LOCUS       NM_031431               4555 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens component of oligomeric golgi complex 3 (COG3), mRNA.
ACCESSION   NM_031431
VERSION     NM_031431.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4555)
  AUTHORS   Duan,R., Marafi,D., Xia,Z.J., Ng,B.G., Maroofian,R., Sumya,F.T.,
            Saad,A.K., Du,H., Fatih,J.M., Hunter,J.V., Elbendary,H.M.,
            Baig,S.M., Abdullah,U., Ali,Z., Efthymiou,S., Murphy,D., Mitani,T.,
            Withers,M.A., Jhangiani,S.N., Coban-Akdemir,Z., Calame,D.G.,
            Pehlivan,D., Gibbs,R.A., Posey,J.E., Houlden,H., Lupashin,V.V.,
            Zaki,M.S., Freeze,H.H. and Lupski,J.R.
  TITLE     Biallelic missense variants in COG3 cause a congenital disorder of
            glycosylation with impairment of retrograde vesicular trafficking
  JOURNAL   J Inherit Metab Dis 46 (6), 1195-1205 (2023)
   PUBMED   37711075
  REMARK    GeneRIF: Biallelic missense variants in COG3 cause a congenital
            disorder of glycosylation with impairment of retrograde vesicular
            trafficking.
REFERENCE   2  (bases 1 to 4555)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4555)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4555)
  AUTHORS   Bailey Blackburn,J., Pokrovskaya,I., Fisher,P., Ungar,D. and
            Lupashin,V.V.
  TITLE     COG Complex Complexities: Detailed Characterization of a Complete
            Set of HEK293T Cells Lacking Individual COG Subunits
  JOURNAL   Front Cell Dev Biol 4, 23 (2016)
   PUBMED   27066481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4555)
  AUTHORS   Ong,Y.S., Tran,T.H., Gounko,N.V. and Hong,W.
  TITLE     TMEM115 is an integral membrane protein of the Golgi complex
            involved in retrograde transport
  JOURNAL   J Cell Sci 127 (Pt 13), 2825-2839 (2014)
   PUBMED   24806965
REFERENCE   6  (bases 1 to 4555)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     Sec34 is implicated in traffic from the endoplasmic reticulum to
            the Golgi and exists in a complex with GTC-90 and ldlBp
  JOURNAL   J Biol Chem 277 (24), 21955-21961 (2002)
   PUBMED   11929878
  REMARK    GeneRIF: Sec34 is implicated in traffic from the endoplasmic
            reticulum to the Golgi and exists in a complex with GTC-90 and
            ldlBp
REFERENCE   7  (bases 1 to 4555)
  AUTHORS   Ungar,D., Oka,T., Brittle,E.E., Vasile,E., Lupashin,V.V.,
            Chatterton,J.E., Heuser,J.E., Krieger,M. and Waters,M.G.
  TITLE     Characterization of a mammalian Golgi-localized protein complex,
            COG, that is required for normal Golgi morphology and function
  JOURNAL   J Cell Biol 157 (3), 405-415 (2002)
   PUBMED   11980916
REFERENCE   8  (bases 1 to 4555)
  AUTHORS   Suvorova,E.S., Kurten,R.C. and Lupashin,V.V.
  TITLE     Identification of a human orthologue of Sec34p as a component of
            the cis-Golgi vesicle tethering machinery
  JOURNAL   J Biol Chem 276 (25), 22810-22818 (2001)
   PUBMED   11292827
REFERENCE   9  (bases 1 to 4555)
  AUTHORS   VanRheenen,S.M., Cao,X., Sapperstein,S.K., Chiang,E.C.,
            Lupashin,V.V., Barlowe,C. and Waters,M.G.
  TITLE     Sec34p, a protein required for vesicle tethering to the yeast Golgi
            apparatus, is in a complex with Sec35p
  JOURNAL   J Cell Biol 147 (4), 729-742 (1999)
   PUBMED   10562277
REFERENCE   10 (bases 1 to 4555)
  AUTHORS   Kim,D.W., Sacher,M., Scarpa,A., Quinn,A.M. and Ferro-Novick,S.
  TITLE     High-copy suppressor analysis reveals a physical interaction
            between Sec34p and Sec35p, a protein implicated in vesicle docking
  JOURNAL   Mol Biol Cell 10 (10), 3317-3329 (1999)
   PUBMED   10512869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606514.4 and AL139326.15.
