LOCUS       NM_173465               2899 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens collagen type XXIII alpha 1 chain (COL23A1), mRNA.
ACCESSION   NM_173465
VERSION     NM_173465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Veit,G., Zwolanek,D., Eckes,B., Niland,S., Kapyla,J., Zweers,M.C.,
            Ishada-Yamamoto,A., Krieg,T., Heino,J., Eble,J.A. and Koch,M.
  TITLE     Collagen XXIII, novel ligand for integrin alpha2beta1 in the
            epidermis
  JOURNAL   J Biol Chem 286 (31), 27804-27813 (2011)
   PUBMED   21652699
  REMARK    GeneRIF: data suggest that extracellular membrane-bound CAIV, but
            not cytosolic CAII, augments transport activity of MCT2 in a
            non-catalytic manner, possibly by facilitating a proton pathway
            other than His-88
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Spivey,K.A., Banyard,J., Solis,L.M., Wistuba,I.I., Barletta,J.A.,
            Gandhi,L., Feldman,H.A., Rodig,S.J., Chirieac,L.R. and Zetter,B.R.
  TITLE     Collagen XXIII: a potential biomarker for the detection of primary
            and recurrent non-small cell lung cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1362-1372 (2010)
   PUBMED   20447926
  REMARK    GeneRIF: High COL23A1 expression is associated with recurrent
            non-small cell lung cancer.
REFERENCE   6  (bases 1 to 2899)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2899)
  AUTHORS   Veit,G., Zimina,E.P., Franzke,C.W., Kutsch,S., Siebolds,U.,
            Gordon,M.K., Bruckner-Tuderman,L. and Koch,M.
  TITLE     Shedding of collagen XXIII is mediated by furin and depends on the
            plasma membrane microenvironment
  JOURNAL   J Biol Chem 282 (37), 27424-27435 (2007)
   PUBMED   17627939
  REMARK    GeneRIF: newly synthesized collagen XXIII either is cleaved inside
            the Golgi/trans-Golgi network or reaches the cell surface, where it
            becomes protected from processing by being localized in lipid
            rafts.
REFERENCE   8  (bases 1 to 2899)
  AUTHORS   Koch,M., Veit,G., Stricker,S., Bhatt,P., Kutsch,S., Zhou,P.,
            Reinders,E., Hahn,R.A., Song,R., Burgeson,R.E., Gerecke,D.R.,
            Mundlos,S. and Gordon,M.K.
  TITLE     Expression of type XXIII collagen mRNA and protein
  JOURNAL   J Biol Chem 281 (30), 21546-21557 (2006)
   PUBMED   16728390
  REMARK    GeneRIF: analysis of collagen XXIII mRNA and protein
REFERENCE   9  (bases 1 to 2899)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   10 (bases 1 to 2899)
  AUTHORS   Banyard,J., Bao,L. and Zetter,B.R.
  TITLE     Type XXIII collagen, a new transmembrane collagen identified in
            metastatic tumor cells
  JOURNAL   J Biol Chem 278 (23), 20989-20994 (2003)
   PUBMED   12644459
  REMARK    GeneRIF: identification and cloning; a new member of the
            transmembrane collagen family, showing structural homology with the
            transmembrane collagens XIII and XXV
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY898961.1 and AW014891.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173465.3.
