241 aacttggttc tgaatatttt taaaccccga gttgttgacc gccttaatct cgtgtccata
     6301 gagcaaaacg tctgctcaga tggatgcgag gcacagcgtc cgcccacgct gctgttttta
     6361 atccatctca gtagagttga acccattcgt ggtattacag ccatttctcg gggaatgtgt
     6421 ttgtttataa ctcactaatg cttaca
//
