LOCUS       NM_032888               7813 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens collagen type XXVII alpha 1 chain (COL27A1), mRNA.
ACCESSION   NM_032888
VERSION     NM_032888.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7813)
  AUTHORS   Satoh,C., Kondoh,T., Shimizu,H., Kinoshita,A., Mishima,H.,
            Nishimura,G., Miyazaki,M., Okano,K., Kumai,Y. and Yoshiura,K.I.
  TITLE     Brothers with novel compound heterozygous mutations in COL27A1
            causing dental and genital abnormalities
  JOURNAL   Eur J Med Genet 64 (2), 104125 (2021)
   PUBMED   33359165
  REMARK    GeneRIF: Brothers with novel compound heterozygous mutations in
            COL27A1 causing dental and genital abnormalities.
REFERENCE   2  (bases 1 to 7813)
  AUTHORS   Gonzaga-Jauregui,C., Yesil,G., Nistala,H., Gezdirici,A., Bayram,Y.,
            Nannuru,K.C., Pehlivan,D., Yuan,B., Jimenez,J., Sahin,Y.,
            Paine,I.S., Akdemir,Z.C., Rajamani,S., Staples,J., Dronzek,J.,
            Howell,K., Fatih,J.M., Smaldone,S., Schlesinger,A.E., Ramirez,N.,
            Cornier,A.S., Kelly,M.A., Haber,R., Chim,S.M., Nieman,K., Wu,N.,
            Walls,J., Poueymirou,W., Siao,C.J., Sutton,V.R., Williams,M.S.,
            Posey,J.E., Gibbs,R.A., Carlo,S., Tegay,D.H., Economides,A.N. and
            Lupski,J.R.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genetics, Regeneron Genetics
            Center
  TITLE     Functional biology of the Steel syndrome founder allele and
            evidence for clan genomics derivation of COL27A1 pathogenic alleles
            worldwide
  JOURNAL   Eur J Hum Genet 28 (9), 1243-1264 (2020)
   PUBMED   32376988
  REMARK    GeneRIF: Functional biology of the Steel syndrome founder allele
            and evidence for clan genomics derivation of COL27A1 pathogenic
            alleles worldwide.
REFERENCE   3  (bases 1 to 7813)
  AUTHORS   Evie,Kritioti., Athina,Theodosiou., Nayia,Nicolaou.,
            Angelos,Alexandrou., Ioannis,Papaevripidou., Elisavet,Efstathiou.,
            Violetta,Christophidou.-Anastasiadou., Carolina,Sismani. and
            Tanteles,G.A.
  TITLE     First reported case of Steel syndrome in the European population: A
            novel homozygous mutation in COL27A1 and review of the literature
  JOURNAL   Eur J Med Genet 63 (7), 103939 (2020)
   PUBMED   32360765
  REMARK    GeneRIF: First reported case of Steel syndrome in the European
            population: A novel homozygous mutation in COL27A1 and review of
            the literature.
            Review article
REFERENCE   4  (bases 1 to 7813)
  AUTHORS   Amlie-Wolf,L., Moyer-Harasink,S., Carr,A.M., Giampietro,P.,
            Schneider,A. and Simon,M.
  TITLE     Three new patients with Steel syndrome and a Puerto Rican specific
            COL27A1 mutation
  JOURNAL   Am J Med Genet A 182 (4), 798-803 (2020)
   PUBMED   31903681
  REMARK    GeneRIF: Three new patients with Steel syndrome and a Puerto Rican
            specific COL27A1 mutation.
REFERENCE   5  (bases 1 to 7813)
  AUTHORS   Meng,W., Adams,M.J., Palmer,C.N.A., Shi,J., Auton,A., Ryan,K.A.,
            Jordan,J.M., Mitchell,B.D., Jackson,R.D., Yau,M.S., McIntosh,A.M.
            and Smith,B.H.
  CONSRTM   23andMe Research Team
  TITLE     Genome-wide association study of knee pain identifies associations
            with GDF5 and COL27A1 in UK Biobank
  JOURNAL   Commun Biol 2, 321 (2019)
   PUBMED   31482140
  REMARK    GeneRIF: two loci in or near GDF5 and COL27A1 that are associated
            with knee pain, were identified.
            Erratum:[Commun Biol. 2020 Mar 26;3(1):149. doi:
            10.1038/s42003-020-0880-x.. PMID: 32218487]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7813)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7813)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   8  (bases 1 to 7813)
  AUTHORS   Jenkins,E., Moss,J.B., Pace,J.M. and Bridgewater,L.C.
