LOCUS       NM_018714               3014 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens component of oligomeric golgi complex 1 (COG1), mRNA.
ACCESSION   NM_018714
VERSION     NM_018714.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Miljkovic,M., Kotur-Stevuljevic,J., Stefanovic,A., Zeljkovic,A.,
            Vekic,J., Gojkovic,T., Bogavac-Stanojevic,N., Nikolic,M.,
            Simic-Ogrizovic,S., Spasojevic-Kalimanovska,V. and
            Jelic-Ivanovic,Z.
  TITLE     Oxidative stress and hemoglobin-cholesterol adduct in renal
            patients with different LDL phenotypes
  JOURNAL   Int Urol Nephrol 48 (10), 1683-1690 (2016)
   PUBMED   27412679
  REMARK    GeneRIF: Chronic renal patients with more atherogenic lipoprotein
            LDL B phenotype are in advanced state of oxidative stress compared
            with control subjects.
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Dechtawewat,T., Paemanee,A., Roytrakul,S., Songprakhon,P.,
            Limjindaporn,T., Yenchitsomanus,P.T., Saitornuang,S.,
            Puttikhunt,C., Kasinrerk,W., Malasit,P. and Noisakran,S.
  TITLE     Mass spectrometric analysis of host cell proteins interacting with
            dengue virus nonstructural protein 1 in dengue virus-infected HepG2
            cells
  JOURNAL   Biochim Biophys Acta 1864 (9), 1270-1280 (2016)
   PUBMED   27108190
  REMARK    GeneRIF: This study reports a novel set of Dengue virus (DENV)
            NS1-interacting host cell proteins in the HepG2 cell line and
            proposes possible roles for human NEK2, TAO1, and COG1 in DENV
            infection.
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Bailey Blackburn,J., Pokrovskaya,I., Fisher,P., Ungar,D. and
            Lupashin,V.V.
  TITLE     COG Complex Complexities: Detailed Characterization of a Complete
            Set of HEK293T Cells Lacking Individual COG Subunits
  JOURNAL   Front Cell Dev Biol 4, 23 (2016)
   PUBMED   27066481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Zeevaert,R., Foulquier,F., Dimitrov,B., Reynders,E., Van
            Damme-Lombaerts,R., Simeonov,E., Annaert,W., Matthijs,G. and
            Jaeken,J.
  TITLE     Cerebrocostomandibular-like syndrome and a mutation in the
            conserved oligomeric Golgi complex, subunit 1
  JOURNAL   Hum Mol Genet 18 (3), 517-524 (2009)
   PUBMED   19008299
  REMARK    GeneRIF: A novel mutation in COG1 was found in two patients with a
            cerebrocostomandibular-like syndrome.
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     The binary interacting network of the conserved oligomeric Golgi
            tethering complex
  JOURNAL   J Biol Chem 279 (23), 24640-24648 (2004)
   PUBMED   15047703
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Loh,E. and Hong,W.
  TITLE     Sec34 is implicated in traffic from the endoplasmic reticulum to
            the Golgi and exists in a complex with GTC-90 and ldlBp
  JOURNAL   J Biol Chem 277 (24), 21955-21961 (2002)
   PUBMED   11929878
  REMARK    GeneRIF: Sec34 is implicated in traffic from the endoplasmic
            reticulum to the Golgi and exists in a complex with GTC-90 and
            ldlBp
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Ungar,D., Oka,T., Brittle,E.E., Vasile,E., Lupashin,V.V.,
            Chatterton,J.E., Heuser,J.E., Krieger,M. and Waters,M.G.
  TITLE     Characterization of a mammalian Golgi-localized protein complex,
            COG, that is required for normal Golgi morphology and function
  JOURNAL   J Cell Biol 157 (3), 405-415 (2002)
   PUBMED   11980916
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Chatterton,J.E., Hirsch,D., Schwartz,J.J., Bickel,P.E.,
            Rosenberg,R.D., Lodish,H.F. and Krieger,M.
  TITLE     Expression cloning of LDLB, a gene essential for normal Golgi
            function and assembly of the ldlCp complex
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 915-920 (1999)
   PUBMED   9927668
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097641.6 and BC021985.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018714.2.
