LOCUS       NM_001858               8740 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens collagen type XIX alpha 1 chain (COL19A1), mRNA.
ACCESSION   NM_001858
VERSION     NM_001858.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8740)
  AUTHORS   Xu,T., Zhou,C.Z., Xiao,J. and Liu,J.
  TITLE     Unique Conformation in a Natural Interruption Sequence of Type XIX
            Collagen Revealed by Its High-Resolution Crystal Structure
  JOURNAL   Biochemistry 57 (7), 1087-1095 (2018)
   PUBMED   29376320
  REMARK    GeneRIF: Naturally occurring interruptions in nonfibrillar collagen
            play key roles in molecular flexibility, collagen degradation, and
            ligand binding. This study focused on a G5G type natural
            interruption sequence G-POALO-G from human type XIX collagen, a
            homotrimer collagen, as this sequence possesses distinct properties
            compared with those of a pathological similar Gly mutation sequence
            in collagen mimic peptides.
REFERENCE   2  (bases 1 to 8740)
  AUTHORS   Oudart,J.B., Monboisse,J.C., Maquart,F.X., Brassart,B.,
            Brassart-Pasco,S. and Ramont,L.
  TITLE     Type XIX collagen: A new partner in the interactions between tumor
            cells and their microenvironment
  JOURNAL   Matrix Biol 57-58, 169-177 (2017)
   PUBMED   27491275
  REMARK    GeneRIF: Type XIX collagen is a new partner in the interactions
            between tumor cells and their microenvironment. (Review)
            Review article
REFERENCE   3  (bases 1 to 8740)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8740)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   5  (bases 1 to 8740)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8740)
  AUTHORS   Gerecke,D.R., Olson,P.F., Koch,M., Knoll,J.H., Taylor,R.,
            Hudson,D.L., Champliaud,M.F., Olsen,B.R. and Burgeson,R.E.
  TITLE     Complete primary structure of two splice variants of collagen XII,
            and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX)
            collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human
            chromosome 6q12-q13
  JOURNAL   Genomics 41 (2), 236-242 (1997)
   PUBMED   9143499
REFERENCE   7  (bases 1 to 8740)
  AUTHORS   Inoguchi,K., Yoshioka,H., Khaleduzzaman,M. and Ninomiya,Y.
  TITLE     The mRNA for alpha 1(XIX) collagen chain, a new member of FACITs,
            contains a long unusual 3' untranslated region and displays many
            unique splicing variants
  JOURNAL   J Biochem 117 (1), 137-146 (1995)
   PUBMED   7775380
REFERENCE   8  (bases 1 to 8740)
  AUTHORS   Myers,J.C., Yang,H., D'Ippolito,J.A., Presente,A., Miller,M.K. and
            Dion,A.S.
  TITLE     The triple-helical region of human type XIX collagen consists of
            multiple collagenous subdomains and exhibits limited sequence
            homology to alpha 1(XVI)
  JOURNAL   J Biol Chem 269 (28), 18549-18557 (1994)
   PUBMED   8034603
REFERENCE   9  (bases 1 to 8740)
  AUTHORS   Myers,J.C., Sun,M.J., D'Ippolito,J.A., Jabs,E.W., Neilson,E.G. and
            Dion,A.S.
  TITLE     Human cDNA clones transcribed from an unusually
            high-molecular-weight RNA encode a new collagen chain
  JOURNAL   Gene 123 (2), 211-217 (1993)
   PUBMED   7916703
REFERENCE   10 (bases 1 to 8740)
  AUTHORS   Yoshioka,H., Zhang,H., Ramirez,F., Mattei,M.G., Moradi-Ameli,M.,
            van der Rest,M. and Gordon,M.K.
  TITLE     Synteny between the loci for a novel FACIT-like collagen locus
            (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans
  JOURNAL   Genomics 13 (3), 884-886 (1992)
   PUBMED   1639419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D38163.1, BC113364.1,
            AL160262.12 and KF510956.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001858.5.
            
            Summary: This gene encodes the alpha chain of type XIX collagen, a
            member of the FACIT collagen family (fibril-associated collagens
            with interrupted helices). Although the function of this collagen
            is not known, other members of this collagen family are found in
            association with fibril-forming collagens such as type I and II,
            and serve to maintain the integrity of the extracellular matrix.