  TITLE     The new collagen gene COL27A1 contains SOX9-responsive enhancer
            elements
  JOURNAL   Matrix Biol 24 (3), 177-184 (2005)
   PUBMED   15922909
  REMARK    GeneRIF: SOX9 may play an important role in the transcriptional
            activation of the newest collagen gene, COL27A1.
REFERENCE   9  (bases 1 to 7813)
  AUTHORS   Boot-Handford,R.P., Tuckwell,D.S., Plumb,D.A., Rock,C.F. and
            Poulsom,R.
  TITLE     A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a
            unique expression pattern and unusual molecular characteristics
            establishes a new clade within the vertebrate fibrillar collagen
            family
  JOURNAL   J Biol Chem 278 (33), 31067-31077 (2003)
   PUBMED   12766169
  REMARK    GeneRIF: type XXVII collagen has unusual molecular features such as
            no minor helical domain, a major helical domain that is short and
            interrupted, and a short chain selection sequence within the NC1
            domain
REFERENCE   10 (bases 1 to 7813)
  AUTHORS   Pace,J.M., Corrado,M., Missero,C. and Byers,P.H.
  TITLE     Identification, characterization and expression analysis of a new
            fibrillar collagen gene, COL27A1
  JOURNAL   Matrix Biol 22 (1), 3-14 (2003)
   PUBMED   12714037
  REMARK    GeneRIF: molecular cloning
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445543.20, BU076480.1,
            BC035728.1, AY149237.1, AL356796.16 and AI808820.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032888.3.
            
            Summary: This gene encodes a member of the fibrillar collagen
            family, and plays a role during the calcification of cartilage and
            the transition of cartilage to bone. The encoded protein product is
            a preproprotein. It includes an N-terminal signal peptide, which is
            followed by an N-terminal propetide, mature peptide and a
            C-terminal propeptide. The N-terminal propeptide contains
            thrombospondin N-terminal-like and laminin G-like domains. The
            mature peptide is a major triple-helical region. The C-terminal
            propeptide, also known as COLFI domain, plays crucial roles in
            tissue growth and repair. Mutations in this gene cause Steel
            syndrome. Alternatively spliced transcript variants have been
            found, but the full-length nature of some variants has not been
            determined. [provided by RefSeq, Sep 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY149237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356083.8/ ENSP00000348385.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL445543.20        25945-25952
            9-23                BU076480.1         1-15
            24-414              BC035728.1         1-391
            415-5997            AY149237.1         1-5583
            5998-7789           AL356796.16        40877-42668
            7790-7813           AI808820.1         14-37               c
FEATURES             Location/Qualifiers
     source          1..7813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7813
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /note="collagen type XXVII alpha 1 chain"
                     /db_xref="GeneID:85301"
                     /db_xref="HGNC:HGNC:22986"
                     /db_xref="MIM:608461"
     exon            1..476
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..5997
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /note="collagen alpha-1(XXVII) chain; collagen, type
                     XXVII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XXVII) chain preproprotein"
                     /protein_id="NP_116277.2"
                     /db_xref="CCDS:CCDS6802.1"
                     /db_xref="GeneID:85301"
                     /db_xref="HGNC:HGNC:22986"
                     /db_xref="MIM:608461"
                     /translation="MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPE
                     DVDILQRLGLSWTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVIPAALGTELALVL
                     SLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLA
                     LELRGRTVTLVTACGQRRVPVLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSI
                     YPVTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLENLTTAT
                     PALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALD
                     PMLPASVGGSTRTPRPAAAQPSQKITATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTA
                     PSSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSS
                     KKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMV
                     PPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSEASKKAGPKSSPRKPVPLRPGKAARDV
                     PLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLM
                     GPPGPKGDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSP
                     GKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGR
                     QGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGER
                     GPPGLDGNPGELGLPGPPGVPGLIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLKGDKG
                     EQGVPGVSGDPGFQGDKGSQGLPGFPGARGKPGPLGKVGDKGSIGFPGPPGPEGFPGD
                     IGPPGDNGPEGMKGKPGARGLPGPRGQLGPEGDEGPMGPPGAPGLEGQPGRKGFPGRP
                     GLDGVKGEPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPPGVPGPKGSMG
                     HPGMPGGMGTPGEPGPQGPPGSRGPPGMRGAKGRRGPRGPDGPAGEQGSRGLKGPPGP
                     QGRPGRPGQQGVAGERGHLGSRGFPGIPGPSGPPGTKGLPGEPGPQGPQGPIGPPGEM
                     GPKGPPGAVGEPGLPGEAGMKGDLGPLGTPGEQGLIGQRGEPGLEGDSGPMGPDGLKG
                     DRGDPGPDGEHGEKGQEGLMGEDGPPGPPGVTGVRGPEGKSGKQGEKGRTGAKGAKGY
                     QGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKGIVGPL
                     GPPGPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGKP
                     GQQGQPGHPGPRGWPGPKGSKGAEGPKGKQGKAGAPGRRGVQGLQGLPGPRGVVGRQG
                     LEGIAGPDGLPGRDGQAGQQGEQGDDGDPGPMGPAGKRGNPGVAGLPGAQGPPGFKGE
                     SGLPGQLGPPGKRGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPGMAGLFGPKGPPGDI
                     GFKGIQGPRGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGSRGDWGLQGPRGPPGPRG
                     RPGPPGPPGGPIQLQQDDLGAAFQTWMDTSGALRPESYSYPDRLVLDQGGEIFKTLHY
                     LSNLIQSIKTPLGTKENPARVCRDLMDCEQKMVDGTYWVDPNLGCSSDTIEVSCNFTH
                     GGQTCLKPITASKVEFAISRVQMNFLHLLSSEVTQHITIHCLNMTVWQEGTGQTPAKQ
                     AVRFRAWNGQIFEAGGQFRPEVSMDGCKVQDGRWHQTLFTFRTQDPQQLPIISVDNLP
                     PASSGKQYRLEVGPACFL"
     exon            477..547
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            548..2322
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2376
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2430
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2484
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2538
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2583
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2637
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2682
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2736
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2781
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2835
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2880
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2934
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..2979
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3033
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3087
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3141
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3195
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3249
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3294
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3348
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3393
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3447
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3501
