LOCUS       NM_000088               5914 bp    mRNA    linear   PRI 24-NOV-2024
DEFINITION  Homo sapiens collagen type I alpha 1 chain (COL1A1), mRNA.
ACCESSION   NM_000088
VERSION     NM_000088.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5914)
  AUTHORS   Gulucu,S., Onal,M. and Karakus,N.
  TITLE     Genetic Polymorphisms of COL1A1 Promoter Region (rs1800012) and
            TGFB1 Signal Peptide (rs1800471): Role in Cervical Insufficiency
            Susceptibility?
  JOURNAL   Reprod Sci 31 (10), 3058-3065 (2024)
   PUBMED   39210235
  REMARK    GeneRIF: Genetic Polymorphisms of COL1A1 Promoter Region
            (rs1800012) and TGFB1 Signal Peptide (rs1800471): Role in Cervical
            Insufficiency Susceptibility?
REFERENCE   2  (bases 1 to 5914)
  AUTHORS   Liu,J., Zhang,X., Yang,M. and Zhang,X.
  TITLE     CircCOL1A1 promotes proliferation, migration, and invasion of
            colorectal cancer (CRC) cells and glutamine metabolism through GLS1
            up-regulation by sponging miR-214-3p
  JOURNAL   J Cancer Res Clin Oncol 150 (4), 211 (2024)
   PUBMED   38662258
  REMARK    GeneRIF: CircCOL1A1 promotes proliferation, migration, and invasion
            of colorectal cancer (CRC) cells and glutamine metabolism through
            GLS1 up-regulation by sponging miR-214-3p.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5914)
  AUTHORS   Zeng,X., Chen,G., Guo,D., Chen,Y. and Hu,X.
  TITLE     Expression, prognostic value and potential immunotherapeutic target
            of COL1A1 in colon cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (15), 120-125 (2023)
   PUBMED   38279475
  REMARK    GeneRIF: Expression, prognostic value and potential
            immunotherapeutic target of COL1A1 in colon cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5914)
  AUTHORS   Chekhun,V., Mushii,O., Zadvornyi,T., Borikun,T., Martyniuk
            capital,O. Cyrillic, Kashuba,E., Kryzhanivska,A., Andriiv,A.,
            Diakiv,I. and Lukianova,N.
  TITLE     FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG
            PATIENTS
  JOURNAL   Exp Oncol 45 (3), 351-363 (2023)
   PUBMED   38186020
  REMARK    GeneRIF: FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF
            YOUNG PATIENTS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5914)
  AUTHORS   Guerin,A., Dupuis,L. and Mendoza-Londono,R.
  TITLE     Caffey Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22855962
REFERENCE   6  (bases 1 to 5914)
  AUTHORS   Steiner,R.D. and Basel,D.
  TITLE     COL1A1/2 Osteogenesis Imperfecta
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301472
REFERENCE   7  (bases 1 to 5914)
  AUTHORS   Malfait,F., Symoens,S. and Syx,D.
  TITLE     Classic Ehlers-Danlos Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301422
REFERENCE   8  (bases 1 to 5914)
  AUTHORS   Ghebrehiwet,B., Peerschke,E.I., Hong,Y., Munoz,P. and Gorevic,P.D.
  TITLE     Short amino acid sequences derived from C1q receptor (C1q-R) show
            homology with the alpha chains of fibronectin and vitronectin
            receptors and collagen type IV
  JOURNAL   J Leukoc Biol 51 (6), 546-556 (1992)
   PUBMED   1377218
REFERENCE   9  (bases 1 to 5914)
  AUTHORS   Nusgens,B.V., Verellen-Dumoulin,C., Hermanns-Le,T., De Paepe,A.,
            Nuytinck,L., Pierard,G.E. and Lapiere,C.M.
  TITLE     Evidence for a relationship between Ehlers-Danlos type VII C in
            humans and bovine dermatosparaxis
  JOURNAL   Nat Genet 1 (3), 214-217 (1992)
   PUBMED   1303238
REFERENCE   10 (bases 1 to 5914)
  AUTHORS   Chessler,S.D. and Byers,P.H.
  TITLE     Defective folding and stable association with protein disulfide
            isomerase/prolyl hydroxylase of type I procollagen with a deletion
            in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat
            pattern
  JOURNAL   J Biol Chem 267 (11), 7751-7757 (1992)
   PUBMED   1339453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015909.14 and AB209597.1.
            
            On Nov 21, 2019 this sequence version replaced NM_000088.3.
            
            Summary: This gene encodes the pro-alpha1 chains of type I collagen
            whose triple helix comprises two alpha1 chains and one alpha2
            chain. Type I is a fibril-forming collagen found in most connective
            tissues and is abundant in bone, cornea, dermis and tendon.
