LOCUS       NM_000089               5072 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens collagen type I alpha 2 chain (COL1A2), mRNA.
ACCESSION   NM_000089
VERSION     NM_000089.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5072)
  AUTHORS   Xu,J., Zhou,K., Gu,H., Zhang,Y., Wu,L., Bian,C., Huang,Z., Chen,G.,
            Cheng,X. and Yin,X.
  TITLE     Exosome miR-4738-3p-mediated regulation of COL1A2 through the
            NF-kappaB and inflammation signaling pathway alleviates
            osteoarthritis low-grade inflammation symptoms
  JOURNAL   Biomol Biomed 24 (3), 520-536 (2024)
   PUBMED   38059912
  REMARK    GeneRIF: Exosome miR-4738-3p-mediated regulation of COL1A2 through
            the NF-kappaB and inflammation signaling pathway alleviates
            osteoarthritis low-grade inflammation symptoms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5072)
  AUTHORS   Mehta,P., Vishvkarma,R., Gupta,S., Chattopadhyay,N. and Rajender,S.
  TITLE     Exome sequencing identified mutations in the WNT1 and COL1A2 genes
            in osteogenesis imperfecta cases
  JOURNAL   Mol Biol Rep 51 (1), 449 (2024)
   PUBMED   38536562
  REMARK    GeneRIF: Exome sequencing identified mutations in the WNT1 and
            COL1A2 genes in osteogenesis imperfecta cases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5072)
  AUTHORS   Kallala,R., Slimani,A., Gassara,Y., Garrach,B., Chouchen,S.,
            Foddha,H., Rouis,A. and Kenani,A.
  TITLE     The association between Dental Fluorosis and COL1A2 gene
            polymorphism among a Tunisian Population
  JOURNAL   BMC Oral Health 24 (1), 376 (2024)
   PUBMED   38519884
  REMARK    GeneRIF: The association between Dental Fluorosis and COL1A2 gene
            polymorphism among a Tunisian Population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5072)
  AUTHORS   Zhang,Y., Wu,X., Liu,Q., Yan,X., Liu,H. and Feng,D.
  TITLE     [Analysis of COL1A1 and COL1A2 gene variants in two fetuses with
            osteogenesis imperfecta]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (7), 821-827 (2023)
   PUBMED   37368383
  REMARK    GeneRIF: [Analysis of COL1A1 and COL1A2 gene variants in two
            fetuses with osteogenesis imperfecta].
REFERENCE   5  (bases 1 to 5072)
  AUTHORS   Yao,G., Deng,L., Long,X., Zhou,Y. and Zhou,X.
  TITLE     An integrated bioinformatic investigation of focal adhesion-related
            genes in glioma followed by preliminary validation of COL1A2 in
            tumorigenesis
  JOURNAL   Aging (Albany NY) 15 (13), 6225-6254 (2023)
   PUBMED   37354488
  REMARK    GeneRIF: An integrated bioinformatic investigation of focal
            adhesion-related genes in glioma followed by preliminary validation
            of COL1A2 in tumorigenesis.
REFERENCE   6  (bases 1 to 5072)
  AUTHORS   Steiner,R.D. and Basel,D.
  TITLE     COL1A1/2 Osteogenesis Imperfecta
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301472
REFERENCE   7  (bases 1 to 5072)
  AUTHORS   Nusgens,B.V., Verellen-Dumoulin,C., Hermanns-Le,T., De Paepe,A.,
            Nuytinck,L., Pierard,G.E. and Lapiere,C.M.
  TITLE     Evidence for a relationship between Ehlers-Danlos type VII C in
            humans and bovine dermatosparaxis
  JOURNAL   Nat Genet 1 (3), 214-217 (1992)
   PUBMED   1303238
REFERENCE   8  (bases 1 to 5072)
  AUTHORS   Chessler,S.D. and Byers,P.H.
  TITLE     Defective folding and stable association with protein disulfide
            isomerase/prolyl hydroxylase of type I procollagen with a deletion
            in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat
            pattern
  JOURNAL   J Biol Chem 267 (11), 7751-7757 (1992)
   PUBMED   1339453
REFERENCE   9  (bases 1 to 5072)
  AUTHORS   Edwards,M.J., Wenstrup,R.J., Byers,P.H. and Cohn,D.H.
  TITLE     Recurrence of lethal osteogenesis imperfecta due to parental
            mosaicism for a mutation in the COL1A2 gene of type I collagen. The
            mosaic parent exhibits phenotypic features of a mild form of the
            disease
  JOURNAL   Hum Mutat 1 (1), 47-54 (1992)
   PUBMED   1301191
REFERENCE   10 (bases 1 to 5072)
  AUTHORS   Bateman,J.F., Moeller,I., Hannagan,M., Chan,D. and Cole,W.G.