            
            Summary: COL23A1 is a member of the transmembrane collagens, a
            subfamily of the nonfibrillar collagens that contain a single pass
            hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed
            12644459]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158895.1, AY898961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390654.8/ ENSP00000375069.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2517              AY898961.1         163-2679
            2518-2899           AW014891.1         20-401              c
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2899
                     /gene="COL23A1"
                     /note="collagen type XXIII alpha 1 chain"
                     /db_xref="GeneID:91522"
                     /db_xref="HGNC:HGNC:22990"
                     /db_xref="MIM:610043"
     exon            1..490
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1819
                     /gene="COL23A1"
                     /note="procollagen, type XXIII, alpha 1; collagen, type
                     XXIII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XXIII) chain"
                     /protein_id="NP_775736.2"
                     /db_xref="CCDS:CCDS4436.1"
                     /db_xref="GeneID:91522"
                     /db_xref="HGNC:HGNC:22990"
                     /db_xref="MIM:610043"
                     /translation="MGPGERAGGGGDAGKGNAAGGGGGGRSATTAGSRAVSALCLLLS
                     VGSAAACLLLGVQAAALQGRVAALEEERELLRRAGPPGALDAWAEPHLERLLREKLDG
                     LAKIRTAREAPSECVCPPGPPGRRGKPGRRGDPGPPGQSGRDGYPGPLGLDGKPGLPG
                     PKGEKGAPGDFGPRGDQGQDGAAGPPGPPGPPGARGPPGDTGKDGPRGAQGPAGPKGE
                     PGQDGEMGPKGPPGPKGEPGVPGKKGDDGTPSQPGPPGPKGEPGSMGPRGENGVDGAP
                     GPKGEPGHRGTDGAAGPRGAPGLKGEQGDTVVIDYDGRILDALKGPPGPQGPPGPPGI
                     PGAKGELGLPGAPGIDGEKGPKGQKGDPGEPGPAGLKGEAGEMGLSGLPGADGLKGEK
                     GESASDSLQESLAQLIVEPGPPGPPGPPGPMGLQGIQGPKGLDGAKGEKGASGERGPS
                     GLPGPVGPPGLIGLPGTKGEKGRPGEPGLDGFPGPRGEKGDRSERGEKGERGVPGRKG
                     VKGQKGEPGPPGLDQPCPVGPDGLPVPGCWHK"
     exon            491..557
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..602
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..610
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..637
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..664
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..691
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..718
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..835
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..871
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..898
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..925
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..970
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1033
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1078
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1156
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1210
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1255
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1345
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1408
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1465
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1492
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1555
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1609
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1636
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1690
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1777
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1816
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2899
                     /gene="COL23A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2879..2884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL23A1"
