LOCUS       NM_001856               5418 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens collagen type XVI alpha 1 chain (COL16A1), mRNA.
ACCESSION   NM_001856
VERSION     NM_001856.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5418)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   2  (bases 1 to 5418)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   3  (bases 1 to 5418)
  AUTHORS   Ragelle,H., Naba,A., Larson,B.L., Zhou,F., Prijic,M.,
            Whittaker,C.A., Del Rosario,A., Langer,R., Hynes,R.O. and
            Anderson,D.G.
  TITLE     Comprehensive proteomic characterization of stem cell-derived
            extracellular matrices
  JOURNAL   Biomaterials 128, 147-159 (2017)
   PUBMED   28327460
REFERENCE   4  (bases 1 to 5418)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 5418)
  AUTHORS   Bedal,K.B., Grassel,S., Spanier,G., Reichert,T.E. and Bauer,R.J.
  TITLE     The NC11 domain of human collagen XVI induces vasculogenic mimicry
            in oral squamous cell carcinoma cells
  JOURNAL   Carcinogenesis 36 (11), 1429-1439 (2015)
   PUBMED   26424749
  REMARK    GeneRIF: The NC11 domain of collagen XVI is a potential biomarker
            for oral squamous cell carcinoma and triggers vasculogenic mimicry
            via upregulation of endothelial receptors VEGFR1, VEGFR2 and uPAR.
REFERENCE   6  (bases 1 to 5418)
  AUTHORS   Grassel,S., Timpl,R., Tan,E.M. and Chu,M.L.
  TITLE     Biosynthesis and processing of type XVI collagen in human
            fibroblasts and smooth muscle cells
  JOURNAL   Eur J Biochem 242 (3), 576-584 (1996)
   PUBMED   9022684
REFERENCE   7  (bases 1 to 5418)
  AUTHORS   Tillet,E., Mann,K., Nischt,R., Pan,T.C., Chu,M.L. and Timpl,R.
  TITLE     Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for
            processing of the N-terminal globular domain
  JOURNAL   Eur J Biochem 228 (1), 160-168 (1995)
   PUBMED   7882999
REFERENCE   8  (bases 1 to 5418)
  AUTHORS   Sires,U.I., Dublet,B., Aubert-Foucher,E., van der Rest,M. and
            Welgus,H.G.
  TITLE     Degradation of the COL1 domain of type XIV collagen by 92-kDa
            gelatinase
  JOURNAL   J Biol Chem 270 (3), 1062-1067 (1995)
   PUBMED   7836360
REFERENCE   9  (bases 1 to 5418)
  AUTHORS   Yamaguchi,N., Kimura,S., McBride,O.W., Hori,H., Yamada,Y.,
            Kanamori,T., Yamakoshi,H. and Nagai,Y.
  TITLE     Molecular cloning and partial characterization of a novel collagen
            chain, alpha 1(XVI), consisting of repetitive collagenous domains
            and cysteine-containing non-collagenous segments
  JOURNAL   J Biochem 112 (6), 856-863 (1992)
   PUBMED   1284248
REFERENCE   10 (bases 1 to 5418)
  AUTHORS   Pan,T.C., Zhang,R.Z., Mattei,M.G., Timpl,R. and Chu,M.L.
  TITLE     Cloning and chromosomal location of human alpha 1(XVI) collagen
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6565-6569 (1992)
   PUBMED   1631157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC064839.1, AC114488.3,
            M92642.1 and S57132.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001856.3.