  TITLE     Lethal perinatal osteogenesis imperfecta due to a type I collagen
            alpha 2(I) Gly to Arg substitution detected by chemical cleavage of
            an mRNA:cDNA sequence mismatch
  JOURNAL   Hum Mutat 1 (1), 55-62 (1992)
   PUBMED   1284475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA457209.1, BC042586.1,
            CF125721.1, BC054498.1 and Z74616.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000089.3.
            
            Summary: This gene encodes the pro-alpha2 chain of type I collagen
            whose triple helix comprises two alpha1 chains and one alpha2
            chain. Type I is a fibril-forming collagen found in most connective
            tissues and is abundant in bone, cornea, dermis and tendon.
            Mutations in this gene are associated with osteogenesis imperfecta
            types I-IV, Ehlers-Danlos syndrome type VIIB, recessive
            Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and
            atypical Marfan syndrome. Symptoms associated with mutations in
            this gene, however, tend to be less severe than mutations in the
            gene for the alpha1 chain of type I collagen (COL1A1) reflecting
            the different role of alpha2 chains in matrix integrity. Three
            transcripts, resulting from the use of alternate polyadenylation
            signals, have been identified for this gene. [provided by R.
            Dalgleish, Feb 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z74616.1, BC054498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297268.11/ ENSP00000297268.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AA457209.1         106-124             c
            20-1781             BC042586.1         1-1762
            1782-2202           CF125721.1         243-663
            2203-5069           BC054498.1         2166-5032
            5070-5072           Z74616.1           5079-5081
FEATURES             Location/Qualifiers
     source          1..5072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..5072
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="collagen type I alpha 2 chain"
                     /db_xref="GeneID:1278"
                     /db_xref="HGNC:HGNC:2198"
                     /db_xref="MIM:120160"
     exon            1..207
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..4238
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="collagen alpha-2(I) chain; collagen I, alpha-2
                     polypeptide; collagen of skin, tendon and bone, alpha-2
                     chain; type I procollagen; alpha 2(I)-collagen; alpha-2
                     type I collagen; alpha 2(I) procollagen; alpha 2 type I
                     procollagen; collagen, type I, alpha 2; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="collagen alpha-2(I) chain precursor"
                     /protein_id="NP_000080.2"
                     /db_xref="CCDS:CCDS34682.1"
                     /db_xref="GeneID:1278"
                     /db_xref="HGNC:HGNC:2198"
                     /db_xref="MIM:120160"
                     /translation="MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGER
                     GPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPP
                     GAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVG
                     PQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGL
                     PGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPA
                     GPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVG
                     AAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGP
                     PGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPR
                     GLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNG
                     DKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGE
                     VGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEP
                     GVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVG
                     APGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGE
                     RGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPP
                     GPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAG
                     PPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGS
                     PGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPA
                     GKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQG
                     LPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGP
                     AGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQI
                     ETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCI
                     RAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLAN
                     YASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKK
                     TNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK"
     exon            208..218