            
            On Nov 23, 2018 this sequence version replaced NM_031431.3.
            
            Summary: This gene encodes a component of the conserved oligomeric
            Golgi (COG) complex which is composed of eight different subunits
            and is required for normal Golgi morphology and localization.
            Defects in the COG complex result in multiple deficiencies in
            protein glycosylation. The protein encoded by this gene is involved
            in ER-Golgi transport.[provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.33184.1, AF349676.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349995.10/ ENSP00000258654.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AL606514.4         33354-33625
            273-419             AL139326.15        8958-9104
            420-481             AL139326.15        11762-11823
            482-647             AL139326.15        12882-13047
            648-722             AL139326.15        13987-14061
            723-815             AL139326.15        15138-15230
            816-941             AL139326.15        15987-16112
            942-1022            AL139326.15        19252-19332
            1023-1066           AL139326.15        23672-23715
            1067-1193           AL139326.15        24169-24295
            1194-1285           AL139326.15        24916-25007
            1286-1425           AL139326.15        26104-26243
            1426-1586           AL139326.15        28909-29069
            1587-1692           AL139326.15        36001-36106
            1693-1817           AL139326.15        42449-42573
            1818-1907           AL139326.15        44522-44611
            1908-2028           AL139326.15        48900-49020
            2029-2117           AL139326.15        51519-51607
            2118-2252           AL139326.15        51717-51851
            2253-2328           AL139326.15        57733-57808
            2329-2456           AL139326.15        62548-62675
            2457-2555           AL139326.15        63439-63537
            2556-4555           AL139326.15        67459-69458
FEATURES             Location/Qualifiers
     source          1..4555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..4555
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /note="component of oligomeric golgi complex 3"
                     /db_xref="GeneID:83548"
                     /db_xref="HGNC:HGNC:18619"
                     /db_xref="MIM:606975"
     exon            1..272
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2585
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /note="tethering factor SEC34; p94; COG complex subunit 3;
                     vesicle-docking protein SEC34 homolog"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 3"
                     /protein_id="NP_113619.3"
                     /db_xref="CCDS:CCDS9398.1"
                     /db_xref="GeneID:83548"
                     /db_xref="HGNC:HGNC:18619"
                     /db_xref="MIM:606975"
                     /translation="MAEAALLLLPEAAAERDAREKLALWDRRPDTTAPLTDRQTDSVL
                     ELKAAAENLPVPAELPIEDLCSLTSQSLPIELTSVVPESTEDILLKGFTSLGMEEERI
                     ETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGFQEQCDAILNDVNSALQHLESLQK
                     QYLFVSNKTGTLHEACEQLLKEQSELVDLAENIQQKLSYFNELETINTKLNSPTLSVN
                     SDGFIPMLAKLDDCITYISSHPNFKDYPIYLLKFKQCLSKALHLMKTYTVNTLQTLTS
                     QLLKRDPSSVPNADNAFTLFYVKFRAAAPKVRTLIEQIELRSEKIPEYQQLLNDIHQC
                     YLDQRELLLGPSIACTVAELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTKPT
                     SKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQNNAEQLGAFA
                     AGVKQMLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKK
                     VPSEASFSDVHLEEGESNSLTKSGSTESLNPRPQTTISPADLHGMWYPTVRRTLVCLS
                     KLYRCIDRAVFQGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIA
                     PFHTEFTIKEISLDLKKTRDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHY
                     LDSKKDVDRHLKSACEQFIQQQTKLFVEQLEEFMTKVSALKTMASQGGPKYTLSQQPW
                     AQPAKVNDLAATAYKTIKTKLPVTLRSMSLYLSNKDTEFILFKPVRNNIQQVFQKFHA
                     LLKEEFSPEDIQIIACPSMEQLSLLLLVSK"
     exon            273..419
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            420..481
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            482..647
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            648..722
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            723..815
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            816..941
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1022
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1066
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1193
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1285
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1425
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1586
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1692
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1817
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1907
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2028
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2117
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2252
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2328
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2456
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2555
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..4555
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4459..4464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /note="hexamer: AATAAA"
     polyA_site      4479
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /note="major polyA site"
     regulatory      4534..4539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /note="hexamer: ATTAAA"
     polyA_site      4555
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
ORIGIN      
        1 gcagtgttgg aagctccggt tctcccggaa gtggcccagg tctctctgtc ggggtcccct
       61 ccatctcgct gctgctgaag gccgcgaggg cggcggcgat ggcggaggcg gcgctgttgc
      121 tgctgcctga ggcggcggcg gagcgggacg ctagggaaaa gctggctctc tgggatcgga
      181 gaccggacac gacggcgccg ctgaccgaca ggcagacgga ctcggtattg gagctgaagg
      241 cggcggcaga gaacttgccg gtgccagctg agcttccaat tgaagacttg tgcagtttaa
      301 catcccagtc actgcccatt gaactgactt cagtagtgcc tgaatctaca gaagacattc
      361 tcttgaaggg cttcacttcc ttaggaatgg aagaagaaag aattgaaacc gcacagcagt
      421 ttttctcatg gtttgcaaag ctgcaaactc agatggatca agatgaagga actaaatata
      481 gacagatgag ggattacttg tctgggtttc aggagcagtg tgatgctata ttgaatgatg
      541 taaacagtgc tcttcagcat ctggagtctt tgcagaaaca gtatcttttt gtgtccaata
      601 agacaggaac cctacatgaa gcctgtgaac agctcctaaa agaacagtcg gaacttgttg
      661 atctggctga aaacattcaa caaaagcttt cctattttaa cgaattggaa actattaaca
      721 caaaattgaa ttcccctaca ttgtcggtga atagtgacgg atttatacct atgctggcca
      781 agttagatga ttgtataaca tatatctcat ctcatcctaa ttttaaagat tatcccatat
      841 atttgctgaa gtttaaacag tgtctttcta aagctttgca cctcatgaag acatatactg
      901 tgaacacact acagaccctc acaagtcagt tactgaaaag ggatccttca tctgtaccta
      961 atgcagacaa tgccttcaca ttattttatg tgaaatttcg agctgctgcc cccaaagtca
     1021 gaactcttat tgaacaaata gaactgcggt ctgaaaaaat acctgaatac caacaactgc
     1081 taaatgatat ccaccagtgt taccttgatc agcgggagct ccttttgggc cctagtattg
     1141 cttgcactgt tgcagagtta accagccaaa ataatagaga tcactgtgcc ttggttcgta
     1201 gtggctgtgc cttcatggtt catgtctgcc aggatgaaca ccaactttac aatgaatttt
     1261 tcacaaaacc aacatcaaaa ttagatgagc ttttggagaa actgtgtgtg tcattgtatg
     1321 atgtcttcag gccattgatc attcatgtta ttcacttaga gactctgtcg gaactttgtg
     1381 ggattcttaa aaatgaggtg cttgaagatc atgtgcagaa caatgctgag caactggggg
