LOCUS       NM_021110               8009 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens collagen type XIV alpha 1 chain (COL14A1), transcript
            variant 1, mRNA.
ACCESSION   NM_021110 XM_044622
VERSION     NM_021110.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8009)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   2  (bases 1 to 8009)
  AUTHORS   Ragelle,H., Naba,A., Larson,B.L., Zhou,F., Prijic,M.,
            Whittaker,C.A., Del Rosario,A., Langer,R., Hynes,R.O. and
            Anderson,D.G.
  TITLE     Comprehensive proteomic characterization of stem cell-derived
            extracellular matrices
  JOURNAL   Biomaterials 128, 147-159 (2017)
   PUBMED   28327460
REFERENCE   3  (bases 1 to 8009)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 8009)
  AUTHORS   Hoffmann,J., Marsh,L.M., Pieper,M., Stacher,E., Ghanim,B.,
            Kovacs,G., Konig,P., Wilkens,H., Haitchi,H.M., Hoefler,G.,
            Klepetko,W., Olschewski,H., Olschewski,A. and Kwapiszewska,G.
  TITLE     Compartment-specific expression of collagens and their processing
            enzymes in intrapulmonary arteries of IPAH patients
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 308 (10), L1002-L1013 (2015)
   PUBMED   25840998
  REMARK    GeneRIF: the intima+media of IPAH vessels, collagens (COL4A5,
            COL14A1, and COL18A1), matrix metalloproteinase (MMP) 19, and a
            disintegrin and metalloprotease (ADAM) 33 were higher expressed,
            whereas MMP10, ADAM17, TIMP1, and TIMP3 were less abundant.
REFERENCE   5  (bases 1 to 8009)
  AUTHORS   Oh,S. and Oh,S.
  TITLE     Epidemiological and genome-wide association study of gastritis or
            gastric ulcer in korean populations
  JOURNAL   Genomics Inform 12 (3), 127-133 (2014)
   PUBMED   25317112
REFERENCE   6  (bases 1 to 8009)
  AUTHORS   Tono-Oka,S., Tanase,S., Miike,T. and Tanaka,H.
  TITLE     Transient expression of collagen type XIV during muscle development
            and its reappearance after denervation and degeneration
  JOURNAL   J Histochem Cytochem 44 (8), 907-918 (1996)
   PUBMED   8756762
REFERENCE   7  (bases 1 to 8009)
  AUTHORS   Schnittger,S., Herbst,H., Schuppan,D., Dannenberg,C., Bauer,M. and
            Fonatsch,C.
  TITLE     Localization of the undulin gene (UND) to human chromosome band
            8q23
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 233-234 (1995)
   PUBMED   7842743
REFERENCE   8  (bases 1 to 8009)
  AUTHORS   Casini,A., Ceni,E., Salzano,R., Schuppan,D., Milani,S.,
            Pellegrini,G. and Surrenti,C.
  TITLE     Regulation of undulin synthesis and gene expression in human
            fat-storing cells by acetaldehyde and transforming growth
            factor-beta 1: comparison with fibronectin
  JOURNAL   Biochem Biophys Res Commun 199 (2), 1019-1026 (1994)
   PUBMED   8135774
REFERENCE   9  (bases 1 to 8009)
  AUTHORS   Just,M., Herbst,H., Hummel,M., Durkop,H., Tripier,D., Stein,H. and
            Schuppan,D.
  TITLE     Undulin is a novel member of the fibronectin-tenascin family of
            extracellular matrix glycoproteins
  JOURNAL   J Biol Chem 266 (26), 17326-17332 (1991)
   PUBMED   1716629
REFERENCE   10 (bases 1 to 8009)
  AUTHORS   Schuppan,D., Cantaluppi,M.C., Becker,J., Veit,A., Bunte,T.,
            Troyer,D., Schuppan,F., Schmid,M., Ackermann,R. and Hahn,E.G.
