LOCUS       NM_001037763            4297 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens collagen type XXVIII alpha 1 chain (COL28A1), mRNA.
ACCESSION   NM_001037763 XM_295195
VERSION     NM_001037763.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Li,L., Ye,H., Chen,Q. and Wei,L.
  TITLE     COL28 promotes proliferation, migration, and EMT of renal tubular
            epithelial cells
  JOURNAL   Ren Fail 45 (1), 2187236 (2023)
   PUBMED   36883360
  REMARK    GeneRIF: COL28 promotes proliferation, migration, and EMT of renal
            tubular epithelial cells.
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 4297)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4297)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   6  (bases 1 to 4297)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   7  (bases 1 to 4297)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 4297)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4297)
  AUTHORS   Veit,G., Kobbe,B., Keene,D.R., Paulsson,M., Koch,M. and Wagener,R.
  TITLE     Collagen XXVIII, a novel von Willebrand factor A domain-containing
            protein with many imperfections in the collagenous domain
  JOURNAL   J Biol Chem 281 (6), 3494-3504 (2006)
   PUBMED   16330543
  REMARK    GeneRIF: Collagen XXVIII is a novel von Willebrand factor A
            domain-containing protein with many imperfections in the
            collagenous domain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004982.1, AJ890451.1 and AC006356.3.
            
            On May 17, 2019 this sequence version replaced NM_001037763.2.
            
            Summary: COL28A1 belongs to a class of collagens containing von
            Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et
            al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ890451.1, BC136892.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399429.8/ ENSP00000382356.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC004982.1         49136-49179         c
            45-726              AJ890451.1         1-682
            727-727             AC004982.1         44769-44769         c
            728-3559            AJ890451.1         684-3515
            3560-4297           AC006356.3         56620-57357         c
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..4297
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /note="collagen type XXVIII alpha 1 chain"
                     /db_xref="GeneID:340267"
                     /db_xref="HGNC:HGNC:22442"
                     /db_xref="MIM:609996"
     exon            1..124
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            125..285
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3539
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /note="collagen alpha-1(XXVIII) chain; collagen, type
                     XXVIII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XXVIII) chain precursor"
                     /protein_id="NP_001032852.2"
                     /db_xref="CCDS:CCDS43553.1"
                     /db_xref="GeneID:340267"
                     /db_xref="HGNC:HGNC:22442"
                     /db_xref="MIM:609996"
                     /translation="MWNRYFVFYLLLLSAFTSQTVSGQRKKGPKSNLLARKSDVQGSI
                     CFIDIVFIVDSSESSKIALFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLAALQFSSSV
                     QIDPPFSSWKDLQTFKQKVKSMNLIGQGTFSYYAISNATRLLKREGRKDGVKVVLLMT
                     DGIDHPKNPDVQSISEDARISGISFITIALSTVVNEAKLRLISGDSSSEPTLLLSDPT
                     LVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGNAQK
                     GEAGERGPGGIPGYKGDKGERGECGKPGIKGDKGSPGPYGPKGPRGIQGITGPPGDPG
                     PKGFQGNKGEPGPPGPYGSPGAPGIGQQGIKGERGQEGRPGAPGPIGVGEPGQPGPRG
                     PEGVPGERGLPGEGFPGPKGEKGSEGPTGPQGLQGLSIKGEKGDIGPVGPQGPMGIPG
                     IGSQGEQGIQGPIGPPGPQGPAGQGLPGSKGEVGQMGPTGPRGPVGIGVQGPKGEPGS
                     IGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGPKGDEGKKGSKGNQGQRG
                     LPGPEGPKGEPGIMGPFGMPGTSIPGPPGPKGDRGGPGIPGFKGEPGLSIRGPKGVQG
