LOCUS       NM_015198               5301 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cordon-bleu WH2 repeat protein (COBL), transcript
            variant 2, mRNA.
ACCESSION   NM_015198
VERSION     NM_015198.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5301)
  AUTHORS   Abdul Majeed,S., Dunzendorfer,H., Weiner,J., Heiker,J.T., Kiess,W.,
            Korner,A. and Landgraf,K.
  TITLE     COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue
            Development Associated with Obesity-Related Metabolic Dysfunction
            in Children
  JOURNAL   Int J Mol Sci 24 (4), 3085 (2023)
   PUBMED   36834493
  REMARK    GeneRIF: COBL, MKX and MYOC Are Potential Regulators of Brown
            Adipose Tissue Development Associated with Obesity-Related
            Metabolic Dysfunction in Children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5301)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5301)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5301)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5301)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5301)
  AUTHORS   Husson,C., Renault,L., Didry,D., Pantaloni,D. and Carlier,M.F.
  TITLE     Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin
            filament assembly
  JOURNAL   Mol Cell 43 (3), 464-477 (2011)
   PUBMED   21816349
  REMARK    GeneRIF: Cordon-Bleu works as a dynamizer of actin assembly by
            combining many properties of profilin with weak filament nucleating
            and powerful filament severing activities and sequestration of
            ADP-actin, which generate oscillatory polymerization kinetics.
REFERENCE   7  (bases 1 to 5301)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5301)
  AUTHORS   de Krom,M., Staal,W.G., Ophoff,R.A., Hendriks,J., Buitelaar,J.,
            Franke,B., de Jonge,M.V., Bolton,P., Collier,D., Curran,S., van
            Engeland,H. and van Ree,J.M.
  TITLE     A common variant in DRD3 receptor is associated with autism
            spectrum disorder
  JOURNAL   Biol Psychiatry 65 (7), 625-630 (2009)
   PUBMED   19058789
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5301)
  AUTHORS   Carroll,E.A., Gerrelli,D., Gasca,S., Berg,E., Beier,D.R., Copp,A.J.
            and Klingensmith,J.
  TITLE     Cordon-bleu is a conserved gene involved in neural tube formation
  JOURNAL   Dev Biol 262 (1), 16-31 (2003)
   PUBMED   14512015
REFERENCE   10 (bases 1 to 5301)
  AUTHORS   Gasca,S., Hill,D.P., Klingensmith,J. and Rossant,J.
  TITLE     Characterization of a gene trap insertion into a novel gene,
            cordon-bleu, expressed in axial structures of the gastrulating
            mouse embryo
  JOURNAL   Dev Genet 17 (2), 141-154 (1995)
   PUBMED   7586755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC111496.1, AB014533.1,
            DA245843.1, BC045771.1 and AC004414.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015198.4.
            
            Summary: This gene encodes a protein that contains WH2 domains
            (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that
            interact with actin. The encoded actin regulator protein is
            required for growth and assembly of brush border microvilli that
            play a role in maintaining intestinal homeostasis. A similar
            protein in mouse functions in midbrain neural tube closure. A
            pseudogene of this gene is located on chromosome X. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, and uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (b) is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150263.1, AB014533.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265136.12/ ENSP00000265136.7
