LOCUS       NM_152890               6834 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens collagen type XXIV alpha 1 chain (COL24A1), transcript
            variant 1, mRNA.
ACCESSION   NM_152890
VERSION     NM_152890.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6834)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6834)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   3  (bases 1 to 6834)
  AUTHORS   Hong,X., Hao,K., Ji,H., Peng,S., Sherwood,B., Di Narzo,A.,
            Tsai,H.J., Liu,X., Burd,I., Wang,G., Ji,Y., Caruso,D., Mao,G.,
            Bartell,T.R., Zhang,Z., Pearson,C., Heffner,L., Cerda,S.,
            Beaty,T.H., Fallin,M.D., Lee-Parritz,A., Zuckerman,B., Weeks,D.E.
            and Wang,X.
  TITLE     Genome-wide approach identifies a novel gene-maternal pre-pregnancy
            BMI interaction on preterm birth
  JOURNAL   Nat Commun 8, 15608 (2017)
   PUBMED   28598419
  REMARK    GeneRIF: The authors show that maternal COL24A1 variants have a
            significant genome-wide interaction with maternal pre-pregnancy
            overweight/obesity on Preterm birth risk, with rs11161721 (PG x
            E=1.8 x 10(-8); empirical PG x E=1.2 x 10(-8)) as the top hit.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6834)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6834)
  AUTHORS   Matsuo,N., Tanaka,S., Gordon,M.K., Koch,M., Yoshioka,H. and
            Ramirez,F.
  TITLE     CREB-AP1 protein complexes regulate transcription of the collagen
            XXIV gene (Col24a1) in osteoblasts
  JOURNAL   J Biol Chem 281 (9), 5445-5452 (2006)
   PUBMED   16373341
REFERENCE   6  (bases 1 to 6834)
  AUTHORS   Koch,M., Laub,F., Zhou,P., Hahn,R.A., Tanaka,S., Burgeson,R.E.,
            Gerecke,D.R., Ramirez,F. and Gordon,M.K.
  TITLE     Collagen XXIV, a vertebrate fibrillar collagen with structural
            features of invertebrate collagens: selective expression in
            developing cornea and bone
  JOURNAL   J Biol Chem 278 (44), 43236-43244 (2003)
   PUBMED   12874293
  REMARK    GeneRIF: collagen XXIV is an ancient molecule that may contribute
            to the regulation of type I collagen fibrillogenesis at specific
            anatomical locations during fetal development
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445427.23, AL356059.27,
            AC104455.2, AL359971.11 and AC099561.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152890.6.
            
            Summary: This gene is a member of the collagen gene family and is
            thought to regulate type I collagen fibrillogenesis during fetal
            development. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY244357.1, BC113654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146982, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370571.7/ ENSP00000359603.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AL445427.23        8883-9314           c
            433-497             AL356059.27        73079-73143         c
            498-1867            AL356059.27        51805-53174         c
            1868-1921           AL356059.27        42285-42338         c
            1922-1975           AL356059.27        39527-39580         c
            1976-2029           AL356059.27        19227-19280         c
            2030-2083           AL356059.27        16134-16187         c
            2084-2128           AC104455.2         113798-113842       c
            2129-2182           AC104455.2         109204-109257       c
            2183-2227           AC104455.2         108014-108058       c
            2228-2281           AC104455.2         100207-100260       c
            2282-2326           AC104455.2         96908-96952         c
            2327-2380           AC104455.2         83953-84006         c
            2381-2425           AC104455.2         81961-82005         c
            2426-2479           AC104455.2         73037-73090         c
            2480-2524           AC104455.2         72916-72960         c
            2525-2578           AC104455.2         72621-72674         c
            2579-2632           AC104455.2         72323-72376         c
            2633-2686           AC104455.2         67234-67287         c
            2687-2740           AC104455.2         37684-37737         c
            2741-2794           AC104455.2         21423-21476         c
            2795-2839           AC104455.2         20310-20354         c
            2840-2893           AC104455.2         15092-15145         c
