LOCUS       NM_001854               7311 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens collagen type XI alpha 1 chain (COL11A1), transcript
            variant A, mRNA.
ACCESSION   NM_001854
VERSION     NM_001854.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7311)
  AUTHORS   Boysen,K.B., Tumer,Z., Bach-Holm,D., Bisgaard,A.M. and Kessel,L.
  TITLE     Microphthalmia and congenital cataract in two patients with
            Stickler syndrome type II: a case report
  JOURNAL   Ophthalmic Genet 45 (3), 313-318 (2024)
   PUBMED   38299479
  REMARK    GeneRIF: Microphthalmia and congenital cataract in two patients
            with Stickler syndrome type II: a case report.
REFERENCE   2  (bases 1 to 7311)
  AUTHORS   Zheng,H., Tan,J., Qin,F., Zheng,Y., Yang,X., Qin,X. and Liao,H.
  TITLE     Analysis of cancer-associated fibroblasts related genes identifies
            COL11A1 associated with lung adenocarcinoma prognosis
  JOURNAL   BMC Med Genomics 17 (1), 97 (2024)
   PUBMED   38649961
  REMARK    GeneRIF: Analysis of cancer-associated fibroblasts related genes
            identifies COL11A1 associated with lung adenocarcinoma prognosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7311)
  AUTHORS   Yu,H., Khanshour,A.M., Ushiki,A., Otomo,N., Koike,Y.,
            Einarsdottir,E., Fan,Y., Antunes,L., Kidane,Y.H., Cornelia,R.,
            Sheng,R.R., Zhang,Y., Pei,J., Grishin,N.V., Evers,B.M.,
            Cheung,J.P.Y., Herring,J.A., Terao,C., Song,Y.Q., Gurnett,C.A.,
            Gerdhem,P., Ikegawa,S., Rios,J.J., Ahituv,N. and Wise,C.A.
  TITLE     Association of genetic variation in COL11A1 with adolescent
            idiopathic scoliosis
  JOURNAL   Elife 12, 89762 (2024)
   PUBMED   38277211
  REMARK    GeneRIF: Association of genetic variation in COL11A1 with
            adolescent idiopathic scoliosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7311)
  AUTHORS   Annunen,S., Korkko,J., Czarny,M., Warman,M.L., Brunner,H.G.,
            Kaariainen,H., Mulliken,J.B., Tranebjaerg,L., Brooks,D.G.,
            Cox,G.F., Cruysberg,J.R., Curtis,M.A., Davenport,S.L.,
            Friedrich,C.A., Kaitila,I., Krawczynski,M.R., Latos-Bielenska,A.,
            Mukai,S., Olsen,B.R., Shinno,N., Somer,M., Vikkula,M.,
            Zlotogora,J., Prockop,D.J. and Ala-Kokko,L.
  TITLE     Splicing mutations of 54-bp exons in the COL11A1 gene cause
            Marshall syndrome, but other mutations cause overlapping
            Marshall/Stickler phenotypes
  JOURNAL   Am J Hum Genet 65 (4), 974-983 (1999)
   PUBMED   10486316
REFERENCE   5  (bases 1 to 7311)
  AUTHORS   Zhidkova,N.I., Justice,S.K. and Mayne,R.
  TITLE     Alternative mRNA processing occurs in the variable region of the
            pro-alpha 1(XI) and pro-alpha 2(XI) collagen chains
  JOURNAL   J Biol Chem 270 (16), 9486-9493 (1995)
   PUBMED   7721876
REFERENCE   6  (bases 1 to 7311)
  AUTHORS   Yoshioka,H., Greenwel,P., Inoguchi,K., Truter,S., Inagaki,Y.,
            Ninomiya,Y. and Ramirez,F.
  TITLE     Structural and functional analysis of the promoter of the human
            alpha 1(XI) collagen gene
  JOURNAL   J Biol Chem 270 (1), 418-424 (1995)
   PUBMED   7814404
REFERENCE   7  (bases 1 to 7311)
  AUTHORS   Mortier,G.
