LOCUS       NM_053051               3996 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens centrobin, centriole duplication and spindle assembly
            protein (CNTROB), transcript variant 1, mRNA.
ACCESSION   NM_053051
VERSION     NM_053051.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Rethi-Nagy,Z., Abraham,E., Sinka,R., Juhasz,S. and Lipinszki,Z.
  TITLE     Protein Phosphatase 4 Is Required for Centrobin Function in DNA
            Damage Repair
  JOURNAL   Cells 12 (18), 2219 (2023)
   PUBMED   37759442
  REMARK    GeneRIF: Protein Phosphatase 4 Is Required for Centrobin Function
            in DNA Damage Repair.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Ryu,N.M. and Kim,J.M.
  TITLE     Centrobin plays a role in the cellular response to DNA damage
  JOURNAL   Cell Cycle 18 (20), 2660-2671 (2019)
   PUBMED   31416397
  REMARK    GeneRIF: Centrobin plays a role in the cellular response to DNA
            damage.
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Ogungbenro,Y.A., Tena,T.C., Gaboriau,D., Lalor,P., Dockery,P.,
            Philipp,M. and Morrison,C.G.
  TITLE     Centrobin controls primary ciliogenesis in vertebrates
  JOURNAL   J Cell Biol 217 (4), 1205-1215 (2018)
   PUBMED   29440264
  REMARK    GeneRIF: Suggest centrobin functions as a positive regulator of
            vertebrate ciliogenesis.
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Jeong,Y., Lee,J., Kim,K., Yoo,J.C. and Rhee,K.
  TITLE     Characterization of NIP2/centrobin, a novel substrate of Nek2, and
            its potential role in microtubule stabilization
  JOURNAL   J Cell Sci 120 (Pt 12), 2106-2116 (2007)
   PUBMED   17535851
  REMARK    GeneRIF: Results report that NIP2, previously identified as
            centrobin, is a novel substrate of Nek2, and that NIP2 has a role
            in stabilizing the microtubule structure.
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Zou,C., Li,J., Bai,Y., Gunning,W.T., Wazer,D.E., Band,V. and Gao,Q.
  TITLE     Centrobin: a novel daughter centriole-associated protein that is
            required for centriole duplication
  JOURNAL   J Cell Biol 171 (3), 437-445 (2005)
   PUBMED   16275750
  REMARK    GeneRIF: Centrobin is a centriole-associated protein that
            asymmetrically localizes to the daughter centriole.
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104581.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_053051.4.
            
            Summary: This gene encodes a centrosomal protein that interacts
            with BRCA2, and is required for centriole duplication and
            cytokinesis. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY160226.1, BC021134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563694.6/ ENSP00000456335.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1144              AC104581.22        95443-96586
            1145-1229           AC104581.22        97375-97459
            1230-1311           AC104581.22        97702-97783
            1312-1468           AC104581.22        98226-98382
            1469-1585           AC104581.22        99603-99719
            1586-1702           AC104581.22        99938-100054
            1703-1801           AC104581.22        100401-100499
            1802-2038           AC104581.22        102750-102986
            2039-2185           AC104581.22        103333-103479
            2186-2319           AC104581.22        106628-106761
            2320-2445           AC104581.22        107360-107485
            2446-2608           AC104581.22        107713-107875
            2609-2867           AC104581.22        108965-109223
            2868-3019           AC104581.22        110808-110959
            3020-3083           AC104581.22        111153-111216
            3084-3254           AC104581.22        111394-111564
            3255-3387           AC104581.22        111724-111856
            3388-3460           AC104581.22        112322-112394
            3461-3996           AC104581.22        112622-113157
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3996
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="centrobin, centriole duplication and spindle
                     assembly protein"
                     /db_xref="GeneID:116840"
                     /db_xref="HGNC:HGNC:29616"