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC111496.1         10-19
            11-388              AB014533.1         1-378
            389-713             DA245843.1         265-589
            714-4469            AB014533.1         704-4459
            4470-4888           BC045771.1         3950-4368
            4889-4889           AC004414.1         56542-56542         c
            4890-5301           BC045771.1         4370-4781
FEATURES             Location/Qualifiers
     source          1..5301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.1"
     gene            1..5301
                     /gene="COBL"
                     /note="cordon-bleu WH2 repeat protein"
                     /db_xref="GeneID:23242"
                     /db_xref="HGNC:HGNC:22199"
                     /db_xref="MIM:610317"
     exon            1..217
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3962
                     /gene="COBL"
                     /note="isoform b is encoded by transcript variant 2;
                     protein cordon-bleu"
                     /codon_start=1
                     /product="protein cordon-bleu isoform b"
                     /protein_id="NP_056013.2"
                     /db_xref="CCDS:CCDS34637.1"
                     /db_xref="GeneID:23242"
                     /db_xref="HGNC:HGNC:22199"
                     /db_xref="MIM:610317"
                     /translation="MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGA
                     LGSQQNLVRMKEALRASTMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSH
                     HALEIRSSETQQPLSFKPNTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVN
                     YLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGI
                     KELYAWDNRRETFRKSSLGNDETDKEKKKFLGFFKVNKRSNSKGCLTTPNSPSMHSRS
                     LTLGPSLSLGSISGVSVKSEMKKRRAPPPPGSGPPVQDKASEKVSLGSQIDLQKKKRR
                     APAPPPPQPPPPSPLIPNRTEDKEENRKSTMVSLPLGSGSHCSPDGAPQVLSEAEETV
                     SVGSCFASEDTTEDSGVMSSPSDIVSLDSQQDSMKYKDKWATDQEDCSDQDLAGTPDL
                     GPQKSPLWEKNGSENSHLRTEKAVTASNDEEDLLIAGEFRKTLAELDEDLEEMEDSYE
                     TDTSSLTSSIHGASNHCPQDAMIPHGDTDAIPVTFIGEVSDDPVDSGLFSNRNNNAGS
                     FDSEGVASRRDSLAPLQAEHSQPHEKAREEVPALHPASHDVGKGIRVALSNISKDGNL
                     METAPRVTSFASNLHTDNLNAKVKDKVYGCADGERTQATERVNSQPVNEKDSNDKNAA
                     LAPTSWHQRGQNPGKSYRLKHGLTTYKIIPPKSEMRCYDRDVSLSTGAIKIDELGNLV
                     SPHATGIRIISLSSSVPEAESQPIGKVREFWRCNSVEKHLGRPSESSARGPPSTPVPT
                     QTQNPESRLQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMGMGHVRVPAAHTTEVTF
                     LKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHGYAEKGYAGKAPVLAAPPVTVKDDR
                     TSSPHSETQGWKDGAQWPCVTPPNNHGEDLAVGAPPRGEVIGPHRKLSTQDRPAAIHR
                     SSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEASSASEPRRAPDGTDPPPPHTSDTQ
                     ACSRELVNGSVRAPGHGEPSHPPGGSGTESHILLEREEKPSVFSTDGNETDSIWPPSI
                     FGPKKKFKPVVQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAEHTGEGRPAKLSYTEA
                     EGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQGSESPLLEDLGLLSPP
                     AIPPPPPPPSQALSAPRTASRFSTGTLSNTADARQALMDAIRSGTGAARLRKVPLLV"
     exon            218..421
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            422..632
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            633..861
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            862..959
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1133
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1272
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1582