            Mutations in this gene are associated with osteogenesis imperfecta
            types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos
            syndrome Classical type, Caffey Disease and idiopathic
            osteoporosis. Reciprocal translocations between chromosomes 17 and
            22, where this gene and the gene for platelet-derived growth factor
            beta are located, are associated with a particular type of skin
            tumor called dermatofibrosarcoma protuberans, resulting from
            unregulated expression of the growth factor. Two transcripts,
            resulting from the use of alternate polyadenylation signals, have
            been identified for this gene. [provided by R. Dalgleish, Feb
            2008].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z74615.1, AB209597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225964.10/ ENSP00000225964.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC015909.14        167934-167950
            18-2415             AB209597.1         1-2398
            2416-2416           AC015909.14        178703-178703
            2417-4738           AB209597.1         2400-4721
            4739-5914           AC015909.14        184289-185464
FEATURES             Location/Qualifiers
     source          1..5914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..5914
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /note="collagen type I alpha 1 chain"
                     /db_xref="GeneID:1277"
                     /db_xref="HGNC:HGNC:2197"
                     /db_xref="MIM:120150"
     exon            1..221
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..4513
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /note="collagen of skin, tendon and bone, alpha-1 chain;
                     pro-alpha-1 collagen type 1; collagen Col1-ColIII-1;
                     collagen alpha 1 chain type I; alpha-1 type I collagen;
                     type I proalpha 1; type I procollagen alpha 1 chain;
                     alpha1(I) procollagen; collagen, type I, alpha 1; collagen
                     Col1-ColIII-2"
                     /codon_start=1
                     /product="collagen alpha-1(I) chain preproprotein"
                     /protein_id="NP_000079.2"
                     /db_xref="CCDS:CCDS11561.1"
                     /db_xref="GeneID:1277"
                     /db_xref="HGNC:HGNC:2197"
                     /db_xref="MIM:120150"
                     /translation="MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNG
                     LRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESP
                     TDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFA
                     PQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMG
                     PRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGA
                     KGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPP
                     GPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADG
                     QPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
                     PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPA
                     GERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPG
                     PPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGP
                     AGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFP
                     GERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPG
                     PKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGA
                     PGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNV
                     GAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETG
                     PAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGF
                     PGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSP
                     GAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAG
                     PQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGS
                     AGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQP
                     PQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDL
                     KMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKD
                     KRHVWFGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMD
                     QQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSR
                     LPIIDVAPLDVGAPDQEFGFDVGPVCFL"
     exon            222..416
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..451
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..487
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..589
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..661
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            662..706
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..760
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            761..814
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            815..868