  TITLE     Stickler Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301479
REFERENCE   8  (bases 1 to 7311)
  AUTHORS   Yoshioka,H. and Ramirez,F.
  TITLE     Pro-alpha 1(XI) collagen. Structure of the amino-terminal
            propeptide and expression of the gene in tumor cell lines
  JOURNAL   J Biol Chem 265 (11), 6423-6426 (1990)
   PUBMED   1690726
REFERENCE   9  (bases 1 to 7311)
  AUTHORS   Bernard,M., Yoshioka,H., Rodriguez,E., Van der Rest,M., Kimura,T.,
            Ninomiya,Y., Olsen,B.R. and Ramirez,F.
  TITLE     Cloning and sequencing of pro-alpha 1 (XI) collagen cDNA
            demonstrates that type XI belongs to the fibrillar class of
            collagens and reveals that the expression of the gene is not
            restricted to cartilagenous tissue
  JOURNAL   J Biol Chem 263 (32), 17159-17166 (1988)
   PUBMED   3182841
REFERENCE   10 (bases 1 to 7311)
  AUTHORS   Henry,I., Bernheim,A., Bernard,M., van der Rest,M., Kimura,T.,
            Jeanpierre,C., Barichard,F., Berger,R., Olsen,B.R., Ramirez,F. et
            al.
  TITLE     Mapping of a human fibrillar collagen gene, pro alpha 1 (XI)
            (COL11A1), to the p21 region of chromosome 1
  JOURNAL   Genomics 3 (1), 87-90 (1988)
   PUBMED   3220479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093150.4, J04177.1,
            AB208844.1, BX476821.1, BU159588.1 and AC099567.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001854.3.
            
            Summary: This gene encodes one of the two alpha chains of type XI
            collagen, a minor fibrillar collagen. Type XI collagen is a
            heterotrimer but the third alpha chain is a post-translationally
            modified alpha 1 type II chain. Mutations in this gene are
            associated with type II Stickler syndrome and with Marshall
            syndrome. A single-nucleotide polymorphism in this gene is also
            associated with susceptibility to lumbar disc herniation. Multiple
            transcript variants have been identified for this gene. [provided
            by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (A) utilizes alternate exon 6,
            designated exon 6A. The encoded isoform (A) has a 39 aa region
            specified by exon 6A, that differs from the corresponding 51 aa
            region encoded by exon 6B in isoform B.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04177.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370096.9/ ENSP00000359114.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC093150.4         113391-113416       c
            27-183              AC093150.4         113234-113390       c
            184-2616            J04177.1           1-2433
            2617-2900           AB208844.1         1591-1874
            2901-3160           J04177.1           2718-2977
            3161-4311           AB208844.1         2151-3301
            4312-4494           BX476821.1         287-469
            4495-4855           J04177.1           4312-4672
            4856-5549           BU159588.1         57-750
            5550-5615           J04177.1           5367-5432
            5616-5619           BU159588.1         817-820
            5620-5638           J04177.1           5437-5455
            5639-5656           BU159588.1         841-858
            5657-5700           J04177.1           5474-5517
            5701-6299           AB208844.1         4691-5289
            6300-7311           AC099567.2         117102-118113       c
FEATURES             Location/Qualifiers
     source          1..7311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.1"
     gene            1..7311
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="collagen type XI alpha 1 chain"
                     /db_xref="GeneID:1301"
                     /db_xref="HGNC:HGNC:2186"
                     /db_xref="MIM:120280"
     exon            1..450
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..5765
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="isoform A preproprotein is encoded by transcript
                     variant A; collagen XI, alpha-1 polypeptide; collagen
