LOCUS       NM_000494               5612 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens collagen type XVII alpha 1 chain (COL17A1), mRNA.
ACCESSION   NM_000494
VERSION     NM_000494.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5612)
  AUTHORS   Turunen,J.A., Tuisku,I.S., Repo,P., Mortenhumer,S., Kawan,S.,
            Jarvinen,R.S., Korsback,A., Immonen,A.T. and Kivela,T.T.
  TITLE     Epithelial recurrent erosion dystrophy (ERED) from the splice site
            altering COL17A1 variant c.3156C>T in families of Finnish-Swedish
            ancestry
  JOURNAL   Acta Ophthalmol 102 (3), 296-305 (2024)
   PUBMED   37289141
  REMARK    GeneRIF: Epithelial recurrent erosion dystrophy (ERED) from the
            splice site altering COL17A1 variant c.3156C>T in families of
            Finnish-Swedish ancestry.
REFERENCE   2  (bases 1 to 5612)
  AUTHORS   Hany,U., Watson,C.M., Liu,L., Smith,C.E.L., Harfoush,A.,
            Poulter,J.A., Nikolopoulos,G., Balmer,R., Brown,C.J., Patel,A.,
            Simmonds,J., Charlton,R., Acosta de Camargo,M.G., Rodd,H.D.,
            Jafri,H., Antanaviciute,A., Moffat,M., Al-Jawad,M., Inglehearn,C.F.
            and Mighell,A.J.
  TITLE     Heterozygous COL17A1 variants are a frequent cause of amelogenesis
            imperfecta
  JOURNAL   J Med Genet 61 (4), 347-355 (2024)
   PUBMED   37979963
  REMARK    GeneRIF: Heterozygous COL17A1 variants are a frequent cause of
            amelogenesis imperfecta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5612)
  AUTHORS   Crespo-Bravo,M., Thorlacius-Ussing,J., Nissen,N.I., Pedersen,R.S.,
            Boisen,M.K., Liljefors,M., Johansen,A.Z., Johansen,J.S.,
            Karsdal,M.A. and Willumsen,N.
  TITLE     Levels of type XVII collagen (BP180) ectodomain are elevated in
            circulation from patients with multiple cancer types and is
            prognostic for patients with metastatic colorectal cancer
  JOURNAL   BMC Cancer 23 (1), 949 (2023)
   PUBMED   37803411
  REMARK    GeneRIF: Levels of type XVII collagen (BP180) ectodomain are
            elevated in circulation from patients with multiple cancer types
            and is prognostic for patients with metastatic colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5612)
  AUTHORS   Ujiie,H.
  TITLE     What's new in the pathogeneses and triggering factors of bullous
            pemphigoid
  JOURNAL   J Dermatol 50 (2), 140-149 (2023)
   PUBMED   36412277
  REMARK    GeneRIF: What's new in the pathogeneses and triggering factors of
            bullous pemphigoid.
            Review article
REFERENCE   5  (bases 1 to 5612)
  AUTHORS   Huang,W.L., Wu,S.F., Huang,X. and Zhou,S.
  TITLE     Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for
            Pancreatic Cancer
  JOURNAL   Dis Markers 2022, 9453549 (2022)
   PUBMED   35722628
  REMARK    GeneRIF: Integrated Analysis of ECT2 and COL17A1 as Potential
            Biomarkers for Pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5612)
  AUTHORS   McGrath,J.A., Gatalica,B., Christiano,A.M., Li,K., Owaribe,K.,
            McMillan,J.R., Eady,R.A. and Uitto,J.
  TITLE     Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a
            hemidesmosomal transmembrane collagen (COL17A1), in generalized
            atrophic benign epidermolysis bullosa
  JOURNAL   Nat Genet 11 (1), 83-86 (1995)
   PUBMED   7550320
REFERENCE   7  (bases 1 to 5612)
  AUTHORS   Pfendner,E.G. and Lucky,A.W.
  TITLE     Junctional Epidermolysis Bullosa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301304
REFERENCE   8  (bases 1 to 5612)
  AUTHORS   Giudice,G.J., Emery,D.J. and Diaz,L.A.
  TITLE     Cloning and primary structural analysis of the bullous pemphigoid
            autoantigen BP180
  JOURNAL   J Invest Dermatol 99 (3), 243-250 (1992)
   PUBMED   1324962
REFERENCE   9  (bases 1 to 5612)
  AUTHORS   Li,K.H., Sawamura,D., Giudice,G.J., Diaz,L.A., Mattei,M.G.,
            Chu,M.L. and Uitto,J.