  TITLE     Undulin, an extracellular matrix glycoprotein associated with
            collagen fibrils
  JOURNAL   J Biol Chem 265 (15), 8823-8832 (1990)
   PUBMED   2187872
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090736.5, DB286127.1,
            AK307716.1, BC140893.1, DA373565.1, AC107877.4 and CF529353.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021110.3.
            
            Summary: This gene encodes the alpha chain of type XIV collagen, a
            member of the FACIT (fibril-associated collagens with interrupted
            triple helices) collagen family. Type XIV collagen interacts with
            the fibril surface and is involved in the regulation of
            fibrillogenesis. [provided by RefSeq, Jan 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.95048.1,
                                           SRR1803614.257150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297848.8/ ENSP00000297848.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC090736.5         57075-57080
            7-42                DB286127.1         1-36
            43-887              AK307716.1         1-845
            888-6374            BC140893.1         651-6137
            6375-6563           DA373565.1         358-546
            6564-7483           AC107877.4         31617-32536
            7484-8009           CF529353.1         18-543              c
FEATURES             Location/Qualifiers
     source          1..8009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..8009
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="collagen type XIV alpha 1 chain"
                     /db_xref="GeneID:7373"
                     /db_xref="HGNC:HGNC:2191"
                     /db_xref="MIM:120324"
     exon            1..239
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            240..364
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..5667
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; undulin (fibronectin-tenascin-related);
                     collagen, type XIV, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XIV) chain isoform 1 precursor"
                     /protein_id="NP_066933.1"
                     /db_xref="CCDS:CCDS34938.1"
                     /db_xref="GeneID:7373"
                     /db_xref="HGNC:HGNC:2191"
                     /db_xref="MIM:120324"
                     /translation="MKIFQRKMRYWLLPPFLAIVYFCTIVQGQVAPPTRLRYNVISHD
                     SIQISWKAPRGKFGGYKLLVTPTSGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAY
                     NKDKESKPAQGQFRIKDLEKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAIADIV
                     ILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTK
                     DEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDII
                     PPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTL
                     CSRVEEQDREIKASAHAITGPPTELITSEVTARSFMVNWTHAPGNVEKYRVVYYPTRG
                     GKPDEVVVDGTVSSTVLKNLMSLTEYQIAVFAIYAHTASEGLRGTETTLALPMASDLL
                     LYDVTENSMRVKWDAVPGASGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLLPNT
                     EYTVTVYAMFGEEASDPVTGQETTLALSPPRNLRISNVGSNSARLTWDPTSRQINGYR
                     IVYNNADGTEINEVEVDPITTFPLKGLTPLTEYTIAIFSIYDEGQSEPLTGVFTTEEV
                     PAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIPVYGGKTEEVVLKEEQDSHVIEG
                     LEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPATTIVPTTSVTSVFQTGIRN
                     LVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEVIGTVMVPGSQNNLLLKPL
                     LPDTEYKVTVTPIYTDGEGVSVSAPGKTLPSSGPQNLRVSEEWYNRLRITWDPPSSPV
                     KGYRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIFASQASGFSDALTGM
                     VKTLFLGVTNLQAKHVEMTSLCAHWQVHRHATAYRVVIESLQDRQKQESTVGGGTTRH
                     CFYGLQPDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIPPAKEVCKAAK
                     ADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLN
                     AYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRS
                     QDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDE
                     LITFVCETASATCPVVHKDGIDLAGFKMMEMFGLVEKDFSSVEGVSMEPGTFNVFPCY
                     QLHKDALVSQPTRYLHPEGLPSDYTISFLFRILPDTPQEPFALWEILNKNSDPLVGVI
                     LDNGGKTLTYFNYDQSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSETLVKVVIDCKQV
                     GEKAMNASANITSDGVEVLGKMVRSRGPGGNSAPFQLQMFDIVCSTSWANTDKCCELP
                     GLRDDESCPDLPHSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEPGPKGPDGPRGEI
                     GLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRDGSPGQ
                     RGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGERGDL
                     QSQAMVRSVARQVCEQLIQSHMARYTAILNQIPSHSSSIRTVQGPPGEPGRPGSPGAP
                     GEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGPAGPSGESRP
                     GSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVRAPHPDQPEFTPVQD
                     ELEAMELWGPGV"
     exon            365..481
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            482..625
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            626..712
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            713..868
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            869..988
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1153
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1315
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1467
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1597
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1743
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1873
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2013
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2140
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2280
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2413
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2473
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2625
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2755
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2878
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3028
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3145
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3292
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3349
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3489
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3613
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3757
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3922
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..3961
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4100
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4243
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4353
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4512
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4590
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4677
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4731
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..4827
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4828..4881
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4935
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..4989
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5061
