LOCUS       NM_001365672            9309 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens cordon-bleu WH2 repeat protein like 1 (COBLL1),
            transcript variant 7, mRNA.
ACCESSION   NM_001365672
VERSION     NM_001365672.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9309)
  AUTHORS   Glunk,V., Laber,S., Sinnott-Armstrong,N., Sobreira,D.R.,
            Strobel,S.M., Batista,T.M., Kubitz,P., Moud,B.N., Ebert,H.,
            Huang,Y., Brandl,B., Garbo,G., Honecker,J., Stirling,D.R.,
            Abdennur,N., Calabuig-Navarro,V., Skurk,T., Ocvirk,S., Stemmer,K.,
            Cimini,B.A., Carpenter,A.E., Dankel,S.N., Lindgren,C.M., Hauner,H.,
            Nobrega,M.A. and Claussnitzer,M.
  TITLE     A non-coding variant linked to metabolic obesity with normal weight
            affects actin remodelling in subcutaneous adipocytes
  JOURNAL   Nat Metab 5 (5), 861-879 (2023)
   PUBMED   37253881
  REMARK    GeneRIF: A non-coding variant linked to metabolic obesity with
            normal weight affects actin remodelling in subcutaneous adipocytes.
REFERENCE   2  (bases 1 to 9309)
  AUTHORS   Kwak,J. and Shin,D.
  TITLE     Gene-Nutrient Interactions in Obesity: COBLL1 Genetic Variants
            Interact with Dietary Fat Intake to Modulate the Incidence of
            Obesity
  JOURNAL   Int J Mol Sci 24 (4), 3758 (2023)
   PUBMED   36835164
  REMARK    GeneRIF: Gene-Nutrient Interactions in Obesity: COBLL1 Genetic
            Variants Interact with Dietary Fat Intake to Modulate the Incidence
            of Obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9309)
  AUTHORS   Lansdon,L.A., Dickinson,A., Arlis,S., Liu,H., Hlas,A., Hahn,A.,
            Bonde,G., Long,A., Standley,J., Tyryshkina,A., Wehby,G., Lee,N.R.,
            Daack-Hirsch,S., Mohlke,K., Girirajan,S., Darbro,B.W.,
            Cornell,R.A., Houston,D.W., Murray,J.C. and Manak,J.R.
  TITLE     Genome-wide analysis of copy-number variation in humans with cleft
            lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as
            clefting genes
  JOURNAL   Am J Hum Genet 110 (1), 71-91 (2023)
   PUBMED   36493769
  REMARK    GeneRIF: Genome-wide analysis of copy-number variation in humans
            with cleft lip and/or cleft palate identifies COBLL1, RIC1, and
            ARHGEF38 as clefting genes.
REFERENCE   4  (bases 1 to 9309)
  AUTHORS   Park,K., Yoo,H.S., Oh,C.K., Lee,J.R., Chung,H.J., Kim,H.N.,
            Kim,S.H., Kee,K.M., Kim,T.Y., Kim,M., Kim,B.G., Ra,J.S., Myung,K.,
            Kim,H., Han,S.H., Seo,M.D., Lee,Y. and Kim,D.W.
  TITLE     Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate
            drug resistance in chronic myeloid leukemia
  JOURNAL   Cancer Med 11 (21), 4005-4020 (2022)
   PUBMED   35352878
  REMARK    GeneRIF: Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1
            regulate drug resistance in chronic myeloid leukemia.
REFERENCE   5  (bases 1 to 9309)
  AUTHORS   Sun,C., Forster,F., Gutsmann,B., Moulla,Y., Stroh,C., Dietrich,A.,
            Schon,M.R., Gartner,D., Lohmann,T., Dressler,M., Stumvoll,M.,
            Bluher,M., Kovacs,P., Breitfeld,J. and Guiu-Jurado,E.
  TITLE     Metabolic Effects of the Waist-To-Hip Ratio Associated Locus
            GRB14/COBLL1 Are Related to GRB14 Expression in Adipose Tissue
  JOURNAL   Int J Mol Sci 23 (15), 8558 (2022)
   PUBMED   35955692
  REMARK    GeneRIF: Metabolic Effects of the Waist-To-Hip Ratio Associated
            Locus GRB14/COBLL1 Are Related to GRB14 Expression in Adipose
            Tissue.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9309)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9309)
  AUTHORS   Gordon,G.J., Dong,L., Yeap,B.Y., Richards,W.G., Glickman,J.N.,
            Edenfield,H., Mani,M., Colquitt,R., Maulik,G., Van Oss,B.,
            Sugarbaker,D.J. and Bueno,R.
