LOCUS       NM_001368882            3148 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens collagen type XIII alpha 1 chain (COL13A1), transcript
            variant 23, mRNA.
ACCESSION   NM_001368882 XM_011539292
VERSION     NM_001368882.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Kim,H., Choi,N., Kim,D.Y., Kim,S.Y., Song,S.Y. and Sung,J.H.
  TITLE     TGF-beta2 and collagen play pivotal roles in the spheroid formation
            and anti-aging of human dermal papilla cells
  JOURNAL   Aging (Albany NY) 13 (16), 19978-19995 (2021)
   PUBMED   34404755
  REMARK    GeneRIF: TGF-beta2 and collagen play pivotal roles in the spheroid
            formation and anti-aging of human dermal papilla cells.
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Koivunen,J., Kemppainen,A.V., Finnila,M.A., Keski-Filppula,R.,
            Haronen,H., Tu,H., Pellikka,H., Heikkinen,A., Kylmaoja,E.,
            Sormunen,R., Miinalainen,I., Saarakkala,S., Izzi,V. and
            Pihlajaniemi,T.
  TITLE     Collagen XIII-derived ectodomain regulates bone angiogenesis and
            intracortical remodeling
  JOURNAL   Matrix Biol 83, 6-25 (2019)
   PUBMED   31220558
  REMARK    GeneRIF: Data suggest that ColXIII has a role in age-dependent
            cortical bone deterioration with possible implications for
            osteoporosis and fracture risk.
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Rodriguez Cruz,P.M., Cossins,J., Estephan,E.P., Munell,F.,
            Selby,K., Hirano,M., Maroofin,R., Mehrjardi,M.Y.V., Chow,G.,
            Carr,A., Manzur,A., Robb,S., Munot,P., Wei Liu,W., Banka,S.,
            Fraser,H., De Goede,C., Zanoteli,E., Conti Reed,U., Sage,A.,
            Gratacos,M., Macaya,A., Dusl,M., Senderek,J., Topf,A., Hofer,M.,
            Knight,R., Ramdas,S., Jayawant,S., Lochmuller,H., Palace,J. and
            Beeson,D.
  TITLE     The clinical spectrum of the congenital myasthenic syndrome
            resulting from COL13A1 mutations
  JOURNAL   Brain 142 (6), 1547-1560 (2019)
   PUBMED   31081514
  REMARK    GeneRIF: patients with COL13A1 mutations present mostly with severe
            early-onset myasthenic syndrome with feeding and breathing
            difficulties
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Juvonen,M., Sandberg,M. and Pihlajaniemi,T.
  TITLE     Patterns of expression of the six alternatively spliced exons
            affecting the structures of the COL1 and NC2 domains of the alpha
            1(XIII) collagen chain in human tissues and cell lines
  JOURNAL   J Biol Chem 267 (34), 24700-24707 (1992)
   PUBMED   1447210
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Juvonen,M. and Pihlajaniemi,T.
  TITLE     Characterization of the spectrum of alternative splicing of alpha 1
            (XIII) collagen transcripts in HT-1080 cells and calvarial tissue
            resulted in identification of two previously unidentified
            alternatively spliced sequences, one previously unidentified exon,
            and nine new mRNA variants
  JOURNAL   J Biol Chem 267 (34), 24693-24699 (1992)
   PUBMED   1447209
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Tikka,L., Elomaa,O., Pihlajaniemi,T. and Tryggvason,K.
  TITLE     Human alpha 1 (XIII) collagen gene. Multiple forms of the gene
            transcripts are generated through complex alternative splicing of
            several short exons
  JOURNAL   J Biol Chem 266 (26), 17713-17719 (1991)
   PUBMED   1894651
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   Pihlajaniemi,T. and Tamminen,M.
