LOCUS       NM_001845               6540 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens collagen type IV alpha 1 chain (COL4A1), transcript
            variant 1, mRNA.
ACCESSION   NM_001845
VERSION     NM_001845.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6540)
  AUTHORS   Kuo,D.S., Labelle-Dumais,C. and Gould,D.B.
  TITLE     COL4A1 and COL4A2 mutations and disease: insights into pathogenic
            mechanisms and potential therapeutic targets
  JOURNAL   Hum Mol Genet 21 (R1), R97-R110 (2012)
   PUBMED   22914737
  REMARK    Review article
REFERENCE   2  (bases 1 to 6540)
  AUTHORS   Plaisier,E. and Ronco,P.
  TITLE     COL4A1-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301768
REFERENCE   3  (bases 1 to 6540)
  AUTHORS   Soininen,R., Huotari,M., Ganguly,A., Prockop,D.J. and Tryggvason,K.
  TITLE     Structural organization of the gene for the alpha 1 chain of human
            type IV collagen
  JOURNAL   J Biol Chem 264 (23), 13565-13571 (1989)
   PUBMED   2701944
REFERENCE   4  (bases 1 to 6540)
  AUTHORS   Soininen,R., Huotari,M., Hostikka,S.L., Prockop,D.J. and
            Tryggvason,K.
  TITLE     The structural genes for alpha 1 and alpha 2 chains of human type
            IV collagen are divergently encoded on opposite DNA strands and
            have an overlapping promoter region
  JOURNAL   J Biol Chem 263 (33), 17217-17220 (1988)
   PUBMED   3182844
REFERENCE   5  (bases 1 to 6540)
  AUTHORS   Poschl,E., Pollner,R. and Kuhn,K.
  TITLE     The genes for the alpha 1(IV) and alpha 2(IV) chains of human
            basement membrane collagen type IV are arranged head-to-head and
            separated by a bidirectional promoter of unique structure
  JOURNAL   EMBO J 7 (9), 2687-2695 (1988)
   PUBMED   2846280
REFERENCE   6  (bases 1 to 6540)
  AUTHORS   Soininen,R., Haka-Risku,T., Prockop,D.J. and Tryggvason,K.
  TITLE     Complete primary structure of the alpha 1-chain of human basement
            membrane (type IV) collagen
  JOURNAL   FEBS Lett 225 (1-2), 188-194 (1987)
   PUBMED   3691802
REFERENCE   7  (bases 1 to 6540)
  AUTHORS   Brazel,D., Oberbaumer,I., Dieringer,H., Babel,W., Glanville,R.W.,
            Deutzmann,R. and Kuhn,K.
  TITLE     Completion of the amino acid sequence of the alpha 1 chain of human
            basement membrane collagen (type IV) reveals 21 non-triplet
            interruptions located within the collagenous domain
  JOURNAL   Eur J Biochem 168 (3), 529-536 (1987)
   PUBMED   3311751
REFERENCE   8  (bases 1 to 6540)
  AUTHORS   Glanville,R.W., Qian,R.Q., Siebold,B., Risteli,J. and Kuhn,K.
  TITLE     Amino acid sequence of the N-terminal aggregation and cross-linking
            region (7S domain) of the alpha 1 (IV) chain of human basement
            membrane collagen
  JOURNAL   Eur J Biochem 152 (1), 213-219 (1985)
   PUBMED   4043082
REFERENCE   9  (bases 1 to 6540)
  AUTHORS   Pihlajaniemi,T., Tryggvason,K., Myers,J.C., Kurkinen,M., Lebo,R.,
            Cheung,M.C., Prockop,D.J. and Boyd,C.D.
  TITLE     cDNA clones coding for the pro-alpha1(IV) chain of human type IV
            procollagen reveal an unusual homology of amino acid sequences in
            two halves of the carboxyl-terminal domain
  JOURNAL   J Biol Chem 260 (12), 7681-7687 (1985)
   PUBMED   2581969
REFERENCE   10 (bases 1 to 6540)
  AUTHORS   Brinker,J.M., Gudas,L.J., Loidl,H.R., Wang,S.Y., Rosenbloom,J.,
            Kefalides,N.A. and Myers,J.C.
