LOCUS       NM_001410881            5547 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens cordon-bleu WH2 repeat protein (COBL), transcript
            variant 8, mRNA.
ACCESSION   NM_001410881 XM_011515235
VERSION     NM_001410881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5547)
  AUTHORS   Abdul Majeed,S., Dunzendorfer,H., Weiner,J., Heiker,J.T., Kiess,W.,
            Korner,A. and Landgraf,K.
  TITLE     COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue
            Development Associated with Obesity-Related Metabolic Dysfunction
            in Children
  JOURNAL   Int J Mol Sci 24 (4), 3085 (2023)
   PUBMED   36834493
  REMARK    GeneRIF: COBL, MKX and MYOC Are Potential Regulators of Brown
            Adipose Tissue Development Associated with Obesity-Related
            Metabolic Dysfunction in Children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5547)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5547)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5547)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5547)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5547)
  AUTHORS   Husson,C., Renault,L., Didry,D., Pantaloni,D. and Carlier,M.F.
  TITLE     Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin
            filament assembly
  JOURNAL   Mol Cell 43 (3), 464-477 (2011)
   PUBMED   21816349
  REMARK    GeneRIF: Cordon-Bleu works as a dynamizer of actin assembly by
            combining many properties of profilin with weak filament nucleating
            and powerful filament severing activities and sequestration of
            ADP-actin, which generate oscillatory polymerization kinetics.
REFERENCE   7  (bases 1 to 5547)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5547)
  AUTHORS   de Krom,M., Staal,W.G., Ophoff,R.A., Hendriks,J., Buitelaar,J.,
            Franke,B., de Jonge,M.V., Bolton,P., Collier,D., Curran,S., van
            Engeland,H. and van Ree,J.M.
  TITLE     A common variant in DRD3 receptor is associated with autism
            spectrum disorder
  JOURNAL   Biol Psychiatry 65 (7), 625-630 (2009)
   PUBMED   19058789
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5547)
  AUTHORS   Carroll,E.A., Gerrelli,D., Gasca,S., Berg,E., Beier,D.R., Copp,A.J.
            and Klingensmith,J.
  TITLE     Cordon-bleu is a conserved gene involved in neural tube formation
  JOURNAL   Dev Biol 262 (1), 16-31 (2003)
   PUBMED   14512015
REFERENCE   10 (bases 1 to 5547)
  AUTHORS   Gasca,S., Hill,D.P., Klingensmith,J. and Rossant,J.
  TITLE     Characterization of a gene trap insertion into a novel gene,
            cordon-bleu, expressed in axial structures of the gastrulating
            mouse embryo
  JOURNAL   Dev Genet 17 (2), 141-154 (1995)
   PUBMED   7586755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005535.2, AC012372.4 and
            AC004414.1.
            
            On Aug 17, 2022 this sequence version replaced XM_011515235.1.
            
            Summary: This gene encodes a protein that contains WH2 domains
            (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that
            interact with actin. The encoded actin regulator protein is
            required for growth and assembly of brush border microvilli that
            play a role in maintaining intestinal homeostasis. A similar
            protein in mouse functions in midbrain neural tube closure. A
            pseudogene of this gene is located on chromosome X. [provided by
            RefSeq, Oct 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3195203.1,
                                           SRR14038193.2168128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC005535.2         150293-150509       c
            218-421             AC005535.2         53441-53644         c
            422-632             AC005535.2         27079-27289         c
            633-861             AC005535.2         24550-24778         c
            862-959             AC005535.2         17802-17899         c