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5097
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5098..5164
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5353
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5431
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5432..5587
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..8009
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6453..6458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="hexamer: AATAAA"
     polyA_site      6470
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="major polyA site"
     regulatory      7885..7890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="hexamer: AATAAA"
     polyA_site      7908
                     /gene="COL14A1"
                     /gene_synonym="UND"
     regulatory      7987..7992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL14A1"
                     /gene_synonym="UND"
                     /note="hexamer: AATAAA"
     polyA_site      8009
                     /gene="COL14A1"
                     /gene_synonym="UND"
ORIGIN      
        1 cctcttatct gatcctgggc tcccagctgg agaggcggag gcagctccag ggggctggaa
       61 gtggaagcgc agcggcagaa ggagagggag agagaaagag agagaggcta attaaaaaag
      121 gatactccga gggaagagag caagggcggt gcgccgccaa ggaccaacta gcggcggagc
      181 ttcgatcttg cctaggcgcg gagagctccc aacctgggct ggaaccttgc ccagcacagg
      241 tggctgctac accccatgta aaaagcggaa aataaaatga agattttcca gcgcaagatg
      301 cggtactggt tgcttccacc ttttttggca attgtttatt tctgcaccat tgtccaaggt
      361 caagtggctc cacccacaag gttaagatat aatgtaatat ctcatgacag tatacagatt
      421 tcatggaagg ctccaagagg gaaatttggt ggttacaaac ttcttgtgac tccaacttca
      481 ggtggaaaaa ctaaccagct gaatctgcag aacactgcaa ctaaagcaat tattcaaggc
      541 cttatgccag accagaatta cacagttcaa attattgcat acaataaaga taaagaaagc
      601 aagccagctc aaggccaatt cagaattaaa gatttagaaa aaagaaagga tccaaagccc
      661 agagtcaaag ttgtggacag aggaaatggg agtagaccat cttcaccaga agaagtgaaa
      721 tttgtctgtc aaactccagc aattgctgac attgtaatcc tggtcgatgg ttcatggagt
      781 attggaagat tcaacttcag actggttcgg catttcttgg aaaacctggt tacagcattc
      841 gatgtgggct cagagaagac acgaattggt cttgcacagt atagtggtga ccccagaata
      901 gaatggcact tgaatgcatt tagcacaaaa gatgaagtga ttgaagctgt ccgaaacctc
      961 ccatataaag gaggaaatac actaacaggt cttgctttga actacatttt tgaaaatagc
     1021 ttcaaaccag aagcaggatc aaggactgga gtatccaaaa ttggcatttt aatcacagat
     1081 ggaaaatccc aagatgacat tattccacca tctagaaatc ttcgtgagtc tggtgtagaa
     1141 ctgtttgcca taggggtgaa aaacgcggat gtgaatgagc tgcaggagat cgcctctgaa
     1201 ccagacagca ctcatgtgta caatgttgcc gaattcgatc tgatgcacac agttgtggag
     1261 agtctgacca ggactctctg ctctagagtg gaagaacagg acagagaaat taaagcctca
     1321 gcccatgcca tcactgggcc gcctacggag ttgattactt ctgaagtcac tgccagaagc
     1381 tttatggtta actggactca tgccccagga aatgtggaaa aatacagagt tgtgtattat
     1441 cctaccaggg gtggaaaacc agacgaggtg gtggtagatg gaactgtatc ttccacagtg
     1501 ttgaaaaact tgatgtcttt aactgaatat cagatagcag tctttgcaat ctatgcccac
     1561 actgctagtg aaggcctacg gggaactgaa actacacttg ctttaccgat ggcttctgac
     1621 cttctactgt acgacgtgac tgagaacagc atgcgagtca aatgggatgc agtgcctggg
     1681 gcctcaggtt acctgatcct ttatgctcct ctaacagagg gcctggctgg ggatgaaaaa
     1741 gagatgaaaa ttggagagac ccacacagat attgaattga gtgggttgtt gcccaataca
     1801 gaatacacag tcacagttta tgccatgttt ggagaagagg ccagtgatcc tgttacggga
     1861 caagaaacaa cattggcttt aagtccacca agaaacctga gaatctccaa tgttggctct
     1921 aacagtgctc gattaacctg ggacccaact tcaagacaga tcaatggtta tcgaattgta
     1981 tataacaatg cagatgggac tgaaatcaat gaggttgaag tcgatcctat tactaccttc
     2041 cctctgaagg gcttgacacc tctcacagag tatactattg ctattttctc catctatgat