                     alpha-1(XI) chain; collagen, type XI, alpha 1; deafness,
                     autosomal dominant 37"
                     /codon_start=1
                     /product="collagen alpha-1(XI) chain isoform A
                     preproprotein"
                     /protein_id="NP_001845.3"
                     /db_xref="CCDS:CCDS778.1"
                     /db_xref="GeneID:1301"
                     /db_xref="HGNC:HGNC:2186"
                     /db_xref="MIM:120280"
                     /translation="MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKA
                     LDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSIL
                     FTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIA
                     DGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEG
                     DIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEA
                     EYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPV
                     EEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDK
                     PTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPA
                     GIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPT
                     ISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGV
                     QGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPP
                     GPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMG
                     PQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQ
                     SGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDR
                     GEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTG
                     FPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGP
                     PGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQ
                     GPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPG
                     ERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGE
                     KGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGEN
                     GPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPG
                     PPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGN
                     PGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPP
                     GEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKG
                     AKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGP
                     PGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPA
                     GPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSK
                     KTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDL
                     QLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKP
                     GSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSG
                     SYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVM
                     INDFGDQNQKFGFEVGPVCFLG"
     exon            451..618
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..832
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..995
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1124
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1241
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1334
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1589
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1652
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1694
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1757
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1832
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1916
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1973
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2027
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2081
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2135
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2189
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2243
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2288
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2342
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2387
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2441