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3555
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3609
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3663
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3708
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3753
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3807
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3861
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3915
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..3969
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4023
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4131
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4185
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4293
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..4347
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4401
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4458
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4512
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4566
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4567..4620
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4621..4674
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4782
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4890
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..4998
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5052
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5115
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5169
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5205
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5206..5223
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5259
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5260..5286
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5287..5352
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5353..5521
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5522..5631
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5850
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..7813
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7785..7790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /note="hexamer: AATAAA"
     polyA_site      7813
                     /gene="COL27A1"
                     /gene_synonym="STLS"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcctc tcctccccca ggccggcggg gaggcagctt ccaccgccct ccgcgcgccc
       61 tcacccggcc ttgctctgcc tccggggacc gccagcagcc cgcctccaaa agtttgatca
      121 tctctctctc tctttttctt gcttcttctt cctttttggt ggaagcagaa aaggaccgag
      181 gcaggggcga gcgcggcgcc cggactcctg ggaccatggg cctggcgcgg gcgcccgcgg
      241 ggccccagcc gcgctgcctg cctgctcggg cgcccctggg cgcggggctg cgctgggggc
      301 gcgggggccg cgcgctctaa gccggcctgg cgcggcgggg cggggggctg gcggccccat
      361 ggggcgcgcc cacacttgcc ccccgggctc gggagcatga agtaggggcc tgccatggga
      421 gcgggatcgg cgcggggggc ccgaggcaca gcggcggcgg cggcggcgcg cggggggggg
      481 tttctcttct cctggatctt agtctcgttt gcctgtcacc tggcctccac ccaaggagct
      541 cctgaagatg tggacatcct ccagcggctg ggcctcagct ggacgaaggc cgggagccct
      601 gcacccccgg gagtcattcc tttccagtcg ggcttcatct ttacgcagcg ggcccggctc
      661 caggctccca cgggcaccgt cattcctgcc gccttgggca cagagctggc actggtgctg
      721 agcctctgct cccaccgggt gaaccatgcc ttcctcttcg ctgtccgcag ccagaaacgc
      781 aagctgcagc tgggcctgca gttcctcccc ggcaagacgg tcgtccacct cgggtcccgg
      841 cgctcagtgg ccttcgacct cgacatgcac gacgggcgct ggcaccacct ggccctcgag
      901 ctccgaggcc gcacagtcac tctggtgact gcctgcgggc agcgccgggt gcctgtcctg
      961 ctgcctttcc acagggaccc tgcactcgac cctgggggct ccttcctctt tgggaagatg
     1021 aacccgcatg cagtccagtt tgaaggtgct ctctgccagt tcagtatcta ccctgtgacg
     1081 caggtcgctc acaattactg tacccacctg aggaagcagt gtggacaggc tgacacgtac
     1141 cagtccccac tgggacctct cttctcccaa gactctggca gaccttttac cttccagtcc
     1201 gacctcgccc tgctaggcct ggagaacttg accactgcca caccagccct ggggtcactg
     1261 ccagcaggca ggggacccag ggggactgtg gcacccgcca cgcccaccaa gccccaaagg
     1321 actagcccca caaaccctca ccagcatatg gcggtgggag gcccagccca aaccccgctg