            The transcript produced from this gene has an unusually large 3'
            UTR which has not been completely sequenced. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38163.1, BC113364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152719, SAMN03267751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620364.5/ ENSP00000480474.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                D38163.1           1-32
            33-3601             BC113364.1         1-3569
            3602-3933           AL160262.12        19743-20074
            3934-4315           KF510956.1         1-382               c
            4316-8740           AL160262.12        20456-24880
FEATURES             Location/Qualifiers
     source          1..8740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..8740
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="collagen type XIX alpha 1 chain"
                     /db_xref="GeneID:1310"
                     /db_xref="HGNC:HGNC:2196"
                     /db_xref="MIM:120165"
     exon            1..85
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            86..208
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3546
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="collagen alpha 1 (Y) chain; collagen XIX, alpha-1
                     polypeptide; collagen alpha-1(XIX) chain; a1 chain of type
                     XIX collagen; collagen, type XIX, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XIX) chain precursor"
                     /protein_id="NP_001849.2"
                     /db_xref="CCDS:CCDS4970.1"
                     /db_xref="GeneID:1310"
                     /db_xref="HGNC:HGNC:2196"
                     /db_xref="MIM:120165"
                     /translation="MRLTGPWKLWLWMSIFLLPASTSVTVRDKTEESCPILRIEGHQL
                     TYDNINKLEVSGFDLGDSFSLRRAFCESDKTCFKLGSALLIRDTIKIFPKGLPEEYSV
                     AAMFRVRRNAKKERWFLWQVLNQQNIPQISIVVDGGKKVVEFMFQATEGDVLNYIFRN
                     RELRPLFDRQWHKLGISIQSQVISLYMDCNLIARRQTDEKDTVDFHGRTVIATRASDG
                     KPVDIELHQLKIYCSANLIAQETCCEISDTKCPEQDGFGNIASSWVTAHASKMSSYLP
                     AKQELKDQCQCIPNKGEAGLPGAPGSPGQKGHKGEPGENGLHGAPGFPGQKGEQGFEG
                     SKGETGEKGEQGEKGDPALAGLNGENGLKGDLGPHGPPGPKGEKGDTGPPGPPALPGS
                     LGIQGPQGPPGKEGQRGRRGKTGPPGKPGPPGPPGPPGIQGIHQTLGGYYNKDNKGND
                     EHEAGGLKGDKGETGLPGFPGSVGPKGQKGEPGEPFTKGEKGDRGEPGVIGSQGVKGE
                     PGDPGPPGLIGSPGLKGQQGSAGSMGPRGPPGDVGLPGEHGIPGKQGIKGEKGDPGGI
                     IGPPGLPGPKGEAGPPGKSLPGEPGLDGNPGAPGPRGPKGERGLPGVHGSPGDIGPQG
                     IGIPGRTGAQGPAGEPGIQGPRGLPGLPGTPGTPGNDGVPGRDGKPGLPGPPGDPIAL
                     PLLGDIGALLKNFCGNCQASVPGLKSNKGEEGGAGEPGKYDSMARKGDIGPRGPPGIP
                     GREGPKGSKGERGYPGIPGEKGDEGLQGIPGIPGAPGPTGPPGLMGRTGHPGPTGAKG
                     EKGSDGPPGKPGPPGPPGIPFNERNGMSSLYKIKGGVNVPSYPGPPGPPGPKGDPGPV
                     GEPGAMGLPGLEGFPGVKGDRGPAGPPGIAGMSGKPGAPGPPGVPGEPGERGPVGDIG
                     FPGPEGPSGKPGINGKDGIPGAQGIMGKPGDRGPKGERGDQGIPGDRGSQGERGKPGL
                     TGMKGAIGPMGPPGNKGSMGSPGHQGPPGSPGIPGIPADAVSFEEIKKYINQEVLRIF
                     EERMAVFLSQLKLPAAMLAAQAYGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGI
                     GLPGSPGLPGTSALGLPGSPGAPGPQGPPGPSGRCNPEDCLYPVSHAHQRTGGN"
     exon            209..283
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            284..383
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            384..507
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            508..783