  TITLE     Restricted homology between human alpha 1 type IV and other
            procollagen chains
  JOURNAL   Proc Natl Acad Sci U S A 82 (11), 3649-3653 (1985)
   PUBMED   2582422
REFERENCE   11 (bases 1 to 6540)
  AUTHORS   Babel,W. and Glanville,R.W.
  TITLE     Structure of human-basement-membrane (type IV) collagen. Complete
            amino-acid sequence of a 914-residue-long pepsin fragment from the
            alpha 1(IV) chain
  JOURNAL   Eur J Biochem 143 (3), 545-556 (1984)
   PUBMED   6434307
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161773.21, X05561.1,
            BC151220.1, Y00706.1, AL390755.5, BC047305.1 and AA678474.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001845.5.
            
            Summary: This gene encodes a type IV collagen alpha protein. Type
            IV collagen proteins are integral components of basement membranes.
            This gene shares a bidirectional promoter with a paralogous gene on
            the opposite strand. The protein consists of an amino-terminal 7S
            domain, a triple-helix forming collagenous domain, and a
            carboxy-terminal non-collagenous domain. It functions as part of a
            heterotrimer and interacts with other extracellular matrix
            components such as perlecans, proteoglycans, and laminins. In
            addition, proteolytic cleavage of the non-collagenous
            carboxy-terminal domain results in a biologically active fragment
            known as arresten, which has anti-angiogenic and tumor suppressor
            properties. Mutations in this gene cause porencephaly,
            cerebrovascular disease, and renal and muscular defects.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375820.10/ ENSP00000364979.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL161773.21        73195-73202         c
            9-16                X05561.1           1-8
            17-1941             BC151220.1         1-1925
            1942-2814           Y00706.1           1677-2549
            2815-2943           X05561.1           2807-2935
            2944-3819           Y00706.1           2679-3554
            3820-3820           AL390755.5         120764-120764       c
            3821-3900           Y00706.1           3556-3635
            3901-4131           BC047305.1         1990-2220
            4132-4132           AL390755.5         116416-116416       c
            4133-5400           BC047305.1         2222-3489
            5401-6442           BC151220.1         5385-6426
            6443-6539           AA678474.1         3-99                c
            6540-6540           AL390755.5         99128-99128         c
FEATURES             Location/Qualifiers
     source          1..6540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..6540
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /note="collagen type IV alpha 1 chain"
                     /db_xref="GeneID:1282"
                     /db_xref="HGNC:HGNC:2202"
                     /db_xref="MIM:120130"
     exon            1..214
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..5140
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; collagen of basement membrane, alpha-1 chain;
                     collagen IV, alpha-1 polypeptide; collagen alpha-1(IV)
                     chain; COL4A1 NC1 domain; arresten"
                     /codon_start=1
                     /product="collagen alpha-1(IV) chain isoform 1
                     preproprotein"
                     /protein_id="NP_001836.3"
                     /db_xref="CCDS:CCDS9511.1"
                     /db_xref="GeneID:1282"
                     /db_xref="HGNC:HGNC:2202"
                     /db_xref="MIM:120130"
                     /translation="MGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGV
                     KGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYP
                     GNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
                     EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKG
                     QMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGE
                     KGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIV
                     IGTGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGE
                     KGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGDQGPPGIPGQ
                     PGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGV
                     AGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMPGRAGSPGRDGH
                     PGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPG
                     GPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKG
                     AVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPG
                     LKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGV
                     PGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQ
                     SGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSS
                     GPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPG
                     TPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGI
                     PGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIG
                     IPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGP
                     AGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSPGIPG
                     SKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGID
                     GVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKG
                     LPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPG
                     PKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGP
                     PGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCL
                     RKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCE
                     APAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRS
                     APFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRR
                     T"
     exon            215..274
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            275..364
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            365..409
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            410..454
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            455..517
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            518..571
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            572..598
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            599..682
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            683..745
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            746..781
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            782..823
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            824..910
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            911..937
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            938..988
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1033
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1087
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1129
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1214
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1250
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1415
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1595
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1666
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1858
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2027
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2120
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2225
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2323
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2474
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2588
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2756
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2846
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2999
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3098
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3188
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3328
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3455
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3536
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3635
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3686
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3872
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4006
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4079
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4151
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4280
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4379
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4592
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4770
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4885
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            4886..5058
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..6540
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6421..6426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /note="hexamer: AATAAA"
     polyA_site      6442
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /note="major polyA site"
     regulatory      6513..6518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
                     /note="hexamer: AATAAA"
     polyA_site      6540
                     /gene="COL4A1"
                     /gene_synonym="BSVD; BSVD1; COL4A1s; PADMAL; RATOR"
ORIGIN      
        1 aggtctccgc ttggagccgc cgcacccggg acggtgcgta gcgctggaag tccggccttc
       61 cgagagctag ctgtccgccg cggcccccgc acgccgggca gccgtccctc gccgcctcgg
      121 gcgcgccacc atggggcccc ggctcagcgt ctggctgctg ctgctgcccg ccgcccttct
      181 gctccacgag gagcacagcc gggccgctgc gaagggtggc tgtgctggct ctggctgtgg
      241 caaatgtgac tgccatggag tgaagggaca aaagggtgaa agaggcctcc cggggttaca
      301 aggtgtcatt gggtttcctg gaatgcaagg acctgagggg ccacagggac caccaggaca
      361 aaagggtgat actggagaac caggactacc tggaacaaaa gggacaagag gacctccggg
      421 agcatctggc taccctggaa acccaggact tcccggaatt cctggccaag acggcccgcc
      481 aggcccccca ggtattccag gatgcaatgg cacaaagggg gagagagggc cgctcgggcc
      541 tcctggcttg cctggtttcg ctggaaatcc cggaccacca ggcttaccag ggatgaaggg
      601 tgatccaggt gagatacttg gccatgtgcc cgggatgctg ttgaaaggtg aaagaggatt
      661 tcccggaatc ccagggactc caggcccacc aggactgcca gggcttcaag gtcctgttgg
      721 gcctccagga tttaccggac caccaggtcc cccaggccct cccggccctc caggtgaaaa
      781 gggacaaatg ggcttaagtt ttcaaggacc aaaaggtgac aagggtgacc aaggggtcag
      841 tgggcctcca ggagtaccag gacaagctca agttcaagaa aaaggagact tcgccaccaa
      901 gggagaaaag ggccaaaaag gtgaacctgg atttcagggg atgccagggg tcggagagaa
      961 aggtgaaccc ggaaaaccag gacccagagg caaacccgga aaagatggtg acaaagggga
     1021 aaaagggagt cccggttttc ctggtgaacc cgggtaccca ggactcatag gccgccaggg
     1081 cccgcaggga gaaaagggtg aagcaggtcc tcctggccca cctggaattg ttataggcac
     1141 aggacctttg ggagaaaaag gagagagggg ctaccctgga actccggggc caagaggaga
     1201 gccaggccca aaaggtttcc caggactacc aggccaaccc ggacctccag gcctccctgt
     1261 acctgggcag gctggtgccc ctggcttccc tggtgaaaga ggagaaaaag gtgaccgagg
     1321 atttcctggt acatctctgc caggaccaag tggaagagat gggctcccgg gtcctcctgg
     1381 ttcccctggg ccccctgggc agcctggcta cacaaatgga attgtggaat gtcagcccgg
     1441 acctccaggt gaccagggtc ctcctggaat tccagggcag ccaggattta taggcgaaat
     1501 tggagagaaa ggtcaaaaag gagagagttg cctcatctgt gatatagacg gatatcgggg
     1561 gcctcccggg ccacagggac ccccgggaga aataggtttc ccagggcagc caggggccaa
     1621 gggcgacaga ggtttgcctg gcagagatgg tgttgcagga gtgccaggcc ctcaaggtac
     1681 accagggctg ataggccagc caggagccaa gggggagcct ggtgagtttt atttcgactt
     1741 gcggctcaaa ggtgacaaag gagacccagg ctttccagga cagcccggca tgccagggag
     1801 agcgggttct cctggaagag atggccatcc gggtcttcct ggccccaagg gctcgccggg
     1861 ttctgtagga ttgaaaggag agcgtggccc ccctggagga gttggattcc caggcagtcg
     1921 tggtgacacc ggcccccctg ggcctccagg atatggtcct gctggtccca ttggtgacaa
     1981 aggacaagca ggctttcctg gaggccctgg atccccaggc ctgccaggtc caaagggtga
     2041 accaggaaaa attgttcctt taccaggccc ccctggagca gaaggactgc cggggtcccc
     2101 aggcttccca ggtccccaag gagaccgagg ctttcccgga accccaggaa ggccaggcct
     2161 gccaggagag aagggcgctg tgggccagcc aggcattgga tttccagggc cccccggccc
     2221 caaaggtgtt gacggcttac ctggagacat ggggccaccg gggactccag gtcgcccggg
     2281 atttaatggc ttacctggga acccaggtgt gcagggccag aagggagagc ctggagttgg
     2341 tctaccggga ctcaaaggtt tgccaggtct tcccggcatt cctggcacac ccggggagaa
     2401 ggggagcatt ggggtaccag gcgttcctgg agaacatgga gcgatcggac cccctgggct
     2461 tcaggggatc agaggtgaac cgggacctcc tggattgcca ggctccgtgg ggtctccagg
     2521 agttccagga ataggccccc ctggagctag gggtccccct ggaggacagg gaccaccggg
     2581 gttgtcaggc cctcctggaa taaaaggaga gaagggtttc cccggattcc ctggactgga
     2641 catgccgggc cctaaaggag ataaaggggc tcaaggactc cctggcataa cgggacagtc
     2701 ggggctccct ggccttcctg gacagcaggg ggctcctggg attcctgggt ttccaggttc
     2761 caagggagaa atgggcgtca tggggacccc cgggcagccg ggctcaccag gaccagtggg
     2821 tgctcctgga ttaccgggtg aaaaagggga ccatggcttt ccgggctcct caggacccag
     2881 gggagaccct ggcttgaaag gtgataaggg ggatgtcggt ctccctggca agcctggctc
     2941 catggataag gtggacatgg gcagcatgaa gggccagaaa ggagaccaag gagagaaagg