            2894-2938           AC104455.2         11332-11376         c
            2939-2992           AL359971.11        53482-53535         c
            2993-3046           AL359971.11        52052-52105         c
            3047-3100           AL359971.11        50700-50753         c
            3101-3154           AL359971.11        49296-49349         c
            3155-3208           AL359971.11        38458-38511         c
            3209-3253           AL359971.11        38123-38167         c
            3254-3298           AL359971.11        37960-38004         c
            3299-3352           AL359971.11        31662-31715         c
            3353-3406           AL359971.11        19224-19277         c
            3407-3460           AL359971.11        17379-17432         c
            3461-3514           AL359971.11        16751-16804         c
            3515-3568           AL359971.11        10884-10937         c
            3569-3676           AL359971.11        10621-10728         c
            3677-3730           AC099561.2         10493-10546
            3731-3838           AC099561.2         12127-12234
            3839-3892           AC099561.2         17506-17559
            3893-3946           AC099561.2         17778-17831
            3947-4003           AC099561.2         18621-18677
            4004-4057           AC099561.2         21261-21314
            4058-4111           AC099561.2         36161-36214
            4112-4165           AC099561.2         36310-36363
            4166-4219           AC099561.2         41812-41865
            4220-4327           AC099561.2         43004-43111
            4328-4435           AC099561.2         73438-73545
            4436-4543           AC099561.2         75533-75640
            4544-4597           AC099561.2         75733-75786
            4598-4660           AC099561.2         76341-76403
            4661-4714           AC099561.2         78626-78679
            4715-4750           AC099561.2         84190-84225
            4751-4786           AC099561.2         98333-98368
            4787-4813           AC099561.2         98477-98503
            4814-4879           AC099561.2         114393-114458
            4880-5048           AC099561.2         115065-115233
            5049-5158           AC099561.2         122394-122503
            5159-5374           AC099561.2         124935-125150
            5375-6834           AC099561.2         129207-130666
FEATURES             Location/Qualifiers
     source          1..6834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..6834
                     /gene="COL24A1"
                     /note="collagen type XXIV alpha 1 chain"
                     /db_xref="GeneID:255631"
                     /db_xref="HGNC:HGNC:20821"
                     /db_xref="MIM:610025"
     exon            1..432
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..5521
                     /gene="COL24A1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagen alpha-1(XXIV) chain; collagen, type
                     XXIV, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XXIV) chain isoform 1
                     precursor"
                     /protein_id="NP_690850.2"
                     /db_xref="CCDS:CCDS41353.1"
                     /db_xref="GeneID:255631"
                     /db_xref="HGNC:HGNC:20821"
                     /db_xref="MIM:610025"
                     /translation="MHLRAHRTRRGKVSPTAKTKSLLHFIVLCVAGVVVHAQEQGIDI
                     LHQLGLGGKDVRHSSPATAVPSASTPLPQGVHLTESGVIFKNDAYIETPFVKILPVNL
                     GQPFTILTGLQSHRVNNAFLFSIRNKNRLQLGVQLLPKKLVVHIRGKQPAVFNYSVHD
                     EQWHSFAITIRNQSVSMFVECGKKYFSTETIPEVQTFDSNSVFTLGSMNNNSIHFEGI
                     VCQLDIIPSAEASADYCRYVKQQCRQADKYQPETSIPCTTLIPTKIPEHSPPPKLFAE
                     KVLSEDTFTEGKSIPNIIKNDSETVYKRQEHQISRSQLSSLQSGNVSAVDLTNHGIQA
                     KEMITEEDTQTNFSLSVTTHRISEAKMNTKEKFSSLLNMSDNITQHDDRVTGLSLFKK
                     MPSILPQIKQDTITNLKKAITANLHTNELMEMQPILNTSLHRVTNEPSVDNHLDLRKE
                     GEFYPDATYPIENSYETELYDYYYYEDLNTMLEMEYLRGPKGDTGPPGPPGPAGIPGP
                     SGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQPVPGEKGDQGLSGLMGPPGMQ
                     GDKGLKGHPGLPGLPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIGSPG
                     EAGQLGPEGERGIPGIRGKKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGL
                     RGSVGPVGPIGPAGIPGPMGLSGNKGLPGIKGDKGEQGTAGELGEPGYPGDKGAVGLP
                     GPPGMRGKSGPSGQTGDPGLQGPSGPPGPEGFPGDIGIPGQNGPEGPKGLLGNRGPPG