            960-1034            AC005535.2         6156-6230           c
            1035-1208           AC012372.4         61231-61404         c
            1209-1347           AC012372.4         10239-10377         c
            1348-1518           AC012372.4         8131-8301           c
            1519-1828           AC004414.1         83301-83610         c
            1829-1926           AC004414.1         70730-70827         c
            1927-3806           AC004414.1         67630-69509         c
            3807-3926           AC004414.1         66464-66583         c
            3927-4190           AC004414.1         65027-65290         c
            4191-5547           AC004414.1         56130-57486         c
FEATURES             Location/Qualifiers
     source          1..5547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.1"
     gene            1..5547
                     /gene="COBL"
                     /note="cordon-bleu WH2 repeat protein"
                     /db_xref="GeneID:23242"
                     /db_xref="HGNC:HGNC:22199"
                     /db_xref="MIM:610317"
     exon            1..217
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..4208
                     /gene="COBL"
                     /note="isoform h is encoded by transcript variant 8;
                     protein cordon-bleu"
                     /codon_start=1
                     /product="protein cordon-bleu isoform h"
                     /protein_id="NP_001397810.1"
                     /db_xref="CCDS:CCDS94104.1"
                     /db_xref="GeneID:23242"
                     /db_xref="HGNC:HGNC:22199"
                     /db_xref="MIM:610317"
                     /translation="MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGA
                     LGSQQNLVRMKEALRASTMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSH
                     HALEIRSSETQQPLSFKPNTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVN
                     YLRTQKAVVRVSPEVPLQNILPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGI
                     KELYAWDNRRETFRKSSLGNDETDKEKKKFLGFFKVNKRSNSKAEQLVLSGADSDEDT
                     SRAAPGRGLNGCLTTPNSPSMHSRSLTLGPSLSLGSISGVSVKSEMKKRRAPPPPGSG
                     PPVQDKASEKVSLGSQIDLQKKKRRAPAPPPPQPPPPSPLIPNRTEDKEENRKSTMGG
                     GRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVVEPLSFPGEGAGSEASDPIPKLSL
                     PLGSGSHCSPDGAPQVLSEAEETVSVGSCFASEDTTEDSGVMSSPSDIVSLDSQQDSM
                     KYKDKWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLRTEKAVTASNDEEDLL
                     IAGEFRKTLAELDEDLEEMEDSYETDTSSLTSSIHGASNHCPQDAMIPHGDTDAIPVT
                     FIGEVSDDPVDSGLFSNRNNNAGSFDSEGVASRRDSLAPLQAEHSQPHEKAREEVPAL
                     HPASHDVGKGIRVALSNISKDGNLMETAPRVTSFASNLHTDNLNAKVKDKVYGCADGE
                     RTQATERVNSQPVNEKDSNDKNAALAPTSWHQRGQNPGKSYRLKHGLTTYKIIPPKSE
                     MRCYDRDVSLSTGAIKIDELGNLVSPHATGIRIISLSSSVPEAESQPIGKVREFWRCN
                     SVEKHLGRPSESSARGPPSTPVPTQTQNPESRLQADPKPISPQQKSAHHEGRNPLGEG
                     RNQPPTMGMGHVRVPAAHTTEVTFLKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHG
                     YAEKGYAGKAPVLAAPPVTVKDDRTSSPHSETQGWKDGAQWPCVTPPNNHGEDLAVGA
                     PPRGEVIGPHRKLSTQDRPAAIHRSSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEA
                     SSASEPRRAPDGTDPPPPHTSDTQACSRELVNGSVRAPGHGEPSHPPGGSGTESHILL
                     EREEKPSVFSTDGNETDSIWPPSIFGPKKKFKPVVQRPVPKDTSLHSALMEAIHSAGG
                     KDRLRKTAEHTGEGRPAKLSYTEAEGERSALLAAIRGHSGTCSLRKVASSASEELQSF
                     RDAALSAQGSESPLLEDLGLLSPPAIPPPPPPPSQALSAPRTASRFSTGTLSNTADAR
                     QALMDAIRSGTGAARLRKVPLLV"
     exon            218..421
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            422..632
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            633..861
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            862..959
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1034
