LOCUS       NM_006348               4658 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens component of oligomeric golgi complex 5 (COG5),
            transcript variant 1, mRNA.
ACCESSION   NM_006348
VERSION     NM_006348.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Tabbarah,S., Tavares,E., Charish,J., Vincent,A., Paterson,A., Di
            Scipio,M., Yin,Y., Mendoza-Londono,R., Maynes,J., Heon,E. and
            Monnier,P.P.
  TITLE     COG5 variants lead to complex early onset retinal degeneration,
            upregulation of PERK and DNA damage
  JOURNAL   Sci Rep 10 (1), 21269 (2020)
   PUBMED   33277529
  REMARK    GeneRIF: COG5 variants lead to complex early onset retinal
            degeneration, upregulation of PERK and DNA damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Ferrer,A., Starosta,R.T., Ranatunga,W., Ungar,D., Kozicz,T.,
            Klee,E., Rust,L.M., Wick,M. and Morava,E.
  TITLE     Fetal glycosylation defect due to ALG3 and COG5 variants detected
            via amniocentesis: Complex glycosylation defect with embryonic
            lethal phenotype
  JOURNAL   Mol Genet Metab 131 (4), 424-429 (2020)
   PUBMED   33187827
  REMARK    GeneRIF: Fetal glycosylation defect due to ALG3 and COG5 variants
            detected via amniocentesis: Complex glycosylation defect with
            embryonic lethal phenotype.
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Bailey Blackburn,J., Pokrovskaya,I., Fisher,P., Ungar,D. and
            Lupashin,V.V.
  TITLE     COG Complex Complexities: Detailed Characterization of a Complete
            Set of HEK293T Cells Lacking Individual COG Subunits
  JOURNAL   Front Cell Dev Biol 4, 23 (2016)
   PUBMED   27066481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     Sec34 is implicated in traffic from the endoplasmic reticulum to
            the Golgi and exists in a complex with GTC-90 and ldlBp
  JOURNAL   J Biol Chem 277 (24), 21955-21961 (2002)
   PUBMED   11929878
  REMARK    GeneRIF: Sec34 is implicated in traffic from the endoplasmic
            reticulum to the Golgi and exists in a complex with GTC-90 and
            ldlBp
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   Ungar,D., Oka,T., Brittle,E.E., Vasile,E., Lupashin,V.V.,
            Chatterton,J.E., Heuser,J.E., Krieger,M. and Waters,M.G.
  TITLE     Characterization of a mammalian Golgi-localized protein complex,
            COG, that is required for normal Golgi morphology and function
  JOURNAL   J Cell Biol 157 (3), 405-415 (2002)
   PUBMED   11980916
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Chen,X., Bykhovskaya,Y., Tidow,N., Hamon,M., Bercovitz,Z.,
            Spirina,O. and Fischel-Ghodsian,N.
  TITLE     The familial mediterranean fever protein interacts and colocalizes
            with a putative Golgi transporter
  JOURNAL   Proc Soc Exp Biol Med 224 (1), 32-40 (2000)
   PUBMED   10782044
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Walter,D.M., Paul,K.S. and Waters,M.G.
  TITLE     Purification and characterization of a novel 13 S hetero-oligomeric
            protein complex that stimulates in vitro Golgi transport
  JOURNAL   J Biol Chem 273 (45), 29565-29576 (1998)
   PUBMED   9792665
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002381.1, AC004855.1 and
            AC004492.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 7, 2020 this sequence version replaced NM_006348.4.