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1680
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..3560
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3680
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3944
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..5301
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBL"
                     /note="hexamer: AATAAA"
     polyA_site      5113
                     /gene="COBL"
                     /note="major polyA site"
     regulatory      5280..5285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBL"
                     /note="hexamer: AATAAA"
     polyA_site      5301
                     /gene="COBL"
                     /note="major polyA site"
ORIGIN      
        1 agagacgatt ccagcccctt ccgtccgccg cgctccgccg ctgtcctccg ccggcccgcg
       61 tgggaggacg atgggtcagc gcggaaaaag tgaatgaggg cggcagcggt ggcggcggta
      121 gccagcgcct gactcggcgg gcccggagca ccgcccgcgt cccggccccc ggcaccatgg
      181 acgcgccgcg cgcctcggcg gccaagcccc cgaccgggag gaagatgaag gctcgtgctc
      241 ccccacctcc tggaaaggct gccactctgc atgtgcacag tgaccagaag cccccccacg
      301 atggggccct cgggtcgcag cagaacttgg ttcgcatgaa ggaggcgctg agggccagca
      361 ccatggacgt caccgtggtc ctgcctagtg ggctggagaa gaggagcgtg ctcaatggga
      421 gccatgcgat gatggaccta ctggttgaac tttgccttca gaaccacctg aatccatccc
      481 accatgccct tgaaattcgg tcttcagaaa cccaacaacc tttgagtttt aagccaaata
      541 ctttgattgg gaccctgaat gtgcatactg tgtttctgaa agaaaaagtt cctgaagaga
      601 aggttaagcc tggtccccct aaggtgcctg agaaatctgt gcgtttggtc gtgaattacc
      661 tgcggacaca aaaagctgtt gtgcgtgtga gccctgaggt tcctctccag aatattctcc
      721 cagtcatttg tgcaaagtgt gaggtcagcc cagagcacgt ggttctcctc agggacaaca
      781 ttgccggaga ggagctggag ctgtccaagt ccctgaacga gctcgggata aaggagctct
      841 acgcgtggga caacagaaga gaaaccttta ggaaatcatc acttggcaat gatgagacag
      901 ataaagagaa gaaaaaattt ctgggatttt tcaaagttaa taaaagaagc aatagtaagg
      961 gctgtttaac gacccccaac tccccatcca tgcactcacg ttctcttacg ctgggtccat
     1021 ccctctcgct gggcagcatc tcaggggtgt ccgtgaagtc ggagatgaag aagcgccgag
     1081 cccctcctcc tccaggttca gggccacctg tgcaagacaa ggcatcggaa aaggtatctc
     1141 ttgggtcaca gattgattta cagaagaaga agcggcgagc gccagctccc cctccaccac
     1201 agccaccacc accgagtccc ctgatcccca accgcactga ggataaggag gagaacagga
     1261 agagcacgat ggtaagcctg cccctggggt ctggcagcca ctgcagcccg gatggagccc
     1321 cgcaggtgct gtcagaggcg gaggagaccg tgtcagttgg cagctgtttt gcgtcggagg
     1381 acacgaccga ggactcagga gtgatgagtt ccccctcaga catcgtctct ctggactcgc
     1441 agcaggacag catgaaatac aaagacaagt gggccacaga ccaggaagac tgcagtgacc
     1501 aggacctcgc tggaacccca gacctgggtc cccagaagag ccccttgtgg gagaagaatg
     1561 gctctgagaa ctcacatctg agaactgaaa aagctgtcac agcctcaaat gatgaagaag
     1621 acctattaat tgctggagag ttccgtaaaa cccttgcaga acttgatgaa gacctggaag
     1681 aaatggaaga cagctatgaa acagacacca gctccctcac cagctccatc catggtgcat
     1741 ccaaccactg cccacaggat gccatgatcc ctcacggcga cacagatgca atcccagtaa
     1801 cattcatagg ggaagtttca gatgatcctg tggattcggg gttgttttcc aatagaaaca
     1861 acaatgctgg gtctttcgac tcggagggtg ttgccagcag gagagactcc ctggcgccac
     1921 ttcaagctga gcacagccag ccccatgaaa aggcaaggga ggaagtacct gccctgcacc
     1981 ccgcttccca tgacgtcgga aaaggaatcc gtgtggcctt atctaacatc tctaaagatg
     2041 ggaatctaat ggaaacggcg cccagggtga cttcttttgc ttcgaatctt cacacagaca
     2101 acctaaatgc aaaagtgaaa gacaaagtgt atggctgtgc tgacggggag aggactcaag
     2161 ccacagagag agtgaattcc caaccggtga atgaaaagga cagcaacgat aaaaacgctg
     2221 ccttggcacc aacatcatgg caccaacgag gccaaaaccc agggaaaagc tacagactta
     2281 agcacggcct cacaacgtat aaaatcattc ctccaaagtc agagatgcga tgttacgaca