                     PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGP
                     VGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGAR
                     GPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQG
                     KPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGD
                     VGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGII
                     GPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKG
                     ARGTRGAVGHLGLMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPG
                     PRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGS
                     EGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIR
                     GGPGRTGLAGAPGPPGVKGSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQG
                     PCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGR
                     EGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIES
                     NTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCE
                     QKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLL
                     SSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQ
                     DGSWHKATFLFHTQEPNQLPVIEVQKLPHLKTERKYYIDSSSVCFL"
     exon            433..497
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1867
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1921
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1975
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2029
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2083
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2128
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2182
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2227
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2281
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2326
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2380
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2425
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2479
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2524
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2578
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2632
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2686
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2740
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2794
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2839
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2893
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2938
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..2992
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3046
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3100
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3154
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3208
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3253
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3298
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3352
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3406
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3460
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3514
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3568
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3676
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3730
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3838
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3892
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..3946
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4003
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4057
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4111
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4165
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4219
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4327
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4435
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4543
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4597
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4660
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4661..4714
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4715..4750
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4751..4786
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4813
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4879
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4880..5048
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5158
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            5159..5374
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..6834
                     /gene="COL24A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6813..6818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL24A1"
                     /note="hexamer: AATAAA"
     polyA_site      6834
                     /gene="COL24A1"
                     /note="major polyA site"
ORIGIN      
        1 actggagtca cagagtcgcc tttgaaccgc aagtgaactt gagtgctgca ctagcagccc
       61 ggctcccgct gccgccggcg ccccgaggcc tcccagtgag gtttacctcc tcgcccgccc
      121 tccccgggga gcgcaaccct gggctcgttc gttaccgagc cagagagcta ggaagcctgt
      181 cctccccttc gggtgctatt tcctacctcc tcccgacttc accccctccc ctcctttttt
      241 tcttgttgcg ggtttgaagc atggttttca tgtgattgtt ttttcccttt ttcatggaca
      301 gtacctgcac cctaagcagt tcagagttgg cttctgtttt ccgttagcgc tttgctgcac
      361 ggacaaatgc atacaaatgc atttaagagc ccacagaaca aggcgtggaa aagtctcccc
      421 cacggcaaaa acgaaatcac ttcttcattt tattgtacta tgtgtggctg gggtggttgt
      481 tcatgcacaa gaacaaggca tagatattct tcatcaacta ggccttggag gcaaagacgt
      541 aagacactca tcaccagcga ctgctgtacc atcagcatct acaccgttac ctcagggggt
      601 ccatttaaca gaatcaggag tcatttttaa aaatgatgct tatatcgaga cacctttcgt
      661 gaaaatttta ccagtcaact tggggcagcc gtttacaata ttaactgggt tacagtcaca
      721 tcgggtgaac aatgcatttc tcttcagcat tagaaataaa aatagactgc aattaggagt
      781 acaattacta cctaaaaaat tagtagtaca cattagagga aagcagcctg cagttttcaa
      841 ctacagtgtt catgatgagc aatggcactc atttgccatt actattagaa accaaagtgt
      901 ctcaatgttt gttgagtgtg gaaagaaata ttttagcaca gagactattc cagaagttca
      961 gacctttgat tctaatagtg tgtttacttt aggaagtatg aataataatt ctatccattt
     1021 tgaaggaata gtatgtcagt tagatattat tccttctgca gaagcatctg cagactactg
     1081 cagatatgtg aaacagcagt gtcgccaagc agacaaatac caacctgaaa caagcattcc
     1141 ttgtacaact ctcataccaa caaagatacc ggaacactct cccccgccca aactatttgc
     1201 tgaaaaagta ctgtcagagg atacatttac tgaaggcaaa agcattccaa atatcataaa
     1261 aaatgattct gaaaccgtgt ataaaagaca agaacaccag atatcaagat ctcagttatc
     1321 ttctcttcag tcaggaaatg tctctgctgt ggatctcaca aaccatggga ttcaggccaa
     1381 agaaatgatc actgaggaag atactcagac aaatttcagc ctgtcagtga ccactcatcg
     1441 catcagtgag gcaaaaatga ataccaaaga gaaatttagc tctctcctaa acatgtctga
     1501 caatatcaca caacatgatg atagagtaac tggtctgtca ctgtttaaga agatgccatc
     1561 tattcttcca caaattaaac aagatacaat tactaatctc aagaaggcta tcacagcaaa
     1621 tctacacact aacgaactca tggaaatgca accaatttta aacacaagct tgcatagagt
     1681 gacaaatgag ccatctgtgg ataatcacct tgatctaagg aaagaaggtg aattttatcc
     1741 tgatgctact tatcccatcg aaaatagcta tgaaactgag ctttatgatt attattatta
     1801 tgaggatcta aatacaatgc ttgaaatgga gtatctgaga gggccaaaag gagacactgg
     1861 acctcccggt ccacctggtc cagcaggtat cccaggtccg tcagggaaga gaggtccacg
     1921 gggcatacca gggccacatg gaaatcctgg tttacctgga ttacctggtc caaagggccc
     1981 caaaggagat ccaggatttt ccccaggtca acctgttcct ggagaaaagg gtgatcaagg
     2041 cctttctgga ttaatgggcc cccctggtat gcaaggtgat aagggtctca aaggacatcc
     2101 tggactccca ggacttccag gtgaacaagg aattccagga tttgctggta atattggttc
     2161 acccggttac cctggcaggc agggtttagc tggaccagaa ggtaatccag gtcctaaagg
     2221 tgcacaaggt tttattggct ctcctggaga agcgggacaa ctgggacctg aaggagaacg
     2281 gggcattcct gggatccgtg gaaagaaggg ttttaagggg agacagggtt ttccaggtga
     2341 ctttggagac agaggccctg ctggtcttga tggcagtcct ggacttgtag gtggcactgg
     2401 tcctccgggg tttcctgggc ttagaggcag tgttggccct gtgggaccaa ttggacctgc
     2461 tggaattcct ggcccaatgg gcctttcagg gaataaagga ctacctggaa tcaaaggtga
     2521 taagggtgaa caaggcacag caggagagct aggagaaccc gggtatcctg gagacaaggg
     2581 tgctgttggt ttaccaggac caccagggat gagaggaaag tcagggcctt caggccaaac
     2641 aggtgaccca ggactccaag gaccatctgg ccctccagga ccagagggtt ttccaggaga
     2701 tattgggatt cctggacaaa acggccctga aggaccaaag ggactccttg gaaatagagg
     2761 acctcctgga cctcctggtc tcaaaggaac tcagggagaa gaaggaccaa ttggagcctt
     2821 tggggaactg gggccaagag gaaaaccagg tcaaaagggg tatgcaggtg aaccaggacc
     2881 agaaggctta aagggagaag taggagatca aggaaatatt ggaaaaattg gtgaaacagg
     2941 acctgttggc ttacctggag aagttgggat gactggaagc attggcgaaa agggagaacg
     3001 tggaagtcca ggcccactag gtccgcaggg agaaaaaggt gttatgggat atccaggtcc
     3061 tcctggggtt ccaggaccta tcggtccatt gggattacct ggtcatgtgg gggcaagagg
     3121 accacctggg agtcaaggtc ctaaaggaca aagaggatca agaggaccag atggtctctt
     3181 aggggaacaa ggtatacaag gtgccaaggg tgaaaaagga gatcaaggaa aaagagggcc
