LOCUS       NM_004645               2634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coilin (COIL), mRNA.
ACCESSION   NM_004645
VERSION     NM_004645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   White,L., Erbay,B. and Blair,G.E.
  TITLE     The Cajal body protein p80-coilin forms a complex with the
            adenovirus L4-22K protein and facilitates the nuclear export of
            adenovirus mRNA
  JOURNAL   mBio 14 (5), e0145923 (2023)
   PUBMED   37795984
  REMARK    GeneRIF: The Cajal body protein p80-coilin forms a complex with the
            adenovirus L4-22K protein and facilitates the nuclear export of
            adenovirus mRNA.
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Lett,K.E., Logan,M.K., McLaurin,D.M. and Hebert,M.D.
  TITLE     Coilin enhances phosphorylation and stability of DGCR8 and promotes
            miRNA biogenesis
  JOURNAL   Mol Biol Cell 32 (20), br4 (2021)
   PUBMED   34319763
  REMARK    GeneRIF: Coilin enhances phosphorylation and stability of DGCR8 and
            promotes miRNA biogenesis.
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Bohmann,K., Ferreira,J.A. and Lamond,A.I.
  TITLE     Mutational analysis of p80 coilin indicates a functional
            interaction between coiled bodies and the nucleolus
  JOURNAL   J Cell Biol 131 (4), 817-831 (1995)
   PUBMED   7490287
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Kusuda,J., Tanuma,R., Gotoh,E., Toyoda,A. and Hashimoto,K.
  TITLE     Assignment of a human autoimmune antigen, p80-coilin gene to
            chromosome 17q21-q23 and of its possible pseudogene to chromosome
            14
  JOURNAL   Hum Genet 95 (2), 233-234 (1995)
   PUBMED   7860074
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Carmo-Fonseca,M., Ferreira,J. and Lamond,A.I.
  TITLE     Assembly of snRNP-containing coiled bodies is regulated in
            interphase and mitosis--evidence that the coiled body is a kinetic
            nuclear structure
  JOURNAL   J Cell Biol 120 (4), 841-852 (1993)
   PUBMED   7679389
REFERENCE   10 (bases 1 to 2634)
  AUTHORS   Andrade,L.E., Chan,E.K., Raska,I., Peebles,C.L., Roos,G. and
            Tan,E.M.
  TITLE     Human autoantibody to a novel protein of the nuclear coiled body:
            immunological characterization and cDNA cloning of p80-coilin
  JOURNAL   J Exp Med 173 (6), 1407-1419 (1991)
   PUBMED   2033369
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004584.2, BC010385.1 and
            AW021880.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004645.2.
            
            Summary: The protein encoded by this gene is an integral component
            of Cajal bodies (also called coiled bodies). Cajal bodies are
            nuclear suborganelles of varying number and composition that are
            involved in the post-transcriptional modification of small nuclear
            and small nucleolar RNAs. The N-terminus of the coilin protein
            directs its self-oligomerization while the C-terminus influences
            the number of nuclear bodies assembled per cell. Differential
            methylation and phosphorylation of coilin likely influences its
            localization among nuclear bodies and the composition and assembly
            of Cajal bodies. This gene has pseudogenes on chromosome 4 and
            chromosome 14. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.621235.1, BC010385.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240316.5/ ENSP00000240316.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC004584.2         26122-26397
            277-1384            AC004584.2         36176-37283
            1385-1471           AC004584.2         37405-37491
            1472-1519           AC004584.2         37738-37785
            1520-1589           AC004584.2         40661-40730
            1590-1678           AC004584.2         45049-45137
            1679-2578           AC004584.2         48018-48917
            2579-2631           BC010385.1         2577-2629
            2632-2634           AW021880.1         356-358
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2634
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /note="coilin"
                     /db_xref="GeneID:8161"
                     /db_xref="HGNC:HGNC:2184"
                     /db_xref="MIM:600272"
     exon            1..276
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1762
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /note="coilin p80"
                     /codon_start=1
                     /product="coilin"
                     /protein_id="NP_004636.1"
                     /db_xref="CCDS:CCDS11592.1"
                     /db_xref="GeneID:8161"
