LOCUS       NM_001855               5223 bp    mRNA    linear   PRI 15-OCT-2023
DEFINITION  Homo sapiens collagen type XV alpha 1 chain (COL15A1), mRNA.
ACCESSION   NM_001855
VERSION     NM_001855.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5223)
  AUTHORS   Schupp JC, Manning EP, Chioccioli M, Kamp JC, Christian L, Ryu C,
            Herzog E, Kuhnel MP, Prasse A, Kaminski N, Jonigk DD and Homer RJ.
  CONSRTM   Yale-MHH-MGH Study Group
  TITLE     Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia:
            Replacement of Normal Lung Capillaries with COL15A1-Positive
            Endothelial Cells
  JOURNAL   Am J Respir Crit Care Med 208 (7), 819-822 (2023)
   PUBMED   37552025
  REMARK    GeneRIF: Alveolar Vascular Remodeling in Nonspecific Interstitial
            Pneumonia: Replacement of Normal Lung Capillaries with
            COL15A1-Positive Endothelial Cells.
REFERENCE   2  (bases 1 to 5223)
  AUTHORS   Kim H, Choi N, Kim DY, Kim SY, Song SY and Sung JH.
  TITLE     TGF-beta2 and collagen play pivotal roles in the spheroid formation
            and anti-aging of human dermal papilla cells
  JOURNAL   Aging (Albany NY) 13 (16), 19978-19995 (2021)
   PUBMED   34404755
  REMARK    GeneRIF: TGF-beta2 and collagen play pivotal roles in the spheroid
            formation and anti-aging of human dermal papilla cells.
REFERENCE   3  (bases 1 to 5223)
  AUTHORS   Lambertini E, Penolazzi L, Angelozzi M, Bergamin LS, Manferdini C,
            Vieceli Dalla Sega F, Paolella F, Lisignoli G and Piva R.
  TITLE     Hypoxia Preconditioning of Human MSCs: a Direct Evidence of
            HIF-1alpha and Collagen Type XV Correlation
  JOURNAL   Cell Physiol Biochem 51 (5), 2237-2249 (2018)
   PUBMED   30537732
  REMARK    GeneRIF: This study identified collagen XV as a new low O2 tension
            sensitive gene, and provided a novel mechanistic evidence that
            directly HIF-1alpha (hypoxia-inducible factor-1 alpha) mediates
            collagen XV expression in response to hypoxia, since it was found
            specifically in vivo recruited at collagen XV promoter, in
            hypoxia-preconditioned mesenchymal stromal cells.
REFERENCE   4  (bases 1 to 5223)
  AUTHORS   Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V,
            Cutillas PR, Balkwill FR and Hynes RO.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   5  (bases 1 to 5223)
  AUTHORS   John H, Radtke K, Standker L and Forssmann WG.
  TITLE     Identification and characterization of novel endogenous proteolytic
            forms of the human angiogenesis inhibitors restin and endostatin
  JOURNAL   Biochim Biophys Acta 1747 (2), 161-170 (2005)
   PUBMED   15698950
REFERENCE   6  (bases 1 to 5223)
  AUTHORS   Hagg PM, Muona A, Lietard J, Kivirikko S and Pihlajaniemi T.
  TITLE     Complete exon-intron organization of the human gene for the alpha1
            chain of type XV collagen (COL15A1) and comparison with the
            homologous COL18A1 gene
  JOURNAL   J Biol Chem 273 (28), 17824-17831 (1998)
   PUBMED   9651385
REFERENCE   7  (bases 1 to 5223)
  AUTHORS   Kivirikko S, Heinamaki P, Rehn M, Honkanen N, Myers JC and
            Pihlajaniemi T.
  TITLE     Primary structure of the alpha 1 chain of human type XV collagen
            and exon-intron organization in the 3' region of the corresponding
            gene
  JOURNAL   J Biol Chem 269 (7), 4773-4779 (1994)
   PUBMED   8106446
REFERENCE   8  (bases 1 to 5223)
  AUTHORS   Muragaki Y, Abe N, Ninomiya Y, Olsen BR and Ooshima A.
  TITLE     The human alpha 1(XV) collagen chain contains a large
            amino-terminal non-triple helical domain with a tandem repeat
            structure and homology to alpha 1(XVIII) collagen
  JOURNAL   J Biol Chem 269 (6), 4042-4046 (1994)
   PUBMED   8307960
REFERENCE   9  (bases 1 to 5223)
  AUTHORS   Myers JC, Kivirikko S, Gordon MK, Dion AS and Pihlajaniemi T.