                     /db_xref="MIM:611425"
     exon            1..1144
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     CDS             875..3586
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="isoform alpha is encoded by transcript variant 1;
                     LYST-interacting protein LIP8; LYST-interacting protein 8;
                     centrosomal BRCA2-interacting protein; centrobin,
                     centrosomal BRCA2 interacting protein"
                     /codon_start=1
                     /product="centrobin isoform alpha"
                     /protein_id="NP_444279.2"
                     /db_xref="CCDS:CCDS11126.1"
                     /db_xref="GeneID:116840"
                     /db_xref="HGNC:HGNC:29616"
                     /db_xref="MIM:611425"
                     /translation="MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRL
                     SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESV
                     RGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQ
                     ALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQL
                     AVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQE
                     TVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEER
                     DAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQ
                     REAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE
                     LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA
                     EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ
                     LLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELP
                     GAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSALGAFHPDHRAER
                     PFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETVPQNNENPSVDLLPPKSGPLT
                     VPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSHSQGSGPSSGSPERGGDGL
                     TFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTDGRGDNVPRRNTDSRLG
                     EIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR"
     exon            1145..1229
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1311
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1468
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1585
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1702
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1801
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2038
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2185
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2319
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2445
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2608
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2867
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3019
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3083
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3254
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3387
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3460
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3996
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="hexamer: AATAAA"
     polyA_site      3654
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="major polyA site"
     regulatory      3685..3690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="hexamer: AATAGA"
     polyA_site      3720
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
                     /note="hexamer: AATAAT"
     polyA_site      3996
                     /gene="CNTROB"
                     /gene_synonym="LIP8; PP1221"
ORIGIN      
        1 acagtgggcg ggaggctgcc aacggttttg agcgtagggg gaggcgtgag agggggatct
       61 caggggagga ggtcaatcgc ttgcccccca ctttggcaaa ttggggactg aggactggaa
      121 gggtggagag taggcggaac caggtggtcg tcggggcaga ggatctcggg ctaggcttga
      181 gggcggcgtg cttcttaggg acgacttagg gcgtgactga gggttcacaa ggtttctttt
      241 ggggtggtcg ggagggagag attctaggga acaaggaagc tcgctatggc tttcttgcca
      301 ggaggggtcg aagggaaagt acaagggagc tggagctgac cctgggtaga acgggtgaag
      361 ggatggggga gcgtgaggtt ccgccctctc ttgagactgg aaccaattga gggactagta
      421 gggcaggggg acagaaattg ggctcctagt ggatttgggt ccgtttccgt tgggacgttt
      481 tgggtgtgag aacttaagag ctcagttgac cggggatagc ctgtgccgga gttgatctgc