            
            Summary: This gene encodes the alpha chain of type XVI collagen, a
            member of the FACIT collagen family (fibril-associated collagens
            with interrupted helices). Members of this collagen family are
            found in association with fibril-forming collagens such as type I
            and II, and serve to maintain the integrity of the extracellular
            matrix. High levels of type XVI collagen have been found in
            fibroblasts and keratinocytes, and in smooth muscle and amnion.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373672.8/ ENSP00000362776.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2716              BC064839.1         303-3018
            2717-2753           AC114488.3         118219-118255       c
            2754-3695           M92642.1           2689-3630
            3696-5181           S57132.1           2227-3712
            5182-5418           AC114488.3         87548-87784         c
FEATURES             Location/Qualifiers
     source          1..5418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..5418
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /note="collagen type XVI alpha 1 chain"
                     /db_xref="GeneID:1307"
                     /db_xref="HGNC:HGNC:2193"
                     /db_xref="MIM:120326"
     exon            1..181
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            182..288
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..5030
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /note="collagen XVI, alpha-1 polypeptide; collagen
                     alpha-1(XVI) chain; alpha 1 type XVI collagen; collagen,
                     type XVI, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XVI) chain precursor"
                     /protein_id="NP_001847.3"
                     /db_xref="CCDS:CCDS41297.1"
                     /db_xref="GeneID:1307"
                     /db_xref="HGNC:HGNC:2193"
                     /db_xref="MIM:120326"
                     /translation="MWVSWAPGLWLLGLWATFGHGANTGAQCPPSQQEGLKLEHSSSL
                     PANVTGFNLIHRLSLMKTSAIKKIRNPKGPLILRLGAAPVTQPTRRVFPRGLPEEFAL
                     VLTLLLKKHTHQKTWYLFQVTDANGYPQISLEVNSQERSLELRAQGQDGDFVSCIFPV
                     PQLFDLRWHKLMLSVAGRVASVHVDCSSASSQPLGPRRPMRPVGHVFLGLDAEQGKPV
                     SFDLQQVHIYCDPELVLEEGCCEILPAGCPPETSKARRDTQSNELIEINPQSEGKVYT
                     RCFCLEEPQNSEVDAQLTGRISQKAERGAKVHQETAADECPPCVHGARDSNVTLAPSG
                     PKGGKGERGLPGPPGSKGEKGARGNDCVRISPDAPLQCAEGPKGEKGESGALGPSGLP
                     GSTGEKGQKGEKGDGGIKGVPGKPGRDGRPGEICVIGPKGQKGDPGFVGPEGLAGEPG
                     PPGLPGPPGIGLPGTPGDPGGPPGPKGDKGSSGIPGKEGPGGKPGKPGVKGEKGDPCE
                     VCPTLPEGFQNFVGLPGKPGPKGEPGDPVPARGDPGIQGIKGEKGEPCLSCSSVVGAQ
                     HLVSSTGASGDVGSPGFGLPGLPGRAGVPGLKGEKGNFGEAGPAGSPGPPGPVGPAGI
                     KGAKGEPCEPCPALSNLQDGDVRVVALPGPSGEKGEPGPPGFGLPGKQGKAGERGLKG
                     QKGDAGNPGDPGTPGTTGRPGLSGEPGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGR
                     PGQPGPKGEQGPEGVGRPGKPGQPGLPGVQGPPGLKGVQGEPGPPGRGVQGPQGEPGA
                     PGLPGIQGLPGPRGPPGPTGEKGAQGSPGVKGATGPVGPPGASVSGPPGRDGQQGQTG
                     LRGTPGEKGPRGEKGEPGECSCPSQGDLIFSGMPGAPGLWMGSSWQPGPQGPPGIPGP
                     PGPPGVPGLQGVPGNNGLPGQPGLTAELGSLPIEQHLLKSICGDCVQGQRAHPGYLVE
                     KGEKGDQGIPGVPGLDNCAQCFLSLERPRAEEARGDNSEGDPGCVGSPGLPGPPGLPG
                     QRGEEGPPGMRGSPGPPGPIGPPGFPGAVGSPGLPGLQGERGLTGLTGDKGEPGPPGQ
                     PGYPGATGPPGLPGIKGERGYTGSAGEKGEPGPPGSEGLPGPPGPAGPRGERGPQGNS
                     GEKGDQGFQGQPGFPGPPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGSPGPPG
                     PPGIQGPAGLDGLDGKDGKPGLRGDPGPAGPPGLMGPPGFKGKTGHPGLPGPKGDCGK
                     PGPPGSTGRPGAEGEPGAMGPQGRPGPPGHVGPPGPPGQPGPAGISAVGLKGDRGATG