  TITLE     Identification of a previously unknown human collagen chain, alpha
            1(XV), characterized by extensive interruptions in the
            triple-helical region
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10144-10148 (1992)
   PUBMED   1279671
REFERENCE   10 (bases 1 to 5223)
  AUTHORS   Huebner K, Cannizzaro LA, Jabs EW, Kivirikko S, Manzone H,
            Pihlajaniemi T and Myers JC.
  TITLE     Chromosomal assignment of a gene encoding a new collagen type
            (COL15A1) to 9q21 --> q22
  JOURNAL   Genomics 14 (2), 220-224 (1992)
   PUBMED   1427836
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY016428.1, BX337171.2,
            AK095885.1, L25286.1 and AL354923.12.
            
            On Nov 23, 2018 this sequence version replaced NM_001855.4.
            
            Summary: This gene encodes the alpha chain of type XV collagen, a
            member of the FACIT collagen family (fibril-associated collagens
            with interrupted helices). Type XV collagen has a wide tissue
            distribution but the strongest expression is localized to basement
            membrane zones so it may function to adhere basement membranes to
            underlying connective tissue stroma. The proteolytically produced
            C-terminal fragment of type XV collagen is restin, a potentially
            antiangiogenic protein that is closely related to endostatin. Mouse
            studies have shown that collagen XV deficiency is associated with
            muscle and microvessel deterioration. [provided by RefSeq, May
            2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375001.8/ ENSP00000364140.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                HY016428.1         196-209
            15-490              BX337171.2         282-757
            491-2349            AK095885.1         401-2259
            2350-4428           L25286.1           2284-4362
            4429-5223           AL354923.12        117750-118544
FEATURES             Location/Qualifiers
     source          1..5223
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..5223
                     /gene="COL15A1"
                     /note="collagen type XV alpha 1 chain"
                     /db_xref="GeneID:1306"
                     /db_xref="HGNC:HGNC:2192"
                     /db_xref="MIM:120325"
     exon            1..166
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..4322
                     /gene="COL15A1"
                     /note="collagen type XV proteoglycan; collagen XV, alpha-1
                     polypeptide; collagen alpha-1(XV) chain; restin;
                     endostatin-XV; collagen, type XV, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XV) chain precursor"
                     /protein_id="NP_001846.3"
                     /db_xref="CCDS:CCDS35081.1"
                     /db_xref="GeneID:1306"
                     /db_xref="HGNC:HGNC:2192"
                     /db_xref="MIM:120325"
                     /translation="MAPRRNNGQCWCLLMLLSVSTPLPAVTQTRGATETASQGHLDLT
                     QLIGVPLPSSVSFVTGYGGFPAYSFGPGANVGRPARTLIPSTFFRDFAISVVVKPSST
                     RGGVLFAITDAFQKVIYLGLRLSGVEDGHQRIILYYTEPGSHVSQEAAAFSVPVMTHR
                     WNRFAMIVQGEEVTLLVNCEEHSRIPFQRSSQALAFESSAGIFMGNAGATGLERFTGS
                     LQQLTVHPDPRTPEELCDPEESSASGETSGLQEADGVAEILEAVTYTQASPKEAKVEP
                     INTPPTPSSPFEDMELSGEPVPEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVD
                     GDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTLSMSTE
                     NPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEAT
                     VGPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEED
                     LAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGE
                     KGDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPP
                     GPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKG
                     ARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFE
                     DTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHI
                     KVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPGPRGPKGDTGLPGFPGLKG
                     EQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRP
                     GLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTA
                     HPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGEN
                     GDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPG
                     FGRPGDPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQ
                     KAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPHQLLPP
                     PNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLS
                     TIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQ
                     KVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLCI
                     ENSFMTDARK"
     exon            167..255
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..803
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..878
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..959
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1107
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1220
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1355
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1508
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1658
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1802
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1856
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1916
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2009
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2135
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2198
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2234
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2375
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2444
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2480
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2564
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2630
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2666
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2729
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2798
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2834
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2888
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2948
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3017
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3059
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3105
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3186
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3236
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3347
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3492
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3557
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3686
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3746
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3806
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3992
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4108
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..5223
                     /gene="COL15A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5091..5096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL15A1"
                     /note="hexamer: ATTATA"
     polyA_site      5113
                     /gene="COL15A1"
     regulatory      5192..5197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL15A1"
                     /note="hexamer: CATAAA"
     polyA_site      5223
                     /gene="COL15A1"
                     /note="major polyA site"
ORIGIN      
        1 attctgcccg ccgccgccgc tgccgagcgc cgcctttgtt ccctgcagga agggcgagcg
       61 cggcggccag cgctcagcga cccttcgtcc tccgctaagc tccaacgctc tgctcgacta
      121 gccgcgcgcc ttccggggct ccgcagaccc gcgagatggc accaaggagg aacaacgggc
      181 agtgctggtg tctgctgatg ctgctctcgg tctccacgcc cctccctgct gtcacccaga
      241 cccgcggtgc gacagagact gcttcccagg gtcacctgga cctcacgcag ctcatcggtg
      301 tcccgctgcc ctcgtccgta tcctttgtca caggctatgg tggcttcccg gcctacagtt
      361 tcgggcctgg tgccaatgtt ggccgcccag ccaggactct catcccatcc accttcttca
      421 gggacttcgc catcagcgtc gtggtgaagc ccagcagcac ccgtggtggc gtgctcttcg
      481 ccatcactga cgccttccag aaggtcatct acctgggcct gcggctctca ggtgtggagg
      541 acggccacca gcggatcatc ctctactaca cggagccagg ctcccatgtg tcccaagagg
      601 ctgctgcctt ctcggtgcct gtgatgaccc acaggtggaa ccgcttcgcc atgattgtcc
      661 agggtgagga agtgaccctc ctcgtgaact gtgaggagca cagccgcatc cccttccagc
      721 ggtcctccca ggctttggct tttgagtcca gcgctggaat cttcatgggc aatgcaggag
      781 ctacagggct cgagagattc actggctccc tccagcagct caccgtgcac cccgacccca
      841 ggactcccga ggagctgtgt gaccctgaag agtcctcggc atctggagag accagtgggc
      901 tgcaggaggc agacggagta gctgagatct tagaagccgt cacctacact caagcctcgc
      961 ccaaagaagc aaaagttgaa cccataaaca cacctccaac tccatcctcc ccctttgaag
     1021 acatggaact ttctggtgaa cctgtacccg aggggaccct ggaaaccacc aacatgagca
     1081 tcatccagca cagcagcccc aaacaagggt ctggtgagat cctgaatgac acactggagg
     1141 gggttcattc tgtggatggt gaccccatta ctgacagcgg ctcaggggct ggggccttcc
     1201 ttgacattgc tgaagaaaag aatttagcag caacagcagc ggggctggcc gaggtgccca
     1261 tcagcactgc tggagaagca gaggccagca gtgtgcccac cgggggacca accctctcta
     1321 tgtccacgga gaacccagag gaaggggtca ctccaggtcc agataatgaa gagcgtttag
     1381 cagcaacagc agcaggggag gccgaggcac tcgccagcat gcctggggaa gtggaggcca