            
            Summary: The protein encoded by this gene is one of eight proteins
            (Cog1-8) which form a Golgi-localized complex (COG) required for
            normal Golgi morphology and function. It is thought that this
            protein is required for steps in the normal medial and trans
            Golgi-associated processing of glycoconjugates and plays a role in
            the organization of the Golgi-localized complex. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1168264.1,
                                           SRR1660805.101027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299886.9/ ENSP00000299886.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC097641.6         44160-44173         c
            15-3014             BC021985.2         1-3000
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3014
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /note="component of oligomeric golgi complex 1"
                     /db_xref="GeneID:9382"
                     /db_xref="HGNC:HGNC:6545"
                     /db_xref="MIM:606973"
     exon            1..330
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2958
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /note="conserved oligomeric Golgi complex protein 1; low
                     density lipoprotein receptor defect B complementing; COG
                     complex subunit 1"
                     /codon_start=1
                     /product="conserved oligomeric Golgi complex subunit 1"
                     /protein_id="NP_061184.1"
                     /db_xref="CCDS:CCDS11692.1"
                     /db_xref="GeneID:9382"
                     /db_xref="HGNC:HGNC:6545"
                     /db_xref="MIM:606973"
                     /translation="MATAATSPALKRLDLRDPAALFETHGAEEIRGLERQVRAEIEHK
                     KEELRQMVGERYRDLIEAADTIGQMRRCAVGLVDAVKATDQYCARLRQAGSAAPRPPR
                     AQQPQQPSQEKFYSMAAQIKLLLEIPEKIWSSMEASQCLHATQLYLLCCHLHSLLQLD
                     SSSSRYSPVLSRFPILIRQVAAASHFRSTILHESKMLLKCQGVSDQAVAEALCSIMLL
                     EESSPRQALTDFLLARKATIQKLLNQPHHGAGIKAQICSLVELLATTLKQAHALFYTL
                     PEGLLPDPALPCGLLFSTLETITGQHPAGKGTGVLQEEMKLCSWFKHLPASIVEFQPT
                     LRTLAHPISQEYLKDTLQKWIHMCNEDIKNGITNLLMYVKSMKGLAGIRDAMWELLTN
                     ESTNHSWDVLCRRLLEKPLLFWEDMMQQLFLDRLQTLTKEGFDSISSSSKELLVSALQ
                     ELESSTSNSPSNKHIHFEYNMSLFLWSESPNDLPSDAAWVSVANRGQFASSGLSMKAQ
                     AISPCVQNFCSALDSKLKVKLDDLLAYLPSDDSSLPKDVSPTQAKSSAFDRYADAGTV
                     QEMLRTQSVACIKHIVDCIRAELQSIEEGVQGQQDALNSAKLHSVLFMARLCQSLGEL
                     CPHLKQCILGKSESSEKPAREFRALRKQGKVKTQEIIPTQAKWQEVKEVLLQQSVMGY
                     QVWSSAVVKVLIHGFTQSLLLDDAGSVLATATSWDELEIQEEAESGSSVTSKIRLPAQ
                     PSWYVQSFLFSLCQEINRVGGHALPKVTLQEMLKSCMVQVVAAYEKLSEEKQIKKEGA
                     FPVTQNRALQLLYDLRYLNIVLTAKGDEVKSGRSKPDSRIEKVTDHLEALIDPFDLDV
                     FTPHLNSNLHRLVQRTSVLFGLVTGTENQLAPRSSTFNSQEPHNILPLASSQIRFGLL
                     PLSMTSTRKAKSTRNIETKAQVVPPARSTAGDPTVPGSLFRQLVSEEDNTSAPSLFKL
                     GWLSSMTK"
     exon            331..575
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            576..757
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            758..928
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1085
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1296
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2088
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2235
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2397
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2525
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2634
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2744
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2820
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3014
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /note="hexamer: AATAAA"