                     ERGLAGLPGQPGPPGHPGPPGEPGTDGAAGKEGPPGKQGFYGPPGPKGDPGAAGQKGQ
                     AGEKGRAGMPGGPGKSGSMGPVGPPGPAGERGHPGAPGPSGSPGLPGVPGSMGDMVNY
                     DEIKRFIRQEIIKMFDERMAYYTSRMQFPMEMAAAPGRPGPPGKDGAPGRPGAPGSPG
                     LPGQIGREGRQGLPGVRGLPGTKGEKGDIGIGIAGENGLPGPPGPQGPPGYGKMGATG
                     PMGQQGIPGIPGPPGPMGQPGKAGHCNPSDCFGAMPMEQQYPPMKTMKGPFG"
     exon            289..363
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            364..481
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            482..605
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            606..872
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            873..953
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1079
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1133
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1160
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1196
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1223
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1286
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1328
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1373
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1409
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1472
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1517
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1613
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1652
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1697
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1724
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1835
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1871
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1982
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2018
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2054
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2099
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2231
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2267
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2375
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2498
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2552
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2594
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2630
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2684
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2753
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2798
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2825
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2885
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2933
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..2987
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3041
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3074
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3191
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3233
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3320
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3365
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3410
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3464
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3518
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3572
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3617
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3671
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3707
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3770
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3842
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3896
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..3941
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..3986
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4040
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4094
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4145