  TITLE     Genomic organization of collagenous domains and chromosomal
            assignment of human 180-kDa bullous pemphigoid antigen-2, a novel
            collagen of stratified squamous epithelium
  JOURNAL   J Biol Chem 266 (35), 24064-24069 (1991)
   PUBMED   1748679
REFERENCE   10 (bases 1 to 5612)
  AUTHORS   Sawamura,D., Li,K.H., Nomura,K., Sugita,Y., Christiano,A.M. and
            Uitto,J.
  TITLE     Bullous pemphigoid antigen: cDNA cloning, cellular expression, and
            evidence for polymorphism of the human gene
  JOURNAL   J Invest Dermatol 96 (6), 908-915 (1991)
   PUBMED   2045679
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA646288.1, M91669.1,
            AL138761.12, AF136185.1 and AI572644.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 12, 2018 this sequence version replaced NM_000494.3.
            
            Summary: This gene encodes the alpha chain of type XVII collagen.
            Unlike most collagens, collagen XVII is a transmembrane protein.
            Collagen XVII is a structural component of hemidesmosomes,
            multiprotein complexes at the dermal-epidermal basement membrane
            zone that mediate adhesion of keratinocytes to the underlying
            membrane. Mutations in this gene are associated with both
            generalized atrophic benign and junctional epidermolysis bullosa.
            Two homotrimeric forms of type XVII collagen exist. The full length
            form is the transmembrane protein. A soluble form, referred to as
            either ectodomain or LAD-1, is generated by proteolytic processing
            of the full length form. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M91669.1, SRR11853567.4354.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648076.2/ ENSP00000497653.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                DA646288.1         2-68
            68-1230             M91669.1           4-1166
            1231-1231           AL138761.12        83637-83637         c
            1232-1450           M91669.1           1168-1386
            1451-1451           AL138761.12        80597-80597         c
            1452-2763           M91669.1           1388-2699
            2764-2764           AL138761.12        64934-64934         c
            2765-2882           M91669.1           2701-2818
            2883-2883           AL138761.12        63837-63837         c
            2884-3051           M91669.1           2820-2987
            3052-3052           AL138761.12        62897-62897         c
            3053-3072           M91669.1           2989-3008
            3073-3073           AL138761.12        62553-62553         c
            3074-3429           M91669.1           3010-3365
            3430-3430           AL138761.12        60500-60500         c
            3431-4733           M91669.1           3367-4669
            4734-5610           AF136185.1         129-1005
            5611-5612           AI572644.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..5612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     gene            1..5612
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /note="collagen type XVII alpha 1 chain"
                     /db_xref="GeneID:1308"
                     /db_xref="HGNC:HGNC:2194"
                     /db_xref="MIM:113811"
     exon            1..158
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..221
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..4663
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /note="collagen XVII, alpha-1 polypeptide; alpha 1 type
                     XVII collagen; bullous pemphigoid antigen 2 (180kD); type
                     XVII collagen alpha-1; bA16H23.2 (collagen, type XVII,
                     alpha 1 (BP180)); 180 kDa bullous pemphigoid antigen 2"
                     /codon_start=1
                     /product="collagen alpha-1(XVII) chain"
                     /protein_id="NP_000485.3"
                     /db_xref="CCDS:CCDS7554.1"
                     /db_xref="GeneID:1308"
                     /db_xref="HGNC:HGNC:2194"
                     /db_xref="MIM:113811"
                     /translation="MDVTKKNKRDGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTA
                     SLGGGSRLEKQSLTHGSSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKT
                     HVTRHAYEGSSSGNSSPEYPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDD
                     VKRLLKGSRSASVSPTRNSSNTLPIPKKGTVETKIVTASSQSVSGTYDATILDANLPS
                     HVWSSTLPAGSSMGTYHNNMTTQSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLST
                     SSSVFGMQNNLAPSLTTLSHGTTTTSTAYGVKKNMPQSPAAVNTGVSTSAACTTSVQS
                     DDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPASIAATSFSEDTLKKEK
                     QAAYNADSGLKAEANGDLKTVSTKGKTTTADIHSYGSSGGGGSGGGGGVGGAGGGPWG
                     PAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARVDELERIRRS
                     ILPYGDSMDRIEKDRLQGMAPAAGADLDKIGLHSDSQEELWMFVRKKLMMEQENGNLR
                     GSPGPKGDMGSPGPKGDRGFPGTPGIPGPLGHPGPQGPKGQKGSVGDPGMEGPMGQRG
                     REGPMGPRGEAGPPGSGEKGERGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPV
                     GLQGLRGEVGLPGVKGDKGPMGPPGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKG
                     AMGPAGPDGHQGPRGEQGLTGMPGIRGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGI
                     KGEPGAPGKIVTSEGSSMLTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQ
                     GPPGPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGPPGSFLSNSETFLSGPPGPPGPP
                     GPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNLQGPPGPPGPQGPKGDKGDPGVPG
                     ALGIPSGPSEGGSSSTMYVSGPPGPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSY
                     LSGVQGPPGPPGPPGPVTTITGETFDYSELASHVVSYLRTSGYGVSLFSSSISSEDIL
                     AVLQRDDVRQYLRQYLMGPRGPPGPPGASGDGSLLSLDYAELSSRILSYMSSSGISIG
                     LPGPPGPPGLPGTSYEELLSLLRGSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSY
                     LHTAGLSFIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELISYLTSPDVRSF
                     IVGPPGPPGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRGSSYSSSMSTGGGGAGS
                     LGAGGAFGEAAGDRGPYGTDIGPGGGYGAAAEGGMYAGNGGLLGADFAGDLDYNELAV
                     RVSESMQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTADLMDFFQTYGAI
                     QGPPGQKGEMGTPGPKGDRGPAGPPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRRSIA
                     VKP"
     exon            222..266
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..371
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..500
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..548
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..584
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..632
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..776
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..935
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1007
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1079
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1148
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1310
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1391
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1436
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1634
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1856
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1886
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1913
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..1940
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2003
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2108
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2171
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2207
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2261
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2297
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2333
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2396
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2432
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2504
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2531
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2567
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2603
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2684
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2720
