LOCUS       NM_153603               2935 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens component of oligomeric golgi complex 7 (COG7), mRNA.
ACCESSION   NM_153603
VERSION     NM_153603.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2935)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2935)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2935)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2935)
  AUTHORS   Climer,L.K., Pokrovskaya,I.D., Blackburn,J.B. and Lupashin,V.V.
  TITLE     Membrane detachment is not essential for COG complex function
  JOURNAL   Mol Biol Cell 29 (8), 964-974 (2018)
   PUBMED   29467253
  REMARK    GeneRIF: TMEM-COG4, COG7 and COG8 subunits restore endogenous COG
            localization to the Golgi membranes
REFERENCE   5  (bases 1 to 2935)
  AUTHORS   Bailey Blackburn,J., Pokrovskaya,I., Fisher,P., Ungar,D. and
            Lupashin,V.V.
  TITLE     COG Complex Complexities: Detailed Characterization of a Complete
            Set of HEK293T Cells Lacking Individual COG Subunits
  JOURNAL   Front Cell Dev Biol 4, 23 (2016)
   PUBMED   27066481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2935)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     The binary interacting network of the conserved oligomeric Golgi
            tethering complex
  JOURNAL   J Biol Chem 279 (23), 24640-24648 (2004)
   PUBMED   15047703
REFERENCE   7  (bases 1 to 2935)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2935)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     Sec34 is implicated in traffic from the endoplasmic reticulum to
            the Golgi and exists in a complex with GTC-90 and ldlBp
  JOURNAL   J Biol Chem 277 (24), 21955-21961 (2002)
   PUBMED   11929878
REFERENCE   9  (bases 1 to 2935)
  AUTHORS   Ungar,D., Oka,T., Brittle,E.E., Vasile,E., Lupashin,V.V.,
            Chatterton,J.E., Heuser,J.E., Krieger,M. and Waters,M.G.
  TITLE     Characterization of a mammalian Golgi-localized protein complex,
            COG, that is required for normal Golgi morphology and function
  JOURNAL   J Cell Biol 157 (3), 405-415 (2002)
   PUBMED   11980916
REFERENCE   10 (bases 1 to 2935)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB444997.1, BC037563.1 and
            R54036.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_153603.3.
            
            Summary: The protein encoded by this gene resides in the golgi, and
            constitutes one of the 8 subunits of the conserved oligomeric Golgi
            (COG) complex, which is required for normal golgi morphology and
            localization. Mutations in this gene are associated with the
            congenital disorder of glycosylation type IIe.[provided by RefSeq,
            May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037563.1, SRR1803615.220993.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307149.10/ ENSP00000305442.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                DB444997.1         11-96
            87-2801             BC037563.1         78-2792
            2802-2935           R54036.1           7-140               c
FEATURES             Location/Qualifiers
     source          1..2935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2935
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /note="component of oligomeric golgi complex 7"
                     /db_xref="GeneID:91949"
                     /db_xref="HGNC:HGNC:18622"
                     /db_xref="MIM:606978"
     exon            1..364
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2508
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /EC_number="3.2.1.113"
                     /note="COG complex subunit 7"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 7"
                     /protein_id="NP_705831.1"
                     /db_xref="CCDS:CCDS10610.1"
                     /db_xref="GeneID:91949"
                     /db_xref="HGNC:HGNC:18622"
                     /db_xref="MIM:606978"
                     /translation="MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKL
                     QLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTS
                     QSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGMQNS
                     LMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQAVDQSKVFVKVFTEIDRMP
                     QLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGAWHTQIQWATQVFQKPH
                     EVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFAKGLEMALLP
                     HLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQELS
                     HSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLD
                     HIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPR
                     SLAGFQESILTDKKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAA
                     PRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPL
                     EYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWL
                     GSIARATMQTYCDAILQIPELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLL
                     KTRPEDYRQVSKGLPRRLATTVATMRSVNY"
     exon            365..513
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            514..630
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            631..799
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            800..882
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1005
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1204
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1332
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1487
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1604
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1670
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1857
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1998
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2082
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2197
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2341
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2935
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /note="hexamer: AATAAA"
     polyA_site      2935
                     /gene="COG7"
                     /gene_synonym="CDG2E"
                     /note="major polyA site"
ORIGIN      
        1 gagggtcatt cccagccgca aactgagtgc gctgagcggg gaagcgcaaa ggggcaagtt
       61 acccgtcctg gcgtttctgg ggttcgcctc ggaggctagc ctcggtgctc tcgcaggctc
      121 gctcgcttct gcatccccgt tgccgcccgg agccaactct taagttctgg acgccaggcc
      181 tgaggcagtt ccgccatgga cttctccaag ttcctggcag acgacttcga cgtgaaggag
      241 tggatcaatg cggccttcag ggccggctcc aaggaggcgg cgtccgggaa ggcggatggc
      301 cacgcagcca ccctggtgat gaagctgcag ctgttcatcc aagaggtgaa ccacgccgtg
      361 gaggaaacaa gtcaccaagc tctccagaac atgcccaaag tgctccgtga tgttgaagcc
      421 ctaaaacagg aggcatcttt cctgaaagaa cagatgattc ttgtcaagga ggacattaaa
      481 aaatttgaac aggacacatc tcaatccatg caggtgttgg tagaaattga ccaagtgaag
      541 tccagaatgc aacttgctgc cgaatctctt caggaagcag ataagtggag cacgttgagc
      601 gccgatattg aggagacatt taagactcag gacatagctg tgatttctgc caagctaaca
      661 ggtatgcaga acagcttaat gatgcttgtt gatacaccag actactcaga aaagtgtgtg
      721 cacttggagg cactgaagaa caggctggag gccctagcca gtccacagat tgtagcggca
      781 ttcacctctc aggctgtaga tcagtccaaa gtgtttgtga aggtgtttac tgaaattgac
      841 cggatgcccc agctcctggc ctactactac aagtgtcaca aggtgcagct tttagcagcc
      901 tggcaagagc tgtgtcaaag tgacctatcc ctggaccggc agcttaccgg actctatgat
      961 gccttgcttg gtgcttggca cacacaaatc cagtgggcta cacaggtttt ccagaagccc
     1021 cacgaggtgg taatggtgct gctgattcag accctggggg ccctcatgcc ctcgctgccc
     1081 tcctgcctca gcaacggcgt ggagagggca gggcccgagc aggagctcac caggctgctg
     1141 gagttctacg acgccaccgc ccacttcgcc aagggcttgg agatggcact gctcccccac
     1201 ctacatgaac acaatctggt aaaagtcacg gagctggtgg atgctgtgta tgatccatac
     1261 aaaccctacc agctgaagta tggcgacatg gaagagagca acctcctcat ccagatgagt
     1321 gctgtgcctc tggagcatgg ggaagtgatt gactgtgtgc aggagctgag ccactccgtg
     1381 aacaagctgt ttggtctggc gtctgcagcc gttgacagat gcgtcagatt caccaatggc
     1441 ctggggacct gcggcctgtt gtcagccctg aaatccctct ttgccaagta tgtgtctgat
     1501 ttcaccagca ctctccagtc catacgaaag aagtgcaaac tggaccacat tcctcccaac
     1561 tccctcttcc aggaagattg gacggctttt cagaactcca ttaggataat agccacctgt
     1621 ggagagcttt tgcggcattg tggggacttc gagcagcagc tagccaacag gattttgtcc
     1681 acagctggga agtatctatc tgattcctgc agcccccgga gcctggctgg ttttcaggag
     1741 agcatcttga cagacaagaa gaactctgcc aagaacccat ggcaagaata taattacctc
     1801 cagaaagata accctgctga atatgccagt ttaatggaaa tactttatac ccttaaggaa
     1861 aaagggtcaa gcaaccacaa cctgctggct gcacctcgag cagcgctgac tcggcttaac
     1921 cagcaggccc accagctggc tttcgattcc gtgttcctgc gcatcaaaca acagctgttg
     1981 cttatttcga agatggacag ctggaatacg gctggcatcg gagaaaccct cacagatgaa
     2041 ctgcccgcct ttagtctcac ccctctcgag tacatcagca acatcgggca gtacatcatg
     2101 tccctccccc tgaatcttga gccatttgtg actcaggagg actctgcctt agagttggca
     2161 ttgcacgctg gaaagctgcc atttcctcct gagcaggggg atgaattgcc cgagctggac
     2221 aacatggctg acaactggct gggctcgatc gccagagcca caatgcagac ctactgtgat
     2281 gcgatcctac agatccctga gctgagccca cactctgcca agcagctggc cactgacatc
     2341 gactatctga tcaacgtgat ggatgccctg ggcctgcagc cgtcccgcac cctccagcac
     2401 atcgtgacgc tactgaagac caggcctgag gactatagac aggtcagcaa aggcctgccc
     2461 cgtcgcctgg ccaccaccgt ggccaccatg cggagtgtga attactgacc ccaccacaca
     2521 ccggaccacc aagagagcca gggctgctgt ttcgcgactc accagcacag atttgctcag
     2581 aaactctgcc caagattggg cagaagttac tttaaaaaga cttggttcag ctggtcacgg
     2641 tggctcacgc ctgtaatccc agcactttgg gaggccaagc cagatggatc atgaagccag
     2701 gagttcgaga ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaaat
     2761 taacagcaga gcgagactct gtctcaaaaa aaaaaaaaaa aaagacttgg ttcatttgta
     2821 taatcaaaaa gagttgtaaa ttaaagatgt attatttatc agagaagact ttttagataa
     2881 tttttttaaa ggatcagatc ttgaaaatgg aataaataac tactgtgaaa tgcaa
//