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1208
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1347
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1518
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1828
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1926
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..3806
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3926
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4190
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..5547
                     /gene="COBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5333..5338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBL"
                     /note="hexamer: AATAAA"
     polyA_site      5359
                     /gene="COBL"
                     /note="major polyA site"
     regulatory      5526..5531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COBL"
                     /note="hexamer: AATAAA"
     polyA_site      5547
                     /gene="COBL"
                     /note="major polyA site"
ORIGIN      
        1 agagacgatt ccagcccctt ccgtccgccg cgctccgccg ctgtcctccg ccggcccgcg
       61 tgggaggacg atgggtcagc gcggaaaaag tgaatgaggg cggcagcggt ggcggcggta
      121 gccagcgcct gactcggcgg gcccggagca ccgcccgcgt cccggccccc ggcaccatgg
      181 acgcgccgcg cgcctcggcg gccaagcccc cgaccgggag gaagatgaag gctcgtgctc
      241 ccccacctcc tggaaaggct gccactctgc atgtgcacag tgaccagaag cccccccacg
      301 atggggccct cgggtcgcag cagaacttgg ttcgcatgaa ggaggcgctg agggccagca
      361 ccatggacgt caccgtggtc ctgcctagtg ggctggagaa gaggagcgtg ctcaatggga
      421 gccatgcgat gatggaccta ctggttgaac tttgccttca gaaccacctg aatccatccc
      481 accatgccct tgaaattcgg tcttcagaaa cccaacaacc tttgagtttt aagccaaata
      541 ctttgattgg gaccctgaat gtgcatactg tgtttctgaa agaaaaagtt cctgaagaga
      601 aggttaagcc tggtccccct aaggtgcctg agaaatctgt gcgtttggtc gtgaattacc
      661 tgcggacaca aaaagctgtt gtgcgtgtga gccctgaggt tcctctccag aatattctcc
      721 cagtcatttg tgcaaagtgt gaggtcagcc cagagcacgt ggttctcctc agggacaaca
      781 ttgccggaga ggagctggag ctgtccaagt ccctgaacga gctcgggata aaggagctct
      841 acgcgtggga caacagaaga gaaaccttta ggaaatcatc acttggcaat gatgagacag
      901 ataaagagaa gaaaaaattt ctgggatttt tcaaagttaa taaaagaagc aatagtaagg
      961 ctgagcagct cgtgctgtcg ggtgcagaca gcgatgagga cacctccagg gctgccccag
     1021 gaaggggttt gaacggctgt ttaacgaccc ccaactcccc atccatgcac tcacgttctc
     1081 ttacgctggg tccatccctc tcgctgggca gcatctcagg ggtgtccgtg aagtcggaga
     1141 tgaagaagcg ccgagcccct cctcctccag gttcagggcc acctgtgcaa gacaaggcat
     1201 cggaaaaggt atctcttggg tcacagattg atttacagaa gaagaagcgg cgagcgccag
     1261 ctccccctcc accacagcca ccaccaccga gtcccctgat ccccaaccgc actgaggata
     1321 aggaggagaa caggaagagc acgatgggtg gtggacggca ggtgccacaa aagcctccca
     1381 gaggcactgc tcggggtcca ccccagttag tgcttccccc acccccgccc taccctcctc
     1441 ccgacacaga cgtggtggag cctctcagct ttcccgggga aggcgctggt tccgaggcct
     1501 cagacccgat acccaaacta agcctgcccc tggggtctgg cagccactgc agcccggatg
     1561 gagccccgca ggtgctgtca gaggcggagg agaccgtgtc agttggcagc tgttttgcgt
     1621 cggaggacac gaccgaggac tcaggagtga tgagttcccc ctcagacatc gtctctctgg
     1681 actcgcagca ggacagcatg aaatacaaag acaagtgggc cacagaccag gaagactgca
     1741 gtgaccagga cctcgctgga accccagacc tgggtcccca gaagagcccc ttgtgggaga
     1801 agaatggctc tgagaactca catctgagaa ctgaaaaagc tgtcacagcc tcaaatgatg
     1861 aagaagacct attaattgct ggagagttcc gtaaaaccct tgcagaactt gatgaagacc
     1921 tggaagaaat ggaagacagc tatgaaacag acaccagctc cctcaccagc tccatccatg
     1981 gtgcatccaa ccactgccca caggatgcca tgatccctca cggcgacaca gatgcaatcc
     2041 cagtaacatt cataggggaa gtttcagatg atcctgtgga ttcggggttg ttttccaata
     2101 gaaacaacaa tgctgggtct ttcgactcgg agggtgttgc cagcaggaga gactccctgg
     2161 cgccacttca agctgagcac agccagcccc atgaaaaggc aagggaggaa gtacctgccc
     2221 tgcaccccgc ttcccatgac gtcggaaaag gaatccgtgt ggccttatct aacatctcta
     2281 aagatgggaa tctaatggaa acggcgccca gggtgacttc ttttgcttcg aatcttcaca