                     /note="hexamer: AATAAA"
     polyA_site      2899
                     /gene="COL23A1"
                     /note="major polyA site"
ORIGIN      
        1 aaactgccca aagtggccgc tgtggaggag ctggctgcgg cgaagggggc gtgcgcggcg
       61 atccgctgct acccggaggc taacccccgc gcccggcgga cctcgtgcct cgggctgtcc
      121 cgcctgctcc tctcgcaccc agcctctgcc ccagcagcac cgccccctcg gagagtccac
      181 gcgcgacgaa cgcgccatgg gcccaggcga gcgcgccggt ggcggcggcg acgcggggaa
      241 gggcaatgcg gcgggcggcg gcggcggagg gcgctcggcg acgacggccg ggtcccgggc
      301 ggtgagcgcg ctgtgcctgc tgctctccgt gggctcggcg gctgcctgcc tgctgctggg
      361 tgtccaggcg gccgcgctgc agggccgggt ggcggcgctc gaggaggagc gggagctgct
      421 gcggcgcgcg gggccgccag gcgccctgga cgcctgggcc gagccgcacc tggagcgcct
      481 gctgcgggag aagttggacg gactagcgaa gatccggact gctcgggaag ctccatccga
      541 atgtgtctgc cccccagggc cccctggacg gcgcggcaag cctgggagaa gaggcgaccc
      601 tggtcctcca gggcaatcag gacgagatgg ctacccggga cccctgggtt tggatggcaa
      661 gcccggactt ccaggcccga aaggggaaaa gggtgcacca ggagactttg gcccccgggg
      721 agaccaagga caagatggag ctgctgggcc tccggggccc cctggacctc ctggggcccg
      781 gggccctcct ggcgacactg ggaaagatgg ccccagggga gcacaaggcc cagcgggccc
      841 caaaggagag cccggacaag acggcgagat gggcccaaag ggacccccag ggcccaaggg
      901 tgagcctgga gtacctggaa agaagggcga cgatgggaca ccaagccagc ctggaccacc
      961 agggcccaag ggcgagccag ggagcatggg gcctcgggga gagaacggtg tggacggtgc
     1021 cccaggaccg aagggggagc ctggccaccg aggcacggat ggagctgcag ggccccgggg
     1081 tgccccaggc ctcaagggcg agcagggaga cacagtggtg atcgactatg atggcaggat
     1141 cttggatgcc ctcaaggggc ctcccggacc acaggggccc ccagggccac cagggatccc
     1201 tggagccaag ggcgagcttg gattgcccgg tgccccagga atcgatggag agaagggccc
     1261 caaaggacag aaaggagacc caggagagcc tgggccagca ggactcaaag gggaagcagg
     1321 cgagatgggc ttgtccggcc tcccgggcgc tgacggcctc aagggggaga agggggagtc
     1381 ggcgtctgac agcctacagg agagcctggc tcagctcata gtggagccag ggccccctgg
     1441 cccccctggc cccccaggcc cgatgggcct ccagggaatc cagggtccca agggcttgga
     1501 tggagcaaag ggagagaagg gtgcgtcggg tgagagaggc cccagcggcc tgcctgggcc
     1561 agttggccca ccgggcctta ttgggctgcc aggaaccaaa ggagagaagg gcagacccgg
     1621 ggagccagga ctagatggtt tccctggacc ccgaggagag aaaggtgatc ggagcgagcg
     1681 tggagagaag ggagaacgag gggtccccgg ccggaaagga gtgaagggcc agaagggcga
     1741 gccgggacca ccaggcctgg accagccgtg tcccgtgggc cccgacgggc tgcctgtgcc
     1801 tggctgctgg cataagtgac ccacaggccc agctcacacc tgtacagatc cgtgtggaca
     1861 tttttaattt ttgtaaaaac aaaacagtaa tatattgatc ttttttcatg gaatgcgcta
     1921 cctgtggcct tttaacattc aagagtatgc ccacccagcc ccaaagccac cggcatgtga
     1981 agctgccgga aagtggacag gccagaccag ggagatgtgt acctgagggg cacccttggg
     2041 cctgggcttt cccaggaagg agatgaaggt agaagcacct ggctcgggca aggctagaaa
     2101 gatgctacgt tgggccttca gtcacctgat cagcagagag actctcagct gtggtactgc
     2161 cctgtaagaa cctgcccccg caaaactctg gagtccctgg gacacaccct atccaagaag
     2221 acccaggggt ggaacagcgg ctgctgttgc tcctggcctc atcagcctcc aaactcaacc
     2281 acaaccagct gcctctgcag ttggacaaga cttggccccc ggacaagact cgcccagcac
     2341 ttgcggctgg gcccggggag cagtgagtgg aaatccccca cgagggtcta gctctaccac
     2401 attcaggagg cctcaggagg ccagcctgcc atgagagcac atgtcctctg gccaggagta
     2461 gtggctgagc tctgtgatcg ctgtgatgtg gacccagctc cagggagcag agtgtcgagg
     2521 atggaggggc ccagcctgga ctgactgcta cttcctgtct ctgtttccat tatcacccag
     2581 agagggacaa gataggacat ggcctggacc agggaggcag gcctcccact cagagtctgg
     2641 gtctcactgg ccccaagtct cccacccaga actctggcca aaaatggctc tctaggtggg
     2701 ctgtgcaggc aaagcaaagc tcagggctgg ttcccagctg gcctgagcag ggggcctgcc
     2761 accagaccca cccacgctct gacgagaggc ttttccacct ccagcaagtg ttcccagcaa
     2821 ccagctccat cctggctgct tgccttccat ttccgtgtag atggagatca ctgtgtgtaa
     2881 taaaccacaa gtgcgtgtc
//