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            784..864
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            865..990
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1053
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1098
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1143
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1197
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1251
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1287
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1341
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1395
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1458
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1500
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1563
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1599
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1635
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1689
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1743
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1797
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1887
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1932
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2010
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2046
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2100
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2154
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2196
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2301
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2355
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2409
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2463
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2517
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2562
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2613
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2658
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2685
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2739
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2784
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2829
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2892
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2928
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..2973
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3144
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3211
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3340
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3418
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..8740
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5538..5543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="hexamer: CATAAA"
     polyA_site      5556
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="major polyA site"
     regulatory      6797..6802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="hexamer: ATTAAA"
     polyA_site      6823
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="hexamer: AGTAAA"
     polyA_site      8399
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
     regulatory      8711..8716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
                     /note="hexamer: AATAAA"
     polyA_site      8740
                     /gene="COL19A1"
                     /gene_synonym="COL9A1L; D6S228E"
ORIGIN      
        1 actcgcaggg agctcactcc tcggcggtgc cgcagccctg tccggactcc actgcgcctc
       61 tgaggggctc aaatacgaat tcaagatccg tggccgttca catggtttca aggcacaatg
      121 agactcactg gcccttggaa actttggctt tggatgtcaa tatttctgct tcctgcttcc
      181 acttccgtga ccgttaggga caagacagaa gagtcatgcc ctatcctgag aatagaggga
      241 catcagctga catatgacaa cataaacaaa cttgaagttt caggttttga tctaggagac
      301 agcttttctc taagacgtgc attttgtgaa agtgataaaa cctgtttcaa attgggaagt
      361 gcacttctta ttagagacac tattaagata tttcccaaag gccttcctga ggagtactca
      421 gtagctgcca tgtttcgagt acgaagaaac gccaaaaagg aacggtggtt tctgtggcag
      481 gttttaaacc agcagaatat tccacagatt tctatagtag ttgatggtgg aaagaaggtg
      541 gtggaattta tgtttcaagc cacagaggga gatgtgttga actacatttt tagaaatcga
      601 gaactccgtc ctttgtttga tcgtcagtgg cacaaacttg gcattagtat acaatcccag
      661 gtcatttcac tttatatgga ttgtaattta attgcgagga ggcagactga tgaaaaggac
      721 actgtggatt tccatggacg gacagttatt gctacgcgag cttcagatgg caagcctgtg
      781 gatattgaac ttcaccaact taaaatctac tgcagtgcaa acctcatagc tcaagaaaca
      841 tgttgtgaaa tatcagatac taagtgccca gagcaggatg gctttggaaa tattgcatca
      901 tcatgggtaa ctgctcatgc cagtaaaatg tcttcatatc tgccagcaaa gcaggaactt
      961 aaagaccagt gccagtgcat tccaaacaag ggagaagcag gattaccagg agctccgggt
     1021 tcacctgggc agaaagggca taaaggagag ccgggtgaaa atggtttaca tggtgctcca
     1081 ggattccctg gtcaaaaggg agagcaaggt tttgaaggca gcaaaggaga aactggtgaa
     1141 aagggtgaac aaggagaaaa aggagatcca gctctggctg gccttaatgg agaaaatggt
     1201 ttgaaaggtg acttgggtcc tcatggtcca cctggcccaa aaggagaaaa gggagataca
     1261 ggacccccag gaccaccagc cttacctggt tccctgggga tacaaggccc ccaaggtcca
     1321 cctggaaaag agggtcagag gggaagacga gggaaaacag gacctcccgg aaaaccagga
     1381 cccccaggac cacctggacc tcctggaata caaggaatac accaaactct tggtggatat
     1441 tataacaagg ataacaaggg aaatgatgaa catgaagctg gaggcctgaa aggagacaag
     1501 ggtgaaactg gactaccagg atttccaggg tctgttggcc ctaaaggaca aaaaggagaa
     1561 cctggagagc cttttacaaa aggagaaaaa ggagatagag gagaacctgg ggtaatagga
     1621 tcacagggag taaagggtga acctggagat cccggacccc ctggtttaat aggaagccca
     1681 ggactaaagg gtcagcaagg atctgcaggc tccatgggac ccagaggacc gccaggagat
     1741 gttggattgc caggagaaca tggtatccca ggaaaacaag gcattaaagg agaaaaggga
     1801 gatccgggtg ggatcatagg ccctcccggg cttccaggtc caaaaggtga ggctggtcct
     1861 ccagggaaaa gcctgccagg ggaaccagga ttagatggaa atcctggagc acctggtcca
     1921 cgtgggccaa agggtgaaag aggacttcca ggtgttcacg gttccccagg ggacataggc
     1981 ccacaaggga taggaattcc tggcagaaca ggcgcccaag gaccagctgg agagccaggt
     2041 attcagggtc ctcgaggtct ccctgggttg ccaggaactc cagggactcc agggaatgat
     2101 ggagttccag ggagagatgg aaagccaggc ctgccaggcc ccccaggtga cccgattgca
     2161 cttcctctct tgggagacat cggtgctttg ctcaagaatt tctgtggcaa ctgccaagcc
     2221 agtgtcccag ggctgaaaag caacaaagga gaagaaggag gtgctggtga gcctggaaag
     2281 tatgattcca tggcccggaa gggtgatata gggccacggg gtcctccagg aatcccagga
     2341 agagagggac caaagggaag caaaggagag cggggctacc ctgggatacc tggggagaaa
     2401 ggcgatgagg gtcttcaagg aattccaggc attccaggtg ctccaggccc gactggaccc
     2461 cctggcttaa tgggaagaac tggacatcct ggtcccacag gagcaaaagg tgaaaagggc
     2521 agcgacggac cccctgggaa acccggacca cctggaccac ctggtattcc atttaatgaa
     2581 cgaaacggca tgagcagttt atataaaatt aagggaggtg tgaatgttcc cagttaccca
     2641 gggccacccg gtcctcctgg cccaaaaggc gatcctggcc cagtgggaga gcctggtgca
     2701 atggggttgc caggattaga aggatttcca ggtgtaaagg gagatcgagg cccagcaggt
     2761 cccccaggaa tagcagggat gtcgggaaaa cctggtgccc cagggcctcc aggagttcca
     2821 ggggaaccgg gtgagagagg acctgttgga gatataggtt tccctggacc agaaggaccc
     2881 tcaggaaagc caggaataaa tggaaaagat ggaataccag gtgctcaggg catcatgggt
     2941 aagcctggag acagaggccc caaaggagaa cgtggtgatc aggggattcc aggagacaga