     2341 gagatgtgtc cctctccacc ggagccatta agattgacga gctggggaac ttggtgagtc
     2401 ctcacgccac cggcatcagg atcatttccc tgtcttcgtc tgtgcctgaa gcagaatctc
     2461 agcccattgg gaaagtcaga gagttctgga ggtgcaactc tgtggaaaaa cacctgggcc
     2521 gaccctcaga gagctctgcc aggggacccc cctccacccc tgtgcccacg cagacgcaga
     2581 atccagagag cagactccaa gcagacccca agccaatatc gccccagcag aagtctgccc
     2641 accatgaggg ccggaacccc ctaggggagg ggagaaacca gccccccacc atgggcatgg
     2701 gtcacgtgag ggtgccagca gctcacacca cagaagtcac atttctcaag cctcagagaa
     2761 gaacgtccag ccagtatgtg gcctctgcca ttgccaagcg cataggagcc ccaaaagtcc
     2821 atgctgatgt ggtgaggcca cacggttatg ccgagaaggg ttatgcaggc aaggcgccag
     2881 tgctggctgc accacctgtc actgtgaaag atgacaggac atccagccca cactcagaga
     2941 cacaaggatg gaaggatggt gcccagtggc cctgtgtcac tcctcccaac aaccacgggg
     3001 aagatttggc agtgggagcc cctcctaggg gggaggtcat tggcccacac aggaagttgt
     3061 ctactcagga cagacctgct gctatccaca gaagctcctg tttctcactg gttcagtctt
     3121 cccagaggga tcgtgtttct gtgggacaga gctgtggttt cagtggaaag caaagcacaa
     3181 gtagccagga ggccagctca gcatctgagc ccagacgcgc acctgatggt acagacccac
     3241 cccctccaca cacatctgac actcaggcct gcagcaggga gctggtcaat ggctctgtgc
     3301 gcgccccagg ccacggcgag ccttcccacc ctccaggagg gtctggcaca gaaagccaca
     3361 ttctcctaga aagagaggaa aagcccagtg tgttctctac agatggaaat gaaacagaca
     3421 gtatttggcc acccagcatt tttgggccga agaaaaaatt caaacctgtt gtccagagac
     3481 cagtcccaaa agacacatcc ctgcactctg ccctgatgga agccatccac tctgcgggag
     3541 ggaaggacag actacgcaag acggcagaac acaccgggga gggcaggcca gcgaaactgt
     3601 cctacacgga ggcagagggc gaacgatctg cactgctggc agctatccgc gggcacagcg
     3661 gcacctgcag cctgaggaag gtggcatcct ctgcttctga ggagctccag agcttccgag
     3721 atgccgcact ctctgctcag ggctcggaaa gtcctctgct agaagacctt ggtcttctgt
     3781 ccccaccagc cattccccca ccaccccctc caccctccca ggctctctct gcaccaagga
     3841 cggcctccag gttcagcacg ggcaccctca gcaacaccgc agacgcaagg caagccttga
     3901 tggacgccat ccgctccggc acaggggctg cgagactgag aaaggtgccc ttgctcgtgt
     3961 gaatgaacag aggccagaga attgcagaaa cccacctgta atatgcccac aggcgtcact
     4021 caaggagtct gcatagccag gaacatcaag ttttggtgtt actttcttgt ctacaggcca
     4081 aatgcgcaca gttgattttc ggtgtgttcc tgtataacgg cttgaaagga aaggagaaga
     4141 tgctgtgtcg ctgcgcagct cgtgtgccaa ggaaatgtgt tttgcctctg aatatcttaa
     4201 gttgctaata aacgattctt gttggcaggt taatgggact ataaatgctg gagcccagca
     4261 ctcacactta attatattta tgggcaaagt aaaaagaatc atgccttaga ctgattttgg
     4321 acctttgaga cttttaccac atacagatgg atgaaactac ttactgattt aagatctttt
     4381 gaattttaga aaaaacatat gaatcagatg gaacaatctg aatgtgatat gctccatgat
     4441 gctgtgtgtt ttggtagtaa gaaaaaaaaa ttgggaggct tttcaaaggt ggctttgtta
     4501 ggtagtaaaa ctgctggatt cttcttcctc aaatatttgg ggctaacact tcacagaggg
     4561 tcacagtcca tgatctgacc aactaagctt ttaaaaatca actattacca cccagaaaac
     4621 agtcctacgt gatcatgtgg ccagggcatg cccgagtcct gcaagggtgg cgggtggctg
     4681 aggtcacacc accactggag tggatgggca gtgccccaca tggacagcca ttccccaggc
     4741 tatgaagtga cataggcctc ccccacggtg cctgtgtacg gagcctgatg acttcactgg
     4801 gagccttctg gaatcctgca gagggtcaag gagcagggat gttggatgcc cacctgtcaa
     4861 gagttcagat caaagttgcg ctgagagcat cacaattttg gttcagcctt gacgcgtttg
     4921 tccaacagct cattggctcc ctttgtatga tatcgtggtc ttctcacatg gtgcccagtc
     4981 accaatattt ataatgaggt ctaactacag cagtagtttt tcatatatat ctctaaaaca
     5041 ttttgttata ttgaaaaaag taatagaaat caagatgtgt tgatgaaata aaatgtgtat
     5101 ctgagtgaga aaacaagtat ggtgaggtca ctttaatgtt tcacagcgat ctcagatcta
     5161 ggcctcaggt agaatggaag ctgttctgca ttcactgatt aacgttgcta aactcttggt
     5221 gaggcacgag ctaccagcca attgctcttc atcacagcta tctgtctttt agtgccacaa
     5281 ataaaagaaa atcaaatctt a
//