  TITLE     The alpha 1 chain of type XIII collagen consists of three
            collagenous and four noncollagenous domains, and its primary
            transcript undergoes complex alternative splicing
  JOURNAL   J Biol Chem 265 (28), 16922-16928 (1990)
   PUBMED   1698771
REFERENCE   9  (bases 1 to 3148)
  AUTHORS   Shows,T.B., Tikka,L., Byers,M.G., Eddy,R.L., Haley,L.L.,
            Henry,W.M., Prockop,D.J. and Tryggvason,K.
  TITLE     Assignment of the human collagen alpha 1 (XIII) chain gene
            (COL13A1) to the q22 region of chromosome 10
  JOURNAL   Genomics 5 (1), 128-133 (1989)
   PUBMED   2767682
REFERENCE   10 (bases 1 to 3148)
  AUTHORS   Tikka,L., Pihlajaniemi,T., Henttu,P., Prockop,D.J. and
            Tryggvason,K.
  TITLE     Gene structure for the alpha 1 chain of a human short-chain
            collagen (type XIII) with alternatively spliced transcripts and
            translation termination codon at the 5' end of the last exon
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7491-7495 (1988)
   PUBMED   2459707
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025426.11, AL138925.17 and
            AC024601.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 7, 2019 this sequence version replaced XM_011539292.3.
            
            Summary: This gene encodes the alpha chain of one of the
            nonfibrillar collagens. The function of this gene product is not
            known, however, it has been detected at low levels in all
            connective tissue-producing cells so it may serve a general
            function in connective tissues. Unlike most of the collagens, which
            are secreted into the extracellular matrix, collagen XIII contains
            a transmembrane domain and the protein has been localized to the
            plasma membrane. The transcripts for this gene undergo complex and
            extensive splicing involving at least eight exons. Like other
            collagens, collagen XIII is a trimer; it is not known whether this
            trimer is composed of one or more than one alpha chain isomer. A
            number of alternatively spliced transcript variants have been
            described, but the full length nature of some of them has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.73679.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645393.2/ ENSP00000496051.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               AC025426.11        32918-33729         c
            813-882             AC025426.11        13197-13266         c
            883-890             AL138925.17        34164-34171
            891-917             AL138925.17        38550-38576
            918-953             AL138925.17        41494-41529
            954-980             AL138925.17        44405-44431
            981-1031            AL138925.17        46869-46919
            1032-1067           AL138925.17        53822-53857
            1068-1094           AL138925.17        54670-54696
            1095-1121           AL138925.17        55780-55806
            1122-1148           AL138925.17        60918-60944
            1149-1175           AL138925.17        61041-61067
            1176-1202           AL138925.17        61916-61942
            1203-1268           AL138925.17        65063-65128
            1269-1376           AL138925.17        69114-69221
            1377-1403           AL138925.17        71299-71325
            1404-1439           AL138925.17        72153-72188
            1440-1484           AC024601.9         156958-157002       c
            1485-1517           AC024601.9         155974-156006       c
            1518-1544           AC024601.9         155203-155229       c
            1545-1607           AC024601.9         154564-154626       c
            1608-1661           AC024601.9         152356-152409       c
            1662-1748           AC024601.9         151497-151583       c
            1749-1802           AC024601.9         150436-150489       c
            1803-1847           AC024601.9         149284-149328       c
            1848-1916           AC024601.9         148419-148487       c
            1917-1940           AC024601.9         147181-147204       c
            1941-2003           AC024601.9         145292-145354       c
            2004-2048           AC024601.9         144204-144248       c
            2049-2201           AC024601.9         143739-143891       c
            2202-2246           AC024601.9         141687-141731       c
            2247-2288           AC024601.9         138900-138941       c