     3001 ggctcacaag gtgaacgggg aaaaccaggc cttacaggca tgaagggggc catcggtcct
     3061 atgggtccac caggaaacaa gggctccatg ggatcccctg gccaccaagg ccctccaggc
     3121 tctccaggca tccctggcat tccggctgat gcagtttcat ttgaagaaat aaagaagtat
     3181 attaatcaag aggtcctaag gatttttgaa gagaggatgg ctgtattcct atcccagctc
     3241 aagctgccag cagcaatgtt ggctgcccaa gcttatggga gacctgggcc accagggaag
     3301 gatgggttgc ctgggccacc aggagaccct ggaccccaag gctacagagg acagaaggga
     3361 gaaagaggtg aacctggaat tgggctgcca gggagtccag gtcttcctgg gacttcagct
     3421 ctgggtttgc caggctcacc aggtgcccca ggcccacagg gccccccagg acccagtgga
     3481 agatgtaacc cagaagattg cctctatcct gtgtctcatg cccatcagcg cacaggtggg
     3541 aattgaacac acctgaagaa gacttggttc ctggtaacat ttccttgcca ctggagctct
     3601 cttaataccg tcaaaccctc atcatctgtg ggttgctttt tttttttttt tttttttttg
     3661 ggagtaagcc aggcattaaa agcaaccgtt tgaatcctat tcctatagca attgcaaatc
     3721 agcatttttt gatttttccc aaattcattc catatgtttt gctttacaat tgctatgatt
     3781 tttactcaga gttttatatg aaatatgcaa gtaaatctta tcgttagttc ttcttcaaaa
     3841 ggaaattgca tcttgtgact tagtagactg atgatgatat ccattttgta gactcatcaa
     3901 catgtggttg gcctttgatt tctgaatttt aaagtttcag acttatcttt tccttggtgt
     3961 ttaaatttac tatcattgct aaacatctcg tcaacttttt tgatatagtg cattgctcct
     4021 gttgaatgtt ttttgactac tttttataac ttaagaattt ttataccatc tacatctatc
     4081 ctacttatgc agaaaaatag gcaataagaa cttcatttta caatttatgt tttcaaaaaa
     4141 aaaatgcagg aaactgtttt atcagggagc ccaaacaccc agcatagcca actactgaaa
     4201 tgattttgtt aattctgtat aatgagctca attcaaagca atcaccactg gcatgaataa
     4261 gtactgcatg aaaagggagt atcaaattcc agttttgtat gagttctgca aaaaaagcct
     4321 aatattctgt ggtcccctca ctcagtctct catttggtaa acagaaagct gttttcccta
     4381 caaggtgctt ggtggtgaag ccaccaagct gtctttggta ctcttaaagc ttcagtggcc
     4441 tagcaagatc tttgggccct tgtatccatt atccttatga cctcatcacc ctcagacttt
     4501 aagacaagaa gccaccatca aaacaaagga tgggatacgt atagaatgga ctcacttgtc
     4561 ctagaagatg aatgtgtagt gtcagcaaat gcatgttaag aaggtgaagc ccaaaagctc
     4621 ttaaggagaa ttgtatttct ccagaagctg cagcaagagg tacagctcaa caaaggaaaa
     4681 ccacaggact ggatatgcaa ctagtgctca gaccaaagag ttcacaccca ctctaaaacc
     4741 atgtcctctg aaaagaaaca aaaatacagt gatcatcaaa tgcctaaaca gtctttctgt
     4801 tggttagctg tacattcatt gaggaactgt tgattggcag gcactgattc tctagaacac
     4861 tgggcatgag gatgttgcag aaatctagat ggtgggtccc acagatgtga gaacatgctg
     4921 caagagcctg ccagccacag caatcaggac tcacagctct tcaaggagca gtgcagattt
     4981 caatttggct aaaacaggat gattgctttt gtctgtttac tgaaaaatga gtttagaaag
     5041 gctagcccac tgacattgga aaaagctgtg aacagagttg tgtctgagga atgtgcctaa
     5101 tttaaggcag ggtttgttcc aatgcatccg tgatttgaac cggttttcat tatagattaa
     5161 tgaactgctg gtcaggtact gtctacaatg gctgtgcata cctataacat tttaggtatt
     5221 tcatattgaa ttatgctgta tatttcaatt ccaagtttat ttattttcca aggttatttt
     5281 atttattgta agcattttga cattgatttt ttttttttcg ttttctttct tgtgcaatac
     5341 ctacaatggt gctgtgtttt aaacttacac aattgggaca tacgtatgtg ttttcttagt
     5401 aaaatggtaa tttatcccga aaaagtgtac atagatctaa aatttggtgc tatgtgtata
     5461 tcttgagctt ttaatttgtt gaattttcta aacgcttaca acttatctgc cactcatatt
     5521 aatttacttg aatttgtcat aaagctaaat attttatatg ttttcaaaga ttattttttc
     5581 atattaatag gttgtttatc tttttgcctg tttgctaatt taaaaatatt tattttatca
     5641 ttttaatgtt ttcatggact tttttgctga tggtaatcaa ctttttttgt tttttggttt
     5701 ttgagttgtt cttgtcatag acataaaaag acaattcatt ttcttgtttt attaactctg
     5761 ttcattttta ttctacaaaa tatgtcatgc attctttctt atgaattgta tatttagaaa
     5821 tctttctaaa taccattaag gcttgactgg ttaattccta tttcaaggat ttggatttat