     2341 cagacaacct aaatgcaaaa gtgaaagaca aagtgtatgg ctgtgctgac ggggagagga
     2401 ctcaagccac agagagagtg aattcccaac cggtgaatga aaaggacagc aacgataaaa
     2461 acgctgcctt ggcaccaaca tcatggcacc aacgaggcca aaacccaggg aaaagctaca
     2521 gacttaagca cggcctcaca acgtataaaa tcattcctcc aaagtcagag atgcgatgtt
     2581 acgacagaga tgtgtccctc tccaccggag ccattaagat tgacgagctg gggaacttgg
     2641 tgagtcctca cgccaccggc atcaggatca tttccctgtc ttcgtctgtg cctgaagcag
     2701 aatctcagcc cattgggaaa gtcagagagt tctggaggtg caactctgtg gaaaaacacc
     2761 tgggccgacc ctcagagagc tctgccaggg gacccccctc cacccctgtg cccacgcaga
     2821 cgcagaatcc agagagcaga ctccaagcag accccaagcc aatatcgccc cagcagaagt
     2881 ctgcccacca tgagggccgg aaccccctag gggaggggag aaaccagccc cccaccatgg
     2941 gcatgggtca cgtgagggtg ccagcagctc acaccacaga agtcacattt ctcaagcctc
     3001 agagaagaac gtccagccag tatgtggcct ctgccattgc caagcgcata ggagccccaa
     3061 aagtccatgc tgatgtggtg aggccacacg gttatgccga gaagggttat gcaggcaagg
     3121 cgccagtgct ggctgcacca cctgtcactg tgaaagatga caggacatcc agcccacact
     3181 cagagacaca aggatggaag gatggtgccc agtggccctg tgtcactcct cccaacaacc
     3241 acggggaaga tttggcagtg ggagcccctc ctagggggga ggtcattggc ccacacagga
     3301 agttgtctac tcaggacaga cctgctgcta tccacagaag ctcctgtttc tcactggttc
     3361 agtcttccca gagggatcgt gtttctgtgg gacagagctg tggtttcagt ggaaagcaaa
     3421 gcacaagtag ccaggaggcc agctcagcat ctgagcccag acgcgcacct gatggtacag
     3481 acccaccccc tccacacaca tctgacactc aggcctgcag cagggagctg gtcaatggct
     3541 ctgtgcgcgc cccaggccac ggcgagcctt cccaccctcc aggagggtct ggcacagaaa
     3601 gccacattct cctagaaaga gaggaaaagc ccagtgtgtt ctctacagat ggaaatgaaa
     3661 cagacagtat ttggccaccc agcatttttg ggccgaagaa aaaattcaaa cctgttgtcc
     3721 agagaccagt cccaaaagac acatccctgc actctgccct gatggaagcc atccactctg
     3781 cgggagggaa ggacagacta cgcaagacgg cagaacacac cggggagggc aggccagcga
     3841 aactgtccta cacggaggca gagggcgaac gatctgcact gctggcagct atccgcgggc
     3901 acagcggcac ctgcagcctg aggaaggtgg catcctctgc ttctgaggag ctccagagct
     3961 tccgagatgc cgcactctct gctcagggct cggaaagtcc tctgctagaa gaccttggtc
     4021 ttctgtcccc accagccatt cccccaccac cccctccacc ctcccaggct ctctctgcac
     4081 caaggacggc ctccaggttc agcacgggca ccctcagcaa caccgcagac gcaaggcaag
     4141 ccttgatgga cgccatccgc tccggcacag gggctgcgag actgagaaag gtgcccttgc
     4201 tcgtgtgaat gaacagaggc cagagaattg cagaaaccca cctgtaatat gcccacaggc
     4261 gtcactcaag gagtctgcat agccaggaac atcaagtttt ggtgttactt tcttgtctac
     4321 aggccaaatg cgcacagttg attttcggtg tgttcctgta taacggcttg aaaggaaagg
     4381 agaagatgct gtgtcgctgc gcagctcgtg tgccaaggaa atgtgttttg cctctgaata
     4441 tcttaagttg ctaataaacg attcttgttg gcaggttaat gggactataa atgctggagc
     4501 ccagcactca cacttaatta tatttatggg caaagtaaaa agaatcatgc cttagactga
     4561 ttttggacct ttgagacttt taccacatac agatggatga aactacttac tgatttaaga
     4621 tcttttgaat tttagaaaaa acatatgaat cagatggaac aatctgaatg tgatatgctc
     4681 catgatgctg tgtgttttgg tagtaagaaa aaaaaattgg gaggcttttc aaaggtggct
     4741 ttgttaggta gtaaaactgc tggattcttc ttcctcaaat atttggggct aacacttcac
     4801 agagggtcac agtccatgat ctgaccaact aagcttttaa aaatcaacta ttaccaccca
     4861 gaaaacagtc ctacgtgatc atgtggccag ggcatgcccg agtcctgcaa gggtggcggg
     4921 tggctgaggt cacaccacca ctggagtgga tgggcagtgc cccacatgga cagccattcc
     4981 ccaggctatg aagtgacata ggcctccccc acggtgcctg tgtacggagc ctgatgactt
     5041 cactgggagc cttctggaat cctgcagagg gtcaaggagc agggatgttg gatgcccacc
     5101 tgtcaagagt tcagatcaaa gttgcgctga gagcatcaca attttggttc agccttgacg
     5161 cgtttgtcca acagctcatt ggctcccttt gtatgatatc gtggtcttct cacatggtgc
     5221 ccagtcacca atatttataa tgaggtctaa ctacagcagt agtttttcat atatatctct
     5281 aaaacatttt gttatattga aaaaagtaat agaaatcaag atgtgttgat gaaataaaat
     5341 gtgtatctga gtgagaaaac aagtatggtg aggtcacttt aatgtttcac agcgatctca
     5401 gatctaggcc tcaggtagaa tggaagctgt tctgcattca ctgattaacg ttgctaaact
     5461 cttggtgagg cacgagctac cagccaattg ctcttcatca cagctatctg tcttttagtg
     5521 ccacaaataa aagaaaatca aatctta
//