     3241 tcatggtctt attggtaaga ctggaaaccc tggagaaaga ggatttcaag ggaaaccagg
     3301 tttacaggga ttgcctggaa gtacaggtga cagaggactt ccaggagagc caggactgcg
     3361 aggactgcaa ggtgatgttg gacctcctgg agaaatgggc atggagggac ctccaggcac
     3421 tgagggagag tctggtctgc aaggtgaacc aggtgcaaag ggagatgttg gaactgctgg
     3481 cagtgttgga ggaactgggg aaccaggttt acggggtgaa ccaggagctc ctggagaaga
     3541 aggtctccag ggaaaagatg ggttaaaggg agtaccagga ggaaggggac ttcctggaga
     3601 ggatggagaa aaaggagaga tgggcttacc aggaattata ggacccttgg gtagatcagg
     3661 ccaaacaggc cttccgggac ctgaaggaat tgtgggaatt ccagggcaaa gaggtcgtcc
     3721 aggaaaaaag ggtgataaag gacaaatagg acccacagga gaagttggaa gcagaggtcc
     3781 tcctggaaaa attgggaaaa gtggtcctaa gggtgccaga ggaactagag gtgctgtggg
     3841 acatttagga ttgatgggac ctgatggaga accaggaatt ccagggtaca ggggccatca
     3901 gggccaacca ggaccctctg gattgccagg acctaaagga gaaaagggct acccaggaga
     3961 agatagcaca gtcctaggac cacctgggcc tcgaggtgaa ccaggtccag tgggggacca
     4021 aggagagaga ggagagcctg gagcagaggg atataagggc catgtgggtg taccaggact
     4081 aagaggtgcc actggacaac aaggaccccc aggcgaacca ggtgaccagg gtgaacaagg
     4141 actaaaagga gagagaggat ctgaaggtaa taaggggaaa aaaggagctc ctggtccttc
     4201 tgggaaacct gggattcctg gacttcaagg cctacttggg ccaaaaggca tacaaggata
     4261 ccatggagca gatggcattt caggaaaccc tggaaaaatt gggccaccag gaaaacaggg
     4321 acttcctggc atcagaggcg gcccaggaag aacaggtctt gctggggctc caggtcctcc
     4381 aggagtaaag ggttcatcag gcttgccagg aagcccagga attcaaggcc caaagggtga
     4441 acaagggcta cctggtcaac ctggaattca aggtaaaaga ggtcaccgag gagcacaagg
     4501 tgatcaagga ccatgtggag accctggcct gaaagggcag cctggagaat atggtgttca
     4561 aggtttgaca ggtttccaag gattcccagg ccctaaaggt cctgaagggg atgctggcat
     4621 tgttgggata tcaggtccta aaggtcctat tggacacaga ggaaacactg gtccccttgg
     4681 cagagaaggt ataataggcc caacaggtag aactggaccc agaggtgaaa agggctttag
     4741 aggtgaaact ggtcctcaag gaccaagagg tcaaccaggg cctccaggtc cacctggagc
     4801 accaggccca agaaagcaaa tggatatcaa tgctgctatt caagccttga ttgaatcaaa
     4861 tactgcccta cagatggaga gctaccagaa tactgaagtg actttaattg accacagtga
     4921 agagatattc aaaaccctga actaccttag caatttattg cacagcatca agaatcctct
     4981 tggcacacga gataacccag cacgaatctg caaagattta cttaactgtg aacaaaaagt
     5041 atcagatgga aaatactgga ttgacccaaa tcttggctgt ccttcagatg ccattgaggt
     5101 tttctgcaat ttcagtgctg gtggccagac atgcttacct cctgtttctg taacaaagtt
     5161 ggagtttgga gttgggaaag tccagatgaa cttccttcat ttactgagtt cggaagccac
     5221 ccatatcatc accattcact gtctaaacac cccaaggtgg acaagcacac aaacaagtgg
     5281 cccaggattg cctattggtt tcaagggatg gaatggccag atttttaaag taaacactct
     5341 acttgaacct aaagtgcttt cagatgactg caagattcaa gatggcagct ggcataaggc
     5401 aacatttctt tttcacaccc aggaacctaa tcaacttcca gtgattgaag tacaaaaact
     5461 tcctcatctc aaaactgaac gaaagtatta cattgacagc agttctgtat gctttctgta
     5521 aagtctctga attagttccg aattcaggct gttggccagg taattgctgc agagggagaa
     5581 ataagacaga cagatacagt cattatgaaa tgcatgtaat aaagcattgg ctaaatctta
     5641 aagaatctca ggaagaacag acttcctcct aagaaggaga aaaggcattt ttaaaggact
     5701 atgattgata aagtatttaa ttcttttaaa aattatattc atctcagctt tcttagagaa
     5761 ttccctagaa ctaaaaattt ataaatatgg aattcttcag ggtatcttat atttttgact
     5821 gagtgcgtag tacccattag acagctggag atgcagagca ctatggagca atactggcta
     5881 atgcttccag atgtgcactg cttctgtcta aaaattacaa gccacagtct aatatgtctt
     5941 attttccaaa acactaagct gtattcaggt ccccgatggg catatacatc ttagccggtg
     6001 atacactacc tcttacgtgt tgcctctttg tgttgcttgg tgctctttcg aaaacaaggt
     6061 gcttatggct ttcatagact atttcctttt tcatctttgt cattctttaa aagtgtatgt
     6121 actggttaca tcaagatatg ttttggttgt tagtacttat tttaatttgt ttggtcacac
     6181 acttaataac acgtgaaact atttatgtga agtccttgtt ttattttaaa attctctttg
     6241 tgtatttgga atcaaagcca gcacattgta acctgtgctt gtacgcaaaa gaattagatt
     6301 tctttgtttt tgttttattt tttaaattgt tgtaaaaatt attataggcc agctacatct
     6361 agtagtaggt ttggggtaca gattgggggt tgtgccatac tgtttttaaa gttcatgatc
     6421 atctggaatg atacttagtg tatatatatt ttgtaaagtt ttaattcagc aaattttttg
     6481 aaattgctgc tgttttaaat tataaaacct ttatatttct gctttgtaga aattatatgt
     6541 tttgtagtat tcattgattt tctttcactg tacttaaatt tagtgttagt actttaaaat
     6601 ttttaattta ccagtcttta aagcaacatc cagaaaaaaa aaagtctttt cccatttaaa
     6661 ataggctcag ccagttcaat gtctccttgt tatcagagaa atattagttc aatactgaaa
     6721 gaaaaatatt atacctcttg gtatctagaa aagcttgttc atccattata aatatatctt
     6781 tagccacagc aaaccacact taacctatct ataataaaaa tgtgctttaa ataa
//