     1381 ctacctgcca agctgtcagc cagtaacgca cttgatccca tgctcccagc ctctgttggc
     1441 ggctctacca gaacgcctcg ccctgcggcc gctcaaccat cacagaagat cacagccacc
     1501 aaaatcccca aaagcctccc taccaagcct tcggcccctt ctacttcaat tgtgcccatc
     1561 aaaagccccc atcctaccca gaaaacagct ccatcttcat ttacaaagtc agccctaccc
     1621 actcagaagc aagtgccacc tacttcccgt ccagttcctg ccagagtctc ccgtcccgca
     1681 gagaagccca tccagaggaa cccgggaatg cccaggcccc caccgcccag cacccggccc
     1741 ctacctccta ccaccagctc ctctaaaaaa cccattccca cactagctcg gactgaggcc
     1801 aagataacca gccatgccag taagccggcc tctgcccgca ccagcaccca caaacctccc
     1861 ccatttactg ctttatcctc atctcctgcc cctactcctg gttctaccag gagtactcgg
     1921 ccaccagcca cgatggtacc tccaacttcg ggcaccagca ctcccagaac agcacctgcc
     1981 gtccccactc ctggctcagc tcccactgga agcaagaagc ccattggatc ggaagcctca
     2041 aagaaagccg gacccaagag cagcccccgg aagcctgtcc ccctcagacc tgggaaggca
     2101 gccagggatg tccccttgag cgatctgaca accaggccta gccccagaca gccccagccc
     2161 agtcagcaga ccaccccggc cctggtattg gccccggcgc aattcctgtc ctccagcccc
     2221 cggcccacga gcagtggcta ttcgatcttc cacctggcag gatctacgcc tttccctctg
     2281 ctgatggggc ctccgggacc caagggagac tgtggcttgc cgggtccccc tgggctacct
     2341 gggctacctg gaatccctgg tgcacgtggg cctcggggtc ctcctgggcc ttatggaaat
     2401 ccaggtctcc ccggccctcc tggagccaaa ggacagaaag gggacccagg gctctcacca
     2461 ggaaaggccc acgatggggc aaagggtgac atgggcttgc ctgggctctc cgggaatcca
     2521 ggacctccgg gacgaaaggg acacaagggc tatcctggac cggcagggca ccccggagaa
     2581 caggggcagc caggacctga gggcagccca ggggccaaag gttaccctgg caggcagggg
     2641 ttacctggac cggtaggaga tcccggcccc aaaggcagca ggggctacat tgggctccca
     2701 gggctcttcg gcctgccagg gtctgatgga gaacgaggcc tgcctggcgt tcctggcaag
     2761 aggggcaaga tgggtatgcc ggggtttcct ggagtctttg gggaaagagg ccctcctgga
     2821 ctggatggaa atcctggaga actgggcctg ccaggccccc ctggagtccc cggcctcatt
     2881 ggtgacttag gagtgttggg tccgattggc tacccgggac ccaagggcat gaagggactg
     2941 atgggcagcg tgggggagcc cggactgaaa ggtgataagg gtgaacaagg ggttccaggt
     3001 gtgtcaggag atcccggatt ccaaggagac aaggggagcc aggggttgcc agggttcccc
     3061 ggtgcacggg ggaagccagg gcctctgggc aaagtcggag acaaaggatc cattgggttt
     3121 cccgggcccc ctggacccga gggattccca ggagacatcg gcccccctgg cgacaatggc
     3181 ccagaaggca tgaagggtaa gcctggagcc cgaggcctgc cgggaccccg tgggcagctg
     3241 gggcccgagg gagatgaggg acccatgggg ccgccagggg cccctggctt ggagggtcag
     3301 cctggcagga aggggtttcc tgggaggccc ggcctggatg gcgtgaaggg ggaaccaggg
     3361 gatcctggtc ggccggggcc tgtgggagag cagggattta tgggattcat tggtctggtc
     3421 ggggagccag gaatcgtggg agaaaagggt gatcgtggca tgatgggacc cccaggcgtg
     3481 cctggaccca aggggtcgat gggtcatcct ggaatgccag gtggtatggg gacccctgga
     3541 gagcctggac cccagggtcc tccaggatct cgaggcccac caggcatgag gggagcaaag
     3601 ggacgtcggg gcccccgagg accggacgga ccagctgggg agcaagggtc caggggcctg
     3661 aagggccctc caggacccca gggcagaccg ggccggcctg gacagcaggg tgtggctggt
     3721 gagcgaggcc acttgggctc gagaggcttt cctggcatcc cgggtccctc aggcccccca
     3781 ggcaccaagg gcctcccagg agaaccgggc cctcagggac cccaggggcc aattgggcct
     3841 ccaggagaga tgggacccaa ggggccgcct ggtgcagtgg gagaaccggg ccttcctggg
     3901 gaagccggga tgaagggtga ccttggaccc ctgggcactc ctggggagca gggcctcatt
     3961 gggcaacggg gagagccagg ccttgagggt gacagtggcc ccatgggacc tgatgggctg
     4021 aagggggaca ggggagaccc agggcctgat ggagaacatg gcgagaaagg ccaggaaggg
     4081 ctgatgggtg aggacgggcc ccccggcccc cctggcgtca ctggtgtccg gggtcctgaa
     4141 ggaaaatcag ggaagcaagg cgagaagggc cgcactggag ccaagggtgc caagggctat
     4201 caaggacagc tgggtgagat gggcgtccct ggagaccctg gaccccctgg cactccaggc
     4261 cctaaagggt cccggggcag cctgggacca acgggtgctc cgggacgcat gggggcccaa
     4321 ggagaaccgg gactggctgg ttatgatgga cacaaaggca ttgtgggacc ccttggacct
     4381 cctggaccaa aaggcgaaaa gggggagcag ggcgaggacg gcaaggctga ggggccccct
     4441 gggccacctg gagatcgggg ccctgtgggt gatcgaggag accgcgggga accgggagac
     4501 cctgggtacc ctggacagga gggtgtgcaa ggcctccgtg gaaagccagg ccagcagggc
     4561 caacccgggc atccgggacc ccgggggtgg ccgggaccca aaggatcgaa aggcgcagag