            
            Summary: The protein encoded by this gene is one of eight proteins
            (Cog1-8) which form a Golgi-localized complex (COG) required for
            normal Golgi morphology and function. The encoded protein is
            organized with conserved oligomeric Golgi complex components 6, 7
            and 8 into a sub-complex referred to as lobe B. Alternative
            splicing results in multiple transcript variants. Mutations in this
            gene result in congenital disorder of glycosylation type
            2I.[provided by RefSeq, Jan 2011].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.27771.1,
                                           SRR11853563.30758.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297135.9/ ENSP00000297135.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC002381.1         169301-169418       c
            119-258             AC002381.1         163474-163613       c
            259-316             AC002381.1         159783-159840       c
            317-371             AC002381.1         153776-153830       c
            372-441             AC002381.1         153609-153678       c
            442-562             AC002381.1         132735-132855       c
            563-693             AC002381.1         18000-18130         c
            694-859             AC004855.1         52709-52874         c
            860-972             AC004855.1         42422-42534         c
            973-1050            AC004855.1         42147-42224         c
            1051-1132           AC004855.1         4554-4635           c
            1133-1337           AC004492.1         143664-143868       c
            1338-1499           AC004492.1         129093-129254       c
            1500-1599           AC004492.1         126822-126921       c
            1600-1710           AC004492.1         103795-103905       c
            1711-1773           AC004492.1         102254-102316       c
            1774-1877           AC004492.1         93918-94021         c
            1878-2115           AC004492.1         81972-82209         c
            2116-2192           AC004492.1         76137-76213         c
            2193-2319           AC004492.1         56621-56747         c
            2320-2399           AC004492.1         56048-56127         c
            2400-4658           AC004492.1         46894-49152         c
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..4658
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="component of oligomeric golgi complex 5"
                     /db_xref="GeneID:10466"
                     /db_xref="HGNC:HGNC:14857"
                     /db_xref="MIM:606821"
     exon            1..118
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2514
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="isoform 1 is encoded by transcript variant 1;
                     conserved oligomeric Golgi complex protein 5; COG complex
                     subunit 5; 13S golgi transport complex 1 90 kDa subunit"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 5
                     isoform 1"
                     /protein_id="NP_006339.4"
                     /db_xref="CCDS:CCDS5742.2"
                     /db_xref="GeneID:10466"
                     /db_xref="HGNC:HGNC:14857"
                     /db_xref="MIM:606821"
                     /translation="MEGGGGSVAVAGLGARGSGAAAATVRELLQDGCYSDFLNEDFDV
                     KTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQM
                     MQTRIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQG
                     QLQGGSREITKAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQ
                     GLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSA
                     VRGGPGRSTMPTPGNTAALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHI
                     CFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYPKLLRLYNDL
                     WKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPY
                     EAAYLSKSLSRLFDPINLVFPPGGRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVS
                     KNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKVVSS
                     QSSFPLAAEQTIISALKAIHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSG
                     KPDVPCSLYMKELQGFIARVMSDYFKHFECLDFVFDNTEAIAQRAVELFIRHASLIRP
                     LGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALG
                     DVIPFSIIIQFLFTRAPAELKSPFQRAEWSHTRFSQWLDDHPSEKDRLLLIRGALEAY
                     VQSVRSREGKEFAPVYPIMVQLLQKAMSALQ"
     exon            119..258
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            259..316
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            317..371
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            372..441
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            442..562
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            563..693
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            694..859
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            860..972
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1050
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1132
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1337
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1499
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1599
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1710
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1773
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1877
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2115
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2192
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2319
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2399
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..4658
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3453..3458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="hexamer: AATAAA"
     polyA_site      3474
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="major polyA site"
     regulatory      4267..4272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="hexamer: AATAAA"
     polyA_site      4286
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
     regulatory      4630..4635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
                     /note="hexamer: ATTAAA"
     polyA_site      4658
                     /gene="COG5"
                     /gene_synonym="CDG2I; GOLTC1; GTC90"
ORIGIN      
        1 gacatcaacc cggcacctgc caacatggaa ggtggcggcg gcagcgtcgc tgtagctggc
       61 ctcggagctc gaggctctgg agcggctgca gctacagtcc gggaacttct gcaggacggg
      121 tgttatagtg actttttaaa cgaagacttt gatgtaaaga cttatacttc tcaatctatt
      181 catcaagctg taattgctga acaactagca aaacttgccc aaggaatcag tcagttggac
      241 agagaactac acttacaggt tgttgcaaga catgaagatt tactggcaca agcaactggg
      301 attgagtcgt tggaaggtgt tcttcagatg atgcagacga gaattggggc tttacaggga
      361 gctgttgata ggataaaagc aaaaattgtt gaaccataca ataagatagt tgcccggact
      421 gcacaactag caagacttca ggttgcctgt gatttgcttc ggaggattat tcgtatcttg
      481 aatctcagta agagactcca aggacaactg caagggggaa gtagagagat aacaaaagct
      541 gctcagagtc tcaatgaact tgattatctt tctcaaggaa tagatctttc tggaatagaa
      601 gtgatagaaa atgatctact ttttattgca agagcccgac ttgaagtgga aaatcaagct
      661 aagcgcctac tagagcaggg tttggagact cagaatccaa ctcaagtcgg aacagctctt
      721 caggttttct ataatcttgg aactttgaag gatactatta ccagtgttgt ggatggatat
      781 tgtgctactt tagaagaaaa tatcaacagt gcattagaca taaaagtttt gactcagcct
      841 tcccagtcag ctgtgagagg gggacctgga cgatctacca tgccaacccc aggaaatact
      901 gcagctttgc gtgcctcatt ctggaccaat atggagaaac ttatggatca tatttatgct
      961 gtttgtggac aggtacaaca tctacaaaaa gtattggcca agaagagaga tcctgtttct
     1021 cacatttgtt tcattgaaga aatagttaag gatggacaac cggaaatttt ctacacattt
     1081 tggaattcag ttactcaggc actttcttct caatttcata tggcaacaaa ctcttcgatg
     1141 tttttgaagc aggcatttga aggagaatac cctaaattat tacgtcttta taatgactta
     1201 tggaagcgtc ttcaacaata cagtcagcat atccaaggga attttaatgc aagtggaact
     1261 acagacctct atgttgacct acaacacatg gaagatgatg cacaagatat attcatacca
     1321 aaaaagccag attatgatcc agaaaaggct ttgaaagact cactacaacc ctatgaggct
