LOCUS       NM_018224                899 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cytochrome c oxidase assembly factor 1 (COA1),
            transcript variant 1, mRNA.
ACCESSION   NM_018224
VERSION     NM_018224.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 899)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 899)
  AUTHORS   Kim,S.K., Nguyen,C., Horton,B.H., Avins,A.L. and Abrams,G.D.
  TITLE     Association of COA1 with Patellar Tendonitis: A Genome-wide
            Association Analysis
  JOURNAL   Med Sci Sports Exerc 53 (11), 2419-2424 (2021)
   PUBMED   34081057
  REMARK    GeneRIF: Association of COA1 with Patellar Tendonitis: A
            Genome-wide Association Analysis.
REFERENCE   3  (bases 1 to 899)
  AUTHORS   Formosa,L.E., Muellner-Wong,L., Reljic,B., Sharpe,A.J.,
            Jackson,T.D., Beilharz,T.H., Stojanovski,D., Lazarou,M.,
            Stroud,D.A. and Ryan,M.T.
  TITLE     Dissecting the Roles of Mitochondrial Complex I Intermediate
            Assembly Complex Factors in the Biogenesis of Complex I
  JOURNAL   Cell Rep 31 (3), 107541 (2020)
   PUBMED   32320651
REFERENCE   4  (bases 1 to 899)
  AUTHORS   Wang,C., Richter-Dennerlein,R., Pacheu-Grau,D., Liu,F., Zhu,Y.,
            Dennerlein,S. and Rehling,P.
  TITLE     MITRAC15/COA1 promotes mitochondrial translation in a ND2
            ribosome-nascent chain complex
  JOURNAL   EMBO Rep 21 (1), e48833 (2020)
   PUBMED   31721420
  REMARK    GeneRIF: MITRAC15/COA1 promotes mitochondrial translation in a ND2
            ribosome-nascent chain complex.
REFERENCE   5  (bases 1 to 899)
  AUTHORS   Fellenberg,J., Sahr,H., Kunz,P., Zhao,Z., Liu,L., Tichy,D. and
            Herr,I.
  TITLE     Restoration of miR-127-3p and miR-376a-3p counteracts the
            neoplastic phenotype of giant cell tumor of bone derived stromal
            cells by targeting COA1, GLE1 and PDIA6
  JOURNAL   Cancer Lett 371 (1), 134-141 (2016)
   PUBMED   26655997
  REMARK    GeneRIF: Restoration of miR-127-3p and miR-376a-3p counteracts the
            neoplastic phenotype of giant cell tumor of bone derived stromal
            cells by targeting COA1, GLE1 and PDIA6.
REFERENCE   6  (bases 1 to 899)
  AUTHORS   Mick,D.U., Dennerlein,S., Wiese,H., Reinhold,R., Pacheu-Grau,D.,
            Lorenzi,I., Sasarman,F., Weraarpachai,W., Shoubridge,E.A.,
            Warscheid,B. and Rehling,P.
  TITLE     MITRAC links mitochondrial protein translocation to
            respiratory-chain assembly and translational regulation
  JOURNAL   Cell 151 (7), 1528-1541 (2012)
   PUBMED   23260140
REFERENCE   7  (bases 1 to 899)
  AUTHORS   Szklarczyk,R., Wanschers,B.F., Cuypers,T.D., Esseling,J.J.,
            Riemersma,M., van den Brand,M.A., Gloerich,J., Lasonder,E., van den
            Heuvel,L.P., Nijtmans,L.G. and Huynen,M.A.
  TITLE     Iterative orthology prediction uncovers new mitochondrial proteins
            and identifies C12orf62 as the human ortholog of COX14, a protein
            involved in the assembly of cytochrome c oxidase
  JOURNAL   Genome Biol 13 (2), R12 (2012)
   PUBMED   22356826
  REMARK    GeneRIF: Human ortholog of fungal COA1 (Cytochrome Oxidase Assembly
            1)
            GeneRIF: Encodes a mitochondrial protein
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005189.2.
            
            On Aug 13, 2020 this sequence version replaced NM_018224.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 3-6, 16-19, and 27-36 all encode the same isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL699782.1, BF184112.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223336.11/ ENSP00000223336.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC005189.2         68053-68147
            96-148              AC005189.2         148924-148976
            149-248             AC005189.2         149942-150041
            249-397             AC005189.2         152177-152325
            398-474             AC005189.2         156927-157003
            475-899             AC005189.2         157895-158319
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..899
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /note="cytochrome c oxidase assembly factor 1"
                     /db_xref="GeneID:55744"
                     /db_xref="HGNC:HGNC:21868"
                     /db_xref="MIM:614769"
     exon            1..95
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     exon            96..148
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..574
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /note="isoform a is encoded by transcript variant 1;
                     cytochrome c oxidase assembly protein 1 homolog;
                     mitochondrial translation regulation assembly intermediate
                     of cytochrome c oxidase protein of 15 kDa; cytochrome c
                     oxidase assembly factor 1 homolog"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor 1 homolog
                     isoform a"
                     /protein_id="NP_060694.2"
                     /db_xref="CCDS:CCDS5471.1"
                     /db_xref="GeneID:55744"
                     /db_xref="HGNC:HGNC:21868"
                     /db_xref="MIM:614769"
                     /translation="MMWQKYAGSRRSMPLGARILFHGVFYAGGFAIVYYLIQKFHSRA
                     LYYKLAVEQLQSHPEAQEALGPPLNIHYLKLIDRENFVDIVDAKLKIPVSGSKSEGLL
                     YVHSSRGGPFQRWHLDEVFLELKDGQQIPVFKLSGENGDEVKKE"
     exon            149..248
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     exon            249..397
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     exon            398..474
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     exon            475..899
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      878..883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /note="hexamer: AATAAA"
     polyA_site      899
                     /gene="COA1"
                     /gene_synonym="C7orf44; MITRAC15"
                     /note="major polyA site"
ORIGIN      
        1 gctggcgcgc aggaccgcgg gcatttaccc gtgctttccc aagcctggaa gaactcgtca
       61 tgctctttgt agcgtggtgc ttctgttgct cacaggacaa cttgcctttg atgattttca
      121 agagagttgt gctatgatgt ggcaaaagta tgcaggaagc aggcggtcaa tgcctctggg
      181 agcaaggatc cttttccacg gtgtgttcta tgccgggggc tttgccattg tgtattacct
      241 cattcaaaag tttcattcca gggctttata ttacaagttg gcagtggagc agctgcagag
      301 ccatcccgag gcacaggaag ctctgggccc tcctctcaac atccattatc tcaagctcat
      361 cgacagggaa aacttcgtgg acattgttga tgccaagttg aagattcctg tctctggatc
      421 caaatcagag ggccttctct acgtccactc atccagaggt ggcccctttc agaggtggca
      481 ccttgacgag gtctttttag agctcaagga tggtcagcag attcctgtgt tcaagctcag
      541 tggggaaaac ggtgatgaag tgaaaaagga gtagagacga cccagaagac ccagcttgct
      601 tctagtccat ccttccctca tctctaccat atggccactg gggtggtggc ccatctcagt
      661 gacagacact cctgcaaccc agttttccag ccaccagtgg gatgatggta tgtgccagca
      721 catggtaatt ttggtgtaat tctaacttgg gcacaacaaa tgctatttgt catttttaaa
      781 ctgaatccga aagaaactcc tattataaat ttaagataat gtaatgtatt tgaaagtgct
      841 ttgtataaaa aagcacatga taaaaggaat cagaattaat aaaatgtttg ttgatcttt
//