  TITLE     Four-gene expression ratio test for survival in patients undergoing
            surgery for mesothelioma
  JOURNAL   J Natl Cancer Inst 101 (9), 678-686 (2009)
   PUBMED   19401544
  REMARK    GeneRIF: The gene ratio test with the COBLL1/ARHGDIA genes for
            survival of patients with malignant pleural mesothelioma has robust
            predictive value.
REFERENCE   8  (bases 1 to 9309)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 9309)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 9309)
  AUTHORS   Carroll,E.A., Gerrelli,D., Gasca,S., Berg,E., Beier,D.R., Copp,A.J.
            and Klingensmith,J.
  TITLE     Cordon-bleu is a conserved gene involved in neural tube formation
  JOURNAL   Dev Biol 262 (1), 16-31 (2003)
   PUBMED   14512015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019181.4.
            
            On May 17, 2019 this sequence version replaced NM_001365672.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.151553.1,
                                           SRR1660803.161661.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652658.2/ ENSP00000498242.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC019181.4         22884-22997
            115-205             AC019181.4         23461-23551
            206-394             AC019181.4         120832-121020
            395-596             AC019181.4         134592-134793
            597-825             AC019181.4         136510-136738
            826-923             AC019181.4         142185-142282
            924-1160            AC019181.4         142396-142632
            1161-1314           AC019181.4         159602-159755
            1315-1389           AC019181.4         160189-160263
            1390-1624           AC019181.4         163951-164185
            1625-1719           AC019181.4         165208-165302
            1720-3287           AC019181.4         168871-170438
            3288-3464           AC019181.4         172310-172486
            3465-9309           AC019181.4         178675-184519
FEATURES             Location/Qualifiers
     source          1..9309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..9309
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="cordon-bleu WH2 repeat protein like 1"
                     /db_xref="GeneID:22837"
                     /db_xref="HGNC:HGNC:23571"
                     /db_xref="MIM:610318"
     exon            1..114
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..205
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3551
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="isoform 4 is encoded by transcript variant 7;
                     cordon-bleu protein-like 1; COBL-like 1"
                     /codon_start=1
                     /product="cordon-bleu protein-like 1 isoform 4"
                     /protein_id="NP_001352601.1"
                     /db_xref="CCDS:CCDS63045.1"
                     /db_xref="GeneID:22837"
                     /db_xref="HGNC:HGNC:23571"
                     /db_xref="MIM:610318"
                     /translation="MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTA
                     FIMEQKENMIDKDVELSVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDL
                     LSAEQNHIKFKPNTPIGMLEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTI
                     VRVSPHASLQELAPIICSKCEFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDV
                     NRESCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTI
                     SKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSP
                     CEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVP
                     PDSASEANSPEELSSPAGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTD
                     IINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRN
                     LKSLGPNQENVVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSE
                     AHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSD
                     SKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGN
                     DDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPK
                     SLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKP
                     KPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSR
                     ASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQ
                     TLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLK
                     TFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKF
                     VDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTA
                     IRSGEAAAKLKRVTIPSNTISVNGRSRLSHSMSPDAQDGH"
     exon            206..394
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..596
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..825
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..923
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1160
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1314
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1389
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1624
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1719
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..3287
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3464
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..9309
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4651..4656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      4681
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="major polyA site"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: AATAAA"
     polyA_site      4755
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
     regulatory      5990..5995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: AATAAA"
     polyA_site      6013
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
     regulatory      6775..6780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: AATGAA"
     polyA_site      6794
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
     regulatory      9274..9279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: AATAAA"
     regulatory      9287..9292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
                     /note="hexamer: AATAAA"
     polyA_site      9295
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
     polyA_site      9309
                     /gene="COBLL1"
                     /gene_synonym="COBLR1"
ORIGIN      
        1 attcaagtcc tggcttgaga gccgagcggc aagagcgcgg gccggggaag ggaagagtag
       61 gagaggaagc cgcgagggag aacaggcgag ctactgtctc ctttggaaaa gaaccagtga
      121 cgcgccgcct gggagctgga gcccgcgcag cgccccgcag ggcgatggac ggccgaaccc
      181 cgcgcccgca ggacgcccca gccaggagaa aaccaaaagc caaggcacca cttcctccag
      241 ctgagaccaa atatactgat gtctcttcag ctgctgattc tgtagaatcc actgctttca
      301 tcatggaaca gaaagaaaac atgatagata aagacgttga actctcagtg gtcctacctg
      361 gggatattat caaatctact actgttcatg gcagtaaacc tatgatggac ttgttgatat
      421 tcctttgtgc acagtatcac ttaaatccat caagttacac aatcgatctg ttgtcagctg
      481 aacagaacca cattaaattt aagccaaaca caccaatagg aatgttggag gtagagaagg
      541 taattttaaa gccaaaaatg ttggataaga aaaaacctac acctataata ccagagaaaa
      601 ctgtgagagt agtgattaat tttaagaaaa cacagaagac catagtgaga gtgagtccac