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            219..233
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            234..269
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            270..362
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            363..416
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..461
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            462..515
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            516..569
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            570..623
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..677
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            678..731
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..776
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..830
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..875
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            876..929
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1028
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1073
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1172
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1226
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1334
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1388
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1487
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1541
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1640
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1694
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1748
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1802
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1856
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1901
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2000
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2108
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2162
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2216
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2270
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2324
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2432
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2486
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2540
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2702
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2810
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2918
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..2972
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3080
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3134
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3242
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3296
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3404
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3663
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3848
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4091
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..5072
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="hexamer: AATAAA"
     polyA_site      4552
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="major polyA site"
     regulatory      5023..5028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="hexamer: AATAAA"
     polyA_site      5040
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
     regulatory      5044..5049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
                     /note="hexamer: AATAAA"
     polyA_site      5072
                     /gene="COL1A2"
                     /gene_synonym="EDSARTH2; EDSCV; OI4"
ORIGIN      
        1 agcaccacgg cagcaggagg tttcggctaa gttggaggta ctggccacga ctgcatgccc
       61 gcgcccgcca ggtgatacct ccgccggtga cccaggggct ctgcgacaca aggagtctgc
      121 atgtctaagt gctagacatg ctcagctttg tggatacgcg gactttgttg ctgcttgcag
      181 taaccttatg cctagcaaca tgccaatctt tacaagagga aactgtaaga aagggcccag
      241 ccggagatag aggaccacgt ggagaaaggg gtccaccagg ccccccaggc agagatggtg
      301 aagatggtcc cacaggccct cctggtccac ctggtcctcc tggcccccct ggtctcggtg
      361 ggaactttgc tgctcagtat gatggaaaag gagttggact tggccctgga ccaatgggct
      421 taatgggacc tagaggccca cctggtgcag ctggagcccc aggccctcaa ggtttccaag
      481 gacctgctgg tgagcctggt gaacctggtc aaactggtcc tgcaggtgct cgtggtccag
      541 ctggccctcc tggcaaggct ggtgaagatg gtcaccctgg aaaacccgga cgacctggtg
      601 agagaggagt tgttggacca cagggtgctc gtggtttccc tggaactcct ggacttcctg
      661 gcttcaaagg cattagggga cacaatggtc tggatggatt gaagggacag cccggtgctc
      721 ctggtgtgaa gggtgaacct ggtgcccctg gtgaaaatgg aactccaggt caaacaggag
      781 cccgtgggct tcctggtgag agaggacgtg ttggtgcccc tggcccagct ggtgcccgtg
      841 gcagtgatgg aagtgtgggt cccgtgggtc ctgctggtcc cattgggtct gctggccctc
      901 caggcttccc aggtgcccct ggccccaagg gtgaaattgg agctgttggt aacgctggtc
      961 ctgctggtcc cgccggtccc cgtggtgaag tgggtcttcc aggcctctcc ggccccgttg
     1021 gacctcctgg taatcctgga gcaaacggcc ttactggtgc caagggtgct gctggccttc