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..922
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            923..976
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1021
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1075
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1120
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1174
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1273
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1318
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1417
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1471
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1579
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1633
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1732
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1786
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1885
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1939
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..1993
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2047
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2101
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2146
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2245
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2353
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2461
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2515
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2569
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2677
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2731
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2785
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2947
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3055
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3163
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3217
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3325
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3379
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3487
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3541
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3649
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3932
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4123
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4366
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..5914
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /note="hexamer: AATAAA"
     polyA_site      5914
                     /gene="COL1A1"
                     /gene_synonym="CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggga gtttctcctc ggggtcggag caggaggcac gcggagtgtg aggccacgca
       61 tgagcggacg ctaaccccct ccccagccac aaagagtcta catgtctagg gtctagacat
      121 gttcagcttt gtggacctcc ggctcctgct cctcttagcg gccaccgccc tcctgacgca
      181 cggccaagag gaaggccaag tcgagggcca agacgaagac atcccaccaa tcacctgcgt
      241 acagaacggc ctcaggtacc atgaccgaga cgtgtggaaa cccgagccct gccggatctg
      301 cgtctgcgac aacggcaagg tgttgtgcga tgacgtgatc tgtgacgaga ccaagaactg
      361 ccccggcgcc gaagtccccg agggcgagtg ctgtcccgtc tgccccgacg gctcagagtc
      421 acccaccgac caagaaacca ccggcgtcga gggacccaag ggagacactg gcccccgagg
      481 cccaagggga cccgcaggcc cccctggccg agatggcatc cctggacagc ctggacttcc
      541 cggacccccc ggaccccccg gacctcccgg accccctggc ctcggaggaa actttgctcc
      601 ccagctgtct tatggctatg atgagaaatc aaccggagga atttccgtgc ctggccccat
      661 gggtccctct ggtcctcgtg gtctccctgg cccccctggt gcacctggtc cccaaggctt
      721 ccaaggtccc cctggtgagc ctggcgagcc tggagcttca ggtcccatgg gtccccgagg
      781 tcccccaggt ccccctggaa agaatggaga tgatggggaa gctggaaaac ctggtcgtcc
      841 tggtgagcgt gggcctcctg ggcctcaggg tgctcgagga ttgcccggaa cagctggcct
      901 ccctggaatg aagggacaca gaggtttcag tggtttggat ggtgccaagg gagatgctgg
      961 tcctgctggt cctaagggtg agcctggcag ccctggtgaa aatggagctc ctggtcagat
     1021 gggcccccgt ggcctgcctg gtgagagagg tcgccctgga gcccctggcc ctgctggtgc
     1081 tcgtggaaat gatggtgcta ctggtgctgc cgggccccct ggtcccaccg gccccgctgg
     1141 tcctcctggc ttccctggtg ctgttggtgc taagggtgaa gctggtcccc aagggccccg
     1201 aggctctgaa ggtccccagg gtgtgcgtgg tgagcctggc ccccctggcc ctgctggtgc
     1261 tgctggccct gctggaaacc ctggtgctga tggacagcct ggtgctaaag gtgccaatgg
     1321 tgctcctggt attgctggtg ctcctggctt ccctggtgcc cgaggcccct ctggacccca
     1381 gggccccggc ggccctcctg gtcccaaggg taacagcggt gaacctggtg ctcctggcag
     1441 caaaggagac actggtgcta agggagagcc tggccctgtt ggtgttcaag gaccccctgg
     1501 ccctgctgga gaggaaggaa agcgaggagc tcgaggtgaa cccggaccca ctggcctgcc
     1561 cggaccccct ggcgagcgtg gtggacctgg tagccgtggt ttccctggcg cagatggtgt
     1621 tgctggtccc aagggtcccg ctggtgaacg tggttctcct ggccctgctg gccccaaagg
     1681 atctcctggt gaagctggtc gtcccggtga agctggtctg cctggtgcca agggtctgac
     1741 tggaagccct ggcagccctg gtcctgatgg caaaactggc ccccctggtc ccgccggtca
     1801 agatggtcgc cccggacccc caggcccacc tggtgcccgt ggtcaggctg gtgtgatggg
     1861 attccctgga cctaaaggtg ctgctggaga gcccggcaag gctggagagc gaggtgttcc