                     PRGPVGAPGLKGDGYPGVPGPRGLPGPPGPMGLRGVGDTGAKGEPGVRGPPGPSGPRG
                     VGTQGPKGDTGQKGLPGPPGPPGYGSQGIKGEQGPQGFPGPKGTMGHGLPGQKGEHGE
                     RGDVGKKGDKGEIGEPGSPGKQGLQGPKGDLGLTKEEIIKLITEICGCGPKCKETPLE
                     LVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATARIGIINYSHKVEKVANLKQFS
                     SKDDFKLAVDNMQYLGEGTYTATALQAANDMFEDARPGVKKVALVITDGQTDSRDKEK
                     LTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNLIATDPEHVYQFDDFFTLQDTL
                     KQKLFQKICEDFDSYLVQIFGSSSPQPGFGMSGEELSESTPEPQKEISESLSVTRDQD
                     EDDKAPEPTWADDLPATTSSEATTTPRPLLSTPVDGAEDPRCLEALKPGNCGEYVVRW
                     YYDKQVNSCARFWFSGCNGSGNRFNSEKECQETCIQG"
     exon            286..842
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            843..863
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..920
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            921..974
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1016
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1043
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1088
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1133
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1187
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1256
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1325
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1394
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1463
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1532
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1601
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1670
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1742
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1811
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1883
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1952
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2021
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2090
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2159
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2228
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2297
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2366
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2447
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2483
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2520
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..3069
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3227
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3366
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..4297
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /note="hexamer: AACAAA"
     polyA_site      4236
                     /gene="COL28A1"
                     /gene_synonym="COL28"
                     /note="major polyA site"
ORIGIN      
        1 aaagacactt ttatttccca cagaacagaa caatatcaaa tagctaactt cacccccaac
       61 cacagtcctt gctgttggca tttactcaac tagtctttaa ttcctgtttg acaaacttta
      121 taaggtgcta caagacagat gatttttcac catctaccat aatgtggaac agatattttg
      181 tcttctatct cctgcttttg tcagcgttta cgagtcaaac agtatccgga caaagaaaga
      241 aaggaccaaa atcaaatttg cttgcaagga aaagtgatgt ccagggctcc atttgtttca
      301 tagatattgt cttcatcgtg gacagctctg aaagttctaa aattgccctc tttgataaac
      361 agaaagattt tgtggatagc ttgagtgaca agattttcca attgactcct ggtcgctcct
      421 tggaatatga catcaaactg gcagcccttc agtttagcag ctctgtccaa attgatccac
      481 ctttttcttc ctggaaggac ctgcagacat ttaagcagaa ggtcaagtct atgaatttaa
      541 tagggcaagg taccttctct tattatgcca tttccaatgc cactaggcta cttaagagag
      601 aagggcgtaa ggatggtgtg aaagtggttt tgctgatgac tgatggcatc gaccatccaa
      661 agaatccaga tgttcaaagt atttctgaag atgccagaat ttcaggaata tcatttatca
      721 ccattgcact ttctacggta gtcaatgaag ccaaacttcg tttgatttct ggggattcat
      781 ccagtgaacc cactttactg ttgagtgatc caacccttgt agataaaatt caagatcgtc
      841 tggatatctt atttgaaaag aagtgtgaac gcaagatttg tgaatgtgag aagggagatc
      901 caggtgatcc agggcctcct ggtacacatg gaaatccagg tatcaaaggt gagcgaggac
      961 caaaaggaaa cccgggcaac gctcaaaaag gagaagctgg agaaagaggt ccagggggaa