     5881 tcaggtaatt tgatgggatg gggaaatata atattgtgtg atgcatatta caaagtggac
     5941 ttgtcacaat gacacaaact cattttttgt aactgggaaa tatgactaaa tttgacgtaa
     6001 ctagagaaac aaggctgtat ccacatggta caagcctttc tcaccctact ctattattta
     6061 ccttcagata ctttttcctg cctcagctct gtacacatga tatgcaacaa agggcagcaa
     6121 gaaatgctgg gtccacctaa tttaacacaa aatgaagttg agattcggca gttgcccaat
     6181 tcctttaata aaaagaaact aaataatttg ggccccaaag tagggtggga agttttcctc
     6241 taaatgactt gatggttgcc aaatcccttg caccatttta ttccattcca aaacatgtgt
     6301 ttatttccac atagatgtta atgatgttca aagcagggga gaagaattat tcaatttcat
     6361 gaataactct tgtttgcact ccagaaaaca acatacatgt ttaaatacaa aataattatg
     6421 ggccatgacg acgattaata ttaaaactgt gatttccata tacaagtatg tttgagttcc
     6481 aatcttacat tttataccaa gttcaaaaca ctttcagata gaagtctttc tatgcaaaga
     6541 ttaaagtatg acttcaattc atatttatgg cctttggaat ccaaagaaaa acagaagaat
     6601 aattcatgga tttgttcatt gttctttcca actgaaggca gtaaccatta cttctaaccg
     6661 taacacaaac acagcaagtt ttaacctttt aaacttttca ctttgtgagc aaagtaaccc
     6721 cataagttta tttccctatt tcatggtatt gtttaaactt taaaatttta gtcacttaaa
     6781 gaacttaagc aattatatta aaatacgttg tctgtgaaaa ttatcatttg atatttggct
     6841 tataaagtaa tttttatgaa tctgttttat gagttaggta agatttagcc tttctgcagt
     6901 ctgtctcatc tgttgggaac ctgtgatata cctccatttg tccacaagat ggtgtttaaa
     6961 acaatttgtt cagaagaact gagcaaacta acagaaatac aaggctacga acagtttagt
     7021 ggacaactaa atcagactct tgcctttgca ctttttttta acttttgtag ataatttttg
     7081 ttaatttgtt ttgttaattt atgtttttcc taattttaag catctttatg aaacaggcac
     7141 agtacccttt ggtttgttga ctgttttgat tttatttctt tggtggatat atatgtactt
     7201 atacacttag ttaacatgca gattaactag tcataactgt ttatacacca ctctcatatt
     7261 ttagtgatca atatgaagac agctaaataa ttatcctact ttttagacag gacagatact
     7321 ctcaacagac aagaaaaaag atttagctta tcacaagaag cagacaattt ataaaactac
     7381 acaatgtcta aactctatgt tgctcagtgt acttaaaatt ttacagttat atttgtataa
     7441 cgtttatatt tttctagaat acatcactat ttacaaaagt acaattagaa acactgtttt
     7501 ttttaagtac cgtttttatt ttcataacac taataataca ctgggattga gaatttctgt
     7561 taagtgtttt gctgacgttg ttttaatgaa tactcaaaaa agctttgcag atttgtccat
     7621 tgctcttgtt cttaaattat ttttcatact tgtctgtatc caccttctga agacacacaa
     7681 gtgtttactg tcgcagtttc ccagcgttat ttcttaatac ttgagtgttg acacattttt
     7741 gtaccatccc ccttttgtac catctctgct cacaaagatt atatgcaggc tttgaagagg
     7801 aggagatgca gaagataatt gaatttgtat cttgtatgcc tatgtaattc aaagtgactt
     7861 agtccattga attgtgttca tttattagtt ggctggttaa gatagcatta attatcttaa
     7921 atttattcaa ctactaaaag tctcaggcaa taggacagat gagtgtcatc atttttattg
     7981 tgtggcatac ttggagctat aatccaaacg ttttactcaa caaaataatg ctagagtaac
     8041 tgatcaattt ggttaaattg aatgaagaac caagtgaaca cagagaaaac ttattcggac
     8101 aagtagaccc agcacagcaa aaatttgtct gaaagataag acaagcttat aagaccaaag
     8161 ctaagtctaa gaaaatctaa atggaaaaaa aattgcgtgt tcagatccaa tagtgagtga
     8221 tgtggtacaa ctggaggagt tagctacttg cttcatgaat ttgtcaaaag tgaatactaa
     8281 taaagtggga ggcttcacta aatgaggggg taaataagat ttaagtttat cagaagtgtg
     8341 tgtattgtgt gaccatacta agcttctggg tgtaagtaaa gatgctggct attttacaac
     8401 tttttattgt attgtgttat gcaaagtaca ttttggagat aaatgttttt cagcacatta
     8461 atgtctttaa attcaggttg tattgggtgt attttacaac tatttatttt taaataacat
     8521 ttagggtgtg ttttccccca ttttgtttgt tctctatctt acctcatcaa actctttacg
     8581 atttaattga atatactcat gttaagtgca atggcattag ttttattcaa aatcccacat
     8641 gggcataatg ctttgaggcc ttgattccta catgttcatt atgcataatg agcttgtcac
     8701 ctatctcagc aataaaggtt ctgaccctat gtcagggaaa
//