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2486
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2540
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2585
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2639
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2684
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2738
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2846
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2900
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..2954
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..2999
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3053
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3098
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3152
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3206
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3260
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3368
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3458
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3512
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3620
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3728
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3782
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3836
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3944
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..3998
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4052
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4106
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4160
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4268
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4322
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4376
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4430
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4484
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4592
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4646
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4647..4700
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4808
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4862
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..4898
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..4952
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5202
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5203..5315
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5316..5384
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5385..5618
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5619..7311
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6278..6283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="hexamer: AATAAA"
     polyA_site      6300
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="major polyA site"
     regulatory      6326..6331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="hexamer: AATAAA"
     polyA_site      6346
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="major polyA site"
     regulatory      7291..7296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="hexamer: AATAAA"
     polyA_site      7311
                     /gene="COL11A1"
                     /gene_synonym="CO11A1; COLL6; DFNA37; STL2"
                     /note="major polyA site"
ORIGIN      
        1 actgacggca tgaagccttt aggggcacac agtactctca gcttgttggt ggaagcccct
       61 catctgcctt cattctgaag gcagggcccg gcagaggaag gatcagaggg tcgcggccgg
      121 agggtcccgg ccggtggggc caactcagag ggagaggaaa gggctagaga cacgaagaac
      181 gcaaaccatc aaatttagaa gaaaaagccc tttgactttt tccccctctc cctccccaat
      241 ggctgtgtag caaacatccc tggcgatacc ttggaaagga cgaagttggt ctgcagtcgc
      301 aatttcgtgg gttgagttca cagttgtgag tgcggggctc ggagatggag ccgtggtcct
      361 ctaggtggaa aacgaaacgg tggctctggg atttcaccgt aacaaccctc gcattgacct
      421 tcctcttcca agctagagag gtcagaggag ctgctccagt tgatgtacta aaagcactag
      481 attttcacaa ttctccagag ggaatatcaa aaacaacggg attttgcaca aacagaaaga
      541 attctaaagg ctcagatact gcttacagag tttcaaagca agcacaactc agtgccccaa
      601 caaaacagtt atttccaggt ggaactttcc cagaagactt ttcaatacta tttacagtaa