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4235
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4271
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4316
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4505
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4572
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4573..4749
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..4827
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..5418
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5164..5169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /note="hexamer: AATAAA"
     polyA_site      5181
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /note="major polyA site"
     regulatory      5399..5404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
                     /note="hexamer: AATAAA"
     polyA_site      5418
                     /gene="COL16A1"
                     /gene_synonym="447AA; FP1572"
ORIGIN      
        1 agtccccggc aggcgtgcgc cgggcagcag acagccggga gagctcgagc gccaggaagc
       61 tggggacccg tgaccgtcac ggagagatag agaaccccta gcggacctga ggaacctggg
      121 ctctgcttcc tccgcctgct gcctggactg ctcagtgagg tggggggatc cccggccacc
      181 ggtgctgtgg ctgtagctga cctctttgga ccgggatgtg ggtatcctgg gctcctggcc
      241 tgtggctgct cggtctttgg gctaccttcg gccatggggc aaatacaggt gcacaatgcc
      301 caccttcaca gcaggaagga ctcaaattgg aacacagtag tagcctgcca gccaacgtga
      361 ctggcttcaa cctcatccac cgactcagcc tcatgaagac gtctgccatc aagaagatcc
      421 gcaaccccaa ggggcctctc atcctgcgcc tgggggcggc ccccgtgacc cagcccacgc
      481 gaagagtatt ccctcggggt ctcccggagg agtttgccct ggtgctgaca ctactgctga
      541 agaaacacac ccaccagaag acgtggtatc tgtttcaagt gaccgatgca aatgggtatc
      601 cacagatatc cctggaagtc aacagccaag agcggagcct ggagctcagg gcccagggcc
      661 aggatggcga ctttgtgtcc tgcatcttcc cagtgcccca gctcttcgac ttgcgttggc
      721 acaagctgat gctgagtgtg gctggacgtg tggcctctgt gcacgtggac tgcagctcag
      781 cctcctccca gcctctgggg ccccgacgac ccatgaggcc tgtgggccat gtatttctag
      841 gcttggatgc tgagcagggc aagcctgtct cgtttgacct tcagcaggtg cacatctact
      901 gtgacccgga gctcgtgctg gaggagggct gctgtgagat tttaccagca gggtgccccc
      961 cagagacctc caaggcccgc cgggacaccc agagcaatga gctcattgag atcaatccac
     1021 agtctgaagg caaggtctac acccgctgct tctgcctgga ggagcctcaa aacagcgagg
     1081 tggatgccca gctgacggga agaatcagcc agaaggcaga aaggggagca aaggtccatc
     1141 aggagacagc agccgatgag tgtccgccct gtgtccatgg tgcccgggac agcaatgtca
     1201 cacttgctcc ctctggcccc aagggaggga aaggtgagcg gggcctgcct ggtccaccag
     1261 gctccaaggg agagaaggga gcacggggca atgactgtgt tcgaatctcc ccggatgccc
     1321 cacttcagtg tgcagaaggc ccgaagggag agaaggggga gtcaggagct ctgggaccct
     1381 caggactccc aggctcaaca ggcgagaagg gccagaaagg cgagaagggc gacggaggca
     1441 tcaagggcgt gccgggaaag ccaggccggg acggccggcc aggagagatc tgtgtcattg
     1501 ggcccaaagg gcagaaggga gaccctggct ttgttgggcc tgaggggctg gcaggagagc
     1561 ctgggccccc cggcctccct ggaccccctg ggataggact gcctgggacc ccgggggatc
     1621 caggtggccc accaggcccc aagggagaca agggcagctc ggggatccca ggaaaggaag
     1681 gccctggtgg gaaacctggg aagccaggtg tgaagggaga gaagggtgac ccctgtgaag
     1741 tgtgcccaac actgcctgaa gggttccaga actttgttgg acttcctgga aagccagggc
     1801 ccaaagggga gcctggtgat cctgtaccag ccaggggaga ccctggcatc caaggcatca
     1861 aaggagagaa gggggagccc tgcttgtcct gcagctcggt tgtaggggcc cagcatcttg
     1921 tgtcctccac aggggccagt ggagatgtgg gttcccctgg ctttggtctg cctggccttc
     1981 cgggtagagc tggggttcca gggctgaaag gagagaaggg taacttcggg gaggcagggc
     2041 cagctggcag tccagggcca ccaggaccag tggggccagc aggcatcaaa ggggcgaagg
     2101 gggagccctg tgagccgtgc ccagccctgt ccaaccttca ggatggggat gtccgtgtgg
     2161 tggccttgcc tggcccatcc ggagagaagg gggaacctgg gcctccaggc tttggcttgc
     2221 caggaaaaca gggcaaggct ggagagcgtg gactgaaggg gcagaagggt gatgctggga
     2281 atcctggaga ccctggaacg ccgggcacca cagggcggcc aggactgtca ggagagcctg