     2101 gaaggacagt cagagcctct gactggagtt tttaccaccg aggaagttcc agcccagcaa
     2161 tacttagaaa ttgatgaggt gacgacagac agttttaggg tgacctggca tcccctctca
     2221 gctgatgaag ggctacacaa attgatgtgg attccagtct atggggggaa gactgaggag
     2281 gttgtcctga aagaagagca ggactcacat gttattgaag gcctggagcc cggtacggag
     2341 tatgaagttt cactattggc cgtacttgat gatggaagcg agagtgaggt ggtgactgct
     2401 gtcgggacca cacttgacag tttttggaca gaaccagcta caaccatagt gcctaccaca
     2461 tctgtgactt cagttttcca gacgggaatc agaaacctag ttgtaggtga tgaaactact
     2521 tctagcctgc gggtaaaatg ggacatttct gacagcgatg tgcagcagtt tagggtgacc
     2581 tacatgacag ctcaagggga ccctgaggaa gaagtcatag gaacggttat ggtgcctgga
     2641 agccagaaca acctccttct gaagcctctg cttcctgata ctgaatacaa agtcacagtg
     2701 actcccatct acacggatgg cgaaggcgtc agcgtctccg ctcctggaaa aaccttacca
     2761 tcctcggggc cccagaactt gcgggtgtcc gaggaatggt ataaccggtt gcgcattacg
     2821 tgggaccccc catcttcccc ggtgaaaggc tatagaattg tctacaaacc tgtcagtgtt
     2881 cctggtccaa cactggaaac gtttgtggga gctgacatta acaccatcct tatcacaaac
     2941 ctcctcagcg gaatggacta caatgtgaag atatttgcct cccaggcctc aggcttcagc
     3001 gacgccctga caggcatggt gaaaacattg ttcttgggtg ttaccaatct ccaagccaaa
     3061 catgttgaaa tgaccagctt gtgtgcccac tggcaggtac atcgccatgc cacagcctat
     3121 agggttgtta tagaatccct ccaggatagg caaaagcaag aatccactgt gggtggaggg
     3181 acaaccaggc attgcttcta tggacttcag cctgattctg aatataaaat cagtgtttat
     3241 acaaagctcc aggagattga aggacctagt gtgagcataa tggaaaaaac acaatcactt
     3301 cctacacgac caccaacttt tcctccaacc attccaccag caaaagaagt atgtaaggcg
     3361 gccaaggctg acctggtatt tatggtggat ggatcctgga gcattggaga tgaaaatttc
     3421 aataagatca tcagctttct atacagcact gttggagccc tgaacaagat tggcacagat
     3481 ggaacccaag ttgcaatggt tcagttcact gatgatccca gaacagaatt taaactaaat
     3541 gcttacaaaa ccaaagagac tcttcttgat gcaattaaac acatttcata caaaggagga
     3601 aatacaaaaa caggaaaagc aattaagtat gttcgagata ccttgttcac tgcagagtca
     3661 ggtacaagaa ggggcatccc aaaggttatc gtggttataa ctgatggaag atcacaagat
     3721 gatgtgaaca aaatctccag ggagatgcaa ttagatggct atagcatttt tgcaattggt
     3781 gtggccgatg cagattactc ggagttggtt agcattggca gtaagcccag cgcacgccat
     3841 gtcttctttg tggatgactt tgacgccttt aagaaaatcg aagatgagtt aattactttt
     3901 gtctgcgaaa cagcatcagc aacctgtcca gtggtacaca aggatggcat tgatcttgca
     3961 ggatttaaga tgatggaaat gtttggtttg gttgaaaaag atttttcatc agtggaaggg
     4021 gtttctatgg agcctggtac cttcaatgtg tttccatgtt accaactcca taaagatgcc
     4081 ctggtttccc agccaaccag gtacttgcac ccagaaggat tgccctccga ctacacaatc
     4141 agttttctat tccggattct tcctgacact ccacaggagc catttgctct ttgggagatt
     4201 ttaaataaaa attctgaccc attggttggg gttattttag acaatggtgg gaaaactcta
     4261 acatatttca actatgacca gagtggggat tttcaaactg ttactttcga aggacctgaa
     4321 attaggaaaa ttttttatgg aagctttcac aagctacaca ttgttgtcag tgagactttg
     4381 gtcaaagtgg ttattgactg caagcaagtg ggtgagaagg caatgaacgc atcagctaat
     4441 atcacgtcag atggtgtaga agtgctaggg aaaatggttc gatcaagagg accaggtgga
     4501 aactctgcac cgttccagtt acagatgttt gatattgttt gctccacatc atgggccaat
     4561 acagacaaat gctgtgaact tccaggcctg agagatgatg agtcttgccc agaccttccc
     4621 cattcctgct cctgttctga aaccaatgaa gtggctctgg gaccagcggg cccaccaggt
     4681 ggtccaggac tccgaggacc aaagggccag caaggtgaac cgggtccaaa gggaccagat
     4741 ggccctcggg gtgaaattgg tctgccagga cctcagggtc cacctggacc tcaaggacca
     4801 agtggtctgt ccattcaagg aatgcccgga atgccaggag aaaaaggaga gaaaggagat
     4861 actggccttc caggtccaca gggtatccca ggaggcgttg gttcaccagg acgtgatggc
     4921 tcaccaggcc agaggggcct tccgggaaag gatggatcct cgggacctcc aggaccacca
     4981 gggccaatag gcattcctgg cacccctgga gtcccaggga tcacaggaag catgggaccg