     1021 ttcctgggta caagggtgac aagggtgaac gtggggaatg tggtaaacca gggataaaag
     1081 gtgacaaggg atccccaggg ccatatggac caaagggacc cagaggaatt cagggaatta
     1141 ctggacctcc aggagaccca ggcccaaagg ggtttcaagg caataagggt gagccaggtc
     1201 ctcctggtcc ttatggttct ccaggagctc ctggaattgg acagcaaggt attaagggag
     1261 aaagaggcca agaaggaaga ccgggagctc caggacccat tggagttggt gagcctggac
     1321 agccaggtcc ccgtggtcct gagggagtac caggagagag gggcttaccc ggagaaggat
     1381 ttccaggacc aaagggtgaa aaaggttctg aaggaccaac tggcccacag ggattacaag
     1441 gcctgtcaat caaaggggag aagggggata taggacctgt gggaccccaa ggaccaatgg
     1501 gtatccctgg aatcgggagt caaggggaac agggaatcca aggtcctatt ggtccacctg
     1561 gtccacaagg gcccgcagga cagggcttac ctggttccaa gggagaagta ggccaaatgg
     1621 gacctacagg ccctcgagga ccagtgggaa ttggagtaca aggtccaaag ggagagccag
     1681 gctcaatagg gctcccagga caaccaggag taccaggaga agatggagct gcagggaaga
     1741 agggagaagc ggggcttccg ggagcaagag gcccagaagg accacctgga aaaggacagc
     1801 ctggccccaa gggtgacgaa ggcaagaaag ggagcaaagg aaatcaagga cagaggggac
     1861 ttccagggcc cgaaggacca aagggtgaac cgggcattat gggccctttt ggaatgcctg
     1921 gaacatcaat tcctggacca cctgggccaa agggagatag aggaggacct gggatacctg
     1981 gatttaaggg agaacctgga ctttctattc gaggaccaaa gggtgtccaa ggccctcggg
     2041 gaccagtggg tgctccagga ctcaaaggtg atggctatcc tggtgtgcct ggacctcgtg
     2101 gattaccagg accccctggg ccgatgggtt tacgtggagt gggagacact ggagcaaagg
     2161 gagagcctgg ggtcagaggc cctccaggtc cttctgggcc tcggggcgta ggaacccaag
     2221 ggccaaaggg tgatactggg cagaaaggct tgcctggccc tcctggcccc cctggctatg
     2281 gatcacaggg aattaaaggg gaacaaggac cacaaggctt cccaggccca aagggcacaa
     2341 tgggccatgg cctcccaggc cagaagggag agcacggaga acggggcgat gtgggaaaga
     2401 aaggtgataa aggagaaatt ggagagcctg gatctccagg aaaacagggt ttacaaggac
     2461 ccaaaggaga cctaggactt acaaaagaag aaattatcaa acttattaca gaaatatgtg
     2521 gttgtgggcc caaatgcaaa gagactccac tagagctggt gtttgtgatc gacagctcag
     2581 aaagcgtggg gccagagaac tttcagatca ttaaaaattt tgtgaagact atggctgacc
     2641 gggttgctct ggaccttgcc acggcccgca taggcataat caactatagc cataaggtgg
     2701 agaaggtggc taatttgaag cagttctcca gcaaggatga cttcaagttg gctgtggaca
     2761 acatgcagta tctgggggaa ggcacataca cagccactgc tctgcaagca gccaacgaca
     2821 tgtttgaaga tgcaaggcca ggtgtaaaaa aagtggcctt ggtcatcact gatggacaga
     2881 cagattctcg tgataaagag aaactgacag aggtggtgaa gaatgccagt gacaccaatg
     2941 tggagatatt tgtgataggg gtggtgaaga aaaatgatcc caactttgaa atattccaca
     3001 aagaaatgaa tctaattgct actgacccag agcatgttta ccagtttgat gatttcttta
     3061 ccctgcaaga caccctgaag caaaaattgt ttcaaaaaat ttgtgaggat tttgattcct
     3121 atctcgttca aatttttggt tcatcgtcac ctcaacctgg atttgggatg tcaggggaag
     3181 aactcagtga atctactcca gagcctcaaa aagaaatttc tgagtcattg agtgtcacca
     3241 gagaccagga tgaagatgat aaggctccag agccaacgtg ggctgatgat ctgcctgcca
     3301 ctacctcatc tgaggccacc accaccccca ggccactgct cagcacccct gtggatgggg
     3361 cagaggatcc tagatgtttg gaagccttga agcctggaaa ctgtggtgaa tatgtggttc
     3421 gatggtatta tgacaaacag gtcaactctt gtgcccgatt ttggttcagt ggctgtaatg
     3481 gctcaggaaa tagattcaac agtgaaaagg aatgtcaaga aacctgcatt caaggatgag
     3541 caagtaaatt ggcctgtctc tatcaaaagc atagaactcc ctaatttcca catattcacc
     3601 caatacaaat acagcactat atttgagtgt atactgagta tttacaactt atacatgtaa
     3661 ttgaattctc actacagccc taggatgtac atattattaa ccacttatat aggtaagaaa
     3721 gctgaggctc tgagaagttt agtaacttgt caactgtcac ccaactaaaa agtttcagag
     3781 ctgaggattt agacttagag ctgtgtaact tcaatacaca gactctatct acttcacaac
     3841 ctgcaatgtg attctgattc ctttaattcc tgttgtatgt actatgtcag ctcaaacccc
     3901 tacccctgtc cctgcccata cctccaccca ctcacctccc taacctcctt atgtccctcg
     3961 cagtagcaag atgtaggtga taggaaggac ttcggtgtga gaattagaaa tgatgtaaat
     4021 gtttacgcag gagtgctggg ataggagtcg ggatggtgag ggtagttaga tttttgcctc
     4081 acttgccctg aaagtggtaa tagggagaaa ccaatctgaa ttacaattac ttaaatgtat
     4141 cacagactgt cactttgtat tcctccaaca tgtttggtaa caagtgttta atgtatgtta
     4201 aaacaaagaa ggtttttata cccttccatt aaaatatgtc agtgggccct tccattttat
     4261 ggagtggaat gggaaggccc ttgacagcca ggaacca
//