     2341 gagttcaggg ccccgcgggg ccaaaaggag aaaagggtga tggctgcact gcctgcccca
     2401 gcctgcaggg gacagtgaca gacatggcag gacggcctgg gcagcccggc cccaaaggag
     2461 agcagggccc cgaaggcgtg ggccgacctg gtaaacccgg ccaacccggt ctaccaggag
     2521 ttcaagggcc cccaggactg aagggcgtgc agggagagcc agggcctcca ggaaggggag
     2581 tccagggacc ccagggggag cctggagccc cgggtttgcc tggcattcag ggacttccgg
     2641 gacctcgggg accacctggc cccactggag agaagggtgc ccagggatct ccaggggtga
     2701 aaggagccac cggacctgtg ggacctcctg gggccagtgt ctctgggcct ccgggccgtg
     2761 atgggcagca aggacagacg ggactcagag gaacaccagg tgaaaaagga ccacgaggag
     2821 agaagggtga gccaggggag tgctcctgcc cctctcaagg agacctcatc ttctctggca
     2881 tgccgggtgc tccgggactt tggatgggca gctcctggca gccgggcccg cagggtccac
     2941 caggtattcc cggaccacca ggcccccctg gagtacctgg gctgcaggga gtgcctggaa
     3001 acaacggttt gccaggacag cctgggctca ctgcagaact gggatcctta ccaattgaac
     3061 agcacctcct taagagtatc tgcggggact gtgtccaggg gcagagggcc cacccagggt
     3121 acctcgtgga gaagggagag aagggagacc agggcatccc tggtgtgcca ggcctcgaca
     3181 actgcgccca gtgctttttg tcactggagc gcccaagagc cgaggaggcc cggggtgaca
     3241 acagtgaggg agatcctggc tgtgttggga gcccaggcct acctggtcct ccgggattgc
     3301 caggccagag aggagaagag ggtccgcctg gcatgagggg ctccccgggt cctccaggcc
     3361 ctatcggccc cccaggtttt cctggtgctg ttggctcccc cggattgcct ggccttcaag
     3421 gagagcgagg tctcacgggc ctgactggag acaaggggga gccgggtcct ccagggcaac
     3481 caggttaccc aggtgccacg ggccccccag gactgcctgg catcaagggg gagcgtggct
     3541 acaccgggtc agcgggagag aaaggagagc cgggcccccc aggatctgaa ggcctcccag
     3601 gccccccagg cccagcgggt cccagaggag agcgaggacc ccaaggtaac tccggtgaga
     3661 agggcgacca gggatttcaa ggccagccag gctttccggg cccaccgggt ccccctggat
     3721 tcccaggcaa agttggatca cctggcccac ctggccctca agcagagaag ggcagcgaag
     3781 ggattcgagg cccatcaggc ctgcctggct cccctgggcc accgggacct cctgggattc
     3841 agggccccgc cggtctggat ggtttggatg ggaaggacgg caagcctggc ttgagggggg
     3901 accctggtcc tgctggcccc cctggactca tgggaccacc gggctttaag gggaaaacag
     3961 gacatcctgg cctcccagga cctaagggtg actgtggcaa accaggtccc cctggcagca
     4021 ctggccggcc tggcgcagag ggtgaacctg gtgccatggg accccaggga agacccggtc
     4081 ccccgggaca cgttgggcca ccagggcctc caggccagcc aggaccagct gggatctctg
     4141 cagtgggtct gaaaggagac cgaggagcca ccggagaaag gggccttgca ggcctcccag
     4201 gccagcccgg cccccctgga caccctggcc ccccaggcga acctggtacg gatggtgcag
     4261 ctggcaaaga gggaccccct ggaaagcagg gattctatgg acctcctggt cccaagggtg
     4321 atccaggagc tgcaggacag aagggccagg caggagagaa ggggagagcc ggcatgcctg
     4381 gtggacctgg caagagtggt tccatggggc ctgttgggcc accgggccct gcaggagaga
     4441 gaggccaccc tggagctccg gggccttcgg ggagccctgg cttgcctggt gtgcctggct
     4501 ccatgggaga catggtgaat tatgatgaaa tcaagaggtt catcagacaa gagatcatta
     4561 aaatgtttga tgagagaatg gcttactaca cctccaggat gcagttcccc atggagatgg
     4621 cggcagctcc gggacgacca gggcctccag ggaaggatgg tgctccgggc aggccaggtg
     4681 ctccagggtc acctgggctc cctggtcaga ttggcagaga aggacggcag ggcttgccag
     4741 gagtaagagg attgcctggt accaaaggtg aaaaagggga cattggtatt ggcattgcag
     4801 gagaaaatgg tcttcccggc cccccaggtc ctcaaggtcc tccaggctat ggcaagatgg
     4861 gtgcaacagg accaatgggc cagcaaggca tccctggcat ccctgggccc ccgggtccca
     4921 tgggccagcc aggcaaggct ggccactgta atccctctga ctgctttggg gccatgccga
     4981 tggagcagca gtacccaccc atgaaaacca tgaaggggcc ttttggctga aattccccac
     5041 ctgcctttgg atgaaagact ccgttgggaa taaatggcca aagcttatag gactctgtga
     5101 caggttgtga atgttttttt tgttgttgtt gttgttttta attgctgtta atatttttta
     5161 aataataaag aaacaaaact atctgccctt tcccttccag tgggttcctc tggtgctgca
     5221 gccagagctc cctgttgccc tccttttccc gtttagtccc aggaacaaaa aagggcattt
     5281 tgggtacagg ggcatatacc tgtaatccta gctattcaag gggctgaggt gggaggatcg
     5341 cctgagccca ggagtttgag accagtctaa gcaacataat gagactcagt ctccgaaaaa
     5401 taaaaattaa aaaataaa
//