     5041 caaggcgccc tgggaccacc tggtgtccct ggagcaaagg gggaacgagg agagcggggt
     5101 gacctgcagt ctcaagccat ggtgagatca gtggcgcgtc aagtatgcga acagctcatc
     5161 cagagtcaca tggccaggta cactgccatc ctcaaccaga ttcccagcca ctcctcatcc
     5221 atccggactg tccaagggcc tcctggggag cctgggaggc caggctcacc tggagcccct
     5281 ggtgaacaag gacccccagg cacaccaggc ttccccggaa atgcaggcgt gccagggacc
     5341 ccaggagaac gaggtctaac tggtatcaaa ggagaaaaag gaaatccagg cgttggaacc
     5401 caaggtccaa gaggcccccc tggaccagca ggaccttcag gggagagtcg gcctggcagc
     5461 cctgggcccc ctggctctcc tggaccaaga ggcccaccag gtcatctggg ggttcctgga
     5521 ccccaaggtc cttctggcca gcctggatat tgtgacccct catcatgttc tgcctatggt
     5581 gtgagagctc cccatccaga tcagccagag ttcacccctg tccaagatga gctggaagcc
     5641 atggaactgt ggggccctgg agtctgatag cctcaggaga aatttgaaga ccaactgcaa
     5701 gaactcttaa ggaatcttgt ttgagaaaat gttgttatgt ggtttgtatg ctacttttgg
     5761 ggggcagggc tcatttcagc agcctaaatc tcctccttgg ataatgttaa tattattatt
     5821 attattaaca aaaaatatat atttttaaaa agttccctta atctatgaca tggtagcaat
     5881 gatttccctt tggtgtctta atggcatgtc agataatttg tttttccaga gaagagagct
     5941 caaagaggaa ttgggaaaaa taaattgaac tctggaatct tctctctcaa gtcctaaaat
     6001 gaacaaacag atatgattgt gtttgaggga aatatgtccc tagcaggaaa agaattcaaa
     6061 gaggttcaaa gaatatgtca cttactccta cttgctgtag gaataacctt gctgataaga
     6121 aaaaaaggga caatattgga gaaactacct cttgtttaat tgatctgtcc aactctgaga
     6181 tcacttggta actggtttca tgtgtatcca aaaatcagca tttggattta agctttctga
     6241 atttggtagt ttaagaaaca gatttagttt ttcagtggtt ttaactcatg tgaaataatg
     6301 attttccacc agctctgatg caaagagata taattttaat gaacgattta tccagcagtg
     6361 tgttccaggg gttgcctctc cttatctacg gggattactt tgtacatgca gataagtttt
     6421 cgcaaaccta tttccatttt cttttgtaag caaataaaac tttaaaacaa tgtatgtgga
     6481 ttctttttcc tgcatttcta agtatcacct taagcttttg tagtcttaac tgagtgtcca
     6541 ccagaaagac aacagttgtc ttcctttagg taagcattca aactttcatt cattcgttta
     6601 ctcactcact cattcattca ttctgagtgc agtagaaaac agaagaagca gttaacttgg
     6661 gactaagaga ttagcgacat tttattgttc atttataatc tagcaggcag caaagaccct
     6721 gcaaatgcat gacctctgct aaataaatgt ttatcaatag ttgactgagg agcccaccta
     6781 tcttctgata ttgaggaaag cctaaaaacc cctagaaggc agagcagaaa tgaggttgaa
     6841 tctaatagac tctaaccctt aaaccatact ttgtcttttg ctcacaaagg aaaaatctag
     6901 gtatttgaga aagatttgaa ttctattatg tgctagttga aatagaaaca aaagagaacc
     6961 ataaatttaa tacgtgctcc ttctctgtaa catctcccta gtaacagcta actttagaaa
     7021 gtagggatgg gatcatttac aactagaagc tggattcttt ctggatcagg aaaaggctaa
     7081 cacgaaggat ggtgtctgtc tgatcaccag gttctctttc tgtccttctc ataatctcct
     7141 gatctttgga gatgaaagat ctcctttcat cttcatctga aggattcttc agatgattca
     7201 tcttcagact tcatctgaag gattcaaaca atctacttgt gtgcctttgg tggggtgggg
     7261 caggggcggg gggcggttct aaacaaatca gtttttttgg tgtctttgca gggaatgaaa
     7321 gaagataatg agcagataat cagcagccat ttcctttcag ttatggtata tgattctgcc
     7381 tgagaaagca ggatttatgg gaaggaaaac ttgtctaagg ctcatcaaga tggcctgacc
     7441 cagagtcacc taagagaact cttccaactt aaatgactag ggtgtgtaat cagttgcttc
     7501 ttattctgtg tctcagattt cctagtccat gacatttaat agtgagtata gagtaggata
     7561 ttctatacat tttagtattt ggcccttgga aacaaagtta aataccatgt cactcagaag
     7621 actctcaaag tttgtgtata aatggcgaag tatacactat gagagattct aatccattca
     7681 catcattctt gagttgtgca aatacacttg gctttgattt cacttggtga tctaaatttg
     7741 tttatttaag ctgcaagaaa gttacattaa tttggaatgt gtcatcactt ggacccagta
     7801 tatcagattt ttattgagta aaatgttaaa aataataagt gtaactcaga ttctggatgt
     7861 tcgagtttac aatacattgc ctgtaataaa agctgattct gaagtgcatt tttcttgact
     7921 tactttggca gaaatatact tatatcttaa tttatagttt gtaagtttat actgttttct
     7981 aaaagtaata aatcatttca tgaaaaata
//