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2774
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2816
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2870
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2930
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..2957
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..2990
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3065
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3116
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3239
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3377
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3446
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3587
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3677
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3788
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3935
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4325
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4463
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4526
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4607
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..5612
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5588..5593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5610
                     /gene="COL17A1"
                     /gene_synonym="BA16H23.2; BP180; BPA-2; BPAG2; EBR2A;
                     ERED; JEB-I; JEB4; LAD-1"
                     /note="major polyA site"
ORIGIN      
        1 aacatttttg aaagatcact cagctttaac acaccttggc tgggtctgga taaaaaaaaa
       61 gtgagcactg caaatttcta gaagaaaaca tcaggagaag aaagagagag ggggatttat
      121 tcaaagttgt ttccaattcc ttcaaaacct caaaccaggt ggctatggta tggatgtaac
      181 caagaaaaac aaacgagatg gaactgaagt cactgagaga attgtcactg aaacagtaac
      241 cacaagactt acatccttac caccaaaagg cgggaccagc aatggctatg ctaaaacagc
      301 ctctcttggt ggagggagcc ggctggagaa acaaagcctg actcatggca gcagcggcta
      361 cataaactca actggaagca cacgaggcca tgcctccacc tctagttaca ggagggctca
      421 ctcacctgcc tccactctgc ccaactcccc aggctcaacc tttgaaagga aaactcacgt
      481 tacccgccat gcgtatgaag ggagctccag tggcaactct tctccggagt accctcggaa
      541 ggaatttgca tcttcttcaa ccagaggacg gagtcaaaca cgagagagtg aaattcgagt
      601 tcgactgcag agtgcgtccc catccacccg atggacagaa ttggatgatg ttaagcgttt
      661 gctcaagggg agtcgatcgg caagtgtgag ccccacccgg aattcctcca acacactccc
      721 catccccaag aaaggcactg tggagaccaa aattgtgaca gcgagctccc agtcggtgtc
      781 aggcacctac gatgcaacga tcctggatgc caaccttccc tcccatgtgt ggtcctccac
      841 cctgcccgcg gggtcctcca tggggaccta tcacaacaac atgacaaccc agagctcatc
      901 cctcctcaac accaatgcct actctgcggg atcagtcttc ggagttccaa acaacatggc
      961 gtcctgctca cccactttgc accctggact cagcacatcc tcctcagtgt ttggcatgca
     1021 gaacaatctg gcccccagct tgaccaccct gtcccatggc accaccacca cttccacagc
     1081 atatggggtg aagaaaaaca tgccccagag tcctgcggct gtgaacactg gcgtttccac
     1141 ctccgccgcc tgcaccacaa gtgtgcagag cgatgacctt ttgcacaagg actgcaagtt
     1201 cctgatccta gagaaagaca acacacctgc caagaaggag atggagctgc tcatcatgac
     1261 caaggacagc gggaaggtct ttacagcctc ccctgccagc atcgctgcaa cttctttttc
     1321 agaagacacc ctaaaaaaag aaaagcaagc tgcctacaat gctgactcag gcctaaaagc
     1381 cgaagctaat ggagacctga agactgtgtc cacaaagggc aagaccacca ctgcagatat
     1441 ccacagctac ggcagcagtg gtggtggtgg cagtggagga ggtggcggtg ttggtggcgc
     1501 tggcggcggc ccttggggac cagcgccagc ctggtgcccc tgcggctcct gctgcagctg
     1561 gtggaagtgg ctgctgggcc tgctgctcac ctggctgcta ctcctggggc tgctcttcgg
     1621 cctcattgct ctggcggagg aggtgaggaa gctgaaggcg cgtgtggatg agctggagag
     1681 gatcaggagg agcatactgc cctatgggga cagcatggat agaatagaaa aggaccgcct
     1741 ccagggcatg gcacccgcgg cgggagcaga cctggacaaa attgggctgc acagtgacag
     1801 ccaggaggag ctctggatgt tcgtgaggaa gaagctaatg atggaacagg aaaatggaaa
     1861 tctccgagga agccctggcc ctaaaggtga catgggaagt ccaggcccta aaggagatcg
     1921 agggttccct gggactccag gtatccctgg gcccttgggc cacccaggtc cacaaggacc
     1981 aaagggtcaa aaaggcagcg tgggagatcc tggcatggaa ggccccatgg gccagagagg
     2041 gcgagaaggc cccatgggac ctcgtggtga ggcagggcct cctggatctg gagagaaagg
     2101 ggaaagaggg gctgctggtg aaccaggtcc tcatggccca cctggtgtcc caggttctgt
     2161 gggtcccaaa ggttccagcg gctctcctgg cccacagggc cctccaggtc ctgtaggtct
