LOCUS       NM_016565                818 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase assembly factor 4 homolog (COA4),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016565
VERSION     NM_016565.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 818)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 818)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 818)
  AUTHORS   Fischer,M., Horn,S., Belkacemi,A., Kojer,K., Petrungaro,C.,
            Habich,M., Ali,M., Kuttner,V., Bien,M., Kauff,F., Dengjel,J.,
            Herrmann,J.M. and Riemer,J.
  TITLE     Protein import and oxidative folding in the mitochondrial
            intermembrane space of intact mammalian cells
  JOURNAL   Mol Biol Cell 24 (14), 2160-2170 (2013)
   PUBMED   23676665
REFERENCE   4  (bases 1 to 818)
  AUTHORS   Bestwick,M., Jeong,M.Y., Khalimonchuk,O., Kim,H. and Winge,D.R.
  TITLE     Analysis of Leigh syndrome mutations in the yeast SURF1 homolog
            reveals a new member of the cytochrome oxidase assembly factor
            family
  JOURNAL   Mol Cell Biol 30 (18), 4480-4491 (2010)
   PUBMED   20624914
REFERENCE   5  (bases 1 to 818)
  AUTHORS   Charpentier,A.H., Bednarek,A.K., Daniel,R.L., Hawkins,K.A.,
            Laflin,K.J., Gaddis,S., MacLeod,M.C. and Aldaz,C.M.
  TITLE     Effects of estrogen on global gene expression: identification of
            novel targets of estrogen action
  JOURNAL   Cancer Res 60 (21), 5977-5983 (2000)
   PUBMED   11085516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002770.3 and AK000434.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016565.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.464421.1,
                                           SRR5189667.154486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355693.5/ ENSP00000347919.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AP002770.3         129009-129009       c
            2-818               AK000434.1         1-817
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..818
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="cytochrome c oxidase assembly factor 4 homolog"
                     /db_xref="GeneID:51287"
                     /db_xref="HGNC:HGNC:24604"
                     /db_xref="MIM:608016"
     exon            1..90
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..818
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..370
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 8; E2-induced gene 2 protein;
                     coiled-coil-helix-coiled-coil-helix domain containing 8"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor 4 homolog,
                     mitochondrial"
                     /protein_id="NP_057649.2"
                     /db_xref="CCDS:CCDS8225.1"
                     /db_xref="GeneID:51287"
                     /db_xref="HGNC:HGNC:24604"
                     /db_xref="MIM:608016"
                     /translation="MSTSVPQGHTWTQRVKKDDEEEDPLDQLISRSGCAASHFAVQEC
                     MAQHQDWRQCQPQVQAFKDCMSEQQARRQEELQRRQEQAGAHH"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="hexamer: ATTAAA"
     polyA_site      719
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="major polyA site"
     regulatory      792..797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="hexamer: AATAAA"
     polyA_site      818
                     /gene="COA4"
                     /gene_synonym="CHCHD8; CMC3; E2IG2"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggatgt acagaggatc cccaaccgcc tgcgaaaccc aagccgccgc gtaggagcgt
       61 gcgttcgggc cctcttctcc cacctgttcg actccccatc cccaggatgt caacctcagt
      121 ccctcaaggc catacctgga cccaacgggt gaagaaagac gatgaggagg aggacccgct
      181 ggaccagctg atctcccgct ctggctgtgc tgcctcccac tttgcagtgc aggagtgcat
      241 ggcccagcac caggactggc ggcaatgcca gccacaggtg caggcgttca aggattgcat
      301 gagtgaacag caggcgaggc ggcaagagga gctgcagagg aggcaagaac aagccggtgc
      361 ccaccactga gaccccaaac cacctatccc cagtagatgg ccctgccaag accagcaccc
      421 agcaagatta tagaggaaga aatcctaaat gctggtgtgg gaggtctaaa acatggggag
      481 agtttttgga tctggagttg agagccatgg gtttggacat gactggcaca aacagctgtc
      541 atatgttcat ggtcagatgt catacattct cagctgtctt gttccaccag tatttaccag
      601 gaaaacaaag aatgtgttaa gggatgctcc cccaccccac atcttaagtc agtgtgccaa
      661 gtactgagat gattttaggg acattttatt ttaaattaaa tttacaatct aatggtaaat
      721 tgattaccta attagtgcct ttctctttca tcacttgttc tggatgtttc aatcagttta
      781 gtggaaggaa aaataaatgg ggaaactttt tattcaaa
//