      661 atgcatcgct tcaagagctt gcccctatta tatgtagcaa atgtgagttt gatccgttgc
      721 atacactatt gttgaaagat tatcaatcgc aggagcctct tgacttgaca aaatctctta
      781 atgacctggg actaagagaa ttatatgcga tggatgtcaa cagagagtcc tgccaaatat
      841 cacaaaacct agatattatg aaggagaaag aaaataaagg gtttttcagt ttttttcaac
      901 gcagtaagaa aaagcgagac caaactgcaa gtgcccctgc aacccctcta gtaaataagc
      961 accgcccaac ttttacaagg tccaatacca tttccaaacc atatatttcc aacaccctgc
     1021 cgtcggatgc acccaagaag aggcgggctc cactgccccc gatgccagca tctcagagtg
     1081 tcccccaaga ccttgcacac atccaggaga ggcctgcttc ttgtatagtg aaatccatga
     1141 gcgtggatga gacagataag agtccctgtg aagcaggaag agtgagggca ggttcactgc
     1201 agctcagcag catgtctgca gggaattcat ctttgagaag gacaaagcga aaagcacctt
     1261 ccccaccctc caaaataccc ccgcatcaaa gtgatgaaaa tagtcgtgtg actgccttac
     1321 agccagtaga tggagttcct ccagacagtg cttcagaagc aaactctcct gaggagctat
     1381 ccagcccagc tggaataagc tctgattata gccttgaaga gatagatgaa aaggaagaac
     1441 tgagtgaagt gcctaaagtt gaagctgaaa atatttctcc gaagtcacaa gatattcctt
     1501 ttgtatctac tgatataata aatacactga aaaatgatcc tgactcagcc cttggcaatg
     1561 gtagtggaga gttctcacaa aactccatgg aagaaaaaca agaaactaaa agcacagatg
     1621 gacaagaacc acacagtgta gtatatgata caagcaatgg aaagaaggta gttgacagta
     1681 taagaaactt gaagtcgttg ggcccaaacc aagagaatgt agttcaaaat gaaataattg
     1741 tctatccaga gaacacagaa gacaatatga aaaatggagt gaagaaaaca gaaatcaatg
     1801 tagaaggtgt tgccaaaaat aacaacattg atatggaagt tgagagacca tcaaactctg
     1861 aggcacatga aactgatact gctataagtt acaaggaaaa ccatctagca gcttcatcag
     1921 taccagatca aaaactgaat caacccagtg cagaaaagac aaaagatgca gcaattcaga
     1981 caaccccttc ttgtaacagt tttgatggga aacaccaaga tcataattta tctgactcca
     2041 aagttgaaga atgtgtgcaa acttcaaata acaacatatc aactcaacac tcatgcttaa
     2101 gttcacaaga ttctgtaaat acctcaaggg aattcaggag tcaaggcacc ctaattatac
     2161 attcagaaga tccgcttacc gtaaaagatc caatttgtgc acatggtaat gatgatcttt
     2221 tgcctcctgt agataggatt gacaaaaatt ccactgcttc ttacctaaag aattacccac
     2281 tttatagaca ggactacaat cccaagccaa aaccttcaaa tgaaattaca cgagagtata
     2341 tacccaaaat tggcatgact acttataaaa tagtgcctcc caaatccttg gaaatatcga
     2401 aagactggca atcagaaacc atagagtata aagatgatca ggacatgcat gctttaggga
     2461 aaaagcacac tcatgagaat gtgaaagaaa ctgccatcca aacagaagat tctgctattt
     2521 ctgaaagccc agaagagcca ctgccaaacc ttaaaccgaa gcctaacctg agaacagagc
     2581 atcaagtgcc cagttctgtg agctcacctg atgatgccat ggttagtcct ctgaaacctg
     2641 ctcccaaaat gacaagagac actggcacag ctccttttgc accaaatttg gaagaaataa
     2701 acaatatttt ggaatcaaaa tttaaatctc gggcttcaaa tgcccaggcc aaacccagct
     2761 cttttttttt gcagatgcag aagagagtat cgggtcacta tgtgacatct gcagctgcca
     2821 agagtgtcca tgctgcccct aatcctgctc caaaagaact gacaaataaa gaggcagaaa
     2881 gggatatgct gccttctccg gagcagactc tttctccctt aagtaaaatg cctcactctg
     2941 ttccacaacc ccttgttgaa aaaactgatg atgatgtcat cggtcaggct cctgctgaag
     3001 cctcccctcc tcccatagct ccaaaacctg tgacaattcc tgctagtcag gtatccacac
     3061 aaaatctgaa gactttgaaa acttttggtg ccccacgacc atactcaagt tctggtcctt
     3121 caccgtttgc tcttgctgta gtgaaaaggt cacagtcttt cagtaaagag cgcaccgagt
     3181 cacctagtgc cagtgcattg gtccaacctc cagccaacac agaggaaggg aagactcatt
     3241 ctgtaaataa atttgtggac atcccacagc ttggtgtgtc tgataaggaa aataactctg
     3301 cacataatga acagaattcc caaataccaa ctccaactga tggcccatca ttcactgtta
     3361 tgagacaaag ttctttaaca ttccaaagct ctgacccaga acagatgcga cagagtttgc
     3421 tgactgcaat ccgttcggga gaggctgctg ccaaattgaa aagggttacc attccatcaa
     3481 atacaatatc tgtgaatgga aggtcaagac tcagccattc catgtcccct gatgcccagg