      661 aaccaaaaaa aggaattcag tctttccttt tatctatata taatgagcat ggtattcagc
      721 aaattggtgt tgaggttggg agatcacctg tttttctgtt tgaagaccac actggaaaac
      781 ctgccccaga agactatccc ctcttcagaa ctgttaacat cgctgacggg aagtggcatc
      841 gggtagcaat cagcgtggag aagaaaactg tgacaatgat tgttgattgt aagaagaaaa
      901 ccacgaaacc acttgataga agtgagagag caattgttga taccaatgga atcacggttt
      961 ttggaacaag gattttggat gaagaagttt ttgaggggga cattcagcag tttttgatca
     1021 caggtgatcc caaggcagca tatgactact gtgagcatta tagtccagac tgtgactctt
     1081 cagcacccaa ggctgctcaa gctcaggaac ctcagataga tgagtatgca ccagaggata
     1141 taatcgaata tgactatgag tatggggaag cagagtataa agaggctgaa agtgtaacag
     1201 agggacccac tgtaactgag gagacaatag cacagacgga ggcaaacatc gttgatgatt
     1261 ttcaagaata caactatgga acaatggaaa gttaccagac agaagctcct aggcatgttt
     1321 ctgggacaaa tgagccaaat ccagttgaag aaatatttac tgaagaatat ctaacgggag
     1381 aggattatga ttcccagagg aaaaattctg aggatacact atatgaaaac aaagaaatag
     1441 acggcaggga ttctgatctt ctggtagatg gagatttagg cgaatatgat ttttatgaat
     1501 ataaagaata tgaagataaa ccaacaagcc cccctaatga agaatttggt ccaggtgtac
     1561 cagcagaaac tgatattaca gaaacaagca taaatggcca tggtgcatat ggagagaaag
     1621 gacagaaagg agaaccagca gtggttgagc ctggtatgct tgtcgaagga ccaccaggac
     1681 cagcaggacc tgcaggtatt atgggtcctc caggtctaca aggccccact ggaccccctg
     1741 gtgaccctgg cgataggggc cccccaggac gtcctggctt accaggggct gatggtctac
     1801 ctggtcctcc tggtactatg ttgatgttac cgttccgtta tggtggtgat ggttccaaag
     1861 gaccaaccat ctctgctcag gaagctcagg ctcaagctat tcttcagcag gctcggattg
     1921 ctctgagagg cccacctggc ccaatgggtc taactggaag accaggtcct gtgggggggc
     1981 ctggttcatc tggggccaaa ggtgagagtg gtgatccagg tcctcagggc cctcgaggcg
     2041 tccagggtcc ccctggtcca acgggaaaac ctggaaaaag gggtcgtcca ggtgcagatg
     2101 gaggaagagg aatgccagga gaacctgggg caaagggaga tcgagggttt gatggacttc
     2161 cgggtctgcc aggtgacaaa ggtcacaggg gtgaacgagg tcctcaaggt cctccaggtc
     2221 ctcctggtga tgatggaatg aggggagaag atggagaaat tggaccaaga ggtcttccag
     2281 gtgaagctgg cccacgaggt ttgctgggtc caaggggaac tccaggagct ccagggcagc
     2341 ctggtatggc aggtgtagat ggccccccag gaccaaaagg gaacatgggt ccccaagggg
     2401 agcctgggcc tccaggtcaa caagggaatc caggacctca gggtcttcct ggtccacaag
     2461 gtccaattgg tcctcctggt gaaaaaggac cacaaggaaa accaggactt gctggacttc
     2521 ctggtgctga tgggcctcct ggtcatcctg ggaaagaagg ccagtctgga gaaaaggggg
     2581 ctctgggtcc ccctggtcca caaggtccta ttggataccc gggcccccgg ggagtaaagg
     2641 gagcagatgg tgtcagaggt ctcaagggat ctaaaggtga aaagggtgaa gatggttttc
     2701 caggattcaa aggtgacatg ggtctaaaag gtgacagagg agaagttggt caaattggcc
     2761 caagagggga agatggccct gaaggaccca aaggtcgagc aggcccaact ggagacccag
     2821 gtccttcagg tcaagcagga gaaaagggaa aacttggagt tccaggatta ccaggatatc
     2881 caggaagaca aggtccaaag ggttccactg gattccctgg gtttccaggt gccaatggag
     2941 agaaaggtgc acggggagta gctggcaaac caggccctcg gggtcagcgt ggtccaacgg
     3001 gtcctcgagg ttcaagaggt gcaagaggtc ccactgggaa acctgggcca aagggcactt
     3061 caggtggcga tggccctcct ggccctccag gtgaaagagg tcctcaagga cctcagggtc
     3121 cagttggatt ccctggacca aaaggccctc ctggaccacc tgggaaggat gggctgccag
     3181 gacaccctgg gcaacgtggg gagactggat ttcaaggcaa gaccggccct cctgggccag
     3241 ggggagtggt tggaccacag ggaccaaccg gtgagactgg tccaataggg gaacgtgggc
     3301 atcctggccc tcctggccct cctggtgagc aaggtcttcc tggtgctgca ggaaaagaag
     3361 gtgcaaaggg tgatccaggt cctcaaggta tctcagggaa agatggacca gcaggattac
     3421 gtggtttccc aggggaaaga ggtcttcctg gagctcaggg tgcacctgga ctgaaaggag
     3481 gggaaggtcc ccagggccca ccaggtccag ttggctcacc aggagaacgt gggtcagcag
     3541 gtacagctgg cccaattggt ttaccagggc gcccgggacc tcagggtcct cctggtccag
     3601 ctggagagaa aggtgctcct ggagaaaaag gtccccaagg gcctgcaggg agagatggag
     3661 ttcaaggtcc tgttggtctc ccagggccag ctggtcctgc cggctcccct ggggaagacg
     3721 gagacaaggg tgaaattggt gagccgggac aaaaaggcag caagggtgac aagggagaaa
     3781 atggccctcc cggtccccca ggtcttcaag gaccagttgg tgcccctgga attgctggag
     3841 gtgatggtga accaggtcct agaggacagc aggggatgtt tgggcaaaaa ggtgatgagg
     3901 gtgccagagg cttccctgga cctcctggtc caataggtct tcagggtctg ccaggcccac
     3961 ctggtgaaaa aggtgaaaat ggggatgttg gtcccatggg gccacctggt cctccaggcc