            2289-2315           AC024601.9         137509-137535       c
            2316-2396           AC024601.9         136576-136656       c
            2397-2432           AC024601.9         133268-133303       c
            2433-2486           AC024601.9         130113-130166       c
            2487-2540           AC024601.9         128567-128620       c
            2541-2576           AC024601.9         126949-126984       c
            2577-2663           AC024601.9         121323-121409       c
            2664-2702           AC024601.9         117249-117287       c
            2703-3148           AC024601.9         115147-115592       c
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3148
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /note="collagen type XIII alpha 1 chain"
                     /db_xref="GeneID:1305"
                     /db_xref="HGNC:HGNC:2190"
                     /db_xref="MIM:120350"
     exon            1..812
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..2705
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /note="isoform 23 is encoded by transcript variant 23;
                     collagen alpha-1(XIII) chain; collagen, type XIII, alpha
                     1"
                     /codon_start=1
                     /product="collagen alpha-1(XIII) chain isoform 23"
                     /protein_id="NP_001355811.1"
                     /db_xref="CCDS:CCDS91251.1"
                     /db_xref="GeneID:1305"
                     /db_xref="HGNC:HGNC:2190"
                     /db_xref="MIM:120350"
                     /translation="MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGS
                     CGLLTLALCSLALSLLAHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKL
                     HSRRRREAPKTSPGCNCPPGPPGPTGRPGLPGDKGAIGMPGRVGVKGQPGEKGSPGDA
                     GLSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGHPGPKGDMGLTGPPGQPGPQGQKGE
                     KGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGH
                     PGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKG
                     EPGIPGTKGDPGAEGKPGPPGLLGKRGQRGEKGAEGSPGLPGLLGQKGEKGDAGNSIG
                     GGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGSKGEPG
                     KGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLPGPPGHDG
                     EKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGEKGETGQAGSPGEKGE
                     AGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEKGFQGEKGDRGPLG
                     LPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGD
                     KGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK"
     exon            813..882
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..890
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..917
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..953
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..980
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1031
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1067
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1094
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1121
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1148
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1175
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1202
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1268
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1376
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1403
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1439
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1484
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1517
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1544
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1607
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1661
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1748
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1802
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1847
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1916
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1940
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2003
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2048
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2201
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2246
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2288
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2315
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2396
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2432