     1441 gtggtgtggc ccccggggag ctggacctct ccatgtccgc ccagagcctc ggggaagagg
     1501 ccactgtggg tccaagcagt gaagacagtt taacaacagc tgcagctgca accgaagtgt
     1561 ccctcagtac ttttgaggat gaggaagcca gtggggtccc cacagatggc ctggctcccc
     1621 tcacagccac catggcccct gagcgggcag tcacttctgg tcctggtgat gaagaagact
     1681 tggcagcagc cacaacagag gagcccctca tcacagctgg gggtgaagag tccggcagcc
     1741 ctccccctga tgggccaccg ctgcccctgc ccacagtggc tcctgaaaga tggatcactc
     1801 cagctcaaag agaacatgtg ggaatgaaag gacaggctgg gcccaaagga gaaaagggtg
     1861 atgctgggga ggagcttcct ggccctcctg aaccttctgg gcctgttgga cccacggcag
     1921 gagcagaagc agagggctct ggcctaggct ggggctcgga cgtcggctct ggctctggtg
     1981 acctggtggg cagtgagcag ctgctgagag gtcctccagg acccccaggg ccacctggct
     2041 tacctgggat tccaggaaaa ccaggaactg atgttttcat gggaccccct ggatctcctg
     2101 gagaggatgg acctgctggt gaacctgggc ccccgggccc tgagggacag cctggagttg
     2161 atggagccac cggccttccc gggatgaaag gggagaaggg agcaagaggg cctaatggct
     2221 cagttggtga aaagggtgac cctggcaaca gaggcttacc tggacccccg gggaaaaagg
     2281 gacaagctgg ccctcctggg gtcatgggac ccccagggcc tcctggaccc cctgggcccc
     2341 caggccctgg atgcacaatg ggacttggat tcgaggatac cgaaggctct ggaagcaccc
     2401 agctattgaa tgaacccaaa ctctccagac caacggctgc aattggtctc aaaggagaga
     2461 aaggagaccg gggacccaag ggagaaaggg ggatggatgg agccagtatt gtgggacccc
     2521 ctgggccgag agggccacct gggcacatca aggtcttgtc taattccttg atcaatatca
     2581 cccatggatt catgaatttc tcggacattc ctgagctggt ggggcctccg gggccggacg
     2641 ggttgcctgg gctgccagga tttccaggtc ctagaggacc aaaaggtgac actggtttac
     2701 ctggctttcc aggactaaaa ggagaacagg gcgagaaggg agagccgggt gccatcctga
     2761 cagaggacat tcctctggaa aggctgatgg ggaaaaaggg tgaacctgga atgcatggag
     2821 ccccaggacc aatggggccc aaaggaccac caggacataa aggagaattt ggccttcccg
     2881 ggcgacctgg tcgcccagga ctgaatggcc tcaagggtac caaaggagat ccaggggtca
     2941 ttatgcaggg cccacctggc ttacctggcc ctccaggccc ccctgggcca cctggagctg
     3001 tgattaacat caaaggagcc attttcccaa tacccgtccg accacactgc aaaatgccag
     3061 ttgatactgc tcatcctggg agtccagagc tcatcacttt tcacggtgtt aaaggagaga
     3121 aaggatcctg gggtcttcct ggctcaaagg gagaaaaagg cgaccaggga gcccagggac
     3181 caccaggtcc tccacttgat ctagcttacc tgagacactt tctgaacaac ttgaaggggg
     3241 agaatggaga caaggggttc aaaggtgaaa aaggagaaaa aggagacatt aatggcagct
     3301 tccttatgtc tgggcctcca ggcctgcccg gaaatccagg cccggctggc caaaaagggg
     3361 agacagtcgt tgggccccaa ggacccccag gtgctcctgg tctgcctggg ccacctggct
     3421 ttggaagacc tggtgatcct gggccaccgg ggcccccggg gccaccagga cctccagcta
     3481 tcctgggagc agctgtggcc cttccaggtc cccctggccc tccaggacag ccagggcttc
     3541 ccggatccag aaacctggtc acagcattca gcaacatgga tgacatgctg cagaaagcgc
     3601 atttggttat agaaggaaca ttcatctacc tgagggacag cactgagttt ttcattcgtg
     3661 ttagagatgg ctggaaaaaa ttacagctgg gagaactgat ccccattcct gccgacagcc
     3721 ctccaccccc tgcgctttcc agcaacccac atcagcttct gcctccacca aaccctattt
     3781 caagtgccaa ttatgagaag cctgctctgc atttggctgc tctgaacatg ccattttctg
     3841 gggacattcg agctgatttt cagtgcttca agcaggccag agctgcagga ctgttgtcca
     3901 cctaccgagc attcttatct tcccatttgc aagatctgtc caccattgtg aggaaagcag
     3961 agagatacag ccttcccata gtgaacctca agggccaagt actttttaat aattgggact
     4021 caattttttc tggccacgga ggtcagttca atatgcatat tccaatatac tcctttgatg
     4081 gtcgagacat aatgacagat ccttcttggc cccagaaagt catttggcat ggctccagcc
     4141 cccatggcgt ccgccttgtg gataactact gtgaagcatg gcgaaccgcg gacacagcgg
     4201 tcacgggact tgcctccccg ctgagcacgg ggaagattct ggaccagaaa gcatacagct
     4261 gtgctaatcg gctaattgtc ctatgtatcg aaaacagttt catgacagac gctaggaagt
     4321 aatggccttc tgatgattct taaagagttt tcaatttttt cttatgtgaa gagttgacac
     4381 tgaaatctaa aatgtttaat tgttgtaaat attacagttt ttttttttta ctacatattc
     4441 tttacaacag caaccaaaga aaacatacct caatacactc aaaactgaag acatagagga
     4501 ctcagatcaa agacaaaatc tgatccatat attggtgcta gattctgcag gaaaccccag
     4561 cagtgtgaac gcatcccaac ataggttaag agcaagttga aaacaaaggc catggcattc
     4621 tgccactgca tccttcagac agttatatcc tccttttaaa ccattgttgt tgagtgtaag
     4681 atgtccttca tgttttctta taaagtcagt gtttagaaat gttacccttt ctaagttata
     4741 tacagatcaa atgctttttt ctttcacgta catccatcat ttgcaactgc tgttcgtaca
     4801 cagaaacagg actgctcaaa tgatcctatt tgtattttct gatgctatca gactctaatg
     4861 tttttttccc taaaatatta ttgccatcat gctttaggaa ttttatattt ttacacaatc
     4921 atattttagt atggtgtctg tttatgtaac tctgacttgc tggaaaagtt gaaactccaa
     4981 ataatctgaa actagaaaag aaatagcaca taattactac cttccccttg gcggctctcc
     5041 tccccaaccc ccaccccaca attttatgac ttccatttgg caattgttga attataactg
     5101 cgactgaaac aaacaggttc atagagatga attttctgag aaacatatat ctacatgttg
     5161 tataattgga ttttttttcc atgtaagtga acataaaaac atcttttccg ggtgctttct
     5221 tca
//