     3541 acggccatta aatgttaccc tgccacacca ctgcacttca cttccacttc agaccaactt
     3601 catactaatg gaacattttg gcaaatgtat attcagatgt acactaatat attatctatt
     3661 aaaatattag aatttgtgtt gtggctttta atgccagaag aaaagttacc agaatttata
     3721 atttatagta attttttgat cttttttttg ccttaagagt tgaatatgct gctttagaac
     3781 tttaaaacaa ggtgtaaatg attttcattt tttacaaatg aaaaataatt cctttgtatt
     3841 gatttcactt accagcacat tctctacaat ggtgacttag acaaaagtat aagattcata
     3901 gactttatat ttgtatgaca tacaactagg acaaacatag atatgacatt tgctgcctca
     3961 gtgtagcaat tggaaatatt tataagttat atgaaagcct gttttgggct gaaagaatga
     4021 tttagaaaac tagtgatacc aaataagtat attcagttca ataattattt tcaatgatga
     4081 atcacttagt gtgaaagact tgccttgtgt attctttatg taattacaaa tcactgtcaa
     4141 ttttatggga agctcatagt attttaatat tttattaaca tggaactctt gtttttttaa
     4201 tctttagaac ttaaattcta caagaatttt aaatattttc tgtatataat tatgacattg
     4261 tcacacagaa attacacatt ttatgtgcca gaagccttaa acatctttct gtgaaaatgc
     4321 tgatatattg tgacagttat ttcacatttg atatgtagag aggaataggg gttagtttat
     4381 gtttatattg aaaaacttta aagactattt ggaagttcca gaaattctgg ttttaattca
     4441 agtaaaatga taaaatagtc attatatagt tcagatgcta atattctaag taataatata
     4501 tatttacatt gaagctaaaa ctgttaagca aaacaatgcc catttgtcgg cttacagctc
     4561 ttccggagtc tagagcctgt tggtgttctg tccctacttt aagaatttaa ttgctcactt
     4621 attctgaaag ctttgttcaa acaagatgat attaaatttg ttttcactaa aactactggg
     4681 atatctgcct cttggggatt tttttttcaa tttaataaaa gcaagttgta tatttggggt
     4741 gctttttaaa atatatagtt tgtgtcaacc agcatattta tttcccttac ctgatgcata
     4801 catttctatt agccagtgaa caaacaagaa atttgtaaga tttaccattt atcagggatc
     4861 cctagtgtac atttaagccc tggcattctg actccaaaat gcatggtcta agcatttaaa
     4921 atgtttagca tagttcctga tacatggcat ggccatctta aatgctaaat gttgctgctg
     4981 ttttccttga atcagttgga gagaccctca tatatagata cttaagttat gttgttataa
     5041 gcaagtagag aaaggagtga atttttttta aaaaattgtg ttgtcataat tatctactta
     5101 taaaaatata aatttggatc cctaatttaa accttcatat attttgagtt ggattgaaga
     5161 cttaaagaca agcgacatgt aagatgtttt caatatatta atatataaga aaggcttaat
     5221 ttatgaagat atgaaagttc ctacaactca tgataagtct acctaataga aatatcagca
     5281 cattattctt acaagaggaa attcaaaagg ccaacaaaca tggaaaaaaa atactcttca
     5341 ctgataatca gggaaataca agttaaaaac atggaaaggt accacatcaa attagcaaaa
     5401 acggaagttt caaaatagca agtgttgtca ggaacatcaa acagtgggaa ctctactgtt
     5461 ggtgggaaaa tacactggca taactaccag ttctgcaata tctagtaaaa ttaaagattc
     5521 cttaccatgt taccttaaat aagtacttat gcacatgcat aaggagacat ctgcaaaaat
     5581 gttcacggca gccttgtgta aaacagcaga aaggggtcct aacccgtgct cagctttagt
     5641 aatgcatata ttcatatgat agacttccac acagcagtcc aaatgaacaa gctagagcta
     5701 tatatgtcag catgaataca tctcaaaaac aagtgacaag agtgagtggt ggaacaagtc
     5761 gtgttttatg aaattagtta cataaagtat aaatataaaa aatgatacta taaattatgg
     5821 ctgtatatgt aggaaaaaaa tttgctggtg gttacctgtg ggaaccaaga aagactgaat
     5881 tgagatttat aagaggcatc aattgtgttc gtagtatttt ataaactgct gtttgaaaac
     5941 aagtgcttat tatattctaa attctagtat acttgtagtt tataattata ataaaataat
     6001 gttttaaagg tcacatagga tttagggggc tatgtatata aaccattaat acatgtatgt
     6061 tctgaaaagt tgccttatcg acaccatttt aggagaacat gtgctatcct gtcaatgggg
     6121 aaagaaattt gtgacaagta gttttcactc atcatatcct aaaataacag cacaaggaag
     6181 atacaggaat ggtctagaac caacttttga ctttcatgta taatttttag catctaggca
     6241 ttttgctttt ccttctttcc tccaatcaag ttatttattt atataatatt aaaattataa
     6301 ttcagattac atatatatga tagagtataa aatacattct ttttcatccc cagcatccca
     6361 ctctcctctc caaagatagc tgttaatatt ttgatatgaa gccctatata gatgtattta