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2486
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2540
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2576
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2663
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2702
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..3148
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3125..3130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /note="hexamer: ATTAAA"
     polyA_site      3148
                     /gene="COL13A1"
                     /gene_synonym="CMS19; COLXIIIA1"
                     /note="major polyA site"
ORIGIN      
        1 atccgatccg tgccgccgca gggagtgtgt caagttacag aggcgccgga atcggcccct
       61 gcgctcctcg ccagccgcca cgacccacct ctgcccatgg ggccctccgt gtgcgcccct
      121 tcgcccgggg actgaaactg actggcccgg gagacacgag gcgcccagaa ggactgacag
      181 cgcggcacca actgctctgc agacacttga agggaaagac tgggcggaga gaaggagagc
      241 cggtcagatt cccctaactt tcctggactt ggaacgttct tcgaaataac ttttttctca
      301 cctaggtgta ccccaattac cgctggttgt gctttttcgg cacttcctct cctactgcta
      361 atttttccgt cctctttgcc gggagcagcg gaaagggacg ttttccagcg atacaagccc
      421 tttccccctg ccccgcagtt tggatagagc cttttggcag cggctgtcgc ctttatttat
      481 tctatttatt tatttattgg ttctcaagac gcgagaggat ggtagcggag cgcacccaca
      541 aagcggcagc caccggtgcc cgcggccctg gggagttggg cgcgcccggg acggtggctc
      601 tggtggcggc gcgggcggag cgcggcgcac ggctgccgag tccagggtcg tgcgggctgc
      661 tgacgctggc cctctgctcg ctggcactca gcctgctcgc ccactttcgg acggccgagc
      721 tgcaggcccg ggtgctgcgc ctggaagcgg agcgcgggga gcagcaaatg gagacggcta
      781 ttttgggacg agtcaatcaa ctgctggacg agaaatggaa gctccactca aggaggcgcc
      841 gggaggcccc aaagacatct ccaggatgta actgcccacc aggacctcct ggtcccactg
      901 gaagacccgg actcccaggg gacaaaggtg ccattgggat gcctggacgt gtgggagtaa
      961 agggccaacc aggcgagaag gggtcccccg gagacgctgg gctgtccatc attggtcccc
     1021 gcggcccccc tggtcaacca ggaactagag gtttccctgg atttccgggt cccattgggc
     1081 tggacggcaa accgggccac ccaggaccaa agggcgacat gggtctgacg ggtcccccag
     1141 gacagccggg accccaggga caaaaaggag aaaagggtca gtgtggagag tacccacacc
     1201 ggctgctgcc tctcctcaat tcagtgcgac tggctccacc cccggtcata aaaaggcgga
     1261 cgttccaggg cgaacagagc caggccagca tccaaggtcc accagggccc ccaggccccc
     1321 ctggaccaag tggacctctg gggcacccag gactgccagg gcctatgggg ccacctggct
     1381 tacctgggcc tcctggacca aagggagacc cagggatcca gggctaccac ggccggaagg
     1441 gagaacgggg catgccaggg atgccaggca agcatggagc caagggggcg cccggaattg
     1501 ccgtggctgg gatgaagggt gagccaggga tcccaggaac caagggagac ccaggagcag
     1561 aagggaagcc ggggccccca ggtttgctgg gaaagagggg gcagaggggt gagaaggggg
     1621 ctgaaggctc ccctgggctt cctggcctcc tggggcagaa gggagagaaa ggcgatgctg
     1681 gcaactccat tggaggaggc agaggggaac ctggccctcc agggctccct gggcccccag
     1741 ggccaaaggg agaagcaggt gtcgatggcc aggttggccc cccagggcag ccaggagaca
     1801 agggggagcg tggagcagct ggagaacagg gaccagatgg ccccaagggc tccaagggag
     1861 aaccagggaa aggagagatg gtggattaca atggaaacat caatgaggct ctccaggaga
     1921 tccggacgct ggccttgatg gggcctcctg gtcttcctgg gcaaattggc ccacctggag
     1981 ctccagggat tccaggccag aagggggaga ttggactgcc aggccctcca ggacacgatg
     2041 gggaaaaggg acctcgcggt aaaccaggag acatgggccc tcctggtccc caaggccccc
     2101 caggaaagga tggacctcca ggagtgaagg gagaaaacgg gcacccaggg agcccaggag
     2161 agaaggggga aaaaggggag acaggacaag caggctcacc gggagagaaa ggagaagccg
     2221 gggagaaggg caatccagga gcagaggttc ctgggctgcc agggccagag gggcctcccg
     2281 gacctccggg gctccaaggt gttcctggac caaaggggga agcaggacta gatggagcaa
     2341 aaggagagaa aggcttccag ggagaaaaag gagaccgtgg tcccctggga ctacccggag
     2401 cttcaggttt ggacggcagg cctgggccac cgggtactcc aggaccaatt ggagttccag
     2461 gcccagcggg accaaagggc gagaggggca gcaaaggaga ccctgggatg acaggaccaa
     2521 cgggagcagc tgggcttcct ggtttacatg gaccacccgg ggacaaggga aaccgggggg
     2581 agagggggaa gaaaggctct agagggccta aaggggataa gggagaccaa ggagcgcctg
     2641 gattagatgc cccctgccca ttgggcgaag atggcttacc agtccaaggc tgctggaaca
     2701 agtgatgcct ctaaccttgg attggcctgt gtgtgtgttt gtacatagaa tatttatttt
     2761 tatacagttt tcactttttg aaaatgccag aagtatgatg catcttacag attattaaaa
     2821 aagaaagaaa aacctgcata ttttgtacag aaaatatcaa cctcttccct tttgtttaca
     2881 agatgttttg tataagccta tgtctctaat acattttttg tttggtcgta atgtctgcat
     2941 gatatttgtg cacatttatt aagtatcgaa gcttaataaa ttattgtgtc ctggtgccaa
     3001 agggggccag ccagaactga ggtgctggct agctcatgtg tgaattcaca taaatgtaga
     3061 ggtccatgat atttgctaag ctaggtgtgt ctaagagtat tttaaaccct tatggatttt
     3121 cattattaaa ggaaatgaaa catggcaa
//