     1381 gcttatctat caaaatcctt atctcgactc ttcgatccta tcaacttggt ttttcccccg
     1441 ggtggtcgta atcctccttc ctctgatgaa cttgatggta ttattaaaac tatagcaagt
     1501 gaactaaatg ttgctgctgt tgatacaaac ctcacattag ctgtgtcaaa aaatgtggca
     1561 aagaccatcc agttatacag tgtaaaatca gagcagcttc tctccacaca aggagatgca
     1621 agtcaggtga ttgggcctct tactgaagga cagagaagaa atgtggcagt agtgaattca
     1681 ttgtataagt tgcaccaatc agtaacaaag gttgtttcca gtcagagctc attcccactg
     1741 gcagctgagc aaactataat ttcagctcta aaggctattc atgctcttat ggaaaatgct
     1801 gtgcaaccct tactcacttc tgtgggagat gctatagagg ccataatcat caccatgcat
     1861 caagaagact tttctgggtc attatccagc tcaggaaaac ctgatgttcc ttgttctctg
     1921 tacatgaagg agctacaagg tttcattgcc agagttatga gtgactattt taaacacttt
     1981 gaatgcttgg attttgtctt tgacaacact gaggctattg cccaaagagc tgttgaactt
     2041 tttatccgcc atgccagtct cataagacct cttggtgaag gtgggaaaat gcgacttgct
     2101 gctgattttg cacagatgga gttggctgtg ggtccattct gtagacgagt atctgattta
     2161 ggaaagtcct atcggatgct gagatcattc agacctctgc tcttccaggc aagtgaacat
     2221 gtagccagta gtcctgcatt gggggatgtg attccgttca gcatcattat tcagtttttg
     2281 ttcacgagag cacccgctga actgaaatct cctttccaga gggcagagtg gtcccacaca
     2341 cgcttctctc agtggctgga tgaccatcca tctgaaaagg acaggctcct cctcatcagg
     2401 ggagccctgg aagcttatgt tcaatcagtg agaagtagag aaggcaaaga atttgcacca
     2461 gtttatccca taatggttca gctgcttcaa aaggctatgt ctgctcttca gtaatgacat
     2521 gaaatctttg ttcatctcca ctttgtgcta acccattcat agttggcagt taaacacata
     2581 ctccaaaaga ctgctactat ctactatttt aagaatgtaa ttgattgttc ggtatttcct
     2641 atcgacgttt atttacctct ttagcactta tactttagca taaaaaatgt tgagttatca
     2701 ccacctttca attccatgga cctgattttt ccagaaagat gttttcctct ttcagatttt
     2761 tgtacaaggc taaaatgtct ttcccatcca taaccaagtc ctcctatggg tacataaacc
     2821 caaagtcccc acttctttta aagggatatg atcaagttat aacatgtacc ctgcttcccc
     2881 caaccctgcc ttcttcacta aataagcatg tagctcagtg gtttccaaat ttggctgcac
     2941 attcatacca atcaccaggg gattttttta aaatcctgat gcccaacttg cactccacat
     3001 taattaacat gtctaggagt gggagcctga cagacaccac tattaaaaaa aaaaaaaatc
     3061 cccaaaatga ttccaataga caacaaagtt gaggaaccac tggcacatcc caagctaaga
     3121 tacaaggtta aatggccttt ttaagtatgt catactggat ctttaaataa agcaaggctt
     3181 ttgttacact ttgtcatgtt attaaaagca gacctttggg ctgtttaacc gtgtaacaaa
     3241 aatgccacgt gaaaaataaa aatttttatt gtatagcaat tctctataaa tagtagataa
     3301 tctaagtcct tattttctga tggctcttgt tccactatta acattgtttt taatttttaa
     3361 aatcctatca gcagcctcct aattagcagt gttaggaatt tgccttatgt tttccatctc
     3421 atctcctgaa cctgttattc tgagaactca taaataaaat tcagccaaga ttaatcaatc
     3481 aatcaatcaa tcagtagacg tcagagataa gcaacttttt tttccattta tttgaaataa
     3541 tatacaagaa tatagtgtgc aaaatttagg ggcaacatca tgaagaagtg tgatgaactg
     3601 aaatcaattt tacagctgtg attcctaacc agaaacacca cttggtaagt aacatgaaaa
     3661 gccatgattg tagctcagag caaaagcagc tgtattgcca atgtatttgc tctaatttta
     3721 gacagttgga ggaaaattaa agtgcaagtg ttgcactgca gtaagtgcaa agtctgcccc
     3781 caccataaag attatgatga caaaatatat ttaagataca tggctgagga gatacagaac
     3841 acgaagttaa aaaatacaat ggtgttgact gtttgttaat agcaccatta cagtgactat
     3901 atcccaatgc tattaactaa ctttaccttg gcctgggcta ggtctccatt ggaaataata
     3961 acggatggct gctgccacct ggtgcatcaa ctcagcatgc catggtaact gcagcaggtg
     4021 gctcttaggc tgggacacca acaccagcca cctgccccat gttctggtag cctcttggca
     4081 ctgaccagac taggagcgcc tatgtttggc acagatgctg agccatgtgg tggttactag
     4141 aggaaaggcc gactcccagc ttctgcttca tttcatcatg tgtacaatac agattaataa
     4201 gcagtaagga gccaatgtat aaacagcagt tacatatttt ttaaattccc ctttcgtaca
     4261 atttaaaata aaacatgtat acacttctcc tctctttcta ctgtacttta gcaccacagg
     4321 atatcaattt tcaagcctat tattacctga tagacatata tgaagtttgg aagaaaaata
     4381 aggcaatttg gtttaaaatg ttgatagttt tagcttaatg ctctaatgga gaaagcaaat
     4441 cctcactcat attattaaat catttcaaga ctcaatgcta tcagtatctt atggtcacac
     4501 gaattgagga caaatggtga gaccttgatc ttcttaagtc tttccatcaa gagtcaatgt
     4561 atatgcaaat atagacttaa gaacataagc atcctggttt aatgttgttg tgagccctgt
     4621 ggaaataaaa ttaaactcag tgaatgttta caaatcaa
//
