LOCUS       NM_007357               2932 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens component of oligomeric golgi complex 2 (COG2),
            transcript variant 1, mRNA.
ACCESSION   NM_007357
VERSION     NM_007357.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2932)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2932)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2932)
  AUTHORS   Bailey Blackburn,J., Pokrovskaya,I., Fisher,P., Ungar,D. and
            Lupashin,V.V.
  TITLE     COG Complex Complexities: Detailed Characterization of a Complete
            Set of HEK293T Cells Lacking Individual COG Subunits
  JOURNAL   Front Cell Dev Biol 4, 23 (2016)
   PUBMED   27066481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2932)
  AUTHORS   Kodera,H., Ando,N., Yuasa,I., Wada,Y., Tsurusaki,Y., Nakashima,M.,
            Miyake,N., Saitoh,S., Matsumoto,N. and Saitsu,H.
  TITLE     Mutations in COG2 encoding a subunit of the conserved oligomeric
            golgi complex cause a congenital disorder of glycosylation
  JOURNAL   Clin Genet 87 (5), 455-460 (2015)
   PUBMED   24784932
  REMARK    GeneRIF: Our data strongly suggest that these compound heterozygous
            mutations in COG2 are causative of CDG.
REFERENCE   6  (bases 1 to 2932)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     The binary interacting network of the conserved oligomeric Golgi
            tethering complex
  JOURNAL   J Biol Chem 279 (23), 24640-24648 (2004)
   PUBMED   15047703
REFERENCE   7  (bases 1 to 2932)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     Sec34 is implicated in traffic from the endoplasmic reticulum to
            the Golgi and exists in a complex with GTC-90 and ldlBp
  JOURNAL   J Biol Chem 277 (24), 21955-21961 (2002)
   PUBMED   11929878
REFERENCE   8  (bases 1 to 2932)
  AUTHORS   Ungar,D., Oka,T., Brittle,E.E., Vasile,E., Lupashin,V.V.,
            Chatterton,J.E., Heuser,J.E., Krieger,M. and Waters,M.G.
  TITLE     Characterization of a mammalian Golgi-localized protein complex,
            COG, that is required for normal Golgi morphology and function
  JOURNAL   J Cell Biol 157 (3), 405-415 (2002)
   PUBMED   11980916
REFERENCE   9  (bases 1 to 2932)
  AUTHORS   Podos,S.D., Reddy,P., Ashkenas,J. and Krieger,M.
  TITLE     LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein
            required for normal Golgi function
  JOURNAL   J Cell Biol 127 (3), 679-691 (1994)
   PUBMED   7962052
REFERENCE   10 (bases 1 to 2932)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC349417.1, AL158214.33,
            DB449302.1, AK312678.1 and BC051906.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007357.2.
            
            Summary: This gene encodes a subunit of the conserved oligomeric
            Golgi complex that is required for maintaining normal structure and
            activity of the Golgi complex. The encoded protein specifically
            interacts with the USO1 vesicle docking protein and may be
            necessary for normal Golgi ribbon formation and trafficking of
            Golgi enzymes. Mutations of this gene are associated with abnormal
            glycosylation within the Golgi apparatus. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Feb
            2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014960.1, SRR1803611.38136.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366669.9/ ENSP00000355629.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DC349417.1         26-47
            23-23               AL158214.33        120046-120046
            24-59               DB449302.1         47-82
            60-2343             AK312678.1         1-2284
            2344-2932           BC051906.1         2255-2843
FEATURES             Location/Qualifiers
     source          1..2932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..2932
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /note="component of oligomeric golgi complex 2"
                     /db_xref="GeneID:22796"
                     /db_xref="HGNC:HGNC:6546"
                     /db_xref="MIM:606974"
     exon            1..198
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2343
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     brefeldin A-sensitive, peripheral Golgi protein; conserved
                     oligomeric Golgi complex protein 2; low density
                     lipoprotein receptor defect C complementing; conserved
                     oligomeric Golgi complex subunit 2; COG complex subunit 2;
                     low density lipoprotein receptor defect C-complementing
                     protein"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 2
                     isoform 1"
                     /protein_id="NP_031383.1"
                     /db_xref="CCDS:CCDS1584.1"
                     /db_xref="GeneID:22796"
                     /db_xref="HGNC:HGNC:6546"
                     /db_xref="MIM:606974"
                     /translation="MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEE
                     LRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSL
                     RSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEA
                     SSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEG
                     LQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMY
                     NKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNP
                     GNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFRE
                     IAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQI
                     LARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSI
                     SRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPS
                     LSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKD
                     KLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPS
                     GGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP"
     exon            199..360
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            361..426
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            427..507
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            508..611
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            612..720
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            721..900
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1025
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1152
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1292
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1354
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1506
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1704
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1777
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1920
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2060
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2241
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2932
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2913..2918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /note="hexamer: AATAAA"
     polyA_site      2932
                     /gene="COG2"
                     /gene_synonym="CDG2Q; LDLC"
                     /note="major polyA site"
ORIGIN      
        1 atgttggcgg aagcggaccc ccctgtgccg tggaaactgg cggtggccgc ggccgccgag
       61 tcggtctgcg cagcctcctg cgttttctcg cttggatctt ggcactgaga ggcggtggcc
      121 ggcgggatgg agaaaagtag gatgaacctg cccaaggggc cggacacgct ctgcttcgac
      181 aaggacgagt tcatgaagga agatttcgat gtcgatcatt ttgtgtctga ctgtaggaag
      241 cgggtccagc tggaagaact gagagatgac ctggagctct actataaact tcttaaaaca
      301 gccatggtcg aactcatcaa caaggattat gcagattttg tcaatctttc aacaaacttg
      361 gttggcatgg acaaagccct caaccagctt tctgtgcctt tgggacaatt acgagaagag
      421 gttctgagcc ttagatcgtc tgtcagtgaa ggaattcggg cagttgatga acgaatgtct
      481 aaacaagagg acattaggaa aaaaaagatg tgtgtattga ggcttataca agttattcgg
      541 tcagttgaga aaattgaaaa aatcttaaac tctcaaagtt ctaaagaaac ctctgcacta
      601 gaagcaagca gccccctttt gactggacaa attttggaga gaattgccac agaatttaat
      661 cagttacagt ttcatgctgt tcaaagcaaa ggcatgcctc ttttggacaa agtaagaccg
      721 cgtatagctg gcattacagc catgttacag cagtcactgg aaggtctcct attagaaggc
      781 cttcagacgt ctgacgtcga tataatacgg cactgcttgc ggacttacgc cacgattgac
      841 aagacacggg acgcggaggc cttagttggc caagtactag tgaaaccata catagacgag
      901 gtgattatag agcagtttgt tgaatctcat cccaatggcc ttcaggtcat gtataataaa
      961 ctcctggagt ttgttcctca ccattgccgc cttcttcgag aagtcacagg aggtgccatc
     1021 tccagtgaaa aaggcaatac tgttcctgga tatgactttt tggtgaattc tgtttggcca
     1081 caaatagtac aaggattaga agaaaagtta ccctcgcttt ttaatcctgg gaatcccgat
     1141 gcatttcatg agaaatatac cataagtatg gattttgtca gaagattgga acggcagtgt
     1201 ggatcacagg ctagtgtaaa gagattaaga gcccatcctg cctatcacag cttcaataag
     1261 aagtggaact tgcctgttta ttttcaaata agatttagag aaatagcggg atccttagaa
     1321 gcagcactta cagatgtcct ggaagatgcc ccagctgaaa gtccgtattg ccttttggct
     1381 tctcatagaa cttggagcag ccttaggagg tgttggtcag atgagatgtt cttgccatta
     1441 ctggtgcatc gcctgtggag actcactctg cagattttgg cacgatactc tgtgtttgtc
     1501 aatgagcttt cactcaggcc catttctaat gaaagtccca aggagatcaa gaaacctttg
     1561 gtaactggta gcaaagaacc ttccatcacc caaggaaaca ctgaagacca aggaagtggt
     1621 ccttcggaaa caaagcctgt ggtttccatt tcccgcactc agctcgtgta tgtggttgca
     1681 gacctggaca agcttcagga gcagcttcca gaactcttgg aaataatcaa gccaaaactt
     1741 gaaatgattg gctttaagaa tttttcttct atctcagcag ccctggagga ctcccagagc
     1801 tctttttcag cctgtgtgcc ctccttgagt agcaagatca tccaggattt aagtgactct
     1861 tgcttcggtt tcctaaaaag cgccctggag gttcccaggc tttaccgaag aaccaataag
     1921 gaggtcccaa ccacagcttc ctcctatgtg gacagtgctc tgaagccctt attccagctt
     1981 cagagcggac acaaggataa gctcaaacaa gcaataattc agcagtggct agaaggcact
     2041 ctcagtgaaa gcactcataa gtactatgaa accgtgtcag atgtattaaa ctctgtgaag
     2101 aagatggaag agagcctgaa aaggctgaaa caagccagaa aaaccactcc cgccaacccc
     2161 gtcggtccca gtggtggcat gagcgacgac gacaaaatca ggctgcagtt ggccctagat
     2221 gttgagtact tgggagagca gatacaaaag ttgggactac aagcaagtga cataaaaagc
     2281 ttctcagctc tcgcagagct tgttgctgct gccaaggacc aggcaacagc agagcagcct
     2341 taagcatctt ggaagatccc gaggttagat tcttaagcaa gagaagagtt ggacttccag
     2401 gctgaagggg agaaagtgac tctgttctct tagcaaccgt ctgtagcaaa gaagtgcttc
     2461 cagcatcact ccagcaacac gcccatgcgt cttctctcag cgtatttggg tcttctttgc
     2521 ccaaaagaac acaaaagcct ttttccattg tatggaagat agtttttaag acatttgaaa
     2581 ctttctacta tagtttacag aacaaattat tttattttta ttgtaaatct tagtgtggaa
     2641 gagctgattt ctaaaatatg attaaagtaa atatatacct atgaatatca agagtcgtct
     2701 ccctgagcct gtagttggaa gtgacgactg taatggaatg atgtcttgta tagaaatgcc
     2761 cttctctgaa ataaagagaa ctcctgggct ttctaaagag gctgcgggaa gccatcctcc
     2821 actcccactg tgtgtgagag cagtgcttct gatcctgctg tcaccccgac ctctggcagg
     2881 agccggcgcc agtaggaaag acctccttcc taaataaaag aagtgtctcc ca
//