     2221 ccaagggctc cgaggtgaag taggacttcc tggtgtcaaa ggtgacaaag gaccaatggg
     2281 accaccagga cccaaaggtg accagggtga gaaaggacct cgaggcctca caggcgagcc
     2341 tggcatgaga ggtttgcctg gtgctgttgg tgagcccggg gctaaaggag caatgggtcc
     2401 tgctggccca gacggacacc aaggcccaag aggtgaacaa ggtcttactg ggatgcctgg
     2461 aatccgtggc ccaccaggac cttctggaga cccaggaaag ccaggtctca caggacccca
     2521 gggacctcag ggacttcccg gtacccctgg ccgaccagga ataaaaggtg aaccaggagc
     2581 tccaggcaag atcgtgactt cggaggggtc atcgatgctc actgtcccag gccccccagg
     2641 acctcctgga gccatgggac ccccaggacc tccaggtgcc ccaggccctg ccggcccagc
     2701 tggtctccca ggacatcaag aagttcttaa tttacaaggt cccccaggcc cacccggccc
     2761 acgcgggcca ccagggcctt ccattccagg cccaccagga ccccgaggcc caccagggga
     2821 gggtttgcca ggcccaccag gcccaccagg atcgttcctg tccaactcag aaaccttcct
     2881 ctccggcccc ccaggcccac ctggcccccc aggtcccaag ggagaccaag gtcccccagg
     2941 ccccagagga caccaaggcg agcaaggcct cccaggtttc tcaacctcag ggtccagttc
     3001 tttcggactc aaccttcagg gaccaccagg cccacctggc ccccagggac ccaaaggtga
     3061 caaaggtgat ccaggtgttc caggggctct tggcattcct agtggtcctt ctgaaggggg
     3121 atcatcaagt accatgtacg tgtcaggccc gccagggccc cctgggcccc ctgggcctcc
     3181 gggctctatc agcagctctg gccaggagat tcagcagtac atctctgagt acatgcagag
     3241 tgacagtatt agatcttacc tatccggagt tcagggtccc ccaggcccac ctggtccccc
     3301 aggacctgtc accaccatca caggcgagac tttcgactac tcagagctgg caagccacgt
     3361 tgtgagctac ttacggactt cggggtacgg tgtcagcttg ttctcgtcct ccatctcttc
     3421 tgaagacatt ctggctgtgc tgcagcggga tgacgtgcgt cagtacctac gtcagtactt
     3481 gatgggccct cggggtccgc cagggccacc aggagccagt ggagatgggt ccctcctgtc
     3541 tttggactat gcagagctga gtagtcgcat tctcagctac atgtcgagtt ctgggatcag
     3601 cattgggctt cctggtcccc cggggccccc tggcttgccg ggaacctcct atgaggagct
     3661 cctctccttg ctgcgagggt ctgaattcag aggcatcgtt ggacccccag gtcccccggg
     3721 tccaccaggg atcccaggca atgtgtggtc cagcatcagc gtggaggacc tctcgtctta
     3781 cttacatact gccggcttgt cattcatccc aggccctcca ggacctcctg gtcccccagg
     3841 gcctcgaggg cccccgggtg tctcaggagc cctggcaacc tatgcagctg aaaacagcga
     3901 cagcttccgg agcgagctga tcagctacct cacaagtcct gatgtgcgca gcttcattgt
     3961 tggcccccca ggccctcctg ggccgcaggg accccctggg gacagccgcc tcctgtccac
     4021 ggatgcctcc cacagtcggg gtagcagctc ctcctcacac agctcatctg tcaggcgggg
     4081 cagctcctac agctcttcca tgagcacagg aggaggtggt gcaggctccc tgggtgcagg
     4141 cggtgccttt ggtgaagctg caggagacag gggtccctat ggcactgaca tcggcccagg
     4201 cggaggctat ggggcagcag cagaaggcgg catgtatgct ggcaatggcg gactattggg
     4261 agctgacttt gctggagatc tggattacaa tgagctggct gtgagggtgt cagagagcat
     4321 gcagcgtcag ggcctactgc aagggatggc ctacactgtc cagggcccac caggccagcc
     4381 tgggccacag gggccacccg gcatcagcaa ggtcttctct gcctacagca acgtgactgc
     4441 ggacctcatg gacttcttcc aaacttatgg agccattcaa ggaccccctg ggcaaaaagg
     4501 agagatgggc actccaggac ccaaaggtga caggggccct gctgggccac caggtcatcc
     4561 tgggccacct ggccctcgag gacacaaggg agaaaaagga gacaaaggtg accaagtcta
     4621 tgctgggcgg agaaggagaa gaagtattgc tgtcaagccg tgagctagcc atggcaggac
     4681 agctcctgga ccaggtctca taatgcatgt ggcacttagg tccaaggtct ccagagggtg
     4741 aaagctggag tctgtcaatg tcctactgag acagcacagc caacctagct agcaacattt
     4801 gttttagtct gaacaatata tacttataga attcagtcaa agatacacaa tctgaaacag
     4861 cttcatgggg tggactctaa cagtagttgc aatgttttag aatgagactt acttctctgc
     4921 tatctagatc tgaactcctt ggcttcttta cttagttcaa gccccagcct aggaaagcca
     4981 gttacataaa agttggctca ggagtcttag agctttacct aaatatgagc ccagaaaacg
     5041 gaggatgggg gtggggcgcc ttcctggagg tgacacttga tgggggtgtg ttctggttac
     5101 tgttctaagg ctgtgccatc agctccttcc tcccctgttc attctgcatt ctctagtcag
     5161 ttggctaaga agtgactctt gcaactaaaa aaattaagaa attcacttcc cctctaggag
     5221 gtgatgatag ggtttctaat ggttatatgt atatcacatt cccatttgct tagaaagtct
     5281 gattgtagct atgattgtcc gtaggcccat actagagttc atggatatgt tatactgaac
     5341 caggccagag caaacagaaa aagaaggttg agggcaatgg acaaggaagg aataaaggga
     5401 gaagagggaa aacagaaaac ctgatgctgg ggacacagca tcagctcaag acgtcaccct
     5461 ccattctgca ctcagaaaat ggcacttggg ggactgggcg cagttggtct ttaaccactt
     5521 ttcaatgtct aaaaacattt gtttgtggtc tataagatga aacatcattt caatcgtaaa
     5581 atttcccatt aaagaagttt ttttttctaa ta
//