     polyA_site      3014
                     /gene="COG1"
                     /gene_synonym="CDG2G; LDLB"
                     /note="major polyA site"
ORIGIN      
        1 gctgacgagt gcaccatggc caccgcggca acctcacccg cgctgaagcg gctggatctg
       61 cgcgaccctg cggctctttt cgagacgcat ggagcggagg agatccgcgg gctggagcgc
      121 caggttcggg ccgagatcga gcacaagaag gaggagctgc ggcagatggt gggcgaacgg
      181 taccgcgacc tgatcgaggc ggccgacacc atcggccaga tgcgccgctg cgccgtgggg
      241 ctagtggacg ccgtgaaggc caccgaccag tactgcgccc gcctccgcca ggccggctcg
      301 gccgcgcccc ggccaccgcg ggcccagcag ccacagcagc catcccagga gaagttctac
      361 agcatggctg cccagatcaa gctactctta gaaattccgg agaagatctg gagctcgatg
      421 gaagcctctc agtgtctcca cgccacacag ctctacctgc tctgctgcca cctccacagc
      481 ctgctccagc tggattcttc tagttcccga tacagtcccg tcctctcccg gtttcctata
      541 ctcatccggc aggtggcagc cgccagccac ttccggtcaa ctattctgca tgaaagcaag
      601 atgttgctca aatgccaagg tgtgtctgac caagctgtgg ccgaggccct gtgctctata
      661 atgctcttag aagagagttc tcctcgccaa gccctcacag acttcctgct ggccagaaag
      721 gcaactattc agaaacttct caaccagcca caccatggtg ctggtatcaa ggctcagatt
      781 tgctcattag tggagttgct ggccaccact ctgaagcaag ctcatgccct tttctacact
      841 ttgccagaag gactgctgcc agatccagcc ctgccatgtg gcttgctctt ctctactctg
      901 gagaccatca caggccagca tcctgccgga aagggcactg gtgtcctgca ggaagagatg
      961 aaactctgca gctggtttaa acacctgcca gcatccatcg tcgagttcca gccaacactc
     1021 cgaacccttg cacatcccat cagtcaggaa tacctgaaag acacgctgca gaaatggatc
     1081 cacatgtgta atgaagacat taaaaatggg atcaccaacc tgctcatgta cgtgaagagc
     1141 atgaagggtc tcgcgggaat ccgggacgcc atgtgggagt tacttaccaa tgagtccacc
     1201 aatcacagct gggatgtgct atgtcggcgg cttctggaga agccgctctt gttctgggaa
     1261 gatatgatgc agcaactgtt ccttgaccga ttacagactc tgacaaaaga aggctttgac
     1321 tccatctcca gtagctccaa ggagctcttg gtttcagctt tgcaggaact tgaaagcagc
     1381 accagcaact ccccttcaaa taagcacatc cactttgagt acaacatgtc gctcttcctc
     1441 tggtctgaga gtcctaatga cctgccttcc gatgcggcct gggtcagcgt ggcaaaccgg
     1501 ggtcagtttg ccagtagcgg cctctccatg aaagcacaag ccatcagccc ttgtgtacag
     1561 aacttctgtt ctgccctgga ttctaagctg aaggttaaac tagatgacct cctggcttac
     1621 ctcccctctg atgactcatc actgcccaag gacgtttctc ccacacaggc caagagttct
     1681 gcctttgaca gatacgcaga tgcggggacc gtgcaggaga tgctgcggac tcagtccgtg
     1741 gcatgcatca agcacatcgt ggactgcatc cgggcagagc tacagagcat tgaagagggt
     1801 gtgcaagggc aacaggatgc cctcaacagt gccaagctgc actcagttct tttcatggcc
     1861 agactctgcc agtccctggg agagctgtgc ccccatctga agcagtgcat cctgggaaaa
     1921 tcagagagct cagagaaacc agcaagggag tttagggctc tgagaaaaca gggaaaggtg
     1981 aaaactcagg aaatcattcc tacacaggcc aagtggcaag aggttaaaga agtactcctc
     2041 cagcagagcg tgatgggcta ccaggtctgg agcagtgcag ttgtgaaagt tttgattcat
     2101 ggattcaccc agtcattact tctagatgat gctggctcag ttctggccac agccaccagc
     2161 tgggatgagc tagaaattca ggaggaggca gagtctggca gcagtgtcac atccaagatc
     2221 cgactccctg cacagccgtc ctggtatgta cagtccttcc tgtttagttt atgccaggaa
     2281 attaatcggg ttggaggcca tgccttgcca aaggtgacat tacaggagat gctgaaaagc
     2341 tgtatggttc aagtagtagc tgcctatgag aaactctccg aagaaaaaca gattaagaaa
     2401 gaaggtgcat ttccagtcac ccagaaccgg gcgctgcagc tgctttatga tctgcgttac
     2461 ctcaacattg ttctgacagc caagggtgac gaggtgaaga gtggccggag caagccagac
     2521 tccagaattg agaaagtgac tgaccacctg gaagccctca ttgatccatt tgacctggac
     2581 gttttcacgc cacacctcaa cagcaacctt catcgcctgg tgcagcgaac ttctgttctg
     2641 tttggattgg tgactggtac agagaatcag ctcgcccccc ggagcagtac gttcaactcc
     2701 caagaacccc ataacatcct gccactggca tccagtcaga tcaggtttgg acttctccca
     2761 ctgagcatga caagcactcg aaaggctaaa tcaaccagaa acatcgaaac aaaagctcag
     2821 gttgtccccc cggcacgctc cacagctggt gacccgacag ttcctggctc cttgttcaga
     2881 cagcttgtca gtgaagaaga caacacgtct gcaccttcat tattcaaact tggctggctc
     2941 tctagtatga ctaagtaaca tggcaacaca tctgtctctc cctaaataaa tactaccaca
     3001 ttatttcttc taaa
//