      541 agcttccagc actcgtagtc gggaagagga gcttcagcag cgctgttgtc ccacagtagg
      601 tcttctgtcc gcacccgctc tgcgctgcac cctcttaacg ctgttcccag gagctgggga
      661 aagggatgct tttgcccact cccatggccc ctggaactgg tggaaacctt tcctctaacc
      721 agaaagcctc gatatcctta attcaccaag gatccttggc gtggagtctt cctcccttct
      781 cccaagtctt tctccgtgaa cttttcctcc tggactttgc taaagcagaa cctcccagct
      841 ctttgctgtc tccggttgtc tcttccctgt attcatggca acatcagctg acagccccag
      901 ttcacccctc ggggcggagg atctcctgag tgattcatca gaaccccctg ggctcaacca
      961 agtgtcgtct gaagtgacct cccagctcta tgcttctttg cgcctcagcc ggcaggcgga
     1021 ggccacggcc cgagcccagc tgtatttacc ctccacctcc ccgcctcatg aagggttaga
     1081 cggcttcgcc caagaattga gtcgaagctt gtcagtcgga ttggaaaaga acttgaagaa
     1141 aaaggatggt tctaagcata tctttgagat ggaaagtgtt cggggtcagc tccagaccat
     1201 gctccaaacc tcacgtgata cagcctatcg ggatcctctc attcctggcg ctggctcaga
     1261 gagacgggaa gaggactcct ttgacagtga tagcacagcc accttgctca acacccggcc
     1321 cctgcaagac ttgtctccat ctagctcagc ccaagccctg gaggagctgt ttccccgcta
     1381 caccagcctt cggccagggc ctccactcaa tcccccagat tttcaggggc tgagagatgc
     1441 attggattca gagcataccc gccgcaagca ttgtgagcgc catattcaga gcctgcagac
     1501 ccgagtgtta gagctacagc aacaattagc cgtggctgtg gctgccgacc gcaagaaaga
     1561 taccatgatt gaacaactgg acaagaccct ggcccgtgtg gtggagggct ggaaccggca
     1621 tgaggctgag cggacagagg ttctcagggg acttcaagag gaacaccagg cagcagagct
     1681 caccagaagc aagcagcagg agacagtaac ccgcctggaa caaagccttt ctgaggccat
     1741 ggaggccctg aatcgtgagc aggaaagtgc cagactgcag caacgggaaa gagagacact
     1801 ggaggaggaa aggcaagctc tgactctgag gttggaggca gaacagcagc ggtgctgtgt
     1861 cctgcaggaa gagcgggatg cagctcgggc tgggcaactg agtgagcatc gagagttgga
     1921 gactcttcgg gctgccctag aagaagaacg gcagacctgg gcccagcaag agcaccagct
     1981 taaggaacac taccaggcgc tgcaggagga gagccaggct cagctggaaa gggagaagga
     2041 gaagagccag agggaagccc aggccgcctg ggagacccag caccagttgg cattggtgca
     2101 gtctgaggtg cggcggctgg aaggagagct ggatacagct cggagagaga gagatgccct
     2161 gcagctggaa atgagcttgg tgcaggcccg gtatgaaagc cagcggatcc agctggagtc
     2221 ggagctggct gtgcagctgg agcagcgggt gacagagcgg ctggcgcagg ctcaggagag
     2281 cagcctacgg caagcagcct ccctcaggga acatcacagg aagcagctgc aggacctgag
     2341 tggacagcac cagcaggagc tggccagtca gctagctcag ttcaaggtgg aaatggcaga
     2401 acgagaggaa cggcaacagc aggtggctga ggactacgag ctcagactgg cccgggagca
     2461 agcgcgagtg tgcgaactgc agagtgggaa ccagcagctg gaggagcagc gggtggagct
     2521 ggtggaaaga ctgcaggcca tgctgcaggc ccactgggat gaggccaacc agctgctcag
     2581 caccactctc ccgccgccca accctccagc tcctcctgct ggaccctcca gccccgggcc
     2641 tcaggagccc gagaaggagg agaggagggt ctggactatg cctcccatgg ccgtggccct
     2701 gaagcctgta ttgcagcaga gccgggaagc aagggacgag ctacctggag cgcctcctgt
     2761 tctttgcagt tcctcctcag atcttagcct cctgttgggc ccctcttttc agagccagca
     2821 ttctttccag cccctggagc ccaaaccaga cctcacttca tccacagctg gggccttctc
     2881 tgcacttggg gccttccatc ccgatcatag ggcagaaagg ccattccctg aggaagatcc
     2941 tggacctgac ggggagggcc tcctaaagca agggctgccg cctgctcagc tggagggcct
     3001 caagaatttt ttgcaccagt tgctggagac agtgccccag aacaatgaga acccttctgt
     3061 cgacctgttg ccccctaagt ctggtcctct gactgtccca tcttgggagg aagcccctca
     3121 agtgccacgt attccaccgc ctgtccacaa aaccaaagtt cccttagcca tggcatccag
     3181 tcttttccgg gtccctgagc ctccctcctc ccattcacaa ggcagtggtc ccagcagtgg
     3241 ttccccagag agaggtggag atgggcttac attcccaagg cagctgatgg aggtgtctca
     3301 actgttgcga ctctaccagg ctcggggctg gggggctctg cctgctgagg atctcctgct
     3361 ctacctgaag aggctggaac acagcgggac tgatggccga ggggataatg tccccagaag
     3421 gaacacagac tcccgcttgg gtgagatccc ccggaaagag attccctccc aggctgtccc
     3481 tcgccgcctt gctacagccc ccaagactga aaaacctccc gcacggaaga aaagtgggca
     3541 ccctgccccg agtagcatga ggagccgggg gggagtctgg agatgagccc ccctaccctc
     3601 tctcctcttt gttctctcat tgttgttatt ttaataaatg ctcattagtc tgtatcagag
     3661 tctctggctc ataggaattt ggaaaataga ggttttgtag ggaatcactt cgtaaagaaa
     3721 ccacatttgg ttgagtactt tttttatatg ttacatgttt atatgtcatt tcctgtggga
     3781 aaagacatga atgctttgga agacggtcta tgacaagatt tggaaagttg gggcggctaa
     3841 gattcagtgg acaaagctaa aacctgcaga gcaatgaact ctgggtggta gtggaattat
     3901 gggtgattct tagtttttta atacgtttct gtattttcca aattttctaa aacaagtata
     3961 tgttacttta ataatcagaa cagacccaaa ctttaa
//