     3001 acaaattgga ccaattggtg agaagggatc ccgaggagac cctgggaccc caggagtgcc
     3061 tggaaaggac gggcaggcag gacagcctgg gcagccagga cctaaaggtg atccaggtat
     3121 aagtggaacc ccaggtgctc caggacttcc gggaccaaaa ggatctgttg gtggaatggg
     3181 cttgccagga acacctggag agaaaggtgt gcctggcatc cctggcccac aaggttcacc
     3241 tggcttacct ggagacaaag gtgcaaaagg agagaaaggg caggcaggcc cacctggcat
     3301 aggcatccca gggctgcgag gtgaaaaggg agatcaaggg atagcgggtt tcccaggaag
     3361 ccctggagag aagggagaaa aaggaagcat tgggatccca ggaatgccag ggtccccagg
     3421 ccttaaaggg tctcccggga gtgttggcta tccaggaagt cctgggctac ctggagaaaa
     3481 aggtgacaaa ggcctcccag gattggatgg catccctggt gtcaaaggag aagcaggtct
     3541 tcctgggact cctggcccca caggcccagc tggccagaaa ggggagccag gcagtgatgg
     3601 aatcccgggg tcagcaggag agaagggtga accaggtcta ccaggaagag gattcccagg
     3661 gtttccaggg gccaaaggag acaaaggttc aaagggtgag gtgggtttcc caggattagc
     3721 cgggagccca ggaattcctg gatccaaagg agagcaagga ttcatgggtc ctccggggcc
     3781 ccagggacag ccggggttac cgggatcccc aggccatgcc acggaggggc ccaaaggaga
     3841 ccgcggacct cagggccagc ctggcctgcc aggacttccg ggacccatgg ggcctccagg
     3901 gcttcctggg attgatggag ttaaaggtga caaaggaaat ccaggctggc caggagcacc
     3961 cggtgtccca gggcccaagg gagaccctgg attccagggc atgcctggta ttggtggctc
     4021 tccaggaatc acaggctcta agggtgatat ggggcctcca ggagttccag gatttcaagg
     4081 tccaaaaggt cttcctggcc tccagggaat taaaggtgat caaggcgatc aaggcgtccc
     4141 gggagctaaa ggtctcccgg gtcctcctgg ccccccaggt ccttacgaca tcatcaaagg
     4201 ggagcccggg ctccctggtc ctgagggccc cccagggctg aaagggcttc agggactgcc
     4261 aggcccgaaa ggccagcaag gtgttacagg attggtgggt atacctggac ctccaggtat
     4321 tcctgggttt gacggtgccc ctggccagaa aggagagatg ggacctgccg ggcctactgg
     4381 tccaagagga tttccaggtc caccaggccc cgatgggttg ccaggatcca tggggccccc
     4441 aggcacccca tctgttgatc acggcttcct tgtgaccagg catagtcaaa caatagatga
     4501 cccacagtgt ccttctggga ccaaaattct ttaccacggg tactctttgc tctacgtgca
     4561 aggcaatgaa cgggcccatg gccaggactt gggcacggcc ggcagctgcc tgcgcaagtt
     4621 cagcacaatg cccttcctgt tctgcaatat taacaacgtg tgcaactttg catcacgaaa
     4681 tgactactcg tactggctgt ccacccctga gcccatgccc atgtcaatgg cacccatcac
     4741 gggggaaaac ataagaccat ttattagtag gtgtgctgtg tgtgaggcgc ctgccatggt
     4801 gatggccgtg cacagccaga ccattcagat cccaccgtgc cccagcgggt ggtcctcgct
     4861 gtggatcggc tactcttttg tgatgcacac cagcgctggt gcagaaggct ctggccaagc
     4921 cctggcgtcc cccggctcct gcctggagga gtttagaagt gcgccattca tcgagtgtca
     4981 cggccgtggg acctgcaatt actacgcaaa cgcttacagc ttttggctcg ccaccataga
     5041 gaggagcgag atgttcaaga agcctacgcc gtccaccttg aaggcagggg agctgcgcac
     5101 gcacgtcagc cgctgccaag tctgtatgag aagaacataa tgaagcctga ctcagctaat
     5161 gtcacaacat ggtgctactt cttcttcttt ttgttaacag caacgaaccc tagaaatata
     5221 tcctgtgtac ctcactgtcc aatatgaaaa ccgtaaagtg ccttatagga atttgcgtaa
     5281 ctaacacacc ctgcttcatt gacctctact tgctgaagga gaaaaagaca gcgataagct
     5341 ttcaatagtg gcataccaaa tggcactttt gatgaaataa aatatcaata ttttctgcaa
     5401 tccaatgcac tgatgtgtga agtgagaact ccatcagaaa accaaagggt gctaggaggt
     5461 gtgggtgcct tccatactgt ttgcccattt tcattcttgt attataatta attttctacc
     5521 cccagagata aatgtttgtt tatatcactg tctagctgtt tcaaaattta ggtcccttgg
     5581 tctgtacaaa taatagcaat gtaaaaatgg ttttttgaac ctccaaatgg aattacagac
     5641 tcagtagcca tatcttccaa ccccccagta taaatttctg tctttctgct atgtgtggta
     5701 ctttgcagct gcttttgcag aaatcacaat tttcctgtgg aataaagatg gtccaaaaat
     5761 agtcaaaaat taaatatata tatatattag taatttatat agatgtcagc aattaggcag
     5821 atcaaggttt agtttaactt ccactgttaa aataaagctt acatagtttt cttcctttga
     5881 aagactgtgc tgtcctttaa cataggtttt taaagactag gatattgaat gtgaaacatc
     5941 cgttttcatt gttcacttct aaaccaaaaa ttatgtgttg ccaaaaccaa acccaggttc
     6001 atgaatatgg tgtctattat agtgaaacat gtactttgag cttattgttt ttattctgta
     6061 ttaaatattt tcagggtttt aaacactaat cacaaactga atgacttgac ttcaaaagca
     6121 acaaccttaa aggccgtcat ttcattagta ttcctcattc tgcatcctgg cttgaaaaac
     6181 agctctgttg aatcacagta tcagtatttt cacacgtaag cacattcggg ccatttccgt
     6241 ggtttctcat gagctgtgtt cacagacctc agcagggcat cgcatggacc gcaggagggc
     6301 agattcggac cactaggcct gaaatgacat ttcactaaaa gtctccaaaa catttctaag
     6361 actactaagg ccttttatgt aatttcttta aatgtgtatt tcttaagaat tcaaatttgt
     6421 aataaaacta tttgtataaa aattaagctt ttattaattt gttgctagta ttgccacaga
     6481 cgcattaaaa gaaacttact gcacaagctg ctaataaatt tgtaagcttt gcatacctta
//