     4021 caagaggccc tcaaggtccc aatggagctg atggaccaca aggaccccca gggtctgttg
     4081 gttcagttgg tggtgttgga gaaaagggtg aacctggaga agcagggaac ccagggcctc
     4141 ctggggaagc aggtgtaggc ggtcccaaag gagaaagagg agagaaaggg gaagctggtc
     4201 cacctggagc tgctggacct ccaggtgcca aggggccacc aggtgatgat ggccctaagg
     4261 gtaacccggg tcctgttggt tttcctggag atcctggtcc tcctggggaa cctggccctg
     4321 caggtcaaga tggtgttggt ggtgacaagg gtgaagatgg agatcctggt caaccgggtc
     4381 ctcctggccc atctggtgag gctggcccac caggtcctcc tggaaaacga ggtcctcctg
     4441 gagctgcagg tgcagaggga agacaaggtg aaaaaggtgc taagggggaa gcaggtgcag
     4501 aaggtcctcc tggaaaaacc ggcccagtcg gtcctcaggg acctgcagga aagcctggtc
     4561 cagaaggtct tcggggcatc cctggtcctg tgggagaaca aggtctccct ggagctgcag
     4621 gccaagatgg accacctggt cctatgggac ctcctggctt acctggtctc aaaggtgacc
     4681 ctggctccaa gggtgaaaag ggacatcctg gtttaattgg cctgattggt cctccaggag
     4741 aacaagggga aaaaggtgac cgagggctcc ctggaactca aggatctcca ggagcaaaag
     4801 gggatggggg aattcctggt cctgctggtc ccttaggtcc acctggtcct ccaggtttac
     4861 caggtcctca aggcccaaag ggtaacaaag gctctactgg acccgctggc cagaaaggtg
     4921 acagtggtct tccagggcct cctgggtctc caggtccacc tggtgaagtc attcagcctt
     4981 taccaatctt gtcctccaaa aaaacgagaa gacatactga aggcatgcaa gcagatgcag
     5041 atgataatat tcttgattac tcggatggaa tggaagaaat atttggttcc ctcaattccc
     5101 tgaaacaaga cattgagcat atgaaatttc caatgggtac tcagaccaat ccagcccgaa
     5161 cttgtaaaga cctgcaactc agccatcctg acttcccaga tggtgaatat tggattgatc
     5221 ctaaccaagg ttgctcagga gattccttca aagtttactg taatttcaca tctggtggtg
     5281 agacttgcat ttatccagac aaaaaatctg agggagtaag aatttcatca tggccaaagg
     5341 agaaaccagg aagttggttt agtgaattta agaggggaaa actgctttca tacttagatg
     5401 ttgaaggaaa ttccatcaat atggtgcaaa tgacattcct gaaacttctg actgcctctg
     5461 ctcggcaaaa tttcacctac cactgtcatc agtcagcagc ctggtatgat gtgtcatcag
     5521 gaagttatga caaagcactt cgcttcctgg gatcaaatga tgaggagatg tcctatgaca
     5581 ataatccttt tatcaaaaca ctgtatgatg gttgtgcgtc cagaaaaggc tatgaaaaga
     5641 ctgtcattga aatcaataca ccaaaaattg atcaagtacc tattgttgat gtcatgatca
     5701 atgactttgg tgatcagaat cagaagttcg gatttgaagt tggtcctgtt tgttttcttg
     5761 gctaagatta agacaaagaa catatcaaat caacagaaaa tataccttgg tgccaccaac
     5821 ccattttgtg ccacatgcaa gttttgaata aggatggtat agaaaacaac gctgcatata
     5881 caggtaccat ttaggaaata ccgatgcctt tgtgggggca gaatcacatg gcaaaagctt
     5941 tgaaaatcat aaagatataa gttggtgtgg ctaagatgga aacagggctg attcttgatt
     6001 cccaattctc aactctcctt ttcctatttg aatttctttg gtgctgtaga aaacaaaaaa
     6061 agaaaaatat atattcataa aaaatatggt gctcattctc atccatccag gatgtactaa
     6121 aacagtgtgt ttaataaatt gtaattattt tgtgtacagt tctatactgt tatctgtgtc
     6181 catttccaaa acttgcacgt gtccctgaat tccatctgac tctaatttta tgagaattgc
     6241 agaactctga tggcaataaa tatatgtatt atgaaaaaat aaagttgtaa tttctgatga
     6301 ctctaagtcc ctttctttgg ttaataataa aatgcctttg tatatattga tgttgaagag
     6361 ttcaattatt tgatgtcgcc aacaaaattc tcagagggca aaaatctgga agacttttgg
     6421 aagcacactc tgatcaactc ttctctgccg acagtcattt tgctgaattt cagccaaaaa
     6481 tattatgcat tttgatgctt tattcaaggc tatacctcaa actttttctt ctcagaatcc
     6541 aggatttcac aggatacttg tatatatgga aaacaagcaa gtttatattt ttggacaggg
     6601 aaatgtgtgt aagaaagtat attaacaaat caatgcctcc gtcaagcaaa caatcatatg
     6661 tatacttttt ttctacgtta tctcatctcc ttgttttcag tgtgcttcaa taatgcaggt
     6721 taatattaaa gatggaaatt aagcaattat ttatgaattt gtgcaatgtt agattttctt
     6781 atcaatcaag ttcttgaatt tgattctaag ttgcatatta taacagtctc gaaaattatt
     6841 ttacttgccc aacaaatatt acttttttcc tttcaagata attttataaa tcatttgacc
     6901 tacctaattg ctaaatgaat aacatatggt ggactgttat taagagtatt tgttttaagt
     6961 cattcaggaa aatctaaact tttttttcca ctaaggtatt tactttaagg tagcttgaaa
     7021 tagcaataca atttaaaaat taaaaactga attttgtatc tattttaagt aatatatgta
     7081 agacttgaaa ataaatgttt tatttcttat ataaagtgtt aaattaattg ataccagatt
     7141 tcactggaac agtttcaact gataatttat gacaaaagaa catacctgta atattgaaat
     7201 taaaaagtga aatttgtcat aaagaatttc ttttattttt gaaatcgagt ttgtaaatgt
     7261 ccttttaaga agggagatat gaatccaata aataaactca agtcttggct a
//