     6421 tatgaagtac atgtgtgcag gtttgttggg ggcttttgtg tgtgtgtgtg tgtgtgtgtg
     6481 tgtgtgtgtg tatgtgtgtt tcttaacatg aaaggaggtc acactctaat actatgtaac
     6541 aacttgcctt ttataccagc agtgttctgg aagagctttt ctttttacac atacagatcg
     6601 atcgtatttc tgttagccat tctattgttt cttgctgcgg tacataatgt tggctggagt
     6661 gaagagattg gggttcagat cacaagtctg ccacttatga gtcatgggat cttgggcaaa
     6721 ttactttctc tatgcttcat tttctcttct gaaaaatgaa ttaatatgaa taaaaatgaa
     6781 ccttatttta aaaacggcag gcaattcatc ttttaaagtt acctgatgtc aatactataa
     6841 gtgaacaggt attatttgcc taatatactc cctattcttt gaggagtgac ccttcttccg
     6901 atttcacctc ttcatgaact gccagatctg gccttggcca ctaggcactg gcaacagcat
     6961 acacactctg tcatcttatc caagtccttg aaatgagacc aatctttgtc ctgagactta
     7021 gttacttata ggtgcttaaa acccaaagcg tcccaattga tacaattatg tatgtgtcta
     7081 attccagttt actttgtacc cactaccagt agagaaaata agtatcaaag aactaagaat
     7141 caaactcatc atttttaaaa tctactgatt ttgataactg acttgaaaga aaagaacttg
     7201 caattagagg tcatagtgaa gatttccagg gtcaaagtga tttctgaggt tttagatgta
     7261 aaaatatctc ctatttattt gctatttcag agttgacaac aagattttta tttgatccac
     7321 atatttaaaa ggtgtgcaaa gattgctact ttacaaaggt cacagaagca gaggagtctc
     7381 agagtcccac atccaattac taatttgttc ttccccatga ctaaatgtag caaatgatga
     7441 agaaactggt gctagatttc aagggatacc agaataggaa gttatttgtt ctgaatcttc
     7501 agttggtttt ccttttctct taaatgttac cactttcctg caaatttcca tccttaatat
     7561 gttagactgt tcatatagat acattgtgtt tacaacaagg aaaaaatgcc accatgtgct
     7621 cagaactttt ttgacaggta ttttgagaag agttgtggaa cattctggta atttgtagag
     7681 atctgttggc atctctgctt cacaaactgg aaaaaatcat ttgtaagtct tgctaattac
     7741 ttttcttgga gaagaaaaaa aatgctacag ttgcaaacaa atgtatagtt ttcaaaaaga
     7801 agcaactttt ttgctcccca gtttattctt agtttccagc ccacgccttg cgatagcgat
     7861 aggcatagtg atggcctcaa ttctttctct cttgcatcca taccttttgc tgtgatagca
     7921 gtgatggcct cagttctttc cctctcttgc atccgtacct tttgctgtgt gactttgcag
     7981 ctcctctcat taaagaggca gagccccctc tcccacccat aggagcaggt tttgagagta
     8041 acagaatgaa gtgaaaatga cactgtgcca gttctaagac cagccctcaa aggttcatgt
     8101 gtttctgctt gctttcactg tatttgaaat gttgctgtga gaaagacatc tctgaaacag
     8161 ctgaatggtc ctaagaaaag gatgagagat gcagggagca gagctcccaa ctgaggccag
     8221 cctagatcac ctaagagcca ggcccccagt ttactctgat gtgtaagcaa taaatgctta
     8281 ccccagcaat accaccaagg tttgtggttg gtttatatac agcattaatg tggcaatagg
     8341 tgcaatacac cctgttaaac aaaccataca catatgactc taaccctaat cataaattga
     8401 ttcagtctgt tcagttccac aacgctgttt cctccagaat ctcacagatg acttactaaa
     8461 tccaacacaa atacacctca gactttctgt ctagctccca accagttaaa agcaattcta
     8521 aatatttttt ttcttagtcg tagtgcaaaa gtatattctc tccctttctc tatagttttc
     8581 tctcattttg tcttcagacc tagaagcatg agagcccagc tgtcaaagtc atctagaccc
     8641 ccttcagaag gtcattaaat ttgtctattt cacaggattg caagataaaa tacagaatgc
     8701 ccagttaaat ttgaacttcg gataaacaac aaattttttt ttagtataag catatcccat
     8761 acaatatttg ggatatactt atatttttat attgtttatc tgacgttcaa gctaactagg
     8821 catcctgtat ttttcttagc taaatctggc aactgtgcta tttcattgaa aacctgaaag
     8881 tgtacaaaga aggaagaagc agaatctgcc atatgagtaa tagaagtgag caggcccagg
     8941 actccctaag tcaagaaacc aagaggcgtc attacggaaa agagtaactc accctgtgtg
     9001 ctccttggta gttctccctc agcgatgccc ccatgttatg aatggggaaa agttcactga
     9061 agggttcata gtgaagaaac tttttggatg atttctgttg gtgggttttg gataccttca
     9121 agggatcaga aaataatata cttaggaaat tttggtaatg tcatcattac tctctacatt
     9181 attattatga cggttacaat tgttaaatct aggtggtggg tatgtgggtt atattgtaca
     9241 tgatttttaa cttgtctgca tgtttgaaat tataataaag tcaataaata aattattgag
     9301 acactcctg
//