     1921 cggaccccct ggcgctgtcg gtcctgctgg caaagatgga gaggctggag ctcagggacc
     1981 ccctggccct gctggtcccg ctggcgagag aggtgaacaa ggccctgctg gctcccccgg
     2041 attccagggt ctccctggtc ctgctggtcc tccaggtgaa gcaggcaaac ctggtgaaca
     2101 gggtgttcct ggagaccttg gcgcccctgg cccctctgga gcaagaggcg agagaggttt
     2161 ccctggcgag cgtggtgtgc aaggtccccc tggtcctgct ggtccccgag gggccaacgg
     2221 tgctcccggc aacgatggtg ctaagggtga tgctggtgcc cctggagctc ccggtagcca
     2281 gggcgcccct ggccttcagg gaatgcctgg tgaacgtggt gcagctggtc ttccagggcc
     2341 taagggtgac agaggtgatg ctggtcccaa aggtgctgat ggctctcctg gcaaagatgg
     2401 cgtccgtggt ctgactggcc ccattggtcc tcctggccct gctggtgccc ctggtgacaa
     2461 gggtgaaagt ggtcccagcg gccctgctgg tcccactgga gctcgtggtg cccccggaga
     2521 ccgtggtgag cctggtcccc ccggccctgc tggctttgct ggcccccctg gtgctgacgg
     2581 ccaacctggt gctaaaggcg aacctggtga tgctggtgct aaaggcgatg ctggtccccc
     2641 tggccctgcc ggacccgctg gaccccctgg ccccattggt aatgttggtg ctcctggagc
     2701 caaaggtgct cgcggcagcg ctggtccccc tggtgctact ggtttccctg gtgctgctgg
     2761 ccgagtcggt cctcctggcc cctctggaaa tgctggaccc cctggccctc ctggtcctgc
     2821 tggcaaagaa ggcggcaaag gtccccgtgg tgagactggc cctgctggac gtcctggtga
     2881 agttggtccc cctggtcccc ctggccctgc tggcgagaaa ggatcccctg gtgctgatgg
     2941 tcctgctggt gctcctggta ctcccgggcc tcaaggtatt gctggacagc gtggtgtggt
     3001 cggcctgcct ggtcagagag gagagagagg cttccctggt cttcctggcc cctctggtga
     3061 acctggcaaa caaggtccct ctggagcaag tggtgaacgt ggtccccctg gtcccatggg
     3121 cccccctgga ttggctggac cccctggtga atctggacgt gagggggctc ctggtgccga
     3181 aggttcccct ggacgagacg gttctcctgg cgccaagggt gaccgtggtg agaccggccc
     3241 cgctggaccc cctggtgctc ctggtgctcc tggtgcccct ggccccgttg gccctgctgg
     3301 caagagtggt gatcgtggtg agactggtcc tgctggtccc gccggtcctg tcggccctgt
     3361 tggcgcccgt ggccccgccg gaccccaagg cccccgtggt gacaagggtg agacaggcga
     3421 acagggcgac agaggcataa agggtcaccg tggcttctct ggcctccagg gtccccctgg
     3481 ccctcctggc tctcctggtg aacaaggtcc ctctggagcc tctggtcctg ctggtccccg
     3541 aggtccccct ggctctgctg gtgctcctgg caaagatgga ctcaacggtc tccctggccc
     3601 cattgggccc cctggtcctc gcggtcgcac tggtgatgct ggtcctgttg gtccccccgg
     3661 ccctcctgga cctcctggtc cccctggtcc tcccagcgct ggtttcgact tcagcttcct
     3721 gccccagcca cctcaagaga aggctcacga tggtggccgc tactaccggg ctgatgatgc
     3781 caatgtggtt cgtgaccgtg acctcgaggt ggacaccacc ctcaagagcc tgagccagca
     3841 gatcgagaac atccggagcc cagagggcag ccgcaagaac cccgcccgca cctgccgtga
     3901 cctcaagatg tgccactctg actggaagag tggagagtac tggattgacc ccaaccaagg
     3961 ctgcaacctg gatgccatca aagtcttctg caacatggag actggtgaga cctgcgtgta
     4021 ccccactcag cccagtgtgg cccagaagaa ctggtacatc agcaagaacc ccaaggacaa
     4081 gaggcatgtc tggttcggcg agagcatgac cgatggattc cagttcgagt atggcggcca
     4141 gggctccgac cctgccgatg tggccatcca gctgaccttc ctgcgcctga tgtccaccga
     4201 ggcctcccag aacatcacct accactgcaa gaacagcgtg gcctacatgg accagcagac
     4261 tggcaacctc aagaaggccc tgctcctcca gggctccaac gagatcgaga tccgcgccga
     4321 gggcaacagc cgcttcacct acagcgtcac tgtcgatggc tgcacgagtc acaccggagc
     4381 ctggggcaag acagtgattg aatacaaaac caccaagacc tcccgcctgc ccatcatcga
     4441 tgtggccccc ttggacgttg gtgccccaga ccaggaattc ggcttcgacg ttggccctgt
     4501 ctgcttcctg taaactccct ccatcccaac ctggctccct cccacccaac caactttccc
     4561 cccaacccgg aaacagacaa gcaacccaaa ctgaaccccc tcaaaagcca aaaaatggga
     4621 gacaatttca catggacttt ggaaaatatt tttttccttt gcattcatct ctcaaactta
     4681 gtttttatct ttgaccaacc gaacatgacc aaaaaccaaa agtgcattca accttaccaa
     4741 aaaaaaaaaa aaaaaaagaa taaataaata actttttaaa aaaggaagct tggtccactt
     4801 gcttgaagac ccatgcgggg gtaagtccct ttctgcccgt tgggcttatg aaaccccaat
     4861 gctgcccttt ctgctccttt ctccacaccc cccttggggc ctcccctcca ctccttccca
     4921 aatctgtctc cccagaagac acaggaaaca atgtattgtc tgcccagcaa tcaaaggcaa
     4981 tgctcaaaca cccaagtggc ccccaccctc agcccgctcc tgcccgccca gcacccccag
     5041 gccctggggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat
     5101 ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc
     5161 ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg
     5221 ggaacgcgtg tcaatccctt gtgccgcagg gctgggcggg agagactgtt ctgttccttg
     5281 tgtaactgtg ttgctgaaag actacctcgt tcttgtcttg atgtgtcacc ggggcaactg
     5341 cctgggggcg gggatggggg cagggtggaa gcggctcccc attttatacc aaaggtgcta
     5401 catctatgtg atgggtgggg tggggaggga atcactggtg ctatagaaat tgagatgccc
     5461 ccccaggcca gcaaatgttc ctttttgttc aaagtctatt tttattcctt gatatttttc
     5521 tttttttttt tttttttttg tggatgggga cttgtgaatt tttctaaagg tgctatttaa
     5581 catgggagga gagcgtgtgc ggctccagcc cagcccgctg ctcactttcc accctctctc
     5641 cacctgcctc tggcttctca ggcctctgct ctccgacctc tctcctctga aaccctcctc
     5701 cacagctgca gcccatcctc ccggctccct cctagtctgt cctgcgtcct ctgtccccgg
     5761 gtttcagaga caacttccca aagcacaaag cagtttttcc ccctaggggt gggaggaagc
     5821 aaaagactct gtacctattt tgtatgtgta taataatttg agatgttttt aattattttg
     5881 attgctggaa taaagcatgt ggaaatgacc caaa
//