     4621 ggaccaaagg gaaagcaagg caaggcaggg gccccaggcc ggaggggggt ccagggcctg
     4681 caggggctgc cagggccccg gggcgtggtg gggagacagg gcctcgaggg catcgctgga
     4741 ccagatgggc ttcctggcag ggacgggcaa gcaggacagc agggggagca gggagacgat
     4801 ggggaccctg gccccatggg ccctgctggg aagagaggaa atccaggtgt ggccggctta
     4861 cctggagcac agggaccccc aggattcaag ggtgagagtg ggttacccgg acagctgggt
     4921 ccccctggca agcgaggaac agagggcaga acggggctcc ctggaaacca gggggagcct
     4981 gggtccaaag gccagccggg cgactctggc gagatgggct tcccaggaat ggcaggtctc
     5041 ttcggaccca agggcccgcc tggagacatt ggcttcaaag gcatccaggg ccctcggggg
     5101 ccacctggct tgatgggaaa ggaaggcatc gtcgggcccc tcggaatcct gggaccttcg
     5161 ggactcccgg gtccgaaggg tgacaaaggc agccgtgggg actggggatt gcaaggtccg
     5221 aggggtcctc ccggccccag agggcggccc ggccccccgg gtcctccagg gggtcctatc
     5281 caattgcaac aagatgatct tggggcagct ttccagacgt ggatggacac cagtggagca
     5341 ctcaggccag agagttacag ctatccagac cggctggtgc tggaccaggg aggagagatc
     5401 tttaaaacct tacactacct cagcaacctc atccagagca ttaagacgcc cctgggcacc
     5461 aaagagaacc ccgcccgggt ctgcagggac ctcatggact gtgagcagaa gatggtggat
     5521 ggtacctact gggtggatcc aaaccttggc tgctcctctg acaccatcga ggtctcctgc
     5581 aacttcactc atggtggaca gacgtgtctc aagcccatca cggcctccaa ggtcgagttt
     5641 gccatcagcc gggtccagat gaatttcctg cacctgctaa gctccgaggt gacccagcac
     5701 atcaccatcc actgccttaa catgaccgtg tggcaggagg gcactgggca gaccccagcc
     5761 aagcaggccg tacgcttccg ggcctggaat ggacagattt ttgaagctgg gggtcagttc
     5821 cggcccgagg tgtccatgga tggctgcaag gtccaagatg gccgctggca tcagacactc
     5881 ttcaccttcc ggacccaaga cccccaacag ctgcccatca tcagtgtgga caacctccct
     5941 cctgcctcat cagggaagca gtaccgcctg gaagttggac ctgcgtgctt cctctgacct
     6001 ctgacctcgt ggccactcta ggcctcacgg aggagggaag aggaagaggc aaggggaggg
     6061 tactgagggg cagatggctc caggagaggc agctcccctg cccaagggtc cttgggcaga
     6121 ccccagctgt tgtctgccca gtagaagtgg gtgggggtag gaggggatag ggtgtccttg
     6181 ggaacaatgg atcccagctt agccccaaag accaaccaaa gagccagcca gagtaagctg
     6241 gacctgcaac ctgcctgagc cccgtggcct ctcagctctg cggccacccc gttccctccc
     6301 cagcttcctg cccaaagagc cccacattca agccaacttg agggaagggg gcgtctcgtc
     6361 agctggtccc tgctagggag ctattgatgt gcaatattag aaaggagaca tgaaaaaagg
     6421 agaaaaggaa agacagaagt gtatatatat attatttaaa caaacaaaaa gaaggtgcgt
     6481 tactattttt ttttcacccg ggaaagaggt gagaggatgg gaaggagcag ccaggcgtgg
     6541 gaagcggcga gatcctcggg ctgggggtgc ccacgtttgc tacctcccac tgtgaaatcg
     6601 ctggtgctca caattgtctc tcacagtgta tgtgattttt ttaaggaaaa aaaaaaatcc
     6661 ctatttaaga ttctgaaggt gctaccatta ttttgccaca gactttgaag aaacttttgg
     6721 atgtggggca tcatccgcat ctttctctct cctccaaatg acaaagtttg gggaattttt
     6781 gaattttcct agcatcgccc ttgtgctcat caggtaatct gctaaggagg aaaaaagaaa
     6841 agaaaaaagg aaaaaaaaaa aaaaaaagca aaacaaaaac aaaaacaaaa accctaccag
     6901 aaaccagaag tagagagatt taccatataa cttatggact ttgaaatgtc tgtcctttta
     6961 aggcagcagg gaggcctggg tgcgaagcat gttggcttgg cccttcacgg tcctggaggg
     7021 aggtgaggct ggccttggaa ggcgtgccct ggagaggtct tgggtgaaaa cttgaccttg
     7081 aagaaaccaa tcacaaaagc ggcgttgggt cagggctagg cttagaggtg aagcatcaac
     7141 atggaaccat ctcaggaagc cgcatcgcct cttccgaggt cctcacttcc aggagcctgt
     7201 ccttgcaaga tgcaatcatc gttcctgctt tttcattgtc attaaattct gtagaaaccc
     7261 attgtcatta gctccaagtg taaatttggg tcaaggagac agaataataa tgggaatctc
     7321 ggagttcgac accatagtga cgttcagcgt cctctgaatt gtgctacatc agcgaacaag
     7381 tcggcgcttg aattggattt tgaggttatt ttaaccatgg aattattttt atagaagggg
     7441 aaaatgtatg tgaaagtctc tatttgtgta tttctctcct aaagttgtgt ctctttggga
     7501 attggatttg atttttatta tttaatacct cactttggcc cgtcccccct cccaacactt
     7561 ctgtatcctc gccctgccgc cccagcctgg acgctctgcg tggaagtgcg tgtttgtagc
     7621 agctcgggcc tcatctcagc gctcggatcc ctcctgctgc cagaatccac tggcctctgt
     7681 ctcattcttg ggttttcctg ctgtcttcgt ttacgtctct gtccacatgt cagtgtatta
     7741 aaaccccaat gggttccgtt tctccttttc ccctctggat tttaaataaa tatttaaaac
     7801 tgaggcaatg gaa
//