                     /db_xref="HGNC:HGNC:2184"
                     /db_xref="MIM:600272"
                     /translation="MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISL
                     IRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDI
                     NLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSK
                     KNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSS
                     PKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLP
                     TELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTP
                     ECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLG
                     RGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTII
                     QNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQ
                     QVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIES
                     PSNTSSTEPA"
     exon            277..1384
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1471
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1519
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1589
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1678
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2634
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="COIL"
                     /gene_synonym="CLN80; p80-coilin"
                     /note="major polyA site"
ORIGIN      
        1 atctctcggc ttccgttgag caccaagcaa gatggcagct tccgagacgg ttaggctacg
       61 gcttcaattt gattacccgc cgccagctac cccgcactgt acggccttct ggcttctggt
      121 cgacttgaac agatgccgag tcgtcacaga tctcattagt ctcatccgcc agcgcttcgg
      181 cttcagttct ggggccttcc taggcctcta cctggagggg gggctcttgc cccccgccga
      241 gagcgcgcgc cttgtgagag acaacgactg cctcagagtt aaattagaag agagaggagt
      301 tgctgagaat tctgtagtca tcagtaatgg tgacattaat ttatctctta gaaaagcaaa
      361 gaagcgggca tttcagttag aggagggtga agaaactgaa ccagattgca aatattcaaa
      421 gaagcattgg aagagtcgag agaacaataa caataatgag aaggtcttgg atctggaacc
      481 aaaagctgtc acagatcaga ctgtcagcaa aaaaaacaag agaaaaaata aagcaacctg
      541 tggcacagtg ggtgatgata acgaagaggc caaaagaaaa tcaccaaaga aaaaggagaa
      601 atgtgaatat aaaaaaaagg ctaagaatcc caagtctccg aaagtacagg cagtgaaaga
      661 ctgggccaat cagagatgta gttctccaaa aggttctgct agaaacagcc ttgttaaagc
      721 caaaaggaaa ggtagtgtaa gcgtttgctc aaaagagagt cccagttcct cctcggagtc
      781 tgaatcttgt gatgaatcta tcagtgatgg tcccagcaaa gtcactttgg aggccagaaa
      841 ttcctcagag aaattaccaa ctgagttatc aaaggaagaa ccctctacca aaaatacaac
      901 tgcagacaaa ctggctataa aacttggctt tagccttacc cccagcaagg gcaagacctc
      961 tggaacaaca tcttccagtt cagactctag tgcagagtca gacgaccaat gcttgatgtc
     1021 atcgagcacc ccggagtgtg ctgcgggttt cttaaagaca gtaggccttt ttgcaggaag
     1081 aggtcgtcca ggcccagggc tgtcatcaca gactgcaggt gctgctggat ggaggcgttc
     1141 tggctcaaat ggtggtggac aggctcctgg tgcttctccc agtgtgtctc tccctgctag
     1201 tttaggaaga ggatggggta gagaagagaa ccttttttct tggaagggag ctaagggacg
     1261 gggcatgcgg gggagaggtc gaggacgagg gcatcctgtt tcctgtgttg taaatagaag
     1321 cactgacaac cagaggcaac agcaattaaa tgacgtggta aaaaattcat ctactattat
     1381 ccagaatcca gtagagacac ccaagaagga ctatagtctg ttaccactgt tagcagctgc
     1441 ccctcaagtt ggagaaaaga ttgcatttaa gcttttggag ctaacatcca gttactctcc
     1501 tgatgtctct gactacaagg aaggaagaat attaagccac aatccagaga cccagcaagt
     1561 agatatagaa attctttcat ccttacctgc cttgagagaa cctgggaaat ttgatttagt
     1621 ttatcacaat gaaaatggag ccgaggtagt ggagtacgct gtgacacagg agagcaagat
     1681 cactgtattt tggaaagagt tgattgaccc aagactgatt attgaatctc caagtaacac
     1741 atcaagtaca gaacctgcct gagtatgacc tctccacctt atagtttatg aatgtcttgt
     1801 ttgtgaaagt gactataacc caaacttttt ttttttttta aagaggattt ggaagttgta
     1861 tggatttttt tgttatcttc actttactgc ataggaaaca atctacctca tcatttaaaa
     1921 tgacatgggt gtcggttttg tagatctttg gtttttttgt caggtttaat ttcagttaac
     1981 aaaatgtaaa acatgacatt ccctgcagat attgttgtat accagtatgg tttcttctct
     2041 ttctttaaat gtttttggcc atcaagtagc agtcgtcagt aggagtttat aataccaaga
     2101 atgtgctgcg tatcttgtct caataagttt taagtaacat ttaaaaatat taaagcatgt
     2161 tatttgacct aattttttag catttgagtt gttccattaa atggagcatc ttgtaaattt
     2221 caagtatttt atacttgcaa ttgttaagag ttaacaggta gttggatttg tcgcagacaa
     2281 tgagttaagg aatcctttca cgtttttccc aactttaaaa ttaaggattc tcaggtccct
     2341 gtgtagagca gtgaaaataa gatgtgcgta tgtgtgtgta tgcctggaga attggtgttt
     2401 cacttcagtg agaggattgg ctgtgagctt cagaccagga aatgtgtcat cttgccaggc
     2461 acctggctga gtgtgctgga gtgaggatct tgaacagaaa cttccttttc tgttattatt
     2521 cactacgaag ctaaaatggc caaatatata ccgtgaaaat tggtttcatt taacaaaaga
     2581 tcagatccct ccttcagctg tacacatttt taaataaaat catattgaac taaa
//