     1441 catttgcagc tggagtcaag cagatgttag aagatgtaca ggagcggctc gtctaccgaa
     1501 cccacatcta tattcagacg gacatcacgg gctataaacc agctcctgga gatctggcat
     1561 atcccgataa gttagtcatg atggagcaga ttgcacagag tttgaaagat gaacagaaga
     1621 aggtaccttc agaagcttca ttttcagatg ttcacttaga agaaggagag tctaacagtc
     1681 tgacaaaatc tggttcaaca gaatccctca atcctagacc acagaccaca atttctccag
     1741 cagatcttca tggaatgtgg tatcctacgg ttcgaagaac tcttgtctgt ctctccaaat
     1801 tatacagatg catagatagg gcagtgttcc aaggattatc acaggaagca ttgtctgcct
     1861 gcattcagtc cttacttgga gcgtcagagt ctatcagcaa aaacaagact cagattgatg
     1921 gacaactttt cttaattaag caccttttga tacttcgtga acaaattgct ccatttcaca
     1981 ctgaattcac cattaaggaa atttccctgg acctcaagaa aactagagat gcagcattta
     2041 aaatcctgaa ccctatgact gtcccaagat tttttaggct gaatagcaac aatgccttga
     2101 tagagttctt gttggagggt actcctgaga taagagaaca ttatcttgac tctaaaaaag
     2161 acgtagaccg tcatctgaaa tcggcctgtg agcagtttat tcagcagcag accaagctgt
     2221 ttgtagaaca gctggaggag ttcatgacaa aggtttcagc gttaaaaaca atggccagtc
     2281 agggaggccc caagtatact ctctcacagc agccttgggc acaaccagca aaggtcaatg
     2341 accttgcggc aactgcatat aagacaataa aaacaaagct gcctgtgaca ttgagaagta
     2401 tgtccttgta cctatccaat aaagataccg agttcatctt gtttaaacct gtgaggaata
     2461 atattcagca agtcttccag aagttccacg ctctgttaaa ggaagagttc agccctgaag
     2521 acatccagat cattgcctgt ccatctatgg aacagctgag ccttctgctg ttggtttcta
     2581 aataagcagg ccagccgggc tgtgcaccta aatgtctgtc tgggaggagc aggctgagaa
     2641 gtcttgcagt ctgcaggaca ccgaggaatc gtatgtggga acgtccccga gaaccacacg
     2701 agcgtgctgc tcagtgctga ctgcagaatg aaatagaagc aaagtgttac aggatcagtg
     2761 ttttcttttc taaaacatca aaatgccaaa gattaatctg tgattggtga taactgcctc
     2821 gtttaaatgg tcacaagaaa tgtgaagaga gagctagggc agacatgcag tgaaatggtt
     2881 ctttgttaaa aatgtgcaat aaaaatagat tacaataagt agtgcaaaga actttacaga
     2941 aatcaagcga attagaaggc ctgtaagagt aaggtttgct aaaacgtgaa acactgtaac
     3001 acttttaacc actgagcatt ccacagtgaa atgttatttc tatgctctta tttaatgtaa
     3061 tgtttctcct gtcatttttg aagttgagtt tggagtagat tggttgcttc tgagaacaca
     3121 ttctgccttc ctgggaagtc ggggtgtcat cctttcctct gtttgatgtg aggtagttta
     3181 aagatacaag gactttgtgt gaagctccag catctgtgcc ccttgaattg cttaggtgca
     3241 gacagttcta aagcaaggag ctgcagcatt ctcatcatag atacgtgcag tatctttaat
     3301 gagtatcttc atggtatgat agtgtgtgtt tgtgagtgcg aagtaccaat taaggtgtct
     3361 taaatttggc gcatagagga gagaaggaaa cctgaggagt agtgttcctc ctgaatgaag
     3421 gttcaggtca ccagccttct gtacactgcc tttggtttta gcagttcttt gaaaagcaaa
     3481 cactttcatg tcctgtctat tcattcagct ggctgtgctg tgctgtggac cagctgtgtg
     3541 gatctctagc ccagctacag cagaatacat tttaccagca aacctaagga tgacaaacac
     3601 tatccacatc tgaaaactac cacaccatat cagggatcat aaattatgca tatctatgaa
     3661 ttttccaaca aattcctact tcctgattgg attggttttg ccgctgatgt taaggcagcc
     3721 agcttcttag ttcaaaaaga attctgagtt tttcaaacac tagtctagag gtggacattg
     3781 tcaggggttc tggaatggga ccaggggacc ttttggtgca gtgggtgcct gtaactcatt
     3841 agacgtactg aggcagcact tctgcagggt gcataccctg attgttgtca tttgtaacag
     3901 gtcacttcct tttcactcag tttaaattgg tgatggacgt tgcttgattg agcttattac
     3961 tctctatttt gagaaggtag aaggtaagag ggcccatatt cattctttgc catgaaatga
     4021 atgaattagg aagattgtat ttacttaact gttttttaaa tacatgttta atgaaataaa
     4081 ctgtaaaata tccagttttg tgtattatat gtacatttga tttttaatag cctttccaaa
     4141 gaaatgaggg catgattatt gtacagtaag tacgtgactg atttaatttg atttacagag
     4201 cggagtgtgt tcttataaaa atatttaatg acattggttc ttgtcttttg atcttttatt
     4261 tctgaaacac tcaaacacct tacaaagtgc tgagtaggta atagtgaccc aacttgtttg
     4321 ctaaatgatt atttgtttaa atctgtacag ttttaagtgt tcacttatac aaagagtgta
     4381 tatactttca aataatttaa aatgctttat attatttggc tagaaattgc tgtttttaat
     4441 aaatgtgaat tttttaaaaa taaagatttt tgcttcctac cttgtcctca cgtgtctgat
     4501 acgtgtgtgc attccttgag gaaaatttct ttaattaaaa ttttaattga gataa
//