     1081 ccggcgttgc tggggctccc ggcctccctg gaccccgcgg tattcctggc cctgttggtg
     1141 ctgccggtgc tactggtgcc agaggacttg ttggtgagcc tggtccagct ggctccaaag
     1201 gagagagcgg taacaagggt gagcccggct ctgctgggcc ccaaggtcct cctggtccca
     1261 gtggtgaaga aggaaagaga ggccctaatg gggaagctgg atctgccggc cctccaggac
     1321 ctcctgggct gagaggtagt cctggttctc gtggtcttcc tggagctgat ggcagagctg
     1381 gcgtcatggg ccctcctggt agtcgtggtg caagtggccc tgctggagtc cgaggaccta
     1441 atggagatgc tggtcgccct ggggagcctg gtctcatggg acccagaggt cttcctggtt
     1501 cccctggaaa tatcggcccc gctggaaaag aaggtcctgt cggcctccct ggcatcgacg
     1561 gcaggcctgg cccaattggc ccagctggag caagaggaga gcctggcaac attggattcc
     1621 ctggacccaa aggccccact ggtgatcctg gcaaaaacgg tgataaaggt catgctggtc
     1681 ttgctggtgc tcggggtgct ccaggtcctg atggaaacaa tggtgctcag ggacctcctg
     1741 gaccacaggg tgttcaaggt ggaaaaggtg aacagggtcc ccctggtcct ccaggcttcc
     1801 agggtctgcc tggcccctca ggtcccgctg gtgaagttgg caaaccagga gaaaggggtc
     1861 tccatggtga gtttggtctc cctggtcctg ctggtccaag aggggaacgc ggtcccccag
     1921 gtgagagtgg tgctgccggt cctactggtc ctattggaag ccgaggtcct tctggacccc
     1981 cagggcctga tggaaacaag ggtgaacctg gtgtggttgg tgctgtgggc actgctggtc
     2041 catctggtcc tagtggactc ccaggagaga ggggtgctgc tggcatacct ggaggcaagg
     2101 gagaaaaggg tgaacctggt ctcagaggtg aaattggtaa ccctggcaga gatggtgctc
     2161 gtggtgctcc tggtgctgta ggtgcccctg gtcctgctgg agccacaggt gaccggggcg
     2221 aagctggggc tgctggtcct gctggtcctg ctggtcctcg gggaagccct ggtgaacgtg
     2281 gtgaggtcgg tcctgctggc cccaatggat ttgctggtcc tgctggtgct gctggtcaac
     2341 ctggtgctaa aggagaaaga ggagccaaag ggcctaaggg tgaaaacggt gttgttggtc
     2401 ccacaggccc cgttggagct gctggcccag ctggtccaaa tggtcccccc ggtcctgctg
     2461 gaagtcgtgg tgatggaggc ccccctggta tgactggttt ccctggtgct gctggacgga
     2521 ctggtccccc aggaccctct ggtatttctg gccctcctgg tccccctggt cctgctggga
     2581 aagaagggct tcgtggtcct cgtggtgacc aaggtccagt tggccgaact ggagaagtag
     2641 gtgcagttgg tccccctggc ttcgctggtg agaagggtcc ctctggagag gctggtactg
     2701 ctggacctcc tggcactcca ggtcctcagg gtcttcttgg tgctcctggt attctgggtc
     2761 tccctggctc gagaggtgaa cgtggtctac caggtgttgc tggtgctgtg ggtgaacctg
     2821 gtcctcttgg cattgccggc cctcctgggg cccgtggtcc tcctggtgct gtgggtagtc
     2881 ctggagtcaa cggtgctcct ggtgaagctg gtcgtgatgg caaccctggg aacgatggtc
     2941 ccccaggtcg cgatggtcaa cccggacaca agggagagcg cggttaccct ggcaatattg
     3001 gtcccgttgg tgctgcaggt gcacctggtc ctcatggccc cgtgggtcct gctggcaaac
     3061 atggaaaccg tggtgaaact ggtccttctg gtcctgttgg tcctgctggt gctgttggcc
     3121 caagaggtcc tagtggccca caaggcattc gtggcgataa gggagagccc ggtgaaaagg
     3181 ggcccagagg tcttcctggc ttaaagggac acaatggatt gcaaggtctg cctggtatcg
     3241 ctggtcacca tggtgatcaa ggtgctcctg gctccgtggg tcctgctggt cctaggggcc
     3301 ctgctggtcc ttctggccct gctggaaaag atggtcgcac tggacatcct ggtacagttg
     3361 gacctgctgg cattcgaggc cctcagggtc accaaggccc tgctggcccc cctggtcccc
     3421 ctggccctcc tggacctcca ggtgtaagcg gtggtggtta tgactttggt tacgatggag
     3481 acttctacag ggctgaccag cctcgctcag caccttctct cagacccaag gactatgaag
     3541 ttgatgctac tctgaagtct ctcaacaacc agattgagac ccttcttact cctgaaggct
     3601 ctagaaagaa cccagctcgc acatgccgtg acttgagact cagccaccca gagtggagca
     3661 gtggttacta ctggattgac cctaaccaag gatgcactat ggatgctatc aaagtatact
     3721 gtgatttctc tactggcgaa acctgtatcc gggcccaacc tgaaaacatc ccagccaaga
     3781 actggtatag gagctccaag gacaagaaac acgtctggct aggagaaact atcaatgctg
     3841 gcagccagtt tgaatataat gtagaaggag tgacttccaa ggaaatggct acccaacttg
     3901 ccttcatgcg cctgctggcc aactatgcct ctcagaacat cacctaccac tgcaagaaca
     3961 gcattgcata catggatgag gagactggca acctgaaaaa ggctgtcatt ctacagggct
     4021 ctaatgatgt tgaacttgtt gctgagggca acagcaggtt cacttacact gttcttgtag
     4081 atggctgctc taaaaagaca aatgaatggg gaaagacaat cattgaatac aaaacaaata
     4141 agccatcacg cctgcccttc cttgatattg cacctttgga catcggtggt gctgaccagg
     4201 aattctttgt ggacattggc ccagtctgtt tcaaataaat gaactcaatc taaattaaaa
     4261 aagaaagaaa tttgaaaaaa ctttctcttt gccatttctt cttcttcttt tttaactgaa
     4321 agctgaatcc ttccatttct tctgcacatc tacttgctta aattgtgggc aaaagagaaa
     4381 aagaaggatt gatcagagca ttgtgcaata cagtttcatt aactccttcc cccgctcccc
     4441 caaaaatttg aatttttttt tcaacactct tacacctgtt atggaaaatg tcaacctttg
     4501 taagaaaacc aaaataaaaa ttgaaaaata aaaaccataa acatttgcac cacttgtggc
     4561 ttttgaatat cttccacaga gggaagttta aaacccaaac ttccaaaggt ttaaactacc
     4621 tcaaaacact ttcccatgag tgtgatccac attgttaggt gctgacctag acagagatga
     4681 actgaggtcc ttgttttgtt ttgttcataa tacaaaggtg ctaattaata gtatttcaga
     4741 tacttgaaga atgttgatgg tgctagaaga atttgagaag aaatactcct gtattgagtt
     4801 gtatcgtgtg gtgtattttt taaaaaattt gatttagcat tcatattttc catcttattc
     4861 ccaattaaaa gtatgcagat tatttgccca aatcttcttc agattcagca tttgttcttt
     4921 gccagtctca ttttcatctt cttccatggt tccacagaag ctttgtttct tgggcaagca
     4981 gaaaaattaa attgtaccta ttttgtatat gtgagatgtt taaataaatt gtgaaaaaaa
     5041 tgaaataaag catgtttggt tttccaaaag aa
//
